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PubMed:10358173 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-5 protein denotes IL-12
T2 14-45 protein denotes IFN regulating factor-1 (IRF-1)
T3 71-73 cell_type denotes NK
T4 78-85 cell_type denotes T cells
T5 87-92 protein denotes IL-12
T6 98-132 protein denotes critical immunoregulatory cytokine
T7 211-221 cell_type denotes CD4+ cells
T8 225-234 cell_type denotes Th1 cells
T9 260-265 protein denotes IL-12
T10 342-347 protein denotes IL-12
T11 405-410 protein denotes IL-12
T12 433-438 DNA denotes IL-12
T13 444-469 DNA denotes IFN-alpha-inducible genes
T14 515-520 protein denotes IL-12
T15 530-540 protein denotes MIP-1alpha
T16 542-551 protein denotes MIP-1beta
T17 553-559 protein denotes IL-1RA
T18 565-596 protein denotes IFN regulatory factor-1 (IRF-1)
T19 598-603 protein denotes IRF-1
T20 609-629 protein denotes transcription factor
T21 643-647 protein denotes IFNs
T22 675-678 cell_type denotes Th1
T23 711-716 protein denotes IL-12
T24 739-744 protein denotes IRF-1
T25 767-776 protein denotes IFN-alpha
T26 793-800 cell_type denotes T cells
T27 808-816 cell_type denotes NK cells
T28 833-838 protein denotes IL-12
T29 862-867 protein denotes IRF-1
T30 923-932 protein denotes IFN-gamma
T31 958-962 protein denotes IL-2
T32 967-972 protein denotes IL-12
T33 997-1002 protein denotes IRF-1
T34 1012-1021 protein denotes IFN-alpha
T35 1026-1031 protein denotes IL-12
T36 1062-1067 protein denotes STAT4
T37 1089-1094 protein denotes IRF-1
T38 1132-1137 protein denotes STAT4
T39 1159-1164 protein denotes IL-12
T40 1197-1221 DNA denotes IRF-1 reporter construct
T41 1235-1240 protein denotes STAT4
T42 1256-1270 DNA denotes IRF-1 promoter
T43 1308-1313 protein denotes IL-12
T44 1335-1340 protein denotes IRF-1
T45 1354-1375 cell_line denotes IL-4-stimulated cells
T46 1381-1385 protein denotes IL-4
T47 1400-1405 protein denotes IL-12
T48 1433-1438 protein denotes IRF-1
T49 1451-1456 protein denotes IRF-1
T50 1492-1497 protein denotes IL-12
T51 1545-1550 protein denotes IL-12
T52 1569-1572 protein denotes IRF
T53 1638-1658 protein denotes transcription factor

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-86 Sentence denotes IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells.
S2 87-300 Sentence denotes IL-12 is a critical immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells to Th1 cells; however, relatively few IL-12 target genes have been identified.
S3 301-470 Sentence denotes To better clarify the molecular basis of IL-12 action, we set out to characterize genes up-regulated by IL-12, first by contrasting IL-12- and IFN-alpha-inducible genes.
S4 471-597 Sentence denotes We identified several genes up-regulated by IL-12, namely, MIP-1alpha, MIP-1beta, IL-1RA, and IFN regulatory factor-1 (IRF-1).
S5 598-689 Sentence denotes IRF-1 is a transcription factor regulated by IFNs that is also essential for Th1 responses.
S6 690-817 Sentence denotes We demonstrated that IL-12 directly up-regulates IRF-1 to the same extent as IFN-alpha in normal human T cells and in NK cells.
S7 818-944 Sentence denotes We showed that IL-12 had a direct effect on IRF-1, an effect not mediated indirectly by the induction of IFN-gamma production.
S8 945-1040 Sentence denotes Furthermore, IL-2 and IL-12 synergistically induced IRF-1, whereas IFN-alpha and IL-12 did not.
S9 1041-1124 Sentence denotes The participation of STAT4 in the regulation of IRF-1 was demonstrated in two ways.
S10 1125-1292 Sentence denotes First, STAT4 was required for the IL-12-dependent transactivation of an IRF-1 reporter construct, and second, STAT4 binding to the IRF-1 promoter was shown using EMSA.
S11 1293-1439 Sentence denotes In contrast to IL-12, no up-regulation of IRF-1 was found in IL-4-stimulated cells, and IL-4 did not block IL-12-dependent up-regulation of IRF-1.
