PubMed:10348340 JSONTXT

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{"project":"DisGeNET5_gene_disease","denotations":[{"id":"10348340-0#83#88#gene6776","span":{"begin":516,"end":521},"obj":"gene6776"},{"id":"10348340-0#83#88#gene6777","span":{"begin":516,"end":521},"obj":"gene6777"},{"id":"10348340-0#35#38#gene6900","span":{"begin":144,"end":154},"obj":"gene6900"},{"id":"10348340-0#73#78#gene6772","span":{"begin":499,"end":504},"obj":"gene6772"},{"id":"10348340-0#0#21#diseaseC0023493","span":{"begin":107,"end":128},"obj":"diseaseC0023493"}],"relations":[{"id":"83#88#gene67760#21#diseaseC0023493","pred":"associated_with","subj":"10348340-0#83#88#gene6776","obj":"10348340-0#0#21#diseaseC0023493"},{"id":"83#88#gene67770#21#diseaseC0023493","pred":"associated_with","subj":"10348340-0#83#88#gene6777","obj":"10348340-0#0#21#diseaseC0023493"},{"id":"35#38#gene69000#21#diseaseC0023493","pred":"associated_with","subj":"10348340-0#35#38#gene6900","obj":"10348340-0#0#21#diseaseC0023493"},{"id":"73#78#gene67720#21#diseaseC0023493","pred":"associated_with","subj":"10348340-0#73#78#gene6772","obj":"10348340-0#0#21#diseaseC0023493"}],"text":"Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells.\nHuman T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro. STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells. We investigated the involvement of STATs in the transformation of T-cells by HTLV-1. HTLV-1-transformed T-cell lines expressed higher amounts of STAT1, STAT3 and STAT5 RNA and proteins than virus-negative T cells. The expression of STAT1 and STAT5 in a human T-cell line was induced by Tax. IL-2 induced the DNA binding activity of STAT3 and STAT5 of a HTLV-1-transformed cell line and then stimulated its proliferation. In contrast, IL-2 did neither in a cell line lacking STAT3 and STAT5. The expression of STAT1, STAT3 and STAT5 mRNAs were also induced by a T-cell mitogen in normal human peripheral blood mononuclear cells. Our results suggest that the induction of STAT1 and STAT5 by Tax enhances cytokine-induced functions of virus-infected T-cells, hence the induction may play a role in IL-2-dependent transformation steps of T-cells by HTLV-1."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":106},"obj":"Sentence"},{"id":"S2","span":{"begin":107,"end":228},"obj":"Sentence"},{"id":"S3","span":{"begin":229,"end":353},"obj":"Sentence"},{"id":"S4","span":{"begin":354,"end":438},"obj":"Sentence"},{"id":"S5","span":{"begin":439,"end":567},"obj":"Sentence"},{"id":"S6","span":{"begin":568,"end":644},"obj":"Sentence"},{"id":"S7","span":{"begin":645,"end":774},"obj":"Sentence"},{"id":"S8","span":{"begin":775,"end":844},"obj":"Sentence"},{"id":"S9","span":{"begin":845,"end":981},"obj":"Sentence"},{"id":"S10","span":{"begin":982,"end":1206},"obj":"Sentence"}],"text":"Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells.\nHuman T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro. STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells. We investigated the involvement of STATs in the transformation of T-cells by HTLV-1. HTLV-1-transformed T-cell lines expressed higher amounts of STAT1, STAT3 and STAT5 RNA and proteins than virus-negative T cells. The expression of STAT1 and STAT5 in a human T-cell line was induced by Tax. IL-2 induced the DNA binding activity of STAT3 and STAT5 of a HTLV-1-transformed cell line and then stimulated its proliferation. In contrast, IL-2 did neither in a cell line lacking STAT3 and STAT5. The expression of STAT1, STAT3 and STAT5 mRNAs were also induced by a T-cell mitogen in normal human peripheral blood mononuclear cells. Our results suggest that the induction of STAT1 and STAT5 by Tax enhances cytokine-induced functions of virus-infected T-cells, hence the induction may play a role in IL-2-dependent transformation steps of T-cells by HTLV-1."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":46},"obj":"NP"},{"id":"C2","span":{"begin":98,"end":105},"obj":"NP"},{"id":"C3","span":{"begin":107,"end":154},"obj":"NP"},{"id":"C4","span":{"begin":200,"end":218},"obj":"NP"},{"id":"C5","span":{"begin":249,"end":270},"obj":"NP"},{"id":"C6","span":{"begin":271,"end":275},"obj":"NP"},{"id":"C7","span":{"begin":420,"end":427},"obj":"NP"},{"id":"C8","span":{"begin":431,"end":437},"obj":"NP"},{"id":"C10","span":{"begin":596,"end":601},"obj":"NP"},{"id":"C9","span":{"begin":586,"end":601},"obj":"NP"},{"id":"C11","span":{"begin":640,"end":643},"obj":"NP"},{"id":"C12","span":{"begin":645,"end":649},"obj":"NP"},{"id":"C13","span":{"begin":658,"end":735},"obj":"NP"},{"id":"C14","span":{"begin":756,"end":759},"obj":"NP"},{"id":"C15","span":{"begin":788,"end":792},"obj":"NP"},{"id":"C16","span":{"begin":838,"end":843},"obj":"NP"},{"id":"C19","span":{"begin":1034,"end":1039},"obj":"NP"},{"id":"C18","span":{"begin":1024,"end":1039