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PubMed:10318773 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-114 Sentence denotes A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis.
T2 115-213 Sentence denotes TR6 (decoy receptor 3 (DcR3)) is a new member of the tumor necrosis factor receptor (TNFR) family.
T3 214-284 Sentence denotes TR6 mRNA is expressed in lung tissues and colon adenocarcinoma, SW480.
T4 285-448 Sentence denotes In addition, the expression of TR6 mRNA was shown in the endothelial cell line and induced by phorbol 12-myristate 13-acetate/ionomycin in Jurkat T leukemia cells.
T5 449-565 Sentence denotes The open reading frame of TR6 encodes 300 amino acids with a 29-residue signal sequence but no transmembrane region.
T6 566-680 Sentence denotes Using histidine-tagged recombinant TR6, we screened soluble forms of TNF-ligand proteins with immunoprecipitation.
T7 681-825 Sentence denotes Here, we demonstrate that TR6 specifically binds two cellular ligands, LIGHT (herpes virus entry mediator (HVEM)-L) and Fas ligand (FasL/CD95L).
T8 826-926 Sentence denotes These bindings were confirmed with HEK 293 EBNA cells transfected with LIGHT cDNA by flow cytometry.
T9 927-982 Sentence denotes TR6 inhibited LIGHT-induced cytotoxicity in HT29 cells.
T10 983-1152 Sentence denotes It has been shown that LIGHT triggers apoptosis of various tumor cells including HT29 cells that express both lymphotoxin beta receptor (LTbetaR) and HVEM/TR2 receptors.
T11 1153-1293 Sentence denotes Our data suggest that TR6 inhibits the interactions of LIGHT with HVEM/TR2 and LTbetaR, thereby suppressing LIGHT- mediated HT29 cell death.
T12 1294-1386 Sentence denotes Thus, TR6 may play a regulatory role for suppressing in FasL- and LIGHT-mediated cell death.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 239-243 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T2 256-261 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 29-71 protein denotes tumor necrosis factor receptor superfamily
T2 73-76 protein denotes TR6
T3 89-94 protein denotes LIGHT
T4 115-118 protein denotes TR6
T5 120-136 protein denotes decoy receptor 3
T6 138-142 protein denotes DcR3
T7 168-212 protein denotes tumor necrosis factor receptor (TNFR) family
T8 214-217 protein denotes TR6
T9 316-319 protein denotes TR6
T10 475-478 protein denotes TR6
T11 601-604 protein denotes TR6
T12 635-638 protein denotes TNF
T13 707-710 protein denotes TR6
T14 752-757 protein denotes LIGHT
T15 759-795 protein denotes herpes virus entry mediator (HVEM)-L
T16 801-811 protein denotes Fas ligand
T17 813-817 protein denotes FasL
T18 818-823 protein denotes CD95L
T19 897-902 protein denotes LIGHT
T20 927-930 protein denotes TR6
T21 941-946 protein denotes LIGHT
T22 1006-1011 protein denotes LIGHT
T23 1093-1118 protein denotes lymphotoxin beta receptor
T24 1120-1127 protein denotes LTbetaR
T25 1133-1137 protein denotes HVEM
T26 1138-1141 protein denotes TR2
T27 1175-1178 protein denotes TR6
T28 1208-1213 protein denotes LIGHT
T29 1219-1223 protein denotes HVEM
T30 1224-1227 protein denotes TR2
T31 1232-1239 protein denotes LTbetaR
T32 1261-1266 protein denotes LIGHT
T33 1300-1303 protein denotes TR6
T34 1350-1354 protein denotes FasL
T35 1360-1365 protein denotes LIGHT

AIMed

Id Subject Object Predicate Lexical cue
T1 73-76 protein denotes TR6
T2 89-94 protein denotes LIGHT
T3 115-118 protein denotes TR6
T4 120-136 protein denotes decoy receptor 3
T5 138-142 protein denotes DcR3
T6 214-217 protein denotes TR6
T7 316-319 protein denotes TR6
T8 475-478 protein denotes TR6
T9 601-604 protein denotes TR6
T10 707-710 protein denotes TR6
T11 752-757 protein denotes LIGHT
T12 759-795 protein denotes herpes virus entry mediator (HVEM)-L
T13 801-811 protein denotes Fas ligand
T14 813-817 protein denotes FasL
T15 818-823 protein denotes CD95L
T16 897-902 protein denotes LIGHT
T17 927-930 protein denotes TR6
T18 941-946 protein denotes LIGHT
T19 1006-1011 protein denotes LIGHT
T20 1093-1118 protein denotes lymphotoxin beta receptor
T21 1120-1127 protein denotes LTbetaR
T22 1133-1137 protein denotes HVEM
T23 1138-1141 protein denotes TR2
T24 1175-1178 protein denotes TR6
T25 1208-1213 protein denotes LIGHT
T26 1219-1223 protein denotes HVEM
T27 1224-1227 protein denotes TR2
T28 1232-1239 protein denotes LTbetaR
T29 1261-1266 protein denotes LIGHT
T30 1300-1303 protein denotes TR6
T31 1350-1354 protein denotes FasL
T32 1360-1365 protein denotes LIGHT

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 168-173 HP_0002664 denotes tumor
T2 239-276 HP_0030078 denotes lung tissues and colon adenocarcinoma
T3 433-441 HP_0001909 denotes leukemia
T4 1042-1047 HP_0002664 denotes tumor

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 29-34 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 168-173 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 256-276 Disease denotes colon adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0002271
T4 433-441 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T5 1042-1047 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 29-34 Phenotype denotes tumor HP:0002664
T2 168-173 Phenotype denotes tumor HP:0002664
T3 433-441 Phenotype denotes leukemia HP:0001909
T4 1042-1047 Phenotype denotes tumor HP:0002664

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 239-243 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T2 256-261 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T3 342-358 Body_part denotes endothelial cell http://purl.obolibrary.org/obo/CL_0000115
T4 544-557 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 239-243 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T2 256-261 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 342-358 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115
T2 1042-1053 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063