PubMed:10359802 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10359802","sourcedb":"PubMed","sourceid":"10359802","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10359802","text":"Different mutator phenotypes in Mlh1- versus Pms2-deficient mice.\nDeficiencies in DNA mismatch repair (MMR) result in increased mutation rates and cancer risk in both humans and mice. Mouse strains homozygous for knockouts of either the Pms2 or Mlh1 MMR gene develop cancer but exhibit very different tumor spectra; only Mlh1(-/-) animals develop intestinal tumors. We carried out a detailed study of the microsatellite mutation spectra in each knockout strain. Five mononucleotide repeat tracts at four different chromosomal locations were studied by using single-molecule PCR or an in vivo forward mutation assay. Three dinucleotide repeat loci also were examined. Surprisingly, the mononucleotide repeat mutation frequency in Mlh1(-/-) mice was 2- to 3-fold higher than in Pms2(-/-) animals. The higher mutation frequency in Mlh1(-/-) mice may be a consequence of some residual DNA repair capacity in the Pms2(-/-) animals. Relevant to this idea, we observed that Pms2(-/-) mice exhibit almost normal levels of Mlh1p, whereas Mlh1(-/-) animals lack both Mlh1p and Pms2p. Comparison between Mlh1(-/-) animals and Mlh1(-/-) and Pms2(-/-) double knockout mice revealed little difference in mutator phenotype, suggesting that Mlh1 nullizygosity is sufficient to inactivate MMR completely. The findings may provide a basis for understanding the greater predisposition to intestinal cancer of Mlh1(-/-) mice. Small differences (2- to 3-fold) in mononucleotide repeat mutation rates may have dramatic effects on tumor development, requiring multiple genetic alterations in coding regions. Alternatively, this strain difference in tumor spectra also may be related to the consequences of the absence of Pms2p compared with the absence of both Pms2p and Mlh1p on as yet little understood cellular processes.","tracks":[{"project":"c_corpus","denotations":[{"id":"T1","span":{"begin":32,"end":36},"obj":"PR:Q9ZRV4"},{"id":"T2","span":{"begin":32,"end":36},"obj":"PR:P38920"},{"id":"T3","span":{"begin":32,"end":36},"obj":"PR:Q54KD8"},{"id":"T5","span":{"begin":32,"end":36},"obj":"PR:Q9JK91"},{"id":"T6","span":{"begin":32,"end":36},"obj":"PR:P97679"},{"id":"T7","span":{"begin":32,"end":36},"obj":"PR:Q9P7W6"},{"id":"T8","span":{"begin":32,"end":36},"obj":"PR:000010442"},{"id":"T9","span":{"begin":32,"end":36},"obj":"PR:P40692"},{"id":"T4","span":{"begin":32,"end":36},"obj":"CVCL_G669"},{"id":"T10","span":{"begin":45,"end":48},"obj":"CHEBI:53396"},{"id":"T13","span":{"begin":45,"end":48},"obj":"CHEBI:53430"},{"id":"T15","span":{"begin":45,"end":48},"obj":"CHEBI:8055"},{"id":"T16","span":{"begin":45,"end":49},"obj":"PR:P54279"},{"id":"T17","span":{"begin":45,"end":49},"obj":"PR:F1NQJ3"},{"id":"T18","span":{"begin":45,"end":49},"obj":"PR:P38920"},{"id":"T19","span":{"begin":45,"end":49},"obj":"PR:000012914"},{"id":"T20","span":{"begin":45,"end":49},"obj":"PR:P54278"},{"id":"T22","span":{"begin":60,"end":64},"obj":"D051379"},{"id":"T24","span":{"begin":60,"end":64},"obj":"10095"},{"id":"T21","span":{"begin":60,"end":64},"obj":"PR:000005054"},{"id":"T23","span":{"begin":60,"end":64},"obj":"O89094"},{"id":"T27","span":{"begin":82,"end":85},"obj":"SO:0000352"},{"id":"T26","span":{"begin":82,"end":85},"obj":"CHEBI:16991"},{"id":"T28","span":{"begin":82,"end":85},"obj":"D004247"},{"id":"T25","span":{"begin":82,"end":85},"obj":"GO:0005574"},{"id":"T29","span":{"begin":86,"end":101},"obj":"GO:0006298"},{"id":"T30","span":{"begin":103,"end":106},"obj":"GO:0006298"},{"id":"T32","span":{"begin":103,"end":106},"obj":"P22897"},{"id":"T33","span":{"begin":103,"end":106},"obj":"PR:000002972"},{"id":"T34","span":{"begin":103,"end":106},"obj":"Q61830"},{"id":"T31","span":{"begin":103,"end":106},"obj":"CVCL_E779"},{"id":"T35","span":{"begin":128,"end":136},"obj":"SO:0000109"},{"id":"T37","span":{"begin":178,"end":182},"obj":"D051379"},{"id":"T39","span":{"begin":178,"end":182},"obj":"10095"},{"id":"T36","span":{"begin":178,"end":182},"obj":"PR:000005054"},{"id":"T38","span":{"begin":178,"end":182},"obj":"O89094"},{"id":"T40","span":{"begin":184,"end":189},"obj":"10090"},{"id":"T41","span":{"begin":184,"end":189},"obj":"D051379"},{"id":"T42","span":{"begin":190,"end":197},"obj":"D013180"},{"id":"T43","span":{"begin":190,"end":197},"obj":"D013180"},{"id":"T44","span":{"begin":237,"end":240},"obj":"CHEBI:53396"},{"id":"T47","span":{"begin":237,"end":240},"obj":"CHEBI:53430"},{"id":"T49","span":{"begin":237,"end":240},"obj":"CHEBI:8055"},{"id":"T50","span":{"begin":237,"end":241},"obj":"PR:P54279"},{"id":"T51","span":{"begin":237,"end":241},"obj":"PR:F1NQJ3"},