> top > docs > PubMed:10381500 > annotations

PubMed:10381500 JSONTXT

Annnotations TAB JSON ListView MergeView

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 55-69 protein denotes erythropoietin
T2 99-113 protein denotes Erythropoietin
T3 115-118 protein denotes EPO
T4 138-142 protein denotes EPOR
T5 230-234 protein denotes EPOR
T6 374-395 cell_type denotes erythroid progenitors
T7 423-447 cell_type denotes EPO-responsive cell type
T8 496-500 protein denotes EPOR
T9 507-541 cell_line denotes growth factor-dependent cell lines
T10 557-561 protein denotes EPOR
T11 577-580 protein denotes EPO
T12 691-731 cell_line denotes interleukin-2 [IL-2]-dependent HT-2 line
T13 746-749 protein denotes EPO
T14 769-773 protein denotes EPOR
T15 815-821 protein denotes STAT-5
T16 836-840 protein denotes MAPK
T17 894-898 protein denotes EPOR
T18 903-907 protein denotes JAK2
T19 956-960 protein denotes IL-2
T20 991-1001 cell_line denotes HT-2 cells
T21 1017-1021 protein denotes EPOR
T22 1027-1038 cell_line denotes Ba/F3 cells
T23 1081-1091 cell_line denotes hybridomas
T24 1128-1134 protein denotes STAT-5
T25 1139-1143 protein denotes MAPK
T26 1159-1162 protein denotes EPO
T27 1192-1220 protein denotes unidentified cellular factor
T28 1259-1263 protein denotes EPOR
T29 1275-1286 cell_line denotes Ba/F3 cells
T30 1364-1367 protein denotes EPO
T31 1386-1396 cell_line denotes HT-2 cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-98 Sentence denotes Genetic evidence for an additional factor required for erythropoietin-induced signal transduction.
S2 99-200 Sentence denotes Erythropoietin (EPO) and its receptor (EPOR) are required for the development of mature erythrocytes.
S3 201-364 Sentence denotes After binding of ligand, the EPOR activates a variety of signaling pathways that ultimately control cellular proliferation, survival, and specific gene expression.
S4 365-625 Sentence denotes Although erythroid progenitors appear to be the principal EPO-responsive cell type in vivo due to the restricted expression of the EPOR, many growth factor-dependent cell lines expressing the EPOR can respond to EPO by activating many or all of these pathways.
S5 626-961 Sentence denotes In the present study, we have identified a cellular context (the interleukin-2 [IL-2]-dependent HT-2 line) in which the EPO stimulation of the EPOR fails to support cellular proliferation, STAT-5 induction, or MAPK activation, despite efficient phosphorylation of the EPOR and JAK2 and inhibition of apoptosis after withdrawal of IL-2.
S6 962-1163 Sentence denotes Interestingly, when we fused HT-2 cells expressing the EPOR with Ba/F3 cells in a complementation assay, the resulting hybridomas proliferated and potently activated STAT-5 and MAPK in response to EPO.
S7 1164-1264 Sentence denotes These data indicate that an unidentified cellular factor is needed to mediate signaling by the EPOR.
S8 1265-1419 Sentence denotes Moreover, Ba/F3 cells apparently express this factor(s) and somatic fusions can, therefore, confer EPO-responsiveness to HT-2 cells that lack this factor.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 99-119 NP denotes Erythropoietin (EPO)
C3 124-127 NP denotes its
C2 124-143 NP denotes its receptor (EPOR)
C4 226-234 NP denotes the EPOR
C6 258-276 NP denotes signaling pathways
C7 277-281 NP denotes that
C5 245-363 NP denotes a variety of signaling pathways that ultimately control cellular proliferation, survival, and specific gene expression
C8 492-500 NP denotes the EPOR
C9 553-561 NP denotes the EPOR
C10 577-580 NP denotes EPO
C11 610-624 NP denotes these pathways
C12 667-732 NP denotes a cellular context (the interleukin-2 [IL-2]-dependent HT-2 line)
C13 736-741 NP denotes which
C14 765-773 NP denotes the EPOR
C15 890-898 NP denotes the EPOR
C16 1013-1021 NP denotes the EPOR
C17 1027-1038 NP denotes Ba/F3 cells
C18 1159-1162 NP denotes EPO
C19 1189-1220 NP denotes an unidentified cellular factor
C20 1255-1263 NP denotes the EPOR
C21 1275-1286 NP denotes Ba/F3 cells
C22 1306-1320 NP denotes this factor(s)
C23 1386-1396 NP denotes HT-2 cells
C24 1397-1401 NP denotes that
C25 1407-1418 NP denotes this factor
R1 C3 C1 coref-pron its,Erythropoietin (EPO)
R2 C4 C2 coref-ident the EPOR,its receptor (EPOR)
R3 C7 C6 coref-relat that,signaling pathways
R4 C8 C4 coref-ident the EPOR,the EPOR
R5 C9 C8 coref-ident the EPOR,the EPOR
R6 C10 C1 coref-ident EPO,Erythropoietin (EPO)
R7 C11 C5 coref-ident these pathways,"a variety of signaling pathways that ultimately control cellular proliferation, survival, and specific gene expression"
R8 C13 C12 coref-relat which,a cellular context (the interleukin-2 [IL-2]-dependent HT-2 line)
R9 C14 C9 coref-ident the EPOR,the EPOR
R10 C15 C14 coref-ident the EPOR,the EPOR
R11 C16 C15 coref-ident the EPOR,the EPOR
R12 C18 C10 coref-ident EPO,EPO
R13 C20 C16 coref-ident the EPOR,the EPOR
R14 C21 C17 coref-ident Ba/F3 cells,Ba/F3 cells
R15 C22 C19 coref-ident this factor(s),an unidentified cellular factor
R16 C24 C23 coref-relat that,HT-2 cells
R17 C25 C22 coref-ident this factor,this factor(s)

