PubMed:10369669 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	0-162	Sentence	denotes	Glycoprotein reglucosylation and nucleotide sugar utilization in the secretory pathway: identification of a nucleoside diphosphatase in the endoplasmic reticulum.
T2	163-333	Sentence	denotes	UDP is generated in the lumen of the endoplasmic reticulum (ER) as a product of the UDP-glucose-dependent glycoprotein reglucosylation in the calnexin/calreticulin cycle.
T3	334-448	Sentence	denotes	We describe here the identification, purification and characterization of an ER enzyme that hydrolyzes UDP to UMP.
T4	449-611	Sentence	denotes	This nucleoside diphosphatase is a ubiquitously expressed, soluble 45 kDa glycoprotein devoid of transmembrane domains and KDEL-related ER localization sequences.
T5	612-771	Sentence	denotes	It requires divalent cations for activity and hydrolyzes UDP, GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate.
T6	772-985	Sentence	denotes	By eliminating UDP, which is an inhibitory product of the UDP-Glc:glycoprotein glucosyltransferase, it is likely to promote reglucosylation reactions involved in glycoprotein folding and quality control in the ER.

Id	Subject	Object	Predicate	Lexical cue
T1	108-132	Gene_or_gene_product	denotes	nucleoside diphosphatase
T2	140-161	Cellular_component	denotes	endoplasmic reticulum
T3	163-166	Simple_chemical	denotes	UDP
T4	187-192	Cellular_component	denotes	lumen
T5	200-221	Cellular_component	denotes	endoplasmic reticulum
T6	223-225	Cellular_component	denotes	ER
T7	247-258	Simple_chemical	denotes	UDP-glucose
T8	305-313	Gene_or_gene_product	denotes	calnexin
T9	314-326	Gene_or_gene_product	denotes	calreticulin
T10	411-413	Cellular_component	denotes	ER
T11	437-440	Simple_chemical	denotes	UDP
T12	444-447	Simple_chemical	denotes	UMP
T13	454-478	Gene_or_gene_product	denotes	nucleoside diphosphatase
T14	572-576	Gene_or_gene_product	denotes	KDEL
T15	585-587	Cellular_component	denotes	ER
T16	624-640	Simple_chemical	denotes	divalent cations
T17	669-672	Simple_chemical	denotes	UDP
T18	674-677	Simple_chemical	denotes	GDP
T19	682-685	Simple_chemical	denotes	IDP
T20	704-718	Simple_chemical	denotes	nucleoside di-
T21	720-725	Simple_chemical	denotes	mono-
T22	729-742	Simple_chemical	denotes	triphosphates
T23	748-770	Simple_chemical	denotes	thiamine pyrophosphate
T24	787-790	Simple_chemical	denotes	UDP
T25	830-837	Simple_chemical	denotes	UDP-Glc
T26	838-870	Gene_or_gene_product	denotes	glycoprotein glucosyltransferase
T27	982-984	Cellular_component	denotes	ER