{"id":"T52","span":{"begin":237,"end":241},"obj":"PR:P38920"},{"id":"T53","span":{"begin":237,"end":241},"obj":"PR:000012914"},{"id":"T54","span":{"begin":237,"end":241},"obj":"PR:P54278"},{"id":"T58","span":{"begin":245,"end":249},"obj":"CVCL_G669"},{"id":"T55","span":{"begin":245,"end":249},"obj":"PR:Q9ZRV4"},{"id":"T56","span":{"begin":245,"end":249},"obj":"PR:P38920"},{"id":"T57","span":{"begin":245,"end":249},"obj":"PR:Q54KD8"},{"id":"T59","span":{"begin":245,"end":249},"obj":"PR:Q9JK91"},{"id":"T60","span":{"begin":245,"end":249},"obj":"PR:P97679"},{"id":"T61","span":{"begin":245,"end":249},"obj":"PR:Q9P7W6"},{"id":"T62","span":{"begin":245,"end":249},"obj":"PR:000010442"},{"id":"T63","span":{"begin":245,"end":249},"obj":"PR:P40692"},{"id":"T64","span":{"begin":250,"end":253},"obj":"GO:0006298"},{"id":"T65","span":{"begin":250,"end":253},"obj":"CVCL_E779"},{"id":"T66","span":{"begin":250,"end":253},"obj":"P22897"},{"id":"T67","span":{"begin":250,"end":253},"obj":"PR:000002972"},{"id":"T68","span":{"begin":250,"end":253},"obj":"Q61830"},{"id":"T69","span":{"begin":254,"end":258},"obj":"SO:0000704"},{"id":"T70","span":{"begin":301,"end":306},"obj":"D009369"},{"id":"T71","span":{"begin":301,"end":306},"obj":"D009369"},{"id":"T75","span":{"begin":321,"end":325},"obj":"CVCL_G669"},{"id":"T72","span":{"begin":321,"end":325},"obj":"PR:Q9ZRV4"},{"id":"T73","span":{"begin":321,"end":325},"obj":"PR:P38920"},{"id":"T74","span":{"begin":321,"end":325},"obj":"PR:Q54KD8"},{"id":"T76","span":{"begin":321,"end":325},"obj":"PR:Q9JK91"},{"id":"T77","span":{"begin":321,"end":325},"obj":"PR:P97679"},{"id":"T78","span":{"begin":321,"end":325},"obj":"PR:Q9P7W6"},{"id":"T79","span":{"begin":321,"end":325},"obj":"PR:000010442"},{"id":"T80","span":{"begin":321,"end":325},"obj":"PR:P40692"},{"id":"T81","span":{"begin":358,"end":364},"obj":"D009369"},{"id":"T82","span":{"begin":358,"end":364},"obj":"D009369"},{"id":"T83","span":{"begin":405,"end":419},"obj":"SO:0000289"},{"id":"T84","span":{"begin":420,"end":428},"obj":"SO:0000109"},{"id":"T85","span":{"begin":467,"end":481},"obj":"CHEBI:29075"},{"id":"T86","span":{"begin":482,"end":488},"obj":"SO:0001068"},{"id":"T87","span":{"begin":565,"end":573},"obj":"CHEBI:25367"},{"id":"T88","span":{"begin":574,"end":577},"obj":"Q41249"},{"id":"T89","span":{"begin":574,"end":577},"obj":"O66148"},{"id":"T90","span":{"begin":574,"end":577},"obj":"Q59987"},{"id":"T91","span":{"begin":574,"end":577},"obj":"Q01289"},{"id":"T92","span":{"begin":574,"end":577},"obj":"O80333"},{"id":"T93","span":{"begin":574,"end":577},"obj":"P15904"},{"id":"T94","span":{"begin":574,"end":577},"obj":"Q9SDT1"},{"id":"T95","span":{"begin":574,"end":577},"obj":"Q39617"},{"id":"T96","span":{"begin":592,"end":599},"obj":"SO:0001030"},{"id":"T97","span":{"begin":600,"end":608},"obj":"SO:0000109"},{"id":"T98","span":{"begin":622,"end":634},"obj":"CHEBI:47885"},{"id":"T99","span":{"begin":635,"end":641},"obj":"SO:0001068"},{"id":"T100","span":{"begin":685,"end":699},"obj":"CHEBI:29075"},{"id":"T101","span":{"begin":700,"end":706},"obj":"SO:0001068"},{"id":"T102","span":{"begin":707,"end":715},"obj":"SO:0000109"},{"id":"T103","span":{"begin":729,"end":733},"obj":"PR:Q9ZRV4"},{"id":"T104","span":{"begin":729,"end":733},"obj":"PR:P38920"},{"id":"T105","span":{"begin":729,"end":733},"obj":"PR:Q54KD8"},{"id":"T107","span":{"begin":729,"end":733},"obj":"PR:Q9JK91"},{"id":"T108","span":{"begin":729,"end":733},"obj":"PR:P97679"},{"id":"T109","span":{"begin":729,"end":733},"obj":"PR:Q9P7W6"},{"id":"T110","span":{"begin":729,"end":733},"obj":"PR:000010442"},{"id":"T111","span":{"begin":729,"end":733},"obj":"PR:P40692"},{"id":"T106","span":{"begin":729,"end":733},"obj":"CVCL_G669"},{"id":"T112","span":{"begin":739,"end":743},"obj":"PR:000005054"},{"id":"T114","span":{"begin":739,"end":743},"obj":"O89094"},{"id":"T113","span":{"begin":739,"end":743},"obj":"D051379"},{"id":"T115","span":{"begin":739,"end":743},"obj":"10095"},{"id":"T117","span":{"begin":756,"end":760},"obj":"PR:000022679"},{"id":"T118","span":{"begin":756,"end":760},"obj":"PR:Q2FZJ6"},{"id":"T119","span":{"begin":756,"end":760},"obj":"PR:A5I112"},{"id":"T120","span":{"begin":756,"end":760},"obj":"PR:P24186"},{"id":"T121","span":{"begin":776,"end":779},"obj":"CHEBI:53396"},{"id":"T124","span":{"begin":776,"end":779},"obj":"CHEBI:53430"},{"id":"T126","span":{"begin":776,"end":779},"obj":"CHEBI:8055"},{"id":"T127","span":{"begin":776,"end":780},"obj":"PR:P54279"},{"id":"T128","span":{"begin":776,"end":780},"obj":"PR:F1NQJ3"},{"id":"T129","span":{"begin":776,"end":780},"obj":"PR:P38920"},{"id":"T130","span":{"begin":776,"end":780},"obj":"PR:000012914"},{"id":"T131","span":{"begin":776,"end":780},"obj":"PR:P54278"},{"id":"T132","span":{"begin":