PubMed:10358756 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	101-114	cell_type	denotes	T lymphocytes
T2	191-213	protein	denotes	cell-surface receptors
T3	215-248	protein	denotes	intracellular signaling molecules
T4	254-283	protein	denotes	nuclear transcription factors
T5	340-368	protein	denotes	T cell transcription factors
T6	409-415	protein	denotes	Ikaros
T7	417-421	protein	denotes	LKLF
T8	427-453	protein	denotes	GATA3 zinc-finger proteins
T9	459-462	protein	denotes	Ets
T10	464-472	protein	denotes	CREB/ATF
T11	478-519	protein	denotes	NF-kappa B/Rel/NFAT transcription factors
T12	525-538	protein	denotes	Stat proteins
T13	544-573	protein	denotes	HMG box transcription factors
T14	582-586	protein	denotes	LEF1
T15	588-592	protein	denotes	TCF1
T16	598-602	protein	denotes	Sox4

Id	Subject	Object	Predicate	Lexical cue
S1	0-68	Sentence	denotes	Transcriptional regulation of T lymphocyte development and function.
S2	69-284	Sentence	denotes	The development and function of T lymphocytes are regulated tightly by signal transduction pathways that include specific cell-surface receptors, intracellular signaling molecules, and nuclear transcription factors.
S3	285-390	Sentence	denotes	Since 1988, several families of functionally important T cell transcription factors have been identified.
S4	391-603	Sentence	denotes	These include the Ikaros, LKLF, and GATA3 zinc-finger proteins; the Ets, CREB/ATF, and NF-kappa B/Rel/NFAT transcription factors; the Stat proteins; and HMG box transcription factors such as LEF1, TCF1, and Sox4.
S5	604-820	Sentence	denotes	In this review, we summarize our current understanding of the transcriptional regulation of T cell development and function with particular emphasis on the results of recent gene targeting and transgenic experiments.
S6	821-1045	Sentence	denotes	In addition to increasing our understanding of the molecular pathways that regulate T cell development and function, these results have suggested novel targets for genetic and pharmacological manipulation of T cell immunity.

Id	Subject	Object	Predicate	Lexical cue
C2	30-67	NP	denotes	T lymphocyte development and function
C1	0-67	NP	denotes	Transcriptional regulation of T lymphocyte development and function
C3	69-114	NP	denotes	The development and function of T lymphocytes
C4	140-168	NP	denotes	signal transduction pathways
C5	169-173	NP	denotes	that
C6	297-368	NP	denotes	several families of functionally important T cell transcription factors
C7	391-396	NP	denotes	These
C9	696-727	NP	denotes	T cell development and function
C8	662-727	NP	denotes	the transcriptional regulation of T cell development and function
C10	868-890	NP	denotes	the molecular pathways
C11	891-895	NP	denotes	that
C12	905-936	NP	denotes	T cell development and function
R1	C3	C2	coref-ident	The development and function of T lymphocytes,T lymphocyte development and function
R2	C5	C4	coref-relat	that,signal transduction pathways
R3	C7	C6	coref-pron	These,several families of functionally important T cell transcription factors
R4	C9	C3	coref-ident	T cell development and function,The development and function of T lymphocytes
R5	C8	C1	coref-ident	the transcriptional regulation of T cell development and function,Transcriptional regulation of T lymphocyte development and function
R6	C11	C10	coref-relat	that,the molecular pathways
R7	C12	C9	coref-ident	T cell development and function,T cell development and function

Id	Subject	Object	Predicate	Lexical cue
T1	0-26	other_name	denotes	Transcriptional regulation
T2	30-54	other_name	denotes	T lymphocyte development
T3	101-114	cell_type	denotes	T lymphocytes
T4	140-168	other_name	denotes	signal transduction pathways
T5	191-213	protein_family_or_group	denotes	cell-surface receptors
T6	215-248	protein_family_or_group	denotes	intracellular signaling molecules
T7	254-283	protein_family_or_group	denotes	nuclear transcription factors
T8	340-368	protein_family_or_group	denotes	T cell transcription factors
T9	409-415	protein_molecule	denotes	Ikaros
T10	417-421	protein_molecule	denotes	LKLF
T11	427-453	protein_family_or_group	denotes	GATA3 zinc-finger proteins
T12	459-462	protein_family_or_group	denotes	Ets
T13	464-472	protein_molecule	denotes	CREB/ATF
T14	478-519	protein_family_or_group	denotes	NF-kappa B/Rel/NFAT transcription factors
T15	525-538	protein_family_or_group	denotes	Stat proteins
T16	544-573	protein_family_or_group	denotes	HMG box transcription factors
T17	582-586	protein_molecule	denotes	LEF1
T18	588-592	protein_molecule	denotes	TCF1
T19	598-602	protein_molecule	denotes	Sox4
T20	666-692	other_name	denotes	transcriptional regulation
T21	696-714	other_name	denotes	T cell development
T22	719-727	other_name	denotes	function
T23	872-890	other_name	denotes	molecular pathways
T24	905-923	other_name	denotes	T cell development
T25	928-936	other_name	denotes	function
T26	1029-1044	other_name	denotes	T cell immunity