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PubMed:10348340 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-46 protein denotes Human T-cell leukemia virus type 1 Tax protein
T2 73-94 DNA denotes STAT1 and STAT5 genes
T3 98-105 cell_type denotes T-cells
T4 107-154 protein denotes Human T-cell leukemia virus type 1 (HTLV-1) Tax
T5 173-180 cell_type denotes T-cells
T6 200-218 protein denotes interleukin (IL)-2
T7 229-233 protein denotes STAT
T8 249-270 protein denotes transcription factors
T9 389-394 protein denotes STATs
T10 420-427 cell_type denotes T-cells
T11 439-470 cell_line denotes HTLV-1-transformed T-cell lines
T12 499-525 RNA denotes STAT1, STAT3 and STAT5 RNA
T13 544-566 cell_type denotes virus-negative T cells
T14 586-591 protein denotes STAT1
T15 596-601 protein denotes STAT5
T16 607-624 cell_line denotes human T-cell line
T17 640-643 protein denotes Tax
T18 645-649 protein denotes IL-2
T19 686-691 protein denotes STAT3
T20 696-701 protein denotes STAT5
T21 788-792 protein denotes IL-2
T22 828-833 protein denotes STAT3
T23 838-843 protein denotes STAT5
T24 863-891 RNA denotes STAT1, STAT3 and STAT5 mRNAs
T25 915-929 protein denotes T-cell mitogen
T26 940-980 cell_type denotes human peripheral blood mononuclear cells
T27 1024-1029 protein denotes STAT1
T28 1034-1039 protein denotes STAT5
T29 1043-1046 protein denotes Tax
T30 1056-1064 protein denotes cytokine
T31 1101-1108 cell_type denotes T-cells
T32 1149-1153 protein denotes IL-2
T33 1188-1195 cell_type denotes T-cells

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10348340-0#83#88#gene6776 516-521 gene6776 denotes STAT5
10348340-0#83#88#gene6777 516-521 gene6777 denotes STAT5
10348340-0#35#38#gene6900 144-154 gene6900 denotes TLV-1) Tax
10348340-0#73#78#gene6772 499-504 gene6772 denotes STAT1
10348340-0#0#21#diseaseC0023493 107-128 diseaseC0023493 denotes Human T-cell leukemia
83#88#gene67760#21#diseaseC0023493 10348340-0#83#88#gene6776 10348340-0#0#21#diseaseC0023493 associated_with STAT5,Human T-cell leukemia
83#88#gene67770#21#diseaseC0023493 10348340-0#83#88#gene6777 10348340-0#0#21#diseaseC0023493 associated_with STAT5,Human T-cell leukemia
35#38#gene69000#21#diseaseC0023493 10348340-0#35#38#gene6900 10348340-0#0#21#diseaseC0023493 associated_with TLV-1) Tax,Human T-cell leukemia
73#78#gene67720#21#diseaseC0023493 10348340-0#73#78#gene6772 10348340-0#0#21#diseaseC0023493 associated_with STAT1,Human T-cell leukemia

