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c_corpus

Id Subject Object Predicate Lexical cue
T1 32-36 PR:Q9ZRV4 denotes Mlh1
T2 32-36 PR:P38920 denotes Mlh1
T3 32-36 PR:Q54KD8 denotes Mlh1
T5 32-36 PR:Q9JK91 denotes Mlh1
T6 32-36 PR:P97679 denotes Mlh1
T7 32-36 PR:Q9P7W6 denotes Mlh1
T8 32-36 PR:000010442 denotes Mlh1
T9 32-36 PR:P40692 denotes Mlh1
T4 32-36 CVCL_G669 denotes Mlh1
T10 45-48 CHEBI:53396 denotes Pms
T13 45-48 CHEBI:53430 denotes Pms
T15 45-48 CHEBI:8055 denotes Pms
T16 45-49 PR:P54279 denotes Pms2
T17 45-49 PR:F1NQJ3 denotes Pms2
T18 45-49 PR:P38920 denotes Pms2
T19 45-49 PR:000012914 denotes Pms2
T20 45-49 PR:P54278 denotes Pms2
T22 60-64 D051379 denotes mice
T24 60-64 10095 denotes mice
T21 60-64 PR:000005054 denotes mice
T23 60-64 O89094 denotes mice
T27 82-85 SO:0000352 denotes DNA
T26 82-85 CHEBI:16991 denotes DNA
T28 82-85 D004247 denotes DNA
T25 82-85 GO:0005574 denotes DNA
T29 86-101 GO:0006298 denotes mismatch repair
T30 103-106 GO:0006298 denotes MMR
T32 103-106 P22897 denotes MMR
T33 103-106 PR:000002972 denotes MMR
T34 103-106 Q61830 denotes MMR
T31 103-106 CVCL_E779 denotes MMR
T35 128-136 SO:0000109 denotes mutation
T37 178-182 D051379 denotes mice
T39 178-182 10095 denotes mice
T36 178-182 PR:000005054 denotes mice
T38 178-182 O89094 denotes mice
T40 184-189 10090 denotes Mouse
T41 184-189 D051379 denotes Mouse
T42 190-197 D013180 denotes strains
T43 190-197 D013180 denotes strains
T44 237-240 CHEBI:53396 denotes Pms
T47 237-240 CHEBI:53430 denotes Pms
T49 237-240 CHEBI:8055 denotes Pms
T50 237-241 PR:P54279 denotes Pms2
T51 237-241 PR:F1NQJ3 denotes Pms2
T52 237-241 PR:P38920 denotes Pms2
T53 237-241 PR:000012914 denotes Pms2
T54 237-241 PR:P54278 denotes Pms2
T58 245-249 CVCL_G669 denotes Mlh1
T55 245-249 PR:Q9ZRV4 denotes Mlh1
T56 245-249 PR:P38920 denotes Mlh1
T57 245-249 PR:Q54KD8 denotes Mlh1
T59 245-249 PR:Q9JK91 denotes Mlh1
T60 245-249 PR:P97679 denotes Mlh1
T61 245-249 PR:Q9P7W6 denotes Mlh1
T62 245-249 PR:000010442 denotes Mlh1
T63 245-249 PR:P40692 denotes Mlh1
T64 250-253 GO:0006298 denotes MMR
T65 250-253 CVCL_E779 denotes MMR
T66 250-253 P22897 denotes MMR
T67 250-253 PR:000002972 denotes MMR
T68 250-253 Q61830 denotes MMR
T69 254-258 SO:0000704 denotes gene
T70 301-306 D009369 denotes tumor
T71 301-306 D009369 denotes tumor
T75 321-325 CVCL_G669 denotes Mlh1
T72 321-325 PR:Q9ZRV4 denotes Mlh1
T73 321-325 PR:P38920 denotes Mlh1
T74 321-325 PR:Q54KD8 denotes Mlh1
T76 321-325 PR:Q9JK91 denotes Mlh1
T77 321-325 PR:P97679 denotes Mlh1
T78 321-325 PR:Q9P7W6 denotes Mlh1
T79 321-325 PR:000010442 denotes Mlh1
T80 321-325 PR:P40692 denotes Mlh1
T81 358-364 D009369 denotes tumors
T82 358-364 D009369 denotes tumors
T83 405-419 SO:0000289 denotes microsatellite
T84 420-428 SO:0000109 denotes mutation