806,"end":814},"obj":"SO:0000109"},{"id":"T133","span":{"begin":828,"end":832},"obj":"PR:Q9ZRV4"},{"id":"T134","span":{"begin":828,"end":832},"obj":"PR:P38920"},{"id":"T135","span":{"begin":828,"end":832},"obj":"PR:Q54KD8"},{"id":"T137","span":{"begin":828,"end":832},"obj":"PR:Q9JK91"},{"id":"T138","span":{"begin":828,"end":832},"obj":"PR:P97679"},{"id":"T139","span":{"begin":828,"end":832},"obj":"PR:Q9P7W6"},{"id":"T140","span":{"begin":828,"end":832},"obj":"PR:000010442"},{"id":"T141","span":{"begin":828,"end":832},"obj":"PR:P40692"},{"id":"T136","span":{"begin":828,"end":832},"obj":"CVCL_G669"},{"id":"T143","span":{"begin":838,"end":842},"obj":"D051379"},{"id":"T145","span":{"begin":838,"end":842},"obj":"10095"},{"id":"T142","span":{"begin":838,"end":842},"obj":"PR:000005054"},{"id":"T144","span":{"begin":838,"end":842},"obj":"O89094"},{"id":"T147","span":{"begin":881,"end":884},"obj":"CHEBI:16991"},{"id":"T149","span":{"begin":881,"end":884},"obj":"D004247"},{"id":"T148","span":{"begin":881,"end":884},"obj":"SO:0000352"},{"id":"T146","span":{"begin":881,"end":884},"obj":"GO:0005574"},{"id":"T150","span":{"begin":881,"end":891},"obj":"GO:0006281"},{"id":"T151","span":{"begin":908,"end":911},"obj":"CHEBI:53396"},{"id":"T154","span":{"begin":908,"end":911},"obj":"CHEBI:53430"},{"id":"T156","span":{"begin":908,"end":911},"obj":"CHEBI:8055"},{"id":"T157","span":{"begin":908,"end":912},"obj":"PR:P54279"},{"id":"T158","span":{"begin":908,"end":912},"obj":"PR:F1NQJ3"},{"id":"T159","span":{"begin":908,"end":912},"obj":"PR:P38920"},{"id":"T160","span":{"begin":908,"end":912},"obj":"PR:000012914"},{"id":"T161","span":{"begin":908,"end":912},"obj":"PR:P54278"},{"id":"T162","span":{"begin":967,"end":970},"obj":"CHEBI:53396"},{"id":"T165","span":{"begin":967,"end":970},"obj":"CHEBI:53430"},{"id":"T167","span":{"begin":967,"end":970},"obj":"CHEBI:8055"},{"id":"T168","span":{"begin":967,"end":971},"obj":"PR:P54279"},{"id":"T169","span":{"begin":967,"end":971},"obj":"PR:F1NQJ3"},{"id":"T170","span":{"begin":967,"end":971},"obj":"PR:P38920"},{"id":"T171","span":{"begin":967,"end":971},"obj":"PR:000012914"},{"id":"T172","span":{"begin":967,"end":971},"obj":"PR:P54278"},{"id":"T173","span":{"begin":977,"end":981},"obj":"PR:000005054"},{"id":"T175","span":{"begin":977,"end":981},"obj":"O89094"},{"id":"T174","span":{"begin":977,"end":981},"obj":"D051379"},{"id":"T176","span":{"begin":977,"end":981},"obj":"10095"},{"id":"T177","span":{"begin":1014,"end":1018},"obj":"PR:Q9ZRV4"},{"id":"T178","span":{"begin":1014,"end":1018},"obj":"PR:P38920"},{"id":"T179","span":{"begin":1014,"end":1018},"obj":"PR:Q54KD8"},{"id":"T181","span":{"begin":1014,"end":1018},"obj":"PR:Q9JK91"},{"id":"T182","span":{"begin":1014,"end":1018},"obj":"PR:P97679"},{"id":"T183","span":{"begin":1014,"end":1018},"obj":"PR:Q9P7W6"},{"id":"T184","span":{"begin":1014,"end":1018},"obj":"PR:000010442"},{"id":"T185","span":{"begin":1014,"end":1018},"obj":"PR:P40692"},{"id":"T180","span":{"begin":1014,"end":1018},"obj":"CVCL_G669"},{"id":"T186","span":{"begin":1029,"end":1033},"obj":"PR:Q9ZRV4"},{"id":"T187","span":{"begin":1029,"end":1033},"obj":"PR:P38920"},{"id":"T188","span":{"begin":1029,"end":1033},"obj":"PR:Q54KD8"},{"id":"T190","span":{"begin":1029,"end":1033},"obj":"PR:Q9JK91"},{"id":"T191","span":{"begin":1029,"end":1033},"obj":"PR:P97679"},{"id":"T192","span":{"begin":1029,"end":1033},"obj":"PR:Q9P7W6"},{"id":"T193","span":{"begin":1029,"end":1033},"obj":"PR:000010442"},{"id":"T194","span":{"begin":1029,"end":1033},"obj":"PR:P40692"},{"id":"T189","span":{"begin":1029,"end":1033},"obj":"CVCL_G669"},{"id":"T195","span":{"begin":1047,"end":1051},"obj":"PR:Q9V853"},{"id":"T196","span":{"begin":1057,"end":1061},"obj":"PR:Q9ZRV4"},{"id":"T197","span":{"begin":1057,"end":1061},"obj":"PR:P38920"},{"id":"T198","span":{"begin":1057,"end":1061},"obj":"PR:Q54KD8"},{"id":"T200","span":{"begin":1057,"end":1061},"obj":"PR:Q9JK91"},{"id":"T201","span":{"begin":1057,"end":1061},"obj":"PR:P97679"},{"id":"T202","span":{"begin":1057,"end":1061},"obj":"PR:Q9P7W6"},{"id":"T203","span":{"begin":1057,"end":1061},"obj":"PR:000010442"},{"id":"T204","span":{"begin":1057,"end":1061},"obj":"PR:P40692"},{"id":"T199","span":{"begin":1057,"end":1061},"obj":"CVCL_G669"},{"id":"T205","span":{"begin":1067,"end":1070},"obj":"CHEBI:53396"},{"id":"T208","span":{"begin":1067,"end":1070},"obj":"CHEBI:53430"},{"id":"T210","span":{"begin":1067,"end":1070},"obj":"CHEBI:8055"},{"id":"T211","span":{"begin":1067,"end":1071},"obj":"PR:P54279"},{"id":"T212","span":{"begin":1067,"end":1071},"obj":"PR:F1NQJ3"},{"id":"T213","span":{"begin":1067,"end":1071},"obj":"PR:P38920"},{"id":"T214","span":{"begin":1067,"end":1071},"obj":"PR:000012914"},{"id":"T215","span":{"begin":1067,"end