PubMed:10381500
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10381500","sourcedb":"PubMed","sourceid":"10381500","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10381500","text":"Genetic evidence for an additional factor required for erythropoietin-induced signal transduction.\nErythropoietin (EPO) and its receptor (EPOR) are required for the development of mature erythrocytes. After binding of ligand, the EPOR activates a variety of signaling pathways that ultimately control cellular proliferation, survival, and specific gene expression. Although erythroid progenitors appear to be the principal EPO-responsive cell type in vivo due to the restricted expression of the EPOR, many growth factor-dependent cell lines expressing the EPOR can respond to EPO by activating many or all of these pathways. In the present study, we have identified a cellular context (the interleukin-2 [IL-2]-dependent HT-2 line) in which the EPO stimulation of the EPOR fails to support cellular proliferation, STAT-5 induction, or MAPK activation, despite efficient phosphorylation of the EPOR and JAK2 and inhibition of apoptosis after withdrawal of IL-2. Interestingly, when we fused HT-2 cells expressing the EPOR with Ba/F3 cells in a complementation assay, the resulting hybridomas proliferated and potently activated STAT-5 and MAPK in response to EPO. These data indicate that an unidentified cellular factor is needed to mediate signaling by the EPOR. Moreover, Ba/F3 cells apparently express this factor(s) and somatic fusions can, therefore, confer EPO-responsiveness to HT-2 cells that lack this factor.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":99,"end":119},"obj":"NP"},{"id":"C3","span":{"begin":124,"end":127},"obj":"NP"},{"id":"C2","span":{"begin":124,"end":143},"obj":"NP"},{"id":"C4","span":{"begin":226,"end":234},"obj":"NP"},{"id":"C6","span":{"begin":258,"end":276},"obj":"NP"},{"id":"C7","span":{"begin":277,"end":281},"obj":"NP"},{"id":"C5","span":{"begin":245,"end":363},"obj":"NP"},{"id":"C8","span":{"begin":492,"end":500},"obj":"NP"},{"id":"C9","span":{"begin":553,"end":561},"obj":"NP"},{"id":"C10","span":{"begin":577,"end":580},"obj":"NP"},{"id":"C11","span":{"begin":610,"end":624},"obj":"NP"},{"id":"C12","span":{"begin":667,"end":732},"obj":"NP"},{"id":"C13","span":{"begin":736,"end":741},"obj":"NP"},{"id":"C14","span":{"begin":765,"end":773},"obj":"NP"},{"id":"C15","span":{"begin":890,"end":898},"obj":"NP"},{"id":"C16","span":{"begin":1013,"end":1021},"obj":"NP"},{"id":"C17","span":{"begin":1027,"end":1038},"obj":"NP"},{"id":"C18","span":{"begin":1159,"end":1162},"obj":"NP"},{"id":"C19","span":{"begin":1189,"end":1220},"obj":"NP"},{"id":"C20","span":{"begin":1255,"end":1263},"obj":"NP"},{"id":"C21","span":{"begin":1275,"end":1286},"obj":"NP"},{"id":"C22","span":{"begin":1306,"end":1320},"obj":"NP"},{"id":"C23","span":{"begin":1386,"end":1396},"obj":"NP"},{"id":"C24","span":{"begin":1397,"end":1401},"obj":"NP"},{"id":"C25","span":{"begin":1407,"end":1418},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-pron","subj":"C3","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C4","obj":"C2"},{"id":"R3","pred":"coref-relat","subj":"C7","obj":"C6"},{"id":"R4","pred":"coref-ident","subj":"C8","obj":"C4"},{"id":"R5","pred":"coref-ident","subj":"C9","obj":"C8"},{"id":"R6","pred":"coref-ident","subj":"C10","obj":"C1"},{"id":"R7","pred":"coref-ident","subj":"C11","obj":"C5"},{"id":"R8","pred":"coref-relat","subj":"C13","obj":"C12"},{"id":"R9","pred":"coref-ident","subj":"C14","obj":"C9"},{"id":"R10","pred":"coref-ident","subj":"C15","obj":"C14"},{"id":"R11","pred":"coref-ident","subj":"C16","obj":"C15"},{"id":"R12","pred":"coref-ident","subj":"C18","obj":"C10"},{"id":"R13","pred":"coref-ident","subj":"C20","obj":"C16"},{"id":"R14