T85 467-481 CHEBI:29075 denotes mononucleotide
T86 482-488 SO:0001068 denotes repeat
T87 565-573 CHEBI:25367 denotes molecule
T88 574-577 Q41249 denotes PCR
T89 574-577 O66148 denotes PCR
T90 574-577 Q59987 denotes PCR
T91 574-577 Q01289 denotes PCR
T92 574-577 O80333 denotes PCR
T93 574-577 P15904 denotes PCR
T94 574-577 Q9SDT1 denotes PCR
T95 574-577 Q39617 denotes PCR
T96 592-599 SO:0001030 denotes forward
T97 600-608 SO:0000109 denotes mutation
T98 622-634 CHEBI:47885 denotes dinucleotide
T99 635-641 SO:0001068 denotes repeat
T100 685-699 CHEBI:29075 denotes mononucleotide
T101 700-706 SO:0001068 denotes repeat
T102 707-715 SO:0000109 denotes mutation
T103 729-733 PR:Q9ZRV4 denotes Mlh1
T104 729-733 PR:P38920 denotes Mlh1
T105 729-733 PR:Q54KD8 denotes Mlh1
T107 729-733 PR:Q9JK91 denotes Mlh1
T108 729-733 PR:P97679 denotes Mlh1
T109 729-733 PR:Q9P7W6 denotes Mlh1
T110 729-733 PR:000010442 denotes Mlh1
T111 729-733 PR:P40692 denotes Mlh1
T106 729-733 CVCL_G669 denotes Mlh1
T112 739-743 PR:000005054 denotes mice
T114 739-743 O89094 denotes mice
T113 739-743 D051379 denotes mice
T115 739-743 10095 denotes mice
T117 756-760 PR:000022679 denotes fold
T118 756-760 PR:Q2FZJ6 denotes fold
T119 756-760 PR:A5I112 denotes fold
T120 756-760 PR:P24186 denotes fold
T121 776-779 CHEBI:53396 denotes Pms
T124 776-779 CHEBI:53430 denotes Pms
T126 776-779 CHEBI:8055 denotes Pms
T127 776-780 PR:P54279 denotes Pms2
T128 776-780 PR:F1NQJ3 denotes Pms2
T129 776-780 PR:P38920 denotes Pms2
T130 776-780 PR:000012914 denotes Pms2
T131 776-780 PR:P54278 denotes Pms2
T132 806-814 SO:0000109 denotes mutation
T133 828-832 PR:Q9ZRV4 denotes Mlh1
T134 828-832 PR:P38920 denotes Mlh1
T135 828-832 PR:Q54KD8 denotes Mlh1
T137 828-832 PR:Q9JK91 denotes Mlh1
T138 828-832 PR:P97679 denotes Mlh1
T139 828-832 PR:Q9P7W6 denotes Mlh1
T140 828-832 PR:000010442 denotes Mlh1
T141 828-832 PR:P40692 denotes Mlh1
T136 828-832 CVCL_G669 denotes Mlh1
T143 838-842 D051379 denotes mice
T145 838-842 10095 denotes mice
T142 838-842 PR:000005054 denotes mice
T144 838-842 O89094 denotes mice
T147 881-884 CHEBI:16991 denotes DNA
T149 881-884 D004247 denotes DNA
T148 881-884 SO:0000352 denotes DNA
T146 881-884 GO:0005574 denotes DNA
T150 881-891 GO:0006281 denotes DNA repair
T151 908-911 CHEBI:53396 denotes Pms
T154 908-911 CHEBI:53430 denotes Pms
T156 908-911 CHEBI:8055 denotes Pms
T157 908-912 PR:P54279 denotes Pms2
T158 908-912 PR:F1NQJ3 denotes Pms2
T159 908-912 PR:P38920 denotes Pms2
T160 908-912 PR:000012914 denotes Pms2
T161 908-912 PR:P54278 denotes Pms2
T162 967-970 CHEBI:53396 denotes Pms
T165 967-970 CHEBI:53430 denotes Pms
T167 967-970 CHEBI:8055 denotes Pms
T168 967-971 PR:P54279 denotes Pms2
T169 967-971 PR:F1NQJ3 denotes Pms2
T170 967-971 PR:P38920 denotes Pms2