":1071},"obj":"PR:P54278"},{"id":"T216","span":{"begin":1093,"end":1097},"obj":"PR:Q9ZRV4"},{"id":"T217","span":{"begin":1093,"end":1097},"obj":"PR:P38920"},{"id":"T218","span":{"begin":1093,"end":1097},"obj":"PR:Q54KD8"},{"id":"T220","span":{"begin":1093,"end":1097},"obj":"PR:Q9JK91"},{"id":"T221","span":{"begin":1093,"end":1097},"obj":"PR:P97679"},{"id":"T222","span":{"begin":1093,"end":1097},"obj":"PR:Q9P7W6"},{"id":"T223","span":{"begin":1093,"end":1097},"obj":"PR:000010442"},{"id":"T224","span":{"begin":1093,"end":1097},"obj":"PR:P40692"},{"id":"T219","span":{"begin":1093,"end":1097},"obj":"CVCL_G669"},{"id":"T225","span":{"begin":1115,"end":1119},"obj":"PR:Q9ZRV4"},{"id":"T226","span":{"begin":1115,"end":1119},"obj":"PR:P38920"},{"id":"T227","span":{"begin":1115,"end":1119},"obj":"PR:Q54KD8"},{"id":"T229","span":{"begin":1115,"end":1119},"obj":"PR:Q9JK91"},{"id":"T230","span":{"begin":1115,"end":1119},"obj":"PR:P97679"},{"id":"T231","span":{"begin":1115,"end":1119},"obj":"PR:Q9P7W6"},{"id":"T232","span":{"begin":1115,"end":1119},"obj":"PR:000010442"},{"id":"T233","span":{"begin":1115,"end":1119},"obj":"PR:P40692"},{"id":"T228","span":{"begin":1115,"end":1119},"obj":"CVCL_G669"},{"id":"T234","span":{"begin":1129,"end":1132},"obj":"CHEBI:53396"},{"id":"T237","span":{"begin":1129,"end":1132},"obj":"CHEBI:53430"},{"id":"T239","span":{"begin":1129,"end":1132},"obj":"CHEBI:8055"},{"id":"T240","span":{"begin":1129,"end":1133},"obj":"PR:P54279"},{"id":"T241","span":{"begin":1129,"end":1133},"obj":"PR:F1NQJ3"},{"id":"T242","span":{"begin":1129,"end":1133},"obj":"PR:P38920"},{"id":"T243","span":{"begin":1129,"end":1133},"obj":"PR:000012914"},{"id":"T244","span":{"begin":1129,"end":1133},"obj":"PR:P54278"},{"id":"T245","span":{"begin":1139,"end":1145},"obj":"SO:0000985"},{"id":"T246","span":{"begin":1146,"end":1159},"obj":"D018345"},{"id":"T247","span":{"begin":1155,"end":1159},"obj":"PR:000005054"},{"id":"T249","span":{"begin":1155,"end":1159},"obj":"O89094"},{"id":"T251","span":{"begin":1225,"end":1229},"obj":"PR:Q9ZRV4"},{"id":"T252","span":{"begin":1225,"end":1229},"obj":"PR:P38920"},{"id":"T253","span":{"begin":1225,"end":1229},"obj":"PR:Q54KD8"},{"id":"T255","span":{"begin":1225,"end":1229},"obj":"PR:Q9JK91"},{"id":"T256","span":{"begin":1225,"end":1229},"obj":"PR:P97679"},{"id":"T257","span":{"begin":1225,"end":1229},"obj":"PR:Q9P7W6"},{"id":"T258","span":{"begin":1225,"end":1229},"obj":"PR:000010442"},{"id":"T259","span":{"begin":1225,"end":1229},"obj":"PR:P40692"},{"id":"T254","span":{"begin":1225,"end":1229},"obj":"CVCL_G669"},{"id":"T260","span":{"begin":1272,"end":1275},"obj":"GO:0006298"},{"id":"T262","span":{"begin":1272,"end":1275},"obj":"P22897"},{"id":"T263","span":{"begin":1272,"end":1275},"obj":"PR:000002972"},{"id":"T264","span":{"begin":1272,"end":1275},"obj":"Q61830"},{"id":"T261","span":{"begin":1272,"end":1275},"obj":"CVCL_E779"},{"id":"T265","span":{"begin":1369,"end":1386},"obj":"D007414"},{"id":"T266","span":{"begin":1369,"end":1386},"obj":"D007414"},{"id":"T267","span":{"begin":1390,"end":1394},"obj":"PR:Q9ZRV4"},{"id":"T268","span":{"begin":1390,"end":1394},"obj":"PR:P38920"},{"id":"T269","span":{"begin":1390,"end":1394},"obj":"PR:Q54KD8"},{"id":"T271","span":{"begin":1390,"end":1394},"obj":"PR:Q9JK91"},{"id":"T272","span":{"begin":1390,"end":1394},"obj":"PR:P97679"},{"id":"T273","span":{"begin":1390,"end":1394},"obj":"PR:Q9P7W6"},{"id":"T274","span":{"begin":1390,"end":1394},"obj":"PR:000010442"},{"id":"T275","span":{"begin":1390,"end":1394},"obj":"PR:P40692"},{"id":"T270","span":{"begin":1390,"end":1394},"obj":"CVCL_G669"},{"id":"T276","span":{"begin":1400,"end":1404},"obj":"PR:000005054"},{"id":"T278","span":{"begin":1400,"end":1404},"obj":"O89094"},{"id":"T277","span":{"begin":1400,"end":1404},"obj":"D051379"},{"id":"T279","span":{"begin":1400,"end":1404},"obj":"10095"},{"id":"T280","span":{"begin":1433,"end":1437},"obj":"PR:000022679"},{"id":"T281","span":{"begin":1433,"end":1437},"obj":"PR:Q2FZJ6"},{"id":"T282","span":{"begin":1433,"end":1437},"obj":"PR:A5I112"},{"id":"T283","span":{"begin":1433,"end":1437},"obj":"PR:P24186"},{"id":"T284","span":{"begin":1442,"end":1456},"obj":"CHEBI:29075"},{"id":"T285","span":{"begin":1457,"end":1463},"obj":"SO:0001068"},{"id":"T286","span":{"begin":1464,"end":1472},"obj":"SO:0000109"},{"id":"T287","span":{"begin":1508,"end":1513},"obj":"D009369"},{"id":"T288","span":{"begin":1508,"end":1513},"obj":"D009369"},{"id":"T289","span":{"begin":1626,"end":1631},"obj":"D009369"},{"id":"T290","span":{"begin":1626,"end":1631},"obj":"D009369"},{"id":"T291","span":{"begin":1698,"end":1701},"obj":"CHEBI:53396"},{"id":"T294","span":{"begin":1698,"end":1701},"obj":"CHEBI:53430"},{"id":"T296","span":{"begin":1698,"end":1701},"obj":