PubMed:10233882 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	22-31	protein	denotes	NF-kappaB
T2	35-65	cell_type	denotes	human CD34(+) bone marrow cell
T3	80-100	protein	denotes	transcription factor
T4	102-111	protein	denotes	NF-kappaB
T5	340-349	protein	denotes	NF-kappaB
T6	353-384	cell_type	denotes	human CD34(+) bone marrow cells
T7	453-484	cell_type	denotes	human CD34(+) bone marrow cells
T8	493-502	protein	denotes	NF-kappaB
T9	589-598	protein	denotes	cytokines
T10	604-631	protein	denotes	tumor necrosis factor alpha
T11	633-646	protein	denotes	interleukin-3
T12	652-700	protein	denotes	granulocyte-macrophage colony-stimulating factor
T13	735-744	protein	denotes	NF-kappaB
T14	771-795	cell_type	denotes	CD34(+) bone marrow cell
T15	878-887	protein	denotes	NF-kappaB
T16	928-967	cell_type	denotes	hematopoietic stem and progenitor cells
T17	1029-1038	protein	denotes	NF-kappaB

Id	Subject	Object	Predicate	Lexical cue
S1	0-75	Sentence	denotes	An essential role for NF-kappaB in human CD34(+) bone marrow cell survival.
S2	76-319	Sentence	denotes	The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types.
S3	320-408	Sentence	denotes	However, a role for NF-kappaB in human CD34(+) bone marrow cells has not been described.
S4	409-701	Sentence	denotes	We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor.
S5	702-829	Sentence	denotes	In addition, we demonstrate that NF-kappaB may be required for human CD34(+) bone marrow cell clonogenic function and survival.
S6	830-1121	Sentence	denotes	These results offer insight into a new role for NF-kappaB in maintaining survival and function in hematopoietic stem and progenitor cells and suggest that proposed strategies involving inhibition of NF-kappaB activation as an adjunct to cancer chemotherapy should be approached with caution.

Id	Subject	Object	Predicate	Lexical cue
C1	22-31	NP	denotes	NF-kappaB
C2	76-100	NP	denotes	The transcription factor
C3	102-111	NP	denotes	NF-kappaB
C4	340-349	NP	denotes	NF-kappaB
C5	353-384	NP	denotes	human CD34(+) bone marrow cells
C6	420-428	NP	denotes	evidence
C7	434-438	NP	denotes	that
C8	449-484	NP	denotes	all human CD34(+) bone marrow cells
C9	493-502	NP	denotes	NF-kappaB
C10	503-507	NP	denotes	that
C11	735-744	NP	denotes	NF-kappaB
C12	878-887	NP	denotes	NF-kappaB
R1	C2	C1	coref-ident	The transcription factor,NF-kappaB
R2	C3	C2	coref-appos	NF-kappaB,The transcription factor
R3	C4	C2	coref-ident	NF-kappaB,The transcription factor
R4	C7	C6	coref-relat	that,evidence
R5	C8	C5	coref-ident	all human CD34(+) bone marrow cells,human CD34(+) bone marrow cells
R6	C10	C9	coref-relat	that,NF-kappaB
R7	C11	C4	coref-ident	NF-kappaB,NF-kappaB
R8	C12	C11	coref-ident	NF-kappaB,NF-kappaB

Id	Subject	Object	Predicate	Lexical cue
T1	22-31	protein_complex	denotes	NF-kappaB
T2	35-65	cell_type	denotes	human CD34(+) bone marrow cell
T3	80-100	protein_family_or_group	denotes	transcription factor
T4	102-111	protein_complex	denotes	NF-kappaB
T5	130-147	other_name	denotes	T-cell activation
T6	149-166	other_name	denotes	B-cell maturation
T7	172-200	virus	denotes	human immunodeficiency virus
T8	282-291	other_name	denotes	apoptosis
T9	340-349	protein_complex	denotes	NF-kappaB
T10	353-384	cell_type	denotes	human CD34(+) bone marrow cells
T11	453-484	cell_type	denotes	human CD34(+) bone marrow cells
T12	493-502	protein_complex	denotes	NF-kappaB
T13	540-571	other_organic_compound	denotes	phorbol 12-myristate 13-acetate
T14	589-598	protein_family_or_group	denotes	cytokines
T15	604-631	protein_molecule	denotes	tumor necrosis factor alpha
T16	633-646	protein_molecule	denotes	interleukin-3
T17	652-700	protein_molecule	denotes	granulocyte-macrophage colony-stimulating factor
T18	735-744	protein_complex	denotes	NF-kappaB
T19	771-795	cell_type	denotes	CD34(+) bone marrow cell
T20	878-887	protein_complex	denotes	NF-kappaB
T21	1029-1038	protein_complex	denotes	NF-kappaB
T22	1067-1086	other_name	denotes	cancer chemotherapy

Id	Subject	Object	Predicate	Lexical cue
T1	178-194	HP_0002721	denotes	immunodeficiency
T2	604-609	HP_0002664	denotes	tumor
T3	1067-1073	HP_0002664	denotes	cancer