T171 967-971 PR:000012914 denotes Pms2
T172 967-971 PR:P54278 denotes Pms2
T173 977-981 PR:000005054 denotes mice
T175 977-981 O89094 denotes mice
T174 977-981 D051379 denotes mice
T176 977-981 10095 denotes mice
T177 1014-1018 PR:Q9ZRV4 denotes Mlh1
T178 1014-1018 PR:P38920 denotes Mlh1
T179 1014-1018 PR:Q54KD8 denotes Mlh1
T181 1014-1018 PR:Q9JK91 denotes Mlh1
T182 1014-1018 PR:P97679 denotes Mlh1
T183 1014-1018 PR:Q9P7W6 denotes Mlh1
T184 1014-1018 PR:000010442 denotes Mlh1
T185 1014-1018 PR:P40692 denotes Mlh1
T180 1014-1018 CVCL_G669 denotes Mlh1
T186 1029-1033 PR:Q9ZRV4 denotes Mlh1
T187 1029-1033 PR:P38920 denotes Mlh1
T188 1029-1033 PR:Q54KD8 denotes Mlh1
T190 1029-1033 PR:Q9JK91 denotes Mlh1
T191 1029-1033 PR:P97679 denotes Mlh1
T192 1029-1033 PR:Q9P7W6 denotes Mlh1
T193 1029-1033 PR:000010442 denotes Mlh1
T194 1029-1033 PR:P40692 denotes Mlh1
T189 1029-1033 CVCL_G669 denotes Mlh1
T195 1047-1051 PR:Q9V853 denotes lack
T196 1057-1061 PR:Q9ZRV4 denotes Mlh1
T197 1057-1061 PR:P38920 denotes Mlh1
T198 1057-1061 PR:Q54KD8 denotes Mlh1
T200 1057-1061 PR:Q9JK91 denotes Mlh1
T201 1057-1061 PR:P97679 denotes Mlh1
T202 1057-1061 PR:Q9P7W6 denotes Mlh1
T203 1057-1061 PR:000010442 denotes Mlh1
T204 1057-1061 PR:P40692 denotes Mlh1
T199 1057-1061 CVCL_G669 denotes Mlh1
T205 1067-1070 CHEBI:53396 denotes Pms
T208 1067-1070 CHEBI:53430 denotes Pms
T210 1067-1070 CHEBI:8055 denotes Pms
T211 1067-1071 PR:P54279 denotes Pms2
T212 1067-1071 PR:F1NQJ3 denotes Pms2
T213 1067-1071 PR:P38920 denotes Pms2
T214 1067-1071 PR:000012914 denotes Pms2
T215 1067-1071 PR:P54278 denotes Pms2
T216 1093-1097 PR:Q9ZRV4 denotes Mlh1
T217 1093-1097 PR:P38920 denotes Mlh1
T218 1093-1097 PR:Q54KD8 denotes Mlh1
T220 1093-1097 PR:Q9JK91 denotes Mlh1
T221 1093-1097 PR:P97679 denotes Mlh1
T222 1093-1097 PR:Q9P7W6 denotes Mlh1
T223 1093-1097 PR:000010442 denotes Mlh1
T224 1093-1097 PR:P40692 denotes Mlh1
T219 1093-1097 CVCL_G669 denotes Mlh1
T225 1115-1119 PR:Q9ZRV4 denotes Mlh1
T226 1115-1119 PR:P38920 denotes Mlh1
T227 1115-1119 PR:Q54KD8 denotes Mlh1
T229 1115-1119 PR:Q9JK91 denotes Mlh1
T230 1115-1119 PR:P97679 denotes Mlh1
T231 1115-1119 PR:Q9P7W6 denotes Mlh1
T232 1115-1119 PR:000010442 denotes Mlh1
T233 1115-1119 PR:P40692 denotes Mlh1
T228 1115-1119 CVCL_G669 denotes Mlh1
T234 1129-1132 CHEBI:53396 denotes Pms
T237 1129-1132 CHEBI:53430 denotes Pms
T239 1129-1132 CHEBI:8055 denotes Pms
T240 1129-1133 PR:P54279 denotes Pms2
T241 1129-1133 PR:F1NQJ3 denotes Pms2
T242 1129-1133 PR:P38920 denotes Pms2
T243 1129-1133 PR:000012914 denotes Pms2
T244 1129-1133 PR:P54278 denotes Pms2
T245 1139-1145 SO:0000985 denotes double
T246 1146-1159 D018345 denotes knockout mice
T247 1155-1159 PR:000005054 denotes mice
T249 1155-1159 O89094 denotes mice