"CHEBI:8055"},{"id":"T297","span":{"begin":1698,"end":1702},"obj":"PR:P54279"},{"id":"T298","span":{"begin":1698,"end":1702},"obj":"PR:F1NQJ3"},{"id":"T299","span":{"begin":1698,"end":1702},"obj":"PR:P38920"},{"id":"T300","span":{"begin":1698,"end":1702},"obj":"PR:000012914"},{"id":"T301","span":{"begin":1698,"end":1702},"obj":"PR:P54278"},{"id":"T302","span":{"begin":1738,"end":1741},"obj":"CHEBI:53396"},{"id":"T305","span":{"begin":1738,"end":1741},"obj":"CHEBI:53430"},{"id":"T307","span":{"begin":1738,"end":1741},"obj":"CHEBI:8055"},{"id":"T308","span":{"begin":1738,"end":1742},"obj":"PR:P54279"},{"id":"T309","span":{"begin":1738,"end":1742},"obj":"PR:F1NQJ3"},{"id":"T310","span":{"begin":1738,"end":1742},"obj":"PR:P38920"},{"id":"T311","span":{"begin":1738,"end":1742},"obj":"PR:000012914"},{"id":"T312","span":{"begin":1738,"end":1742},"obj":"PR:P54278"},{"id":"T313","span":{"begin":1748,"end":1752},"obj":"PR:Q9ZRV4"},{"id":"T314","span":{"begin":1748,"end":1752},"obj":"PR:P38920"},{"id":"T315","span":{"begin":1748,"end":1752},"obj":"PR:Q54KD8"},{"id":"T317","span":{"begin":1748,"end":1752},"obj":"PR:Q9JK91"},{"id":"T318","span":{"begin":1748,"end":1752},"obj":"PR:P97679"},{"id":"T319","span":{"begin":1748,"end":1752},"obj":"PR:Q9P7W6"},{"id":"T320","span":{"begin":1748,"end":1752},"obj":"PR:000010442"},{"id":"T321","span":{"begin":1748,"end":1752},"obj":"PR:P40692"},{"id":"T316","span":{"begin":1748,"end":1752},"obj":"CVCL_G669"},{"id":"T322","span":{"begin":1791,"end":1800},"obj":"UBERON:0004529"}],"attributes":[{"subj":"T1","pred":"source","obj":"c_corpus"},{"subj":"T2","pred":"source","obj":"c_corpus"},{"subj":"T3","pred":"source","obj":"c_corpus"},{"subj":"T5","pred":"source","obj":"c_corpus"},{"subj":"T6","pred":"source","obj":"c_corpus"},{"subj":"T7","pred":"source","obj":"c_corpus"},{"subj":"T8","pred":"source","obj":"c_corpus"},{"subj":"T9","pred":"source","obj":"c_corpus"},{"subj":"T4","pred":"source","obj":"c_corpus"},{"subj":"T10","pred":"source","obj":"c_corpus"},{"subj":"T13","pred":"source","obj":"c_corpus"},{"subj":"T15","pred":"source","obj":"c_corpus"},{"subj":"T16","pred":"source","obj":"c_corpus"},{"subj":"T17","pred":"source","obj":"c_corpus"},{"subj":"T18","pred":"source","obj":"c_corpus"},{"subj":"T19","pred":"source","obj":"c_corpus"},{"subj":"T20","pred":"source","obj":"c_corpus"},{"subj":"T22","pred":"source","obj":"c_corpus"},{"subj":"T24","pred":"source","obj":"c_corpus"},{"subj":"T21","pred":"source","obj":"c_corpus"},{"subj":"T23","pred":"source","obj":"c_corpus"},{"subj":"T27","pred":"source","obj":"c_corpus"},{"subj":"T26","pred":"source","obj":"c_corpus"},{"subj":"T28","pred":"source","obj":"c_corpus"},{"subj":"T25","pred":"source","obj":"c_corpus"},{"subj":"T29","pred":"source","obj":"c_corpus"},{"subj":"T30","pred":"source","obj":"c_corpus"},{"subj":"T32","pred":"source","obj":"c_corpus"},{"subj":"T33","pred":"source","obj":"c_corpus"},{"subj":"T34","pred":"source","obj":"c_corpus"},{"subj":"T31","pred":"source","obj":"c_corpus"},{"subj":"T35","pred":"source","obj":"c_corpus"},{"subj":"T37","pred":"source","obj":"c_corpus"},{"subj":"T39","pred":"source","obj":"c_corpus"},{"subj":"T36","pred":"source","obj":"c_corpus"},{"subj":"T38","pred":"source","obj":"c_corpus"},{"subj":"T40","pred":"source","obj":"c_corpus"},{"subj":"T41","pred":"source","obj":"c_corpus"},{"subj":"T42","pred":"source","obj":"c_corpus"},{"subj":"T43","pred":"source","obj":"c_corpus"},{"subj":"T44","pred":"source","obj":"c_corpus"},{"subj":"T47","pred":"source","obj":"c_corpus"},{"subj":"T49","pred":"source","obj":"c_corpus"},{"subj":"T50","pred":"source","obj":"c_corpus"},{"subj":"T51","pred":"source","obj":"c_corpus"},{"subj":"T52","pred":"source","obj":"c_corpus"},{"subj":"T53","pred":"source","obj":"c_corpus"},{"subj":"T54","pred":"source","obj":"c_corpus"},{"subj":"T58","pred":"source","obj":"c_corpus"},{"subj":"T55","pred":"source","obj":"c_corpus"},{"subj":"T56","pred":"source","obj":"c_corpus"},{"subj":"T57","pred":"source","obj":"c_corpus"},{"subj":"T59","pred":"source","obj":"c_corpus"},{"subj":"T60","pred":"source","obj":"c_corpus"},{"subj":"T61","pred":"source","obj":"c_corpus"},{"subj":"T62","pred":"source","obj":"c_corpus"},{"subj":"T63","pred":"source","obj":"c_corpus"},{"subj":"T64","pred":"source","obj":"c_corpus"},{"subj":"T65","pred":"source","obj":"c_corpus"},{"subj":"T66","pred":"source","obj":"c_corpus"},{"subj":"T67","pred":"source","obj":"c_corpus"},{"subj":"T68","pred":"source","obj":"c_corpus"},{"subj":"T69","pred":"source","obj":"c_corpus"},{"subj":"T70","pred":"source","obj":"c_corpus"},{"subj":"T71","pred":"source","obj":"c_corpus"},{"subj":"T75","pred":"source","obj":"c_corpus"},{"subj":"T72","pred":"source","obj":"c_corpus"},{"subj":"T73","pred