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-106 Sentence denotes Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells.
S2 107-228 Sentence denotes Human T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro.
S3 229-353 Sentence denotes STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells.
S4 354-438 Sentence denotes We investigated the involvement of STATs in the transformation of T-cells by HTLV-1.
S5 439-567 Sentence denotes HTLV-1-transformed T-cell lines expressed higher amounts of STAT1, STAT3 and STAT5 RNA and proteins than virus-negative T cells.
S6 568-644 Sentence denotes The expression of STAT1 and STAT5 in a human T-cell line was induced by Tax.
S7 645-774 Sentence denotes IL-2 induced the DNA binding activity of STAT3 and STAT5 of a HTLV-1-transformed cell line and then stimulated its proliferation.
S8 775-844 Sentence denotes In contrast, IL-2 did neither in a cell line lacking STAT3 and STAT5.
S9 845-981 Sentence denotes The expression of STAT1, STAT3 and STAT5 mRNAs were also induced by a T-cell mitogen in normal human peripheral blood mononuclear cells.
S10 982-1206 Sentence denotes Our results suggest that the induction of STAT1 and STAT5 by Tax enhances cytokine-induced functions of virus-infected T-cells, hence the induction may play a role in IL-2-dependent transformation steps of T-cells by HTLV-1.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-46 NP denotes Human T-cell leukemia virus type 1 Tax protein
C2 98-105 NP denotes T-cells
C3 107-154 NP denotes Human T-cell leukemia virus type 1 (HTLV-1) Tax
C4 200-218 NP denotes interleukin (IL)-2
C5 249-270 NP denotes transcription factors
C6 271-275 NP denotes that
C7 420-427 NP denotes T-cells
C8 431-437 NP denotes HTLV-1
C10 596-601 NP denotes STAT5
C9 586-601 NP denotes STAT1 and STAT5
C11 640-643 NP denotes Tax
C12 645-649 NP denotes IL-2
C13 658-735 NP denotes the DNA binding activity of STAT3 and STAT5 of a HTLV-1-transformed cell line
C14 756-759 NP denotes its
C15 788-792 NP denotes IL-2
C16 838-843 NP denotes STAT5
C19 1034-1039 NP denotes STAT5
C18 1024-1039 NP denotes STAT1 and STAT5
C20 1043-1046 NP denotes Tax
C17 1007-1046 NP denotes the induction of STAT1 and STAT5 by Tax
C21 1116-1129 NP denotes the induction
C22 1188-1195 NP denotes T-cells
C23 1199-1205 NP denotes HTLV-1
R1 C3 C1 coref-ident Human T-cell leukemia virus type 1 (HTLV-1) Tax,Human T-cell leukemia virus type 1 Tax protein
R2 C6 C5 coref-relat that,transcription factors
R3 C7 C2 coref-ident T-cells,T-cells
R4 C12 C4 coref-ident IL-2,interleukin (IL)-2
R5 C14 C13 coref-pron its,the DNA binding activity of STAT3 and STAT5 of a HTLV-1-transformed cell line
R6 C15 C12 coref-ident IL-2,IL-2
R7 C16 C10 coref-ident STAT5,STAT5
R8 C19 C16 coref-ident STAT5,STAT5
R9 C18 C9 coref-ident STAT1 and STAT5,STAT1 and STAT5
R10 C20 C11 coref-ident Tax,Tax
R11 C21 C17 coref-ident the induction,the induction of STAT1 and STAT5 by Tax
R12 C22 C7 coref-ident T-cells,T-cells
R13 C23 C8 coref-ident HTLV-1,HTLV-1

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-34 virus denotes Human T-cell leukemia virus type 1
T2 98-105 cell_type denotes T-cells
T3 107-141 virus denotes Human T-cell leukemia virus type 1
T4 143-149 virus denotes HTLV-1
T5 173-180 cell_type denotes T-cells
T6 200-218 protein_molecule denotes interleukin (IL)-2
T7 229-233 protein_family_or_group denotes STAT
T8 249-270 protein_family_or_group denotes transcription factors
T9 389-394 protein_family_or_group denotes STATs
T10 420-427 cell_type denotes T-cells
T11 431-437 virus denotes HTLV-1
T12 439-445 virus denotes HTLV-1
T13 544-566 cell_type denotes virus-negative T cells
T14 586-591 protein_molecule denotes STAT1
T15 596-601 protein_molecule denotes STAT5
T16 607-624 cell_line denotes human T-cell line
T17 640-643 protein_molecule denotes Tax
T18 645-649 protein_molecule denotes IL-2
T19 686-691 protein_molecule denotes STAT3
T20 696-701 protein_molecule denotes STAT5
T21 707-713 virus denotes HTLV-1
T22 788-792 protein_molecule denotes IL-2
T23 828-833 protein_molecule denotes STAT3
T24 838-843 protein_molecule denotes STAT5
T25 915-929 protein_molecule denotes T-cell mitogen
T26 940-945 cell_type denotes human
T27 946-962 tissue denotes peripheral blood
T28 1024-1029 protein_molecule denotes STAT1
T29 1034-1039 protein_molecule denotes STAT5
T30 1043-1046 protein_molecule denotes Tax
T31 1056-1064 protein_family_or_group denotes cytokine
T32 1101-1108 cell_type denotes T-cells
T33 1149-1153 protein_molecule denotes IL-2
T34 1188-1195 cell_type denotes T-cells
T35 1199-1205 virus denotes HTLV-1

DisGeNET

Id Subject Object Predicate Lexical cue
T0 35-38 gene:6900 denotes Tax
T1 0-21 disease:C0023493 denotes Human T-cell leukemia
T2 73-78 gene:6772 denotes STAT1
T3 0-21 disease:C0023493 denotes Human T-cell leukemia
T4 83-88 gene:6776 denotes STAT5
T5 0-21 disease:C0023493 denotes Human T-cell leukemia
T6 83-88 gene:6777 denotes STAT5
T7 0-21 disease:C0023493 denotes Human T-cell leukemia
R1 T0 T1 associated_with Tax,Human T-cell leukemia
R2 T2 T3 associated_with STAT1,Human T-cell leukemia
R3 T4 T5 associated_with STAT5,Human T-cell leukemia
R4 T6 T7 associated_with STAT5,Human T-cell leukemia

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 120-128 HP_0001909 denotes leukemia