T251 1225-1229 PR:Q9ZRV4 denotes Mlh1
T252 1225-1229 PR:P38920 denotes Mlh1
T253 1225-1229 PR:Q54KD8 denotes Mlh1
T255 1225-1229 PR:Q9JK91 denotes Mlh1
T256 1225-1229 PR:P97679 denotes Mlh1
T257 1225-1229 PR:Q9P7W6 denotes Mlh1
T258 1225-1229 PR:000010442 denotes Mlh1
T259 1225-1229 PR:P40692 denotes Mlh1
T254 1225-1229 CVCL_G669 denotes Mlh1
T260 1272-1275 GO:0006298 denotes MMR
T262 1272-1275 P22897 denotes MMR
T263 1272-1275 PR:000002972 denotes MMR
T264 1272-1275 Q61830 denotes MMR
T261 1272-1275 CVCL_E779 denotes MMR
T265 1369-1386 D007414 denotes intestinal cancer
T266 1369-1386 D007414 denotes intestinal cancer
T267 1390-1394 PR:Q9ZRV4 denotes Mlh1
T268 1390-1394 PR:P38920 denotes Mlh1
T269 1390-1394 PR:Q54KD8 denotes Mlh1
T271 1390-1394 PR:Q9JK91 denotes Mlh1
T272 1390-1394 PR:P97679 denotes Mlh1
T273 1390-1394 PR:Q9P7W6 denotes Mlh1
T274 1390-1394 PR:000010442 denotes Mlh1
T275 1390-1394 PR:P40692 denotes Mlh1
T270 1390-1394 CVCL_G669 denotes Mlh1
T276 1400-1404 PR:000005054 denotes mice
T278 1400-1404 O89094 denotes mice
T277 1400-1404 D051379 denotes mice
T279 1400-1404 10095 denotes mice
T280 1433-1437 PR:000022679 denotes fold
T281 1433-1437 PR:Q2FZJ6 denotes fold
T282 1433-1437 PR:A5I112 denotes fold
T283 1433-1437 PR:P24186 denotes fold
T284 1442-1456 CHEBI:29075 denotes mononucleotide
T285 1457-1463 SO:0001068 denotes repeat
T286 1464-1472 SO:0000109 denotes mutation
T287 1508-1513 D009369 denotes tumor
T288 1508-1513 D009369 denotes tumor
T289 1626-1631 D009369 denotes tumor
T290 1626-1631 D009369 denotes tumor
T291 1698-1701 CHEBI:53396 denotes Pms
T294 1698-1701 CHEBI:53430 denotes Pms
T296 1698-1701 CHEBI:8055 denotes Pms
T297 1698-1702 PR:P54279 denotes Pms2
T298 1698-1702 PR:F1NQJ3 denotes Pms2
T299 1698-1702 PR:P38920 denotes Pms2
T300 1698-1702 PR:000012914 denotes Pms2
T301 1698-1702 PR:P54278 denotes Pms2
T302 1738-1741 CHEBI:53396 denotes Pms
T305 1738-1741 CHEBI:53430 denotes Pms
T307 1738-1741 CHEBI:8055 denotes Pms
T308 1738-1742 PR:P54279 denotes Pms2
T309 1738-1742 PR:F1NQJ3 denotes Pms2
T310 1738-1742 PR:P38920 denotes Pms2
T311 1738-1742 PR:000012914 denotes Pms2
T312 1738-1742 PR:P54278 denotes Pms2
T313 1748-1752 PR:Q9ZRV4 denotes Mlh1
T314 1748-1752 PR:P38920 denotes Mlh1
T315 1748-1752 PR:Q54KD8 denotes Mlh1
T317 1748-1752 PR:Q9JK91 denotes Mlh1
T318 1748-1752 PR:P97679 denotes Mlh1
T319 1748-1752 PR:Q9P7W6 denotes Mlh1
T320 1748-1752 PR:000010442 denotes Mlh1
T321 1748-1752 PR:P40692 denotes Mlh1
T316 1748-1752 CVCL_G669 denotes Mlh1
T322 1791-1800 UBERON:0004529 denotes processes

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 301-306 DiseaseOrPhenotypicFeature denotes tumor 0005070
T2 347-364 DiseaseOrPhenotypicFeature denotes intestinal tumors 0021118