":"source","obj":"c_corpus"},{"subj":"T74","pred":"source","obj":"c_corpus"},{"subj":"T76","pred":"source","obj":"c_corpus"},{"subj":"T77","pred":"source","obj":"c_corpus"},{"subj":"T78","pred":"source","obj":"c_corpus"},{"subj":"T79","pred":"source","obj":"c_corpus"},{"subj":"T80","pred":"source","obj":"c_corpus"},{"subj":"T81","pred":"source","obj":"c_corpus"},{"subj":"T82","pred":"source","obj":"c_corpus"},{"subj":"T83","pred":"source","obj":"c_corpus"},{"subj":"T84","pred":"source","obj":"c_corpus"},{"subj":"T85","pred":"source","obj":"c_corpus"},{"subj":"T86","pred":"source","obj":"c_corpus"},{"subj":"T87","pred":"source","obj":"c_corpus"},{"subj":"T88","pred":"source","obj":"c_corpus"},{"subj":"T89","pred":"source","obj":"c_corpus"},{"subj":"T90","pred":"source","obj":"c_corpus"},{"subj":"T91","pred":"source","obj":"c_corpus"},{"subj":"T92","pred":"source","obj":"c_corpus"},{"subj":"T93","pred":"source","obj":"c_corpus"},{"subj":"T94","pred":"source","obj":"c_corpus"},{"subj":"T95","pred":"source","obj":"c_corpus"},{"subj":"T96","pred":"source","obj":"c_corpus"},{"subj":"T97","pred":"source","obj":"c_corpus"},{"subj":"T98","pred":"source","obj":"c_corpus"},{"subj":"T99","pred":"source","obj":"c_corpus"},{"subj":"T100","pred":"source","obj":"c_corpus"},{"subj":"T101","pred":"source","obj":"c_corpus"},{"subj":"T102","pred":"source","obj":"c_corpus"},{"subj":"T103","pred":"source","obj":"c_corpus"},{"subj":"T104","pred":"source","obj":"c_corpus"},{"subj":"T105","pred":"source","obj":"c_corpus"},{"subj":"T107","pred":"source","obj":"c_corpus"},{"subj":"T108","pred":"source","obj":"c_corpus"},{"subj":"T109","pred":"source","obj":"c_corpus"},{"subj":"T110","pred":"source","obj":"c_corpus"},{"subj":"T111","pred":"source","obj":"c_corpus"},{"subj":"T106","pred":"source","obj":"c_corpus"},{"subj":"T112","pred":"source","obj":"c_corpus"},{"subj":"T114","pred":"source","obj":"c_corpus"},{"subj":"T113","pred":"source","obj":"c_corpus"},{"subj":"T115","pred":"source","obj":"c_corpus"},{"subj":"T117","pred":"source","obj":"c_corpus"},{"subj":"T118","pred":"source","obj":"c_corpus"},{"subj":"T119","pred":"source","obj":"c_corpus"},{"subj":"T120","pred":"source","obj":"c_corpus"},{"subj":"T121","pred":"source","obj":"c_corpus"},{"subj":"T124","pred":"source","obj":"c_corpus"},{"subj":"T126","pred":"source","obj":"c_corpus"},{"subj":"T127","pred":"source","obj":"c_corpus"},{"subj":"T128","pred":"source","obj":"c_corpus"},{"subj":"T129","pred":"source","obj":"c_corpus"},{"subj":"T130","pred":"source","obj":"c_corpus"},{"subj":"T131","pred":"source","obj":"c_corpus"},{"subj":"T132","pred":"source","obj":"c_corpus"},{"subj":"T133","pred":"source","obj":"c_corpus"},{"subj":"T134","pred":"source","obj":"c_corpus"},{"subj":"T135","pred":"source","obj":"c_corpus"},{"subj":"T137","pred":"source","obj":"c_corpus"},{"subj":"T138","pred":"source","obj":"c_corpus"},{"subj":"T139","pred":"source","obj":"c_corpus"},{"subj":"T140","pred":"source","obj":"c_corpus"},{"subj":"T141","pred":"source","obj":"c_corpus"},{"subj":"T136","pred":"source","obj":"c_corpus"},{"subj":"T143","pred":"source","obj":"c_corpus"},{"subj":"T145","pred":"source","obj":"c_corpus"},{"subj":"T142","pred":"source","obj":"c_corpus"},{"subj":"T144","pred":"source","obj":"c_corpus"},{"subj":"T147","pred":"source","obj":"c_corpus"},{"subj":"T149","pred":"source","obj":"c_corpus"},{"subj":"T148","pred":"source","obj":"c_corpus"},{"subj":"T146","pred":"source","obj":"c_corpus"},{"subj":"T150","pred":"source","obj":"c_corpus"},{"subj":"T151","pred":"source","obj":"c_corpus"},{"subj":"T154","pred":"source","obj":"c_corpus"},{"subj":"T156","pred":"source","obj":"c_corpus"},{"subj":"T157","pred":"source","obj":"c_corpus"},{"subj":"T158","pred":"source","obj":"c_corpus"},{"subj":"T159","pred":"source","obj":"c_corpus"},{"subj":"T160","pred":"source","obj":"c_corpus"},{"subj":"T161","pred":"source","obj":"c_corpus"},{"subj":"T162","pred":"source","obj":"c_corpus"},{"subj":"T165","pred":"source","obj":"c_corpus"},{"subj":"T167","pred":"source","obj":"c_corpus"},{"subj":"T168","pred":"source","obj":"c_corpus"},{"subj":"T169","pred":"source","obj":"c_corpus"},{"subj":"T170","pred":"source","obj":"c_corpus"},{"subj":"T171","pred":"source","obj":"c_corpus"},{"subj":"T172","pred":"source","obj":"c_corpus"},{"subj":"T173","pred":"source","obj":"c_corpus"},{"subj":"T175","pred":"source","obj":"c_corpus"},{"subj":"T174","pred":"source","obj":"c_corpus"},{"subj":"T176","pred":"source","obj":"c_corpus"},{"subj":"T177","pred":"source","obj":"c_corpus"},{"subj":"T178","pred":"source","obj":"c_corpus"},{"subj":"T179","pred":"source","obj":"c_corpus"},{"subj":"T181","pred":"source","obj":"c_corpus"},{"subj":"T182","pred":"source","obj":"c_corpus"},{"subj":"T183