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PubMed:10233875 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-9 protein denotes NF-kappaB
T2 37-67 DNA denotes C5a-induced interleukin-8 gene
T3 82-99 cell_type denotes mononuclear cells
T4 151-164 protein denotes interleukin-8
T5 166-170 protein denotes IL-8
T6 187-221 cell_type denotes peripheral blood mononuclear cells
T7 223-227 cell_type denotes PBMC
T8 302-306 protein denotes IL-8
T9 358-376 cell_type denotes unstimulated cells
T10 389-393 protein denotes IL-8
T11 439-448 RNA denotes IL-8 mRNA
T12 495-501 protein denotes kappaB
T13 542-546 protein denotes AP-1
T14 555-562 protein denotes NF-IL-6
T15 605-624 cell_line denotes C5a-stimulated PBMC
T16 738-742 protein denotes IL-8
T17 780-786 protein denotes kappaB
T18 808-812 protein denotes IL-8
T19 849-874 cell_line denotes RAW264.7 macrophage cells
T20 912-927 DNA denotes kappaB sequence
T21 933-945 protein denotes IkappaBalpha
T22 950-971 DNA denotes IL-8 promoter regions
T23 985-998 DNA denotes reporter gene
T24 1058-1070 DNA denotes kappaB sites
T25 1096-1136 DNA denotes dominant negative IkappaBalpha construct
T26 1226-1237 protein denotes Gi proteins
T27 1261-1273 protein denotes C5a receptor
T28 1318-1322 protein denotes IL-8
T29 1395-1409 cell_line denotes RAW264.7 cells
T30 1438-1447 protein denotes NF-kappaB
T31 1487-1491 protein denotes IL-8

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-100 Sentence denotes NF-kappaB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells.
S2 101-229 Sentence denotes C5a, a potent peptide chemoattractant, stimulates interleukin-8 (IL-8) secretion from peripheral blood mononuclear cells (PBMC).
S3 230-388 Sentence denotes Experiments were conducted to understand the mechanisms for C5a-induced IL-8 production, which was 14-fold greater than that in unstimulated cells by 2 hours.
S4 389-541 Sentence denotes IL-8 secretion was accompanied by accumulation of IL-8 mRNA in the cytosol and by nuclear expression of a kappaB DNA binding activity within 30 minutes.
S5 542-743 Sentence denotes AP-1 but not NF-IL-6 DNA binding activity was also detected in C5a-stimulated PBMC; however, its delayed expression (maximal at 4 hours) suggested a less important role in the rapid production of IL-8.
S6 744-972 Sentence denotes The correlation between C5a-induced kappaB binding activity and IL-8 gene expression was examined in the RAW264.7 macrophage cells using reporter genes directed by the kappaB sequence from IkappaBalpha and IL-8 promoter regions.
S7 973-1182 Sentence denotes C5a-induced reporter gene expression was abolished by introducing mutations into the kappaB sites and by coexpression of a dominant negative IkappaBalpha construct resistant to agonist-induced phosphorylation.
S8 1183-1410 Sentence denotes Pertussis toxin, which ADP-ribosylates the Gi proteins known to couple to the C5a receptor, produced minimal inhibition of C5a-induced IL-8 expression and had little effect on C5a-induced calcium mobilization in RAW264.7 cells.
S9 1411-1599 Sentence denotes These results suggest that NF-kappaB activation is required for C5a-induced IL-8 gene expression and that this response is mediated primarily through a pertussis toxin-insensitive pathway.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-20 NP denotes NF-kappaB activation
C2 101-104 NP denotes C5a
C3 106-138 NP denotes a potent peptide chemoattractant
C4 151-181 NP denotes interleukin-8 (IL-8) secretion
C5 290-317 NP denotes C5a-induced IL-8 production
C6 319-324 NP denotes which
C7 389-403 NP denotes IL-8 secretion
C8 542-583 NP denotes AP-1 but not NF-IL-6 DNA binding activity
C9 635-638 NP denotes its
C10 845-874 NP denotes the RAW264.7 macrophage cells
C11 1183-1198 NP denotes Pertussis toxin
C12 1200-1205 NP denotes which
C13 1395-1409 NP denotes RAW264.7 cells
C14 1438-1458 NP denotes NF-kappaB activation
R1 C3 C2 coref-appos a potent peptide chemoattractant,C5a
R2 C6 C5 coref-relat which,C5a-induced IL-8 production
R3 C7 C4 coref-ident IL-8 secretion,interleukin-8 (IL-8) secretion
R4 C9 C8 coref-pron its,AP-1 but not NF-IL-6 DNA binding activity
R5 C12 C11 coref-relat which,Pertussis toxin
R6 C13 C10 coref-ident RAW264.7 cells,the RAW264.7 macrophage cells
R7 C14 C1 coref-ident NF-kappaB activation,NF-kappaB activation

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-9 protein_complex denotes NF-kappaB
T2 37-40 peptide denotes C5a
T3 82-99 cell_type denotes mononuclear cells
T4 101-104 peptide denotes C5a
T5 108-122 peptide denotes potent peptide
T6 151-164 protein_molecule denotes interleukin-8
T7 166-170 protein_molecule denotes IL-8
T8 187-203 cell_type denotes peripheral blood
T9 204-221 cell_type denotes mononuclear cells
T10 223-227 cell_type denotes PBMC
T11 290-293 peptide denotes C5a
T12 302-306 protein_molecule denotes IL-8
T13 358-376 cell_type denotes unstimulated cells
T14 389-393 protein_molecule denotes IL-8
T15 439-443 protein_molecule denotes IL-8
T16 471-489 other_name denotes nuclear expression
T17 495-501 protein_molecule denotes kappaB
T18 542-546 protein_molecule denotes AP-1
T19 555-562 protein_molecule denotes NF-IL-6
T20 605-608 peptide denotes C5a
T21 620-624 cell_type denotes PBMC
T22 738-742 protein_molecule denotes IL-8
T23 768-771 peptide denotes C5a
T24 780-786 protein_molecule denotes kappaB
T25 808-812 protein_molecule denotes IL-8
T26 849-874 cell_line denotes RAW264.7 macrophage cells
T27 912-927 DNA_domain_or_region denotes kappaB sequence
T28 933-945 protein_molecule denotes IkappaBalpha
T29 950-954 protein_molecule denotes IL-8
T30 973-976 peptide denotes C5a
T31 985-998 DNA_family_or_group denotes reporter gene
T32 1058-1070 DNA_domain_or_region denotes kappaB sites
T33 1096-1113 DNA_molecule denotes dominant negative
T34 1114-1126 protein_molecule denotes IkappaBalpha
T35 1150-1181 other_name denotes agonist-induced phosphorylation
T36 1183-1198 other_organic_compound denotes Pertussis toxin
T37 1206-1209 nucleotide denotes ADP
T38 1226-1237 protein_family_or_group denotes Gi proteins
T39 1261-1264 peptide denotes C5a
T40 1306-1309 peptide denotes C5a
T41 1318-1322 protein_molecule denotes IL-8
T42 1359-1362 peptide denotes C5a
T43 1371-1378 atom denotes calcium
T44 1395-1409 cell_line denotes RAW264.7 cells
T45 1438-1447 protein_complex denotes NF-kappaB
T46 1475-1478 peptide denotes C5a
T47 1487-1491 protein_molecule denotes IL-8
T48 1563-1578 other_organic_compound denotes pertussis toxin