S12 1440-1659 Sentence denotes Therefore, IRF-1 may be an important contributor to IL-12 signaling, and we speculate that the defective IL-12 responses seen in IRF-1-/- mice might be attributable, in part, to the absence of this transcription factor.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-5 NP denotes IL-12
C2 87-92 NP denotes IL-12
C3 96-132 NP denotes a critical immunoregulatory cytokine
C4 133-137 NP denotes that
C5 405-410 NP denotes IL-12
C6 515-520 NP denotes IL-12
C7 565-596 NP denotes IFN regulatory factor-1 (IRF-1)
C8 598-603 NP denotes IRF-1
C9 607-647 NP denotes a transcription factor regulated by IFNs
C10 648-652 NP denotes that
C11 711-716 NP denotes IL-12
C12 739-744 NP denotes IRF-1
C13 833-838 NP denotes IL-12
C14 862-867 NP denotes IRF-1
C15 967-972 NP denotes IL-12
C16 997-1002 NP denotes IRF-1
C17 1026-1031 NP denotes IL-12
C18 1062-1067 NP denotes STAT4
C19 1089-1094 NP denotes IRF-1
C20 1132-1137 NP denotes STAT4
C21 1308-1313 NP denotes IL-12
C22 1335-1340 NP denotes IRF-1
C23 1433-1438 NP denotes IRF-1
C24 1451-1456 NP denotes IRF-1
C25 1633-1658 NP denotes this transcription factor
R1 C2 C1 coref-ident IL-12,IL-12
R2 C4 C3 coref-relat that,a critical immunoregulatory cytokine
R3 C5 C2 coref-ident IL-12,IL-12
R4 C6 C5 coref-ident IL-12,IL-12
R5 C8 C7 coref-ident IRF-1,IFN regulatory factor-1 (IRF-1)
R6 C10 C9 coref-relat that,a transcription factor regulated by IFNs
R7 C11 C6 coref-ident IL-12,IL-12
R8 C12 C8 coref-ident IRF-1,IRF-1
R9 C13 C11 coref-ident IL-12,IL-12
R10 C14 C12 coref-ident IRF-1,IRF-1
R11 C15 C13 coref-ident IL-12,IL-12
R12 C16 C14 coref-ident IRF-1,IRF-1
R13 C17 C15 coref-ident IL-12,IL-12
R14 C19 C16 coref-ident IRF-1,IRF-1
R15 C20 C18 coref-ident STAT4,STAT4
R16 C21 C17 coref-ident IL-12,IL-12
R17 C22 C19 coref-ident IRF-1,IRF-1
R18 C23 C22 coref-ident IRF-1,IRF-1
R19 C24 C23 coref-ident IRF-1,IRF-1
R20 C25 C24 coref-ident this transcription factor,IRF-1

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-5 protein_molecule denotes IL-12
T2 14-39 protein_molecule denotes IFN regulating factor-1 (
T3 39-44 protein_molecule denotes IRF-1
T4 71-73 cell_type denotes NK
T5 78-85 cell_type denotes T cells
T6 87-92 protein_molecule denotes IL-12
T7 98-132 protein_family_or_group denotes critical immunoregulatory cytokine
T8 147-177 other_name denotes cell-mediated immune responses
T9 211-221 cell_type denotes CD4+ cells
T10 225-234 cell_type denotes Th1 cells
T11 260-265 protein_molecule denotes IL-12
T12 342-347 protein_molecule denotes IL-12
T13 405-410 protein_molecule denotes IL-12
T14 433-438 protein_molecule denotes IL-12
T15 444-447 protein_family_or_group denotes IFN
T16 515-520 protein_molecule denotes IL-12
T17 530-540 protein_molecule denotes MIP-1alpha
T18 542-551 protein_molecule denotes MIP-1beta
T19 553-559 protein_molecule denotes IL-1RA
T20 565-590 protein_molecule denotes IFN regulatory factor-1 (
T21 590-595 protein_molecule denotes IRF-1
T22 598-603 protein_molecule denotes IRF-1
T23 609-629 protein_family_or_group denotes transcription factor
T24 643-647 protein_family_or_group denotes IFNs
T25 675-678 cell_type denotes Th1
T26 711-716 protein_molecule denotes IL-12
T27 726-738 other_name denotes up-regulates
T28 739-744 protein_molecule denotes IRF-1
T29 767-776 protein_molecule denotes IFN-alpha
T30 793-800 cell_type denotes T cells
T31 808-816 cell_type denotes NK cells
T32 833-838 protein_molecule denotes IL-12
T33 862-867 protein_molecule denotes IRF-1
T34 923-932 protein_molecule denotes IFN-gamma
T35 958-962 protein_molecule denotes IL-2
T36 967-972 protein_molecule denotes IL-12
T37 997-1002 protein_molecule denotes IRF-1
T38 1012-1021 protein_molecule denotes IFN-alpha
T39 1026-1031 protein_molecule denotes IL-12
T40 1062-1067 protein_molecule denotes STAT4
T41 1089-1094 protein_molecule denotes IRF-1
T42 1132-1137 protein_molecule denotes STAT4
T43 1159-1164 protein_molecule denotes IL-12
T44 1197-1202 protein_molecule denotes IRF-1
T45 1235-1240 protein_molecule denotes STAT4
T46 1256-1261 protein_molecule denotes IRF-1
T47 1287-1291 other_name denotes EMSA
T48 1308-1313 protein_molecule denotes IL-12
T49 1318-1331 other_name denotes up-regulation
T50 1335-1340 protein_molecule denotes IRF-1
T51 1354-1358 protein_molecule denotes IL-4
T52 1381-1385 protein_molecule denotes IL-4
T53 1400-1405 protein_molecule denotes IL-12
T54 1433-1438 protein_molecule denotes IRF-1
T55 1451-1456 protein_molecule denotes IRF-1
T56 1492-1497 protein_molecule denotes IL-12
T57 1545-1550 protein_molecule denotes IL-12
T58 1569-1572 protein_family_or_group denotes IRF
T59 1638-1658 protein_family_or_group denotes transcription factor