PubMed:10381655 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":0,"end":9},"obj":"protein"},{"id":"T2","span":{"begin":30,"end":78},"obj":"protein"},{"id":"T3","span":{"begin":115,"end":124},"obj":"protein"},{"id":"T4","span":{"begin":198,"end":215},"obj":"cell_line"},{"id":"T5","span":{"begin":308,"end":317},"obj":"protein"},{"id":"T6","span":{"begin":336,"end":366},"obj":"protein"},{"id":"T7","span":{"begin":492,"end":502},"obj":"protein"},{"id":"T8","span":{"begin":504,"end":508},"obj":"protein"},{"id":"T9","span":{"begin":552,"end":561},"obj":"protein"},{"id":"T10","span":{"begin":610,"end":619},"obj":"RNA"},{"id":"T11","span":{"begin":694,"end":703},"obj":"protein"},{"id":"T12","span":{"begin":709,"end":728},"obj":"protein"},{"id":"T13","span":{"begin":772,"end":781},"obj":"protein"},{"id":"T14","span":{"begin":865,"end":874},"obj":"protein"},{"id":"T15","span":{"begin":935,"end":944},"obj":"protein"},{"id":"T16","span":{"begin":1012,"end":1021},"obj":"protein"},{"id":"T17","span":{"begin":1065,"end":1075},"obj":"cell_type"},{"id":"T18","span":{"begin":1122,"end":1147},"obj":"cell_type"}],"text":"NF-kappaB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type.\nRecently NF-kappaB has been shown to have both proapoptotic and antiapoptotic functions. In T cell hybridomas, both T cell activators and glucocorticoids induce apoptosis. Here we show that blockade of NF-kappaB activity, using a dominant negative IkappaBalpha, has opposite effects on these two apoptotic signals. Treatment with PMA plus ionomycin (P/I) results in the upregulation of Fas Ligand (FasL) and induction of apoptosis. Inhibition of NF-kappaB activity inhibits the P/I mediated induction of FasL mRNA and decreases the level of apoptosis in these cultures, thus establishing NF-kappaB as a proapoptotic factor in this context. Conversely, inhibition of NF-kappaB confers a tenfold increase in glucocorticoid mediated apoptosis, establishing that NF-kappaB also functions as an antiapoptotic factor. We conclude that NF-kappaB is a context-dependent apoptosis regulator. Our data suggests that NF-kappaB may function as an antiapoptotic factor in thymocytes while functioning as a proapoptotic factor in mature peripheral T cells."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":9},"obj":"NP"},{"id":"C2","span":{"begin":115,"end":124},"obj":"NP"},{"id":"C3","span":{"begin":217,"end":259},"obj":"NP"},{"id":"C4","span":{"begin":267,"end":276},"obj":"NP"},{"id":"C5","span":{"begin":308,"end":326},"obj":"NP"},{"id":"C6","span":{"begin":392,"end":419},"obj":"NP"},{"id":"C7","span":{"begin":527,"end":536},"obj":"NP"},{"id":"C8","span":{"begin":552,"end":570},"obj":"NP"},{"id":"C9","span":{"begin":647,"end":656},"obj":"NP"},{"id":"C10","span":{"begin":694,"end":703},"obj":"NP"},{"id":"C11","span":{"begin":707,"end":728},"obj":"NP"},{"id":"C12","span":{"begin":772,"end":781},"obj":"NP"},{"id":"C13","span":{"begin":865,"end":874},"obj":"NP"},{"id":"C14","span":{"begin":893,"end":916},"obj":"NP"},{"id":"C15","span":{"begin":935,"end":944},"obj":"NP"},{"id":"C16","span":{"begin":1012,"end":1021},"obj":"NP"},{"id":"C17","span":{"begin":1038,"end":1061},"obj":"NP"},{"id":"C18","span":{"begin":1097,"end":1118},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C6","obj":"C3"},{"id":"R3","pred":"coref-ident","subj":"C7","obj":"C4"},{"id":"R4","pred":"coref-ident","subj":"C8","obj":"C5"},{"id":"R5","pred":"coref-ident","subj":"C9","obj":"C7"},{"id":"R6","pred":"coref-ident","subj":"C10","obj":"C2"},{"id":"R7","pred":"coref-ident","subj":"C12","obj":"C10"},{"id":"R8","pred":"coref-ident","subj":"C13","obj":"C12"},{"id":"R9","pred":"coref-ident","subj":"C15","obj":"C13"},{"id":"R10","pred":"coref-ident","subj":"C16","obj":"C15"},{"id":"R11","pred":"coref-ident","subj":"C17","obj":"C14"},{"id":"R12","pred":"coref-ident","subj":"C18","obj":"C11"}],"text":"NF-kappaB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type.\nRecently NF-kappaB has been shown to have both proapoptotic and antiapoptotic functions. In T cell hybridomas, both T cell activators and glucocorticoids induce apoptosis. Here we show that blockade of NF-kappaB activity, using a dominant negative IkappaBalpha, has opposite effects on these two apoptotic signals. Treatment with PMA plus ionomycin (P/I) results in the upregulation of Fas Ligand (FasL) and induction of apoptosis. Inhibition of NF-kappaB activity inhibits the P/I mediated induction of FasL mRNA and decreases the level of apoptosis in these cultures, thus establishing NF-kappaB as a proapoptotic factor in this context. Conversely, inhibition of NF-kappaB confers a tenfold increase in glucocorticoid mediated apoptosis, establishing that NF-kappaB also functions as an antiapoptotic factor. We conclude that NF-kappaB is a context-dependent apoptosis regulator. Our data suggests that NF-kappaB may function as an antiapoptotic factor in thymocytes while functioning as a proapoptotic factor in mature peripheral T cells."