","pred":"coref-ident","subj":"C21","obj":"C17"},{"id":"R15","pred":"coref-ident","subj":"C22","obj":"C19"},{"id":"R16","pred":"coref-relat","subj":"C24","obj":"C23"},{"id":"R17","pred":"coref-ident","subj":"C25","obj":"C22"}],"attributes":[{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C12","pred":"source","obj":"genia-medco-coref"},{"subj":"C13","pred":"source","obj":"genia-medco-coref"},{"subj":"C14","pred":"source","obj":"genia-medco-coref"},{"subj":"C15","pred":"source","obj":"genia-medco-coref"},{"subj":"C16","pred":"source","obj":"genia-medco-coref"},{"subj":"C17","pred":"source","obj":"genia-medco-coref"},{"subj":"C18","pred":"source","obj":"genia-medco-coref"},{"subj":"C19","pred":"source","obj":"genia-medco-coref"},{"subj":"C20","pred":"source","obj":"genia-medco-coref"},{"subj":"C21","pred":"source","obj":"genia-medco-coref"},{"subj":"C22","pred":"source","obj":"genia-medco-coref"},{"subj":"C23","pred":"source","obj":"genia-medco-coref"},{"subj":"C24","pred":"source","obj":"genia-medco-coref"},{"subj":"C25","pred":"source","obj":"genia-medco-coref"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":187,"end":199},"obj":"HP_0001901"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":55,"end":69},"obj":"protein"},{"id":"T2","span":{"begin":99,"end":113},"obj":"protein"},{"id":"T3","span":{"begin":115,"end":118},"obj":"protein"},{"id":"T4","span":{"begin":138,"end":142},"obj":"protein"},{"id":"T5","span":{"begin":230,"end":234},"obj":"protein"},{"id":"T6","span":{"begin":374,"end":395},"obj":"cell_type"},{"id":"T7","span":{"begin":423,"end":447},"obj":"cell_type"},{"id":"T8","span":{"begin":496,"end":500},"obj":"protein"},{"id":"T9","span":{"begin":507,"end":541},"obj":"cell_line"},{"id":"T10","span":{"begin":557,"end":561},"obj":"protein"},{"id":"T11","span":{"begin":577,"end":580},"obj":"protein"},{"id":"T12","span":{"begin":691,"end":731},"obj":"cell_line"},{"id":"T13","span":{"begin":746,"end":749},"obj":"protein"},{"id":"T14","span":{"begin":769,"end":773},"obj":"protein"},{"id":"T15","span":{"begin":815,"end":821},"obj":"protein"},{"id":"T16","span":{"begin":836,"end":840},"obj":"protein"},{"id":"T17","span":{"begin":894,"end":898},"obj":"protein"},{"id":"T18","span":{"begin":903,"end":907},"obj":"protein"},{"id":"T19","span":{"begin":956,"end":960},"obj":"protein"},{"id":"T20","span":{"begin":991,"end":1001},"obj":"cell_line"},{"id":"T21","span":{"begin":1017,"end":1021},"obj":"protein"},{"id":"T22","span":{"begin":1027,"end":1038},"obj":"cell_line"},{"id":"T23","span":{"begin":1081,"end":1091},"obj":"cell_line"},{"id":"T24","span":{"begin":1128,"end":1134},"obj":"protein"},{"id":"T25","span":{"begin":1139,"end":1143},"obj":"protein"},{"id":"T26","span":{"begin":1159,"end":1162},"obj":"protein"},{"id":"T27","span":{"begin":1192,"end":1220},"obj":"protein"},{"id":"T28","span":{"begin":1259,"end":1263},"obj":"protein"},{"id":"T29","span":{"begin":1275,"end":1286},"obj":"cell_line"},{"id":"T30","span":{"begin":1364,"end":1367},"obj":"protein"},{"id":"T31","span":{"begin":1386,"end":1396},"obj":"cell_line"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"},{"subj":"T19","pred":"source","obj":"jnlpba-st-training"},{"subj":"T20","pred":"source","obj":"jnlpba-st-training"},{"subj":"T21","pred":"source","obj":"jnlpba-st-training"},{"subj":"T22","pred":"source","obj":"jnlpba-st-training"},{"subj":"T23","pred":"source","obj":"jnlpba-st-training"},{"subj":"T24","pred":"source","obj":"jnlpba-st-training"},{"subj":"T25","pred":"source","obj":"jnlpba-st-training"},{"subj":"T26","pred":"source","obj":"jnlpba-st-training"},{"subj":"T27","pred":"source","obj":"jnlpba-st-training"},{"subj":"T28","pred":"source","obj":"jnlpba-st-training"},{"subj":"T29","pred":"source","obj":"jnlpba-st-training"},{"subj":"T30","pred