PubMed:10369681 JSONTXT

{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":0,"end":120},"obj":"Sentence"},{"id":"T2","span":{"begin":121,"end":292},"obj":"Sentence"},{"id":"T3","span":{"begin":293,"end":381},"obj":"Sentence"},{"id":"T4","span":{"begin":382,"end":548},"obj":"Sentence"},{"id":"T5","span":{"begin":549,"end":679},"obj":"Sentence"},{"id":"T6","span":{"begin":680,"end":853},"obj":"Sentence"},{"id":"T7","span":{"begin":854,"end":973},"obj":"Sentence"},{"id":"T8","span":{"begin":974,"end":1043},"obj":"Sentence"}],"text":"Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization.\nWe searched for proteins that interact with Ras in interleukin (IL)-2-stimulated or IL-2-deprived cells, and found that the transcription factor Aiolos interacts with Ras. The Ras-Aiolos interaction was confirmed in vitro and in vivo by co-immunoprecipitation. Indirect immunofluorescence shows that IL-2 controls the cellular distribution of Aiolos and induces its tyrosine phosphorylation, required for dissociation from Ras. We also identified functional Aiolos-binding sites in the Bcl-2 promoter, which are able to activate the luciferase reporter gene. Mutation of Aiolos-binding sites within the Bcl-2 promoter inhibits transactivation of the reporter gene luciferase, suggesting direct control of Bcl-2 expression by Aiolos. Co-transfection experiments confirm that Aiolos induces Bcl-2 expression and prevents apoptosis in IL-2-deprived cells. We propose a model for the regulation of Bcl-2 expression via Aiolos."}

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{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":120},"obj":"Sentence"},{"id":"S2","span":{"begin":121,"end":292},"obj":"Sentence"},{"id":"S3","span":{"begin":293,"end":381},"obj":"Sentence"},{"id":"S4","span":{"begin":382,"end":548},"obj":"Sentence"},{"id":"S5","span":{"begin":549,"end":679},"obj":"Sentence"},{"id":"S6","span":{"begin":680,"end":853},"obj":"Sentence"},{"id":"S7","span":{"begin":854,"end":973},"obj":"Sentence"},{"id":"S8","span":{"begin":974,"end":1043},"obj":"Sentence"}],"text":"Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization.\nWe searched for proteins that interact with Ras in interleukin (IL)-2-stimulated or IL-2-deprived cells, and found that the transcription factor Aiolos interacts with Ras. The Ras-Aiolos interaction was confirmed in vitro and in vivo by co-immunoprecipitation. Indirect immunofluorescence shows that IL-2 controls the cellular distribution of Aiolos and induces its tyrosine phosphorylation, required for dissociation from Ras. We also identified functional Aiolos-binding sites in the Bcl-2 promoter, which are able to activate the luciferase reporter gene. Mutation of Aiolos-binding sites within the Bcl-2 promoter inhibits transactivation of the reporter gene luciferase, suggesting direct control of Bcl-2 expression by Aiolos. Co-transfection experiments confirm that Aiolos induces Bcl-2 expression and prevents apoptosis in IL-2-deprived cells. We propose a model for the regulation of Bcl-2 expression via Aiolos."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":27},"obj":"NP"},{"id":"C2","span":{"begin":73,"end":89},"obj":"NP"},{"id":"C3","span":{"begin":137,"end":145},"obj":"NP"},{"id":"C4","span":{"begin":146,"end":150},"obj":"NP"},{"id":"C5","span":{"begin":165,"end":168},"obj":"NP"},{"id":"C6","span":{"begin":241,"end":272},"obj":"NP"},{"id":"C7","span":{"begin":288,"end":291},"obj":"NP"},{"id":"C8","span":{"begin":464,"end":470},"obj":"NP"},{"id":"C9","span":{"begin":483,"end":486},"obj":"NP"},{"id":"C10","span":{"begin":544,"end":547},"obj":"NP"},{"id":"C12","span":{"begin":603,"end":621},"obj":"NP"},{"id":"C11","span":{"begin":568,"end":621},"obj":"NP"},{"id":"C13","span":{"begin":623,"end":628},"obj":"NP"},{"id":"C14","span":{"begin":720,"end":738},"obj":"NP"},{"id":"C15","span":{"begin":826,"end":842},"obj":"NP"},{"id":"C16","span":{"begin":846,"end":852},"obj":"NP"},{"id":"C17","span":{"begin":895,"end":901},"obj":"NP"},{"id":"C18","span":{"begin":910,"end":926},"obj":"NP"},{"id":"C19","span":{"begin":1015,"end":1031},"obj":"NP"},{"id":"C20","span":{"begin":1036,"end":1042},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-relat","subj":"C4","obj":"C3"},{"id":"R2","pred":"coref-ident","subj":"C6","obj":"C1"},{"id":"R3","pred":"coref-ident","subj":"C7","obj":"C5"},{"id":"R4","pred":"coref-ident","subj":"C8","obj":"C6"},{"id":"R5","pred":"coref-pron","subj":"C9","obj":"C8"},{"id":"R6","pred":"coref-ident","subj":"C10","obj":"C7"},{"id":"R7","pred":"coref-relat","subj":"C13","obj":"C11"},{"id":"R8","pred":"coref-ident","subj":"C14","obj":"C12"},{"id":"R9","pred":"coref-ident","subj":"C15","obj":"C2"},{"id":"R10","pred":"coref-ident","subj":"C16","obj":"C8"},{"id":"R11","pred":"coref-ident","subj":"C17","obj":"C16"},{"id":"R12","pred":"coref-ident","subj":"C18","obj":"C15"},{"id":"R13","pred":"coref-ident","subj":"C19","obj":"C18"},{"id":"R14","pred":"coref-ident","subj":"C20","obj":"C17"}],"text":"Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization.