PubMed:10352273 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":14,"end":18},"obj":"protein"},{"id":"T2","span":{"begin":110,"end":132},"obj":"protein"},{"id":"T3","span":{"begin":133,"end":137},"obj":"protein"},{"id":"T4","span":{"begin":195,"end":202},"obj":"cell_type"},{"id":"T5","span":{"begin":212,"end":230},"obj":"cell_type"},{"id":"T6","span":{"begin":241,"end":245},"obj":"protein"},{"id":"T7","span":{"begin":410,"end":422},"obj":"cell_type"},{"id":"T8","span":{"begin":445,"end":457},"obj":"cell_type"},{"id":"T9","span":{"begin":478,"end":482},"obj":"protein"},{"id":"T10","span":{"begin":626,"end":645},"obj":"protein"},{"id":"T11","span":{"begin":658,"end":679},"obj":"DNA"},{"id":"T12","span":{"begin":757,"end":770},"obj":"cell_type"},{"id":"T13","span":{"begin":784,"end":803},"obj":"cell_line"},{"id":"T14","span":{"begin":935,"end":944},"obj":"protein"},{"id":"T15","span":{"begin":954,"end":964},"obj":"protein"},{"id":"T16","span":{"begin":1101,"end":1113},"obj":"cell_type"},{"id":"T17","span":{"begin":1210,"end":1214},"obj":"protein"},{"id":"T18","span":{"begin":1228,"end":1240},"obj":"cell_type"},{"id":"T19","span":{"begin":1259,"end":1296},"obj":"cell_line"},{"id":"T20","span":{"begin":1312,"end":1343},"obj":"protein"},{"id":"T21","span":{"begin":1376,"end":1403},"obj":"cell_type"},{"id":"T22","span":{"begin":1415,"end":1430},"obj":"cell_type"}],"text":"Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence.\nThe costimulatory molecule CD28 has a restricted tissue distribution and is expressed on T cells and some plasmacytoma cells. Although CD28 is constitutively expressed, its expression is transiently down-regulated following T cell activation and declines progressively with in vitro senescence. In vivo, CD8+ T cells and, less frequently, CD4+ T cells may completely lose CD28 surface expression during chronic infections and with aging. This correlates with changes of nuclear protein-binding activities to two motifs, site alpha and beta, within the CD28 minimal promoter. Both alpha- and beta-bound complexes are found only in lymphoid tissues, in CD28+ T cells, and in some transformed B cells. These complexes are coordinately expressed except during replicative senescence, which is characterized by the down-modulation of site beta- but not site alpha-binding activities. In contrast, T cell activation induces a parallel decline in both site alpha- and beta-binding activities. CD4+ and CD8+ T cells differ in their beta-binding profiles, which may explain the more pronounced down-regulation of CD28 in senescent CD8+ T cells. In vivo expanded CD4+CD28null and CD8+CD28null T cells uniformly lack alpha- and beta-bound complexes, resembling the pattern seen in chronically activated cells and not of senescent cells."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":14,"end":18},"obj":"protein_molecule"},{"id":"T2","span":{"begin":40,"end":59},"obj":"other_name"},{"id":"T3","span":{"begin":110,"end":132},"obj":"protein_family_or_group"},{"id":"T4","span":{"begin":133,"end":137},"obj":"protein_molecule"},{"id":"T5","span":{"begin":144,"end":174},"obj":"other_name"},{"id":"T6","span":{"begin":195,"end":202},"obj":"cell_type"},{"id":"T7","span":{"begin":212,"end":230},"obj":"cell_type"},{"id":"T8","span":{"begin":241,"end":245},"obj":"protein_molecule"},{"id":"T9","span":{"begin":330,"end":347},"obj":"other_name"},{"id":"T10","span":{"begin":410,"end":422},"obj":"cell_type"},{"id":"T11","span":{"begin":445,"end":457},"obj":"cell_type"},{"id":"T12","span":{"begin":478,"end":482},"obj":"protein_molecule"},{"id":"T13","span":{"begin":509,"end":527},"obj":"other_name"},{"id":"T14","span":{"begin":576,"end":610},"obj":"other_name"},{"id":"T15","span":{"begin":658,"end":662},"obj":"protein_molecule"},{"id":"T16","span":{"begin":736,"end":752},"obj":"tissue"},{"id":"T17","span":{"begin":757,"end":770},"obj":"cell_type"},{"id":"T18","span":{"begin":784,"end":803},"obj":"cell_line"},{"id":"T19","span":{"begin":862,"end":884},"obj":"other_name"},{"id":"T20","span":{"begin":935,"end":944},"obj":"protein_domain_or_region"},{"id":"T21","span":{"begin":954,"end":964},"obj":"protein_domain_or_region"},{"id":"T22","span":{"begin":964,"end":983},"obj":"other_name"},{"id":"T23","span":{"begin":998,"end":1015},"obj":"other_name"},{"id":"T24","span":{"begin":1101,"end":1113},"obj":"cell_type"},{"id":"T25","span":{"begin":1130,"end":1151},"obj":"other_name"},{"id":"T26","span":{"begin":1210,"end":1214},"obj":"protein_molecule"},{"id":"T27","span":{"begin":1228,"end":1240},"obj":"cell_type"},{"id":"T28","span":{"begin":1376,"end":1403},"obj":"cell_type"},{"id":"T29","span":{"begin":1415,"end":1430},"obj":"cell_type"}],"text":"Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence.\nThe costimulatory molecule CD28 has a restricted tissue distribution and is expressed on T cells and some plasmacytoma cells. Although CD28 is constitutively expressed, its expression is transiently down-regulated following T cell activation and declines progressively with in vitro senescence. In vivo, CD8+ T cells and, less frequently, CD4+ T cells may completely lose CD28 surface expression during chronic infections and with aging. This correlates with changes of nuclear protein-binding activities to two motifs, site alpha and beta, within the CD28 minimal promoter. Both alpha- and beta-bound complexes are found only in lymphoid tissues, in CD28+ T cells, and in some transformed B cells. These complexes are coordinately expressed except during replicative senescence, which is characterized by the down-modulation of site beta- but not site alpha-binding activities. In contrast, T cell activation induces a parallel decline in both site alpha- and beta-binding activities. CD4+ and CD8+ T cells differ in their beta-binding profiles, which may explain the more pronounced down-regulation of CD28 in senescent CD8+ T cells. In vivo expanded CD4+CD28null and CD8+CD28null T cells uniformly lack alpha- and beta-bound complexes, resembling the pattern seen in chronically activated cells and not of senescent cells."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":105},"obj":"Sentence"},{"id":"S2","span":{"begin":106,"end":231},"obj":"Sentence"},{"id":"S3","span":{"begin":232,"end":400},"obj":"Sentence"},{"id":"S4","span":{"begin":401,"end":543},"obj":"Sentence"},{"id":"S5","span":{"begin":544,"end":680},"obj":"Sentence"},{"id":"S6","span":{"begin":681,"end":804},"obj":"Sentence"},{"id":"S7","span":{"begin":805,"end":984},"obj":"Sentence"},{"id":"S8","span":{"begin":985,"end":1091},"obj":"Sentence"},{"id":"S9","span":{"begin":1092,"end":1241},"obj":"Sentence"},{"id":"S10","span":{"begin":1242,"end":1431},"obj":"Sentence"}],"text":"Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence.\nThe costimulatory molecule CD28 has a restricted tissue distribution and is expressed on T cells and some plasmacytoma cells. Although CD28 is constitutively expressed, its expression is transiently down-regulated following T cell activation and declines progressively with in vitro senescence. In vivo, CD8+ T cells and, less frequently, CD4+ T cells may completely lose CD28 surface expression during chronic infections and with aging. This correlates with changes of nuclear protein-binding activities to two motifs, site alpha and beta, within the CD28 minimal promoter. Both alpha- and beta-bound complexes are found only in lymphoid tissues, in CD28+ T cells, and in some transformed B cells. These complexes are coordinately expressed except during replicative senescence, which is characterized by the down-modulation of site beta- but not site alpha-binding activities. In contrast, T cell activation induces a parallel decline in both site alpha- and beta-binding activities. CD4+ and CD8+ T cells differ in their beta-binding profiles, which may explain the more pronounced down-regulation of CD28 in senescent CD8+ T cells. In vivo expanded CD4+CD28null and CD8+CD28null T cells uniformly lack alpha- and beta-bound complexes, resembling the pattern seen in chronically activated cells and not of senescent cells."