","pred":"source","obj":"c_corpus"},{"subj":"T184","pred":"source","obj":"c_corpus"},{"subj":"T185","pred":"source","obj":"c_corpus"},{"subj":"T180","pred":"source","obj":"c_corpus"},{"subj":"T186","pred":"source","obj":"c_corpus"},{"subj":"T187","pred":"source","obj":"c_corpus"},{"subj":"T188","pred":"source","obj":"c_corpus"},{"subj":"T190","pred":"source","obj":"c_corpus"},{"subj":"T191","pred":"source","obj":"c_corpus"},{"subj":"T192","pred":"source","obj":"c_corpus"},{"subj":"T193","pred":"source","obj":"c_corpus"},{"subj":"T194","pred":"source","obj":"c_corpus"},{"subj":"T189","pred":"source","obj":"c_corpus"},{"subj":"T195","pred":"source","obj":"c_corpus"},{"subj":"T196","pred":"source","obj":"c_corpus"},{"subj":"T197","pred":"source","obj":"c_corpus"},{"subj":"T198","pred":"source","obj":"c_corpus"},{"subj":"T200","pred":"source","obj":"c_corpus"},{"subj":"T201","pred":"source","obj":"c_corpus"},{"subj":"T202","pred":"source","obj":"c_corpus"},{"subj":"T203","pred":"source","obj":"c_corpus"},{"subj":"T204","pred":"source","obj":"c_corpus"},{"subj":"T199","pred":"source","obj":"c_corpus"},{"subj":"T205","pred":"source","obj":"c_corpus"},{"subj":"T208","pred":"source","obj":"c_corpus"},{"subj":"T210","pred":"source","obj":"c_corpus"},{"subj":"T211","pred":"source","obj":"c_corpus"},{"subj":"T212","pred":"source","obj":"c_corpus"},{"subj":"T213","pred":"source","obj":"c_corpus"},{"subj":"T214","pred":"source","obj":"c_corpus"},{"subj":"T215","pred":"source","obj":"c_corpus"},{"subj":"T216","pred":"source","obj":"c_corpus"},{"subj":"T217","pred":"source","obj":"c_corpus"},{"subj":"T218","pred":"source","obj":"c_corpus"},{"subj":"T220","pred":"source","obj":"c_corpus"},{"subj":"T221","pred":"source","obj":"c_corpus"},{"subj":"T222","pred":"source","obj":"c_corpus"},{"subj":"T223","pred":"source","obj":"c_corpus"},{"subj":"T224","pred":"source","obj":"c_corpus"},{"subj":"T219","pred":"source","obj":"c_corpus"},{"subj":"T225","pred":"source","obj":"c_corpus"},{"subj":"T226","pred":"source","obj":"c_corpus"},{"subj":"T227","pred":"source","obj":"c_corpus"},{"subj":"T229","pred":"source","obj":"c_corpus"},{"subj":"T230","pred":"source","obj":"c_corpus"},{"subj":"T231","pred":"source","obj":"c_corpus"},{"subj":"T232","pred":"source","obj":"c_corpus"},{"subj":"T233","pred":"source","obj":"c_corpus"},{"subj":"T228","pred":"source","obj":"c_corpus"},{"subj":"T234","pred":"source","obj":"c_corpus"},{"subj":"T237","pred":"source","obj":"c_corpus"},{"subj":"T239","pred":"source","obj":"c_corpus"},{"subj":"T240","pred":"source","obj":"c_corpus"},{"subj":"T241","pred":"source","obj":"c_corpus"},{"subj":"T242","pred":"source","obj":"c_corpus"},{"subj":"T243","pred":"source","obj":"c_corpus"},{"subj":"T244","pred":"source","obj":"c_corpus"},{"subj":"T245","pred":"source","obj":"c_corpus"},{"subj":"T246","pred":"source","obj":"c_corpus"},{"subj":"T247","pred":"source","obj":"c_corpus"},{"subj":"T249","pred":"source","obj":"c_corpus"},{"subj":"T251","pred":"source","obj":"c_corpus"},{"subj":"T252","pred":"source","obj":"c_corpus"},{"subj":"T253","pred":"source","obj":"c_corpus"},{"subj":"T255","pred":"source","obj":"c_corpus"},{"subj":"T256","pred":"source","obj":"c_corpus"},{"subj":"T257","pred":"source","obj":"c_corpus"},{"subj":"T258","pred":"source","obj":"c_corpus"},{"subj":"T259","pred":"source","obj":"c_corpus"},{"subj":"T254","pred":"source","obj":"c_corpus"},{"subj":"T260","pred":"source","obj":"c_corpus"},{"subj":"T262","pred":"source","obj":"c_corpus"},{"subj":"T263","pred":"source","obj":"c_corpus"},{"subj":"T264","pred":"source","obj":"c_corpus"},{"subj":"T261","pred":"source","obj":"c_corpus"},{"subj":"T265","pred":"source","obj":"c_corpus"},{"subj":"T266","pred":"source","obj":"c_corpus"},{"subj":"T267","pred":"source","obj":"c_corpus"},{"subj":"T268","pred":"source","obj":"c_corpus"},{"subj":"T269","pred":"source","obj":"c_corpus"},{"subj":"T271","pred":"source","obj":"c_corpus"},{"subj":"T272","pred":"source","obj":"c_corpus"},{"subj":"T273","pred":"source","obj":"c_corpus"},{"subj":"T274","pred":"source","obj":"c_corpus"},{"subj":"T275","pred":"source","obj":"c_corpus"},{"subj":"T270","pred":"source","obj":"c_corpus"},{"subj":"T276","pred":"source","obj":"c_corpus"},{"subj":"T278","pred":"source","obj":"c_corpus"},{"subj":"T277","pred":"source","obj":"c_corpus"},{"subj":"T279","pred":"source","obj":"c_corpus"},{"subj":"T280","pred":"source","obj":"c_corpus"},{"subj":"T281","pred":"source","obj":"c_corpus"},{"subj":"T282","pred":"source","obj":"c_corpus"},{"subj":"T283","pred":"source","obj":"c_corpus"},{"subj":"T284","pred":"source","obj":"c_corpus"},{"subj":"T285","pred":"source","obj":"c_corpus"},{"subj":"T286","pred":"source","obj":"c_corpus"},{"subj":"T287","pred":"source