T3 1369-1386 DiseaseOrPhenotypicFeature denotes intestinal cancer 0005814
T4 1508-1513 DiseaseOrPhenotypicFeature denotes tumor 0005070
T5 1626-1631 DiseaseOrPhenotypicFeature denotes tumor 0005070

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-65 DRI_Background denotes Different mutator phenotypes in Mlh1- versus Pms2-deficient mice.
T2 66-183 DRI_Background denotes Deficiencies in DNA mismatch repair (MMR) result in increased mutation rates and cancer risk in both humans and mice.
T3 184-365 DRI_Background denotes Mouse strains homozygous for knockouts of either the Pms2 or Mlh1 MMR gene develop cancer but exhibit very different tumor spectra; only Mlh1(-/-) animals develop intestinal tumors.
T4 366-461 DRI_Approach denotes We carried out a detailed study of the microsatellite mutation spectra in each knockout strain.
T5 462-615 DRI_Background denotes Five mononucleotide repeat tracts at four different chromosomal locations were studied by using single-molecule PCR or an in vivo forward mutation assay.
T6 616-666 DRI_Background denotes Three dinucleotide repeat loci also were examined.
T7 667-794 DRI_Background denotes Surprisingly, the mononucleotide repeat mutation frequency in Mlh1(-/-) mice was 2- to 3-fold higher than in Pms2(-/-) animals.
T8 795-926 DRI_Background denotes The higher mutation frequency in Mlh1(-/-) mice may be a consequence of some residual DNA repair capacity in the Pms2(-/-) animals.
T9 927-1073 DRI_Outcome denotes Relevant to this idea, we observed that Pms2(-/-) mice exhibit almost normal levels of Mlh1p, whereas Mlh1(-/-) animals lack both Mlh1p and Pms2p.
T10 1074-1287 DRI_Background denotes Comparison between Mlh1(-/-) animals and Mlh1(-/-) and Pms2(-/-) double knockout mice revealed little difference in mutator phenotype, suggesting that Mlh1 nullizygosity is sufficient to inactivate MMR completely.
T11 1288-1405 DRI_Background denotes The findings may provide a basis for understanding the greater predisposition to intestinal cancer of Mlh1(-/-) mice.
T12 1406-1584 DRI_Approach denotes Small differences (2- to 3-fold) in mononucleotide repeat mutation rates may have dramatic effects on tumor development, requiring multiple genetic alterations in coding regions.
T13 1585-1801 DRI_Unspecified denotes Alternatively, this strain difference in tumor spectra also may be related to the consequences of the absence of Pms2p compared with the absence of both Pms2p and Mlh1p on as yet little understood cellular processes.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 147-153 HP_0002664 denotes cancer
T2 267-273 HP_0002664 denotes cancer
T3 301-306 HP_0002664 denotes tumor
T4 358-364 HP_0002664 denotes tumors
T5 1380-1386 HP_0002664 denotes cancer
T6 1508-1513 HP_0002664 denotes tumor
T7 1626-1631 HP_0002664 denotes tumor