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":14,"end":29},"obj":"NP"},{"id":"C2","span":{"begin":82,"end":104},"obj":"NP"},{"id":"C3","span":{"begin":106,"end":137},"obj":"NP"},{"id":"C4","span":{"begin":241,"end":245},"obj":"NP"},{"id":"C6","span":{"begin":275,"end":278},"obj":"NP"},{"id":"C5","span":{"begin":275,"end":289},"obj":"NP"},{"id":"C7","span":{"begin":330,"end":347},"obj":"NP"},{"id":"C8","span":{"begin":614,"end":624},"obj":"NP"},{"id":"C9","span":{"begin":626,"end":645},"obj":"NP"},{"id":"C10","span":{"begin":681,"end":717},"obj":"NP"},{"id":"C11","span":{"begin":805,"end":820},"obj":"NP"},{"id":"C12","span":{"begin":862,"end":884},"obj":"NP"},{"id":"C13","span":{"begin":886,"end":891},"obj":"NP"},{"id":"C14","span":{"begin":998,"end":1015},"obj":"NP"},{"id":"C15","span":{"begin":1092,"end":1113},"obj":"NP"},{"id":"C16","span":{"begin":1124,"end":1129},"obj":"NP"},{"id":"C17","span":{"begin":1210,"end":1214},"obj":"NP"},{"id":"C18","span":{"begin":1312,"end":1343},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C4","obj":"C3"},{"id":"R2","pred":"coref-pron","subj":"C6","obj":"C4"},{"id":"R3","pred":"coref-ident","subj":"C5","obj":"C1"},{"id":"R4","pred":"coref-appos","subj":"C9","obj":"C8"},{"id":"R5","pred":"coref-ident","subj":"C11","obj":"C10"},{"id":"R6","pred":"coref-ident","subj":"C12","obj":"C2"},{"id":"R7","pred":"coref-relat","subj":"C13","obj":"C12"},{"id":"R8","pred":"coref-ident","subj":"C14","obj":"C7"},{"id":"R9","pred":"coref-pron","subj":"C16","obj":"C15"},{"id":"R10","pred":"coref-ident","subj":"C17","obj":"C4"},{"id":"R11","pred":"coref-ident","subj":"C18","obj":"C11"}],"text":"Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence.\nThe costimulatory molecule CD28 has a restricted tissue distribution and is expressed on T cells and some plasmacytoma cells. Although CD28 is constitutively expressed, its expression is transiently down-regulated following T cell activation and declines progressively with in vitro senescence. In vivo, CD8+ T cells and, less frequently, CD4+ T cells may completely lose CD28 surface expression during chronic infections and with aging. This correlates with changes of nuclear protein-binding activities to two motifs, site alpha and beta, within the CD28 minimal promoter. Both alpha- and beta-bound complexes are found only in lymphoid tissues, in CD28+ T cells, and in some transformed B cells. These complexes are coordinately expressed except during replicative senescence, which is characterized by the down-modulation of site beta- but not site alpha-binding activities. In contrast, T cell activation induces a parallel decline in both site alpha- and beta-binding activities. CD4+ and CD8+ T cells differ in their beta-binding profiles, which may explain the more pronounced down-regulation of CD28 in senescent CD8+ T cells. In vivo expanded CD4+CD28null and CD8+CD28null T cells uniformly lack alpha- and beta-bound complexes, resembling the pattern seen in chronically activated cells and not of senescent cells."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":212,"end":224},"obj":"HP_0011857"}],"text":"Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence.\nThe costimulatory molecule CD28 has a restricted tissue distribution and is expressed on T cells and some plasmacytoma cells. Although CD28 is constitutively expressed, its expression is transiently down-regulated following T cell activation and declines progressively with in vitro senescence. In vivo, CD8+ T cells and, less frequently, CD4+ T cells may completely lose CD28 surface expression during chronic infections and with aging. This correlates with changes of nuclear protein-binding activities to two motifs, site alpha and beta, within the CD28 minimal promoter. Both alpha- and beta-bound complexes are found only in lymphoid tissues, in CD28+ T cells, and in some transformed B cells. These complexes are coordinately expressed except during replicative senescence, which is characterized by the down-modulation of site beta- but not site alpha-binding activities. In contrast, T cell activation induces a parallel decline in both site alpha- and beta-binding activities. CD4+ and CD8+ T cells differ in their beta-binding profiles, which may explain the more pronounced down-regulation of CD28 in senescent CD8+ T cells. In vivo expanded CD4+CD28null and CD8+CD28null T cells uniformly lack alpha- and beta-bound complexes, resembling the pattern seen in chronically activated cells and not of senescent cells."}