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PubMed:10352273 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-18 protein denotes CD28
T2 110-132 protein denotes costimulatory molecule
T3 133-137 protein denotes CD28
T4 195-202 cell_type denotes T cells
T5 212-230 cell_type denotes plasmacytoma cells
T6 241-245 protein denotes CD28
T7 410-422 cell_type denotes CD8+ T cells
T8 445-457 cell_type denotes CD4+ T cells
T9 478-482 protein denotes CD28
T10 626-645 protein denotes site alpha and beta
T11 658-679 DNA denotes CD28 minimal promoter
T12 757-770 cell_type denotes CD28+ T cells
T13 784-803 cell_line denotes transformed B cells
T14 935-944 protein denotes site beta
T15 954-964 protein denotes site alpha
T16 1101-1113 cell_type denotes CD8+ T cells
T17 1210-1214 protein denotes CD28
T18 1228-1240 cell_type denotes CD8+ T cells
T19 1259-1296 cell_line denotes CD4+CD28null and CD8+CD28null T cells
T20 1312-1343 protein denotes alpha- and beta-bound complexes
T21 1376-1403 cell_type denotes chronically activated cells
T22 1415-1430 cell_type denotes senescent cells

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-18 protein_molecule denotes CD28
T2 40-59 other_name denotes regulatory pathways
T3 110-132 protein_family_or_group denotes costimulatory molecule
T4 133-137 protein_molecule denotes CD28
T5 144-174 other_name denotes restricted tissue distribution
T6 195-202 cell_type denotes T cells
T7 212-230 cell_type denotes plasmacytoma cells
T8 241-245 protein_molecule denotes CD28
T9 330-347 other_name denotes T cell activation
T10 410-422 cell_type denotes CD8+ T cells
T11 445-457 cell_type denotes CD4+ T cells
T12 478-482 protein_molecule denotes CD28
T13 509-527 other_name denotes chronic infections
T14 576-610 other_name denotes nuclear protein-binding activities
T15 658-662 protein_molecule denotes CD28
T16 736-752 tissue denotes lymphoid tissues
T17 757-770 cell_type denotes CD28+ T cells
T18 784-803 cell_line denotes transformed B cells
T19 862-884 other_name denotes replicative senescence
T20 935-944 protein_domain_or_region denotes site beta
T21 954-964 protein_domain_or_region denotes site alpha
T22 964-983 other_name denotes -binding activities
T23 998-1015 other_name denotes T cell activation
T24 1101-1113 cell_type denotes CD8+ T cells
T25 1130-1151 other_name denotes beta-binding profiles
T26 1210-1214 protein_molecule denotes CD28
T27 1228-1240 cell_type denotes CD8+ T cells
T28 1376-1403 cell_type denotes chronically activated cells
T29 1415-1430 cell_type denotes senescent cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-105 Sentence denotes Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence.
S2 106-231 Sentence denotes The costimulatory molecule CD28 has a restricted tissue distribution and is expressed on T cells and some plasmacytoma cells.
S3 232-400 Sentence denotes Although CD28 is constitutively expressed, its expression is transiently down-regulated following T cell activation and declines progressively with in vitro senescence.
S4 401-543 Sentence denotes In vivo, CD8+ T cells and, less frequently, CD4+ T cells may completely lose CD28 surface expression during chronic infections and with aging.
S5 544-680 Sentence denotes This correlates with changes of nuclear protein-binding activities to two motifs, site alpha and beta, within the CD28 minimal promoter.
S6 681-804 Sentence denotes Both alpha- and beta-bound complexes are found only in lymphoid tissues, in CD28+ T cells, and in some transformed B cells.
S7 805-984 Sentence denotes These complexes are coordinately expressed except during replicative senescence, which is characterized by the down-modulation of site beta- but not site alpha-binding activities.
S8 985-1091 Sentence denotes In contrast, T cell activation induces a parallel decline in both site alpha- and beta-binding activities.
S9 1092-1241 Sentence denotes CD4+ and CD8+ T cells differ in their beta-binding profiles, which may explain the more pronounced down-regulation of CD28 in senescent CD8+ T cells.
S10 1242-1431 Sentence denotes In vivo expanded CD4+CD28null and CD8+CD28null T cells uniformly lack alpha- and beta-bound complexes, resembling the pattern seen in chronically activated cells and not of senescent cells.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 14-29 NP denotes CD28 expression
C2 82-104 NP denotes replicative senescence
C3 106-137 NP denotes The costimulatory molecule CD28
C4 241-245 NP denotes CD28
C6 275-278 NP denotes its
C5 275-289 NP denotes its expression
C7 330-347 NP denotes T cell activation
C8 614-624 NP denotes two motifs
C9 626-645 NP denotes site alpha and beta
C10 681-717 NP denotes Both alpha- and beta-bound complexes
C11 805-820 NP denotes These complexes
C12 862-884 NP denotes replicative senescence
C13 886-891 NP denotes which
C14 998-1015 NP denotes T cell activation
C15 1092-1113 NP denotes CD4+ and CD8+ T cells
C16 1124-1129 NP denotes their
C17 1210-1214 NP denotes CD28
C18 1312-1343 NP denotes alpha- and beta-bound complexes
R1 C4 C3 coref-ident CD28,The costimulatory molecule CD28
R2 C6 C4 coref-pron its,CD28
R3 C5 C1 coref-ident its expression,CD28 expression
R4 C9 C8 coref-appos site alpha and beta,two motifs
R5 C11 C10 coref-ident These complexes,Both alpha- and beta-bound complexes
R6 C12 C2 coref-ident replicative senescence,replicative senescence
R7 C13 C12 coref-relat which,replicative senescence
R8 C14 C7 coref-ident T cell activation,T cell activation
R9 C16 C15 coref-pron their,CD4+ and CD8+ T cells
R10 C17 C4 coref-ident CD28,CD28
R11 C18 C11 coref-ident alpha- and beta-bound complexes,These complexes

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 212-224 HP_0011857 denotes plasmacytoma