","obj":"c_corpus"},{"subj":"T288","pred":"source","obj":"c_corpus"},{"subj":"T289","pred":"source","obj":"c_corpus"},{"subj":"T290","pred":"source","obj":"c_corpus"},{"subj":"T291","pred":"source","obj":"c_corpus"},{"subj":"T294","pred":"source","obj":"c_corpus"},{"subj":"T296","pred":"source","obj":"c_corpus"},{"subj":"T297","pred":"source","obj":"c_corpus"},{"subj":"T298","pred":"source","obj":"c_corpus"},{"subj":"T299","pred":"source","obj":"c_corpus"},{"subj":"T300","pred":"source","obj":"c_corpus"},{"subj":"T301","pred":"source","obj":"c_corpus"},{"subj":"T302","pred":"source","obj":"c_corpus"},{"subj":"T305","pred":"source","obj":"c_corpus"},{"subj":"T307","pred":"source","obj":"c_corpus"},{"subj":"T308","pred":"source","obj":"c_corpus"},{"subj":"T309","pred":"source","obj":"c_corpus"},{"subj":"T310","pred":"source","obj":"c_corpus"},{"subj":"T311","pred":"source","obj":"c_corpus"},{"subj":"T312","pred":"source","obj":"c_corpus"},{"subj":"T313","pred":"source","obj":"c_corpus"},{"subj":"T314","pred":"source","obj":"c_corpus"},{"subj":"T315","pred":"source","obj":"c_corpus"},{"subj":"T317","pred":"source","obj":"c_corpus"},{"subj":"T318","pred":"source","obj":"c_corpus"},{"subj":"T319","pred":"source","obj":"c_corpus"},{"subj":"T320","pred":"source","obj":"c_corpus"},{"subj":"T321","pred":"source","obj":"c_corpus"},{"subj":"T316","pred":"source","obj":"c_corpus"},{"subj":"T322","pred":"source","obj":"c_corpus"}]},{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":301,"end":306},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":347,"end":364},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":1369,"end":1386},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1508,"end":1513},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1626,"end":1631},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005070"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0021118"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0005814"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0005070"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0005070"},{"subj":"T1","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T2","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T3","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T4","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T5","pred":"source","obj":"PMID_GLOBAL"}]},{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T1","span":{"begin":0,"end":65},"obj":"DRI_Background"},{"id":"T2","span":{"begin":66,"end":183},"obj":"DRI_Background"},{"id":"T3","span":{"begin":184,"end":365},"obj":"DRI_Background"},{"id":"T4","span":{"begin":366,"end":461},"obj":"DRI_Approach"},{"id":"T5","span":{"begin":462,"end":615},"obj":"DRI_Background"},{"id":"T6","span":{"begin":616,"end":666},"obj":"DRI_Background"},{"id":"T7","span":{"begin":667,"end":794},"obj":"DRI_Background"},{"id":"T8","span":{"begin":795,"end":926},"obj":"DRI_Background"},{"id":"T9","span":{"begin":927,"end":1073},"obj":"DRI_Outcome"},{"id":"T10","span":{"begin":1074,"end":1287},"obj":"DRI_Background"},{"id":"T11","span":{"begin":1288,"end":1405},"obj":"DRI_Background"},{"id":"T12","span":{"begin":1406,"end":1584},"obj":"DRI_Approach"},{"id":"T13","span":{"begin":1585,"end":1801},"obj":"DRI_Unspecified"}],"attributes":[{"subj":"T1","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T2","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T3","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T4","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T5","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T6","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T7","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T8","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T9","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T10","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T11","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T12","pred":"source","obj":"UseCases_ArguminSci_Discourse"},{"subj":"T13","pred":"source","obj":"UseCases_ArguminSci_Discourse"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":147,"end":153},"obj":"HP_0002664"},{"id":"T2","span":{"begin":267,"end":273},"obj":"HP_0002664"},{"id":"T3","span":{"begin":301,"end":306},"obj":"HP_0002664"},{"id":"T4","span":{"begin":358,"end":364},"obj":"HP_0002664"},{"id":"T5","span":{"begin":1380,"end":1386},"obj":"HP_0002664"},{"id":"T6","span":{"begin":1508,"end":1513},"obj":"HP_0002664"},{"id":"T7","span":{"begin":1626,"end":1631},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"c_corpus","color":"#ec9893","default":true},{"id":"PMID_GLOBAL","color":"#93a7ec"},{"id":"UseCases_ArguminSci_Discourse","color":"#c1ec93"},{"id":"PubmedHPO","color":"#ec93db"}]}]}}