},"obj":"NP"},{"id":"C20","span":{"begin":1043,"end":1046},"obj":"NP"},{"id":"C17","span":{"begin":1007,"end":1046},"obj":"NP"},{"id":"C21","span":{"begin":1116,"end":1129},"obj":"NP"},{"id":"C22","span":{"begin":1188,"end":1195},"obj":"NP"},{"id":"C23","span":{"begin":1199,"end":1205},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C3","obj":"C1"},{"id":"R2","pred":"coref-relat","subj":"C6","obj":"C5"},{"id":"R3","pred":"coref-ident","subj":"C7","obj":"C2"},{"id":"R4","pred":"coref-ident","subj":"C12","obj":"C4"},{"id":"R5","pred":"coref-pron","subj":"C14","obj":"C13"},{"id":"R6","pred":"coref-ident","subj":"C15","obj":"C12"},{"id":"R7","pred":"coref-ident","subj":"C16","obj":"C10"},{"id":"R8","pred":"coref-ident","subj":"C19","obj":"C16"},{"id":"R9","pred":"coref-ident","subj":"C18","obj":"C9"},{"id":"R10","pred":"coref-ident","subj":"C20","obj":"C11"},{"id":"R11","pred":"coref-ident","subj":"C21","obj":"C17"},{"id":"R12","pred":"coref-ident","subj":"C22","obj":"C7"},{"id":"R13","pred":"coref-ident","subj":"C23","obj":"C8"}],"text":"Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells.\nHuman T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro. STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells. We investigated the involvement of STATs in the transformation of T-cells by HTLV-1. HTLV-1-transformed T-cell lines expressed higher amounts of STAT1, STAT3 and STAT5 RNA and proteins than virus-negative T cells. The expression of STAT1 and STAT5 in a human T-cell line was induced by Tax. IL-2 induced the DNA binding activity of STAT3 and STAT5 of a HTLV-1-transformed cell line and then stimulated its proliferation. In contrast, IL-2 did neither in a cell line lacking STAT3 and STAT5. The expression of STAT1, STAT3 and STAT5 mRNAs were also induced by a T-cell mitogen in normal human peripheral blood mononuclear cells. Our results suggest that the induction of STAT1 and STAT5 by Tax enhances cytokine-induced functions of virus-infected T-cells, hence the induction may play a role in IL-2-dependent transformation steps of T-cells by HTLV-1."}

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{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":35,"end":38},"obj":"gene:6900"},{"id":"T1","span":{"begin":0,"end":21},"obj":"disease:C0023493"},{"id":"T2","span":{"begin":73,"end":78},"obj":"gene:6772"},{"id":"T3","span":{"begin":0,"end":21},"obj":"disease:C0023493"},{"id":"T4","span":{"begin":83,"end":88},"obj":"gene:6776"},{"id":"T5","span":{"begin":0,"end":21},"obj":"disease:C0023493"},{"id":"T6","span":{"begin":83,"end":88},"obj":"gene:6777"},{"id":"T7","span":{"begin":0,"end":21},"obj":"disease:C0023493"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells.\nHuman T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro. STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells. We investigated the involvement of STATs in the transformation of T-cells by HTLV-1. HTLV-1-transformed T-cell lines expressed higher amounts of STAT1, STAT3 and STAT5 RNA and proteins than virus-negative T cells. The expression of STAT1 and STAT5 in a human T-cell line was induced by Tax. IL-2 induced the DNA binding activity of STAT3 and STAT5 of a HTLV-1-transformed cell line and then stimulated its proliferation. In contrast, IL-2 did neither in a cell line lacking STAT3 and STAT5. The expression of STAT1, STAT3 and STAT5 mRNAs were also induced by a T-cell mitogen in normal human peripheral blood mononuclear cells. Our results suggest that the induction of STAT1 and STAT5 by Tax enhances cytokine-induced functions of virus-infected T-cells, hence the induction may play a role in IL-2-dependent transformation steps of T-cells by HTLV-1."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":120,"end":128},"obj":"HP_0001909"}],"text":"Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells.\nHuman T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro. STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells. We investigated the involvement of STATs in the transformation of T-cells by HTLV-1. HTLV-1-transformed T-cell lines expressed higher amounts of STAT1, STAT3 and STAT5 RNA and proteins than virus-negative T cells. The expression of STAT1 and STAT5 in a human T-cell line was induced by Tax. IL-2 induced the DNA binding activity of STAT3 and STAT5 of a HTLV-1-transformed cell line and then stimulated its proliferation. In contrast, IL-2 did neither in a cell line lacking STAT3 and STAT5. The expression of STAT1, STAT3 and STAT5 mRNAs were also induced by a T-cell mitogen in normal human peripheral blood mononuclear cells. Our results suggest that the induction of STAT1 and STAT5 by Tax enhances cytokine-induced functions of virus-infected T-cells, hence the induction may play a role in IL-2-dependent transformation steps of T-cells by HTLV-1."}