\nWe searched for proteins that interact with Ras in interleukin (IL)-2-stimulated or IL-2-deprived cells, and found that the transcription factor Aiolos interacts with Ras. The Ras-Aiolos interaction was confirmed in vitro and in vivo by co-immunoprecipitation. Indirect immunofluorescence shows that IL-2 controls the cellular distribution of Aiolos and induces its tyrosine phosphorylation, required for dissociation from Ras. We also identified functional Aiolos-binding sites in the Bcl-2 promoter, which are able to activate the luciferase reporter gene. Mutation of Aiolos-binding sites within the Bcl-2 promoter inhibits transactivation of the reporter gene luciferase, suggesting direct control of Bcl-2 expression by Aiolos. Co-transfection experiments confirm that Aiolos induces Bcl-2 expression and prevents apoptosis in IL-2-deprived cells. We propose a model for the regulation of Bcl-2 expression via Aiolos."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":6},"obj":"protein_molecule"},{"id":"T2","span":{"begin":7,"end":27},"obj":"protein_family_or_group"},{"id":"T3","span":{"begin":37,"end":47},"obj":"other_name"},{"id":"T4","span":{"begin":51,"end":58},"obj":"cell_type"},{"id":"T5","span":{"begin":73,"end":78},"obj":"protein_molecule"},{"id":"T6","span":{"begin":165,"end":168},"obj":"protein_family_or_group"},{"id":"T7","span":{"begin":245,"end":265},"obj":"protein_family_or_group"},{"id":"T8","span":{"begin":266,"end":272},"obj":"protein_molecule"},{"id":"T9","span":{"begin":288,"end":291},"obj":"protein_family_or_group"},{"id":"T10","span":{"begin":297,"end":300},"obj":"protein_family_or_group"},{"id":"T11","span":{"begin":300,"end":307},"obj":"protein_molecule"},{"id":"T12","span":{"begin":358,"end":380},"obj":"other_name"},{"id":"T13","span":{"begin":382,"end":409},"obj":"other_name"},{"id":"T14","span":{"begin":421,"end":425},"obj":"protein_molecule"},{"id":"T15","span":{"begin":464,"end":470},"obj":"protein_molecule"},{"id":"T16","span":{"begin":487,"end":495},"obj":"amino_acid_monomer"},{"id":"T17","span":{"begin":544,"end":547},"obj":"protein_family_or_group"},{"id":"T18","span":{"begin":579,"end":585},"obj":"protein_molecule"},{"id":"T19","span":{"begin":607,"end":612},"obj":"protein_molecule"},{"id":"T20","span":{"begin":654,"end":664},"obj":"protein_molecule"},{"id":"T21","span":{"begin":692,"end":698},"obj":"protein_molecule"},{"id":"T22","span":{"begin":724,"end":729},"obj":"protein_molecule"},{"id":"T23","span":{"begin":771,"end":784},"obj":"DNA_domain_or_region"},{"id":"T24","span":{"begin":785,"end":795},"obj":"protein_molecule"},{"id":"T25","span":{"begin":826,"end":831},"obj":"protein_molecule"},{"id":"T26","span":{"begin":846,"end":852},"obj":"protein_molecule"},{"id":"T27","span":{"begin":895,"end":901},"obj":"protein_molecule"},{"id":"T28","span":{"begin":910,"end":915},"obj":"protein_molecule"},{"id":"T29","span":{"begin":940,"end":949},"obj":"other_name"},{"id":"T30","span":{"begin":953,"end":957},"obj":"protein_molecule"},{"id":"T31","span":{"begin":1015,"end":1020},"obj":"protein_molecule"},{"id":"T32","span":{"begin":1036,"end":1042},"obj":"protein_molecule"}],"text":"Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization.\nWe searched for proteins that interact with Ras in interleukin (IL)-2-stimulated or IL-2-deprived cells, and found that the transcription factor Aiolos interacts with Ras. The Ras-Aiolos interaction was confirmed in vitro and in vivo by co-immunoprecipitation. Indirect immunofluorescence shows that IL-2 controls the cellular distribution of Aiolos and induces its tyrosine phosphorylation, required for dissociation from Ras. We also identified functional Aiolos-binding sites in the Bcl-2 promoter, which are able to activate the luciferase reporter gene. Mutation of Aiolos-binding sites within the Bcl-2 promoter inhibits transactivation of the reporter gene luciferase, suggesting direct control of Bcl-2 expression by Aiolos. Co-transfection experiments confirm that Aiolos induces Bcl-2 expression and prevents apoptosis in IL-2-deprived cells. We propose a model for the regulation of Bcl-2 expression via Aiolos."}