":"source","obj":"jnlpba-st-training"},{"subj":"T31","pred":"source","obj":"jnlpba-st-training"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":98},"obj":"Sentence"},{"id":"S2","span":{"begin":99,"end":200},"obj":"Sentence"},{"id":"S3","span":{"begin":201,"end":364},"obj":"Sentence"},{"id":"S4","span":{"begin":365,"end":625},"obj":"Sentence"},{"id":"S5","span":{"begin":626,"end":961},"obj":"Sentence"},{"id":"S6","span":{"begin":962,"end":1163},"obj":"Sentence"},{"id":"S7","span":{"begin":1164,"end":1264},"obj":"Sentence"},{"id":"S8","span":{"begin":1265,"end":1419},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S7","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S8","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":55,"end":69},"obj":"protein_molecule"},{"id":"T2","span":{"begin":99,"end":113},"obj":"protein_family_or_group"},{"id":"T3","span":{"begin":115,"end":118},"obj":"protein_family_or_group"},{"id":"T4","span":{"begin":138,"end":142},"obj":"protein_family_or_group"},{"id":"T5","span":{"begin":230,"end":234},"obj":"protein_family_or_group"},{"id":"T6","span":{"begin":301,"end":323},"obj":"other_name"},{"id":"T7","span":{"begin":374,"end":395},"obj":"cell_type"},{"id":"T8","span":{"begin":423,"end":426},"obj":"protein_family_or_group"},{"id":"T9","span":{"begin":496,"end":500},"obj":"protein_family_or_group"},{"id":"T10","span":{"begin":507,"end":541},"obj":"cell_line"},{"id":"T11","span":{"begin":557,"end":561},"obj":"protein_family_or_group"},{"id":"T12","span":{"begin":577,"end":580},"obj":"protein_family_or_group"},{"id":"T13","span":{"begin":691,"end":731},"obj":"cell_line"},{"id":"T14","span":{"begin":746,"end":749},"obj":"protein_family_or_group"},{"id":"T15","span":{"begin":769,"end":773},"obj":"protein_family_or_group"},{"id":"T16","span":{"begin":815,"end":821},"obj":"protein_molecule"},{"id":"T17","span":{"begin":836,"end":840},"obj":"protein_family_or_group"},{"id":"T18","span":{"begin":861,"end":886},"obj":"other_name"},{"id":"T19","span":{"begin":894,"end":898},"obj":"protein_family_or_group"},{"id":"T20","span":{"begin":903,"end":907},"obj":"protein_molecule"},{"id":"T21","span":{"begin":956,"end":960},"obj":"protein_molecule"},{"id":"T22","span":{"begin":991,"end":1001},"obj":"cell_line"},{"id":"T23","span":{"begin":1017,"end":1021},"obj":"protein_family_or_group"},{"id":"T24","span":{"begin":1027,"end":1038},"obj":"cell_line"},{"id":"T25","span":{"begin":1044,"end":1065},"obj":"other_name"},{"id":"T26","span":{"begin":1081,"end":1091},"obj":"cell_line"},{"id":"T27","span":{"begin":1128,"end":1134},"obj":"protein_molecule"},{"id":"T28","span":{"begin":1139,"end":1143},"obj":"protein_family_or_group"},{"id":"T29","span":{"begin":1159,"end":1162},"obj":"protein_family_or_group"},{"id":"T30","span":{"begin":1192,"end":1220},"obj":"protein_family_or_group"},{"id":"T31","span":{"begin":1259,"end":1263},"obj":"protein_family_or_group"},{"id":"T32","span":{"begin":1275,"end":1286},"obj":"cell_line"},{"id":"T33","span":{"begin":1364,"end":1367},"obj":"protein_family_or_group"},{"id":"T34","span":{"begin":1386,"end":1396},"obj":"cell_line"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"},{"subj":"T28","pred":"source","obj":"GENIAcorpus"},{"subj":"T29","pred":"source","obj":"GENIAcorpus"},{"subj":"T30","pred":"source","obj":"GENIAcorpus"},{"subj":"T31","pred":"source","obj":"GENIAcorpus"},{"subj":"T32","pred":"source","obj":"GENIAcorpus"},{"subj":"T33","pred":"source","obj":"GENIAcorpus"},{"subj":"T34","pred":"source","obj":"GENIAcorpus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#93ecbd","default":true},{"id":"PubmedHPO","color":"#eca393"},{"id":"jnlpba-st-training","color":"#939dec"},{"id":"pubmed-sentences-benchmark","color":"#b7ec93"},{"id":"GENIAcorpus","color":"#ec93d1"}]}]}}