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":105},"obj":"Sentence"},{"id":"S2","span":{"begin":106,"end":194},"obj":"Sentence"},{"id":"S3","span":{"begin":195,"end":277},"obj":"Sentence"},{"id":"S4","span":{"begin":278,"end":420},"obj":"Sentence"},{"id":"S5","span":{"begin":421,"end":537},"obj":"Sentence"},{"id":"S6","span":{"begin":538,"end":745},"obj":"Sentence"},{"id":"S7","span":{"begin":746,"end":917},"obj":"Sentence"},{"id":"S8","span":{"begin":918,"end":988},"obj":"Sentence"},{"id":"S9","span":{"begin":989,"end":1148},"obj":"Sentence"}],"text":"NF-kappaB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type.\nRecently NF-kappaB has been shown to have both proapoptotic and antiapoptotic functions. In T cell hybridomas, both T cell activators and glucocorticoids induce apoptosis. Here we show that blockade of NF-kappaB activity, using a dominant negative IkappaBalpha, has opposite effects on these two apoptotic signals. Treatment with PMA plus ionomycin (P/I) results in the upregulation of Fas Ligand (FasL) and induction of apoptosis. Inhibition of NF-kappaB activity inhibits the P/I mediated induction of FasL mRNA and decreases the level of apoptosis in these cultures, thus establishing NF-kappaB as a proapoptotic factor in this context. Conversely, inhibition of NF-kappaB confers a tenfold increase in glucocorticoid mediated apoptosis, establishing that NF-kappaB also functions as an antiapoptotic factor. We conclude that NF-kappaB is a context-dependent apoptosis regulator. Our data suggests that NF-kappaB may function as an antiapoptotic factor in thymocytes while functioning as a proapoptotic factor in mature peripheral T cells."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":9},"obj":"protein_complex"},{"id":"T2","span":{"begin":115,"end":124},"obj":"protein_complex"},{"id":"T3","span":{"begin":198,"end":215},"obj":"cell_line"},{"id":"T4","span":{"begin":222,"end":239},"obj":"other_name"},{"id":"T5","span":{"begin":244,"end":259},"obj":"lipid"},{"id":"T6","span":{"begin":267,"end":276},"obj":"other_name"},{"id":"T7","span":{"begin":308,"end":317},"obj":"protein_molecule"},{"id":"T8","span":{"begin":336,"end":366},"obj":"protein_molecule"},{"id":"T9","span":{"begin":402,"end":419},"obj":"other_name"},{"id":"T10","span":{"begin":436,"end":439},"obj":"other_organic_compound"},{"id":"T11","span":{"begin":445,"end":454},"obj":"other_organic_compound"},{"id":"T12","span":{"begin":456,"end":459},"obj":"other_organic_compound"},{"id":"T13","span":{"begin":492,"end":502},"obj":"protein_molecule"},{"id":"T14","span":{"begin":504,"end":508},"obj":"protein_molecule"},{"id":"T15","span":{"begin":527,"end":536},"obj":"other_name"},{"id":"T16","span":{"begin":552,"end":561},"obj":"protein_complex"},{"id":"T17","span":{"begin":584,"end":587},"obj":"other_organic_compound"},{"id":"T18","span":{"begin":610,"end":614},"obj":"protein_molecule"},{"id":"T19","span":{"begin":647,"end":656},"obj":"other_name"},{"id":"T20","span":{"begin":694,"end":703},"obj":"protein_complex"},{"id":"T21","span":{"begin":709,"end":728},"obj":"protein_molecule"},{"id":"T22","span":{"begin":772,"end":781},"obj":"protein_molecule"},{"id":"T23","span":{"begin":836,"end":845},"obj":"other_name"},{"id":"T24","span":{"begin":865,"end":874},"obj":"protein_complex"},{"id":"T25","span":{"begin":896,"end":916},"obj":"other_name"},{"id":"T26","span":{"begin":935,"end":944},"obj":"protein_complex"},{"id":"T27","span":{"begin":950,"end":967},"obj":"other_name"},{"id":"T28","span":{"begin":968,"end":977},"obj":"other_name"},{"id":"T29","span":{"begin":1012,"end":1021},"obj":"protein_complex"},{"id":"T30","span":{"begin":1065,"end":1075},"obj":"cell_type"},{"id":"T31","span":{"begin":1122,"end":1147},"obj":"cell_type"}],"text":"NF-kappaB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type.\nRecently NF-kappaB has been shown to have both proapoptotic and antiapoptotic functions. In T cell hybridomas, both T cell activators and glucocorticoids induce apoptosis. Here we show that blockade of NF-kappaB activity, using a dominant negative IkappaBalpha, has opposite effects on these two apoptotic signals. Treatment with PMA plus ionomycin (P/I) results in the upregulation of Fas Ligand (FasL) and induction of apoptosis. Inhibition of NF-kappaB activity inhibits the P/I mediated induction of FasL mRNA and decreases the level of apoptosis in these cultures, thus establishing NF-kappaB as a proapoptotic factor in this context. Conversely, inhibition of NF-kappaB confers a tenfold increase in glucocorticoid mediated apoptosis, establishing that NF-kappaB also functions as an antiapoptotic factor. We conclude that NF-kappaB is a context-dependent apoptosis regulator. Our data suggests that NF-kappaB may function as an antiapoptotic factor in thymocytes while functioning as a proapoptotic factor in mature peripheral T cells."}