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 55-69 protein_molecule denotes erythropoietin
T2 99-113 protein_family_or_group denotes Erythropoietin
T3 115-118 protein_family_or_group denotes EPO
T4 138-142 protein_family_or_group denotes EPOR
T5 230-234 protein_family_or_group denotes EPOR
T6 301-323 other_name denotes cellular proliferation
T7 374-395 cell_type denotes erythroid progenitors
T8 423-426 protein_family_or_group denotes EPO
T9 496-500 protein_family_or_group denotes EPOR
T10 507-541 cell_line denotes growth factor-dependent cell lines
T11 557-561 protein_family_or_group denotes EPOR
T12 577-580 protein_family_or_group denotes EPO
T13 691-731 cell_line denotes interleukin-2 [IL-2]-dependent HT-2 line
T14 746-749 protein_family_or_group denotes EPO
T15 769-773 protein_family_or_group denotes EPOR
T16 815-821 protein_molecule denotes STAT-5
T17 836-840 protein_family_or_group denotes MAPK
T18 861-886 other_name denotes efficient phosphorylation
T19 894-898 protein_family_or_group denotes EPOR
T20 903-907 protein_molecule denotes JAK2
T21 956-960 protein_molecule denotes IL-2
T22 991-1001 cell_line denotes HT-2 cells
T23 1017-1021 protein_family_or_group denotes EPOR
T24 1027-1038 cell_line denotes Ba/F3 cells
T25 1044-1065 other_name denotes complementation assay
T26 1081-1091 cell_line denotes hybridomas
T27 1128-1134 protein_molecule denotes STAT-5
T28 1139-1143 protein_family_or_group denotes MAPK
T29 1159-1162 protein_family_or_group denotes EPO
T30 1192-1220 protein_family_or_group denotes unidentified cellular factor
T31 1259-1263 protein_family_or_group denotes EPOR
T32 1275-1286 cell_line denotes Ba/F3 cells
T33 1364-1367 protein_family_or_group denotes EPO
T34 1386-1396 cell_line denotes HT-2 cells

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 187-199 HP_0001901 denotes erythrocytes