> top > docs > PubMed:10369681 > annotations

PubMed:10369681 JSONTXT

Annnotations TAB JSON ListView MergeView

PMID_GLOBAL

Id Subject Object Predicate Lexical cue
T1 0-120 Sentence denotes Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization.
T2 121-292 Sentence denotes We searched for proteins that interact with Ras in interleukin (IL)-2-stimulated or IL-2-deprived cells, and found that the transcription factor Aiolos interacts with Ras.
T3 293-381 Sentence denotes The Ras-Aiolos interaction was confirmed in vitro and in vivo by co-immunoprecipitation.
T4 382-548 Sentence denotes Indirect immunofluorescence shows that IL-2 controls the cellular distribution of Aiolos and induces its tyrosine phosphorylation, required for dissociation from Ras.
T5 549-679 Sentence denotes We also identified functional Aiolos-binding sites in the Bcl-2 promoter, which are able to activate the luciferase reporter gene.
T6 680-853 Sentence denotes Mutation of Aiolos-binding sites within the Bcl-2 promoter inhibits transactivation of the reporter gene luciferase, suggesting direct control of Bcl-2 expression by Aiolos.
T7 854-973 Sentence denotes Co-transfection experiments confirm that Aiolos induces Bcl-2 expression and prevents apoptosis in IL-2-deprived cells.
T8 974-1043 Sentence denotes We propose a model for the regulation of Bcl-2 expression via Aiolos.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-6 protein denotes Aiolos
T2 7-27 protein denotes transcription factor
T3 51-58 cell_type denotes T cells
T4 73-78 protein denotes Bcl-2
T5 165-168 protein denotes Ras
T6 172-224 cell_line denotes interleukin (IL)-2-stimulated or IL-2-deprived cells
T7 245-265 protein denotes transcription factor
T8 266-272 protein denotes Aiolos
T9 288-291 protein denotes Ras
T10 297-300 protein denotes Ras
T11 300-307 protein denotes -Aiolos
T12 421-425 protein denotes IL-2
T13 464-470 protein denotes Aiolos
T14 544-547 protein denotes Ras
T15 579-599 DNA denotes Aiolos-binding sites
T16 607-621 DNA denotes Bcl-2 promoter
T17 654-678 DNA denotes luciferase reporter gene
T18 692-712 DNA denotes Aiolos-binding sites
T19 724-738 DNA denotes Bcl-2 promoter
T20 771-795 DNA denotes reporter gene luciferase
T21 826-831 protein denotes Bcl-2
T22 846-852 protein denotes Aiolos
T23 895-901 protein denotes Aiolos
T24 910-915 protein denotes Bcl-2
T25 953-972 cell_line denotes IL-2-deprived cells
T26 1015-1020 protein denotes Bcl-2
T27 1036-1042 protein denotes Aiolos

