PubMed:10358756 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":101,"end":114},"obj":"cell_type"},{"id":"T2","span":{"begin":191,"end":213},"obj":"protein"},{"id":"T3","span":{"begin":215,"end":248},"obj":"protein"},{"id":"T4","span":{"begin":254,"end":283},"obj":"protein"},{"id":"T5","span":{"begin":340,"end":368},"obj":"protein"},{"id":"T6","span":{"begin":409,"end":415},"obj":"protein"},{"id":"T7","span":{"begin":417,"end":421},"obj":"protein"},{"id":"T8","span":{"begin":427,"end":453},"obj":"protein"},{"id":"T9","span":{"begin":459,"end":462},"obj":"protein"},{"id":"T10","span":{"begin":464,"end":472},"obj":"protein"},{"id":"T11","span":{"begin":478,"end":519},"obj":"protein"},{"id":"T12","span":{"begin":525,"end":538},"obj":"protein"},{"id":"T13","span":{"begin":544,"end":573},"obj":"protein"},{"id":"T14","span":{"begin":582,"end":586},"obj":"protein"},{"id":"T15","span":{"begin":588,"end":592},"obj":"protein"},{"id":"T16","span":{"begin":598,"end":602},"obj":"protein"}],"text":"Transcriptional regulation of T lymphocyte development and function.\nThe development and function of T lymphocytes are regulated tightly by signal transduction pathways that include specific cell-surface receptors, intracellular signaling molecules, and nuclear transcription factors. Since 1988, several families of functionally important T cell transcription factors have been identified. These include the Ikaros, LKLF, and GATA3 zinc-finger proteins; the Ets, CREB/ATF, and NF-kappa B/Rel/NFAT transcription factors; the Stat proteins; and HMG box transcription factors such as LEF1, TCF1, and Sox4. In this review, we summarize our current understanding of the transcriptional regulation of T cell development and function with particular emphasis on the results of recent gene targeting and transgenic experiments. In addition to increasing our understanding of the molecular pathways that regulate T cell development and function, these results have suggested novel targets for genetic and pharmacological manipulation of T cell immunity."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":68},"obj":"Sentence"},{"id":"S2","span":{"begin":69,"end":284},"obj":"Sentence"},{"id":"S3","span":{"begin":285,"end":390},"obj":"Sentence"},{"id":"S4","span":{"begin":391,"end":603},"obj":"Sentence"},{"id":"S5","span":{"begin":604,"end":820},"obj":"Sentence"},{"id":"S6","span":{"begin":821,"end":1045},"obj":"Sentence"}],"text":"Transcriptional regulation of T lymphocyte development and function.\nThe development and function of T lymphocytes are regulated tightly by signal transduction pathways that include specific cell-surface receptors, intracellular signaling molecules, and nuclear transcription factors. Since 1988, several families of functionally important T cell transcription factors have been identified. These include the Ikaros, LKLF, and GATA3 zinc-finger proteins; the Ets, CREB/ATF, and NF-kappa B/Rel/NFAT transcription factors; the Stat proteins; and HMG box transcription factors such as LEF1, TCF1, and Sox4. In this review, we summarize our current understanding of the transcriptional regulation of T cell development and function with particular emphasis on the results of recent gene targeting and transgenic experiments. In addition to increasing our understanding of the molecular pathways that regulate T cell development and function, these results have suggested novel targets for genetic and pharmacological manipulation of T cell immunity."}

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