PubMed:10233882 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":22,"end":31},"obj":"protein"},{"id":"T2","span":{"begin":35,"end":65},"obj":"cell_type"},{"id":"T3","span":{"begin":80,"end":100},"obj":"protein"},{"id":"T4","span":{"begin":102,"end":111},"obj":"protein"},{"id":"T5","span":{"begin":340,"end":349},"obj":"protein"},{"id":"T6","span":{"begin":353,"end":384},"obj":"cell_type"},{"id":"T7","span":{"begin":453,"end":484},"obj":"cell_type"},{"id":"T8","span":{"begin":493,"end":502},"obj":"protein"},{"id":"T9","span":{"begin":589,"end":598},"obj":"protein"},{"id":"T10","span":{"begin":604,"end":631},"obj":"protein"},{"id":"T11","span":{"begin":633,"end":646},"obj":"protein"},{"id":"T12","span":{"begin":652,"end":700},"obj":"protein"},{"id":"T13","span":{"begin":735,"end":744},"obj":"protein"},{"id":"T14","span":{"begin":771,"end":795},"obj":"cell_type"},{"id":"T15","span":{"begin":878,"end":887},"obj":"protein"},{"id":"T16","span":{"begin":928,"end":967},"obj":"cell_type"},{"id":"T17","span":{"begin":1029,"end":1038},"obj":"protein"}],"text":"An essential role for NF-kappaB in human CD34(+) bone marrow cell survival.\nThe transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":75},"obj":"Sentence"},{"id":"S2","span":{"begin":76,"end":319},"obj":"Sentence"},{"id":"S3","span":{"begin":320,"end":408},"obj":"Sentence"},{"id":"S4","span":{"begin":409,"end":701},"obj":"Sentence"},{"id":"S5","span":{"begin":702,"end":829},"obj":"Sentence"},{"id":"S6","span":{"begin":830,"end":1121},"obj":"Sentence"}],"text":"An essential role for NF-kappaB in human CD34(+) bone marrow cell survival.\nThe transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":22,"end":31},"obj":"NP"},{"id":"C2","span":{"begin":76,"end":100},"obj":"NP"},{"id":"C3","span":{"begin":102,"end":111},"obj":"NP"},{"id":"C4","span":{"begin":340,"end":349},"obj":"NP"},{"id":"C5","span":{"begin":353,"end":384},"obj":"NP"},{"id":"C6","span":{"begin":420,"end":428},"obj":"NP"},{"id":"C7","span":{"begin":434,"end":438},"obj":"NP"},{"id":"C8","span":{"begin":449,"end":484},"obj":"NP"},{"id":"C9","span":{"begin":493,"end":502},"obj":"NP"},{"id":"C10","span":{"begin":503,"end":507},"obj":"NP"},{"id":"C11","span":{"begin":735,"end":744},"obj":"NP"},{"id":"C12","span":{"begin":878,"end":887},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-appos","subj":"C3","obj":"C2"},{"id":"R3","pred":"coref-ident","subj":"C4","obj":"C2"},{"id":"R4","pred":"coref-relat","subj":"C7","obj":"C6"},{"id":"R5","pred":"coref-ident","subj":"C8","obj":"C5"},{"id":"R6","pred":"coref-relat","subj":"C10","obj":"C9"},{"id":"R7","pred":"coref-ident","subj":"C11","obj":"C4"},{"id":"R8","pred":"coref-ident","subj":"C12","obj":"C11"}],"text":"An essential role for NF-kappaB in human CD34(+) bone marrow cell survival.\nThe transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":22,"end":31},"obj":"protein_complex"},{"id":"T2","span":{"begin":35,"end":65},"obj":"cell_type"},{"id":"T3","span":{"begin":80,"end":100},"obj":"protein_family_or_group"},{"id":"T4","span":{"begin":102,"end":111},"obj":"protein_complex"},{"id":"T5","span":{"begin":130,"end":147},"obj":"other_name"},{"id":"T6","span":{"begin":149,"end":166},"obj":"other_name"},{"id":"T7","span":{"begin":172,"end":200},"obj":"virus"},{"id":"T8","span":{"begin":282,"end":291},"obj":"other_name"},{"id":"T9","span":{"begin":340,"end":349},"obj":"protein_complex"},{"id":"T10","span":{"begin":353,"end":384},"obj":"cell_type"},{"id":"T11","span":{"begin":453,"end":484},"obj":"cell_type"},{"id":"T12","span":{"begin":493,"end":502},"obj":"protein_complex"},{"id":"T13","span":{"begin":540,"end":571},"obj":"other_organic_compound"},{"id":"T14","span":{"begin":589,"end":598},"obj":"protein_family_or_group"},{"id":"T15","span":{"begin":604,"end":631},"obj":"protein_molecule"},{"id":"T16","span":{"begin":633,"end":646},"obj":"protein_molecule"},{"id":"T17","span":{"begin":652,"end":700},"obj":"protein_molecule"},{"id":"T18","span":{"begin":735,"end":744},"obj":"protein_complex"},{"id":"T19","span":{"begin":771,"end":795},"obj":"cell_type"},{"id":"T20","span":{"begin":878,"end":887},"obj":"protein_complex"},{"id":"T21","span":{"begin":1029,"end":1038},"obj":"protein_complex"},{"id":"T22","span":{"begin":1067,"end":1086},"obj":"other_name"}],"text":"An essential role for NF-kappaB in human CD34(+) bone marrow cell survival.\nThe transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":178,"end":194},"obj":"HP_0002721"},{"id":"T2","span":{"begin":604,"end":609},"obj":"HP_0002664"},{"id":"T3","span":{"begin":1067,"end":1073},"obj":"HP_0002664"}],"text":"An essential role for NF-kappaB in human CD34(+) bone marrow cell survival.\nThe transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described. We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor. In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival. These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution."}