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-120 Sentence denotes Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization.
S2 121-292 Sentence denotes We searched for proteins that interact with Ras in interleukin (IL)-2-stimulated or IL-2-deprived cells, and found that the transcription factor Aiolos interacts with Ras.
S3 293-381 Sentence denotes The Ras-Aiolos interaction was confirmed in vitro and in vivo by co-immunoprecipitation.
S4 382-548 Sentence denotes Indirect immunofluorescence shows that IL-2 controls the cellular distribution of Aiolos and induces its tyrosine phosphorylation, required for dissociation from Ras.
S5 549-679 Sentence denotes We also identified functional Aiolos-binding sites in the Bcl-2 promoter, which are able to activate the luciferase reporter gene.
S6 680-853 Sentence denotes Mutation of Aiolos-binding sites within the Bcl-2 promoter inhibits transactivation of the reporter gene luciferase, suggesting direct control of Bcl-2 expression by Aiolos.
S7 854-973 Sentence denotes Co-transfection experiments confirm that Aiolos induces Bcl-2 expression and prevents apoptosis in IL-2-deprived cells.
S8 974-1043 Sentence denotes We propose a model for the regulation of Bcl-2 expression via Aiolos.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-27 NP denotes Aiolos transcription factor
C2 73-89 NP denotes Bcl-2 expression
C3 137-145 NP denotes proteins
C4 146-150 NP denotes that
C5 165-168 NP denotes Ras
C6 241-272 NP denotes the transcription factor Aiolos
C7 288-291 NP denotes Ras
C8 464-470 NP denotes Aiolos
C9 483-486 NP denotes its
C10 544-547 NP denotes Ras
C12 603-621 NP denotes the Bcl-2 promoter
C11 568-621 NP denotes functional Aiolos-binding sites in the Bcl-2 promoter
C13 623-628 NP denotes which
C14 720-738 NP denotes the Bcl-2 promoter
C15 826-842 NP denotes Bcl-2 expression
C16 846-852 NP denotes Aiolos
C17 895-901 NP denotes Aiolos
C18 910-926 NP denotes Bcl-2 expression
C19 1015-1031 NP denotes Bcl-2 expression
C20 1036-1042 NP denotes Aiolos
R1 C4 C3 coref-relat that,proteins
R2 C6 C1 coref-ident the transcription factor Aiolos,Aiolos transcription factor
R3 C7 C5 coref-ident Ras,Ras
R4 C8 C6 coref-ident Aiolos,the transcription factor Aiolos
R5 C9 C8 coref-pron its,Aiolos
R6 C10 C7 coref-ident Ras,Ras
R7 C13 C11 coref-relat which,functional Aiolos-binding sites in the Bcl-2 promoter
R8 C14 C12 coref-ident the Bcl-2 promoter,the Bcl-2 promoter
R9 C15 C2 coref-ident Bcl-2 expression,Bcl-2 expression
R10 C16 C8 coref-ident Aiolos,Aiolos
R11 C17 C16 coref-ident Aiolos,Aiolos
R12 C18 C15 coref-ident Bcl-2 expression,Bcl-2 expression
R13 C19 C18 coref-ident Bcl-2 expression,Bcl-2 expression
R14 C20 C17 coref-ident Aiolos,Aiolos

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-6 protein_molecule denotes Aiolos
T2 7-27 protein_family_or_group denotes transcription factor
T3 37-47 other_name denotes cell death
T4 51-58 cell_type denotes T cells
T5 73-78 protein_molecule denotes Bcl-2
T6 165-168 protein_family_or_group denotes Ras
T7 245-265 protein_family_or_group denotes transcription factor
T8 266-272 protein_molecule denotes Aiolos
T9 288-291 protein_family_or_group denotes Ras
T10 297-300 protein_family_or_group denotes Ras
T11 300-307 protein_molecule denotes -Aiolos
T12 358-380 other_name denotes co-immunoprecipitation
T13 382-409 other_name denotes Indirect immunofluorescence
T14 421-425 protein_molecule denotes IL-2
T15 464-470 protein_molecule denotes Aiolos
T16 487-495 amino_acid_monomer denotes tyrosine
T17 544-547 protein_family_or_group denotes Ras
T18 579-585 protein_molecule denotes Aiolos
T19 607-612 protein_molecule denotes Bcl-2
T20 654-664 protein_molecule denotes luciferase
T21 692-698 protein_molecule denotes Aiolos
T22 724-729 protein_molecule denotes Bcl-2
T23 771-784 DNA_domain_or_region denotes reporter gene
T24 785-795 protein_molecule denotes luciferase
T25 826-831 protein_molecule denotes Bcl-2
T26 846-852 protein_molecule denotes Aiolos
T27 895-901 protein_molecule denotes Aiolos
T28 910-915 protein_molecule denotes Bcl-2
T29 940-949 other_name denotes apoptosis
T30 953-957 protein_molecule denotes IL-2
T31 1015-1020 protein_molecule denotes Bcl-2
T32 1036-1042 protein_molecule denotes Aiolos