PubMed:10229231 JSON TXT

Annnotations TAB JSON ListView MergeView

Id	Subject	Object	Predicate	Lexical cue
T1	14-24	protein	denotes	Fas ligand
T2	54-77	DNA	denotes	apoptosis-linked gene 4
T3	222-235	cell_type	denotes	T lymphocytes
T4	255-258	protein	denotes	Fas
T5	258-269	protein	denotes	/Fas ligand
T6	271-275	protein	denotes	FasL
T7	371-377	protein	denotes	ALG-4F
T8	381-401	protein	denotes	truncated transcript
T9	440-444	protein	denotes	FasL
T10	492-509	protein	denotes	full-length ALG-4
T11	535-539	protein	denotes	FasL
T12	598-603	protein	denotes	ALG-4
T13	636-640	protein	denotes	FasL
T14	657-661	protein	denotes	FasL
T15	843-847	protein	denotes	FasL

Id	Subject	Object	Predicate	Lexical cue
S1	0-78	Sentence	denotes	Regulation of Fas ligand expression and cell death by apoptosis-linked gene 4.
S2	79-165	Sentence	denotes	Programmed cell death is a process required for the normal development of an organism.
S3	166-289	Sentence	denotes	One of the best understood apoptotic pathways occurs in T lymphocytes and is mediated by Fas/Fas ligand (FasL) interaction.
S4	290-473	Sentence	denotes	During studies of apoptosis induced by T cell-receptor engagement, we identified ALG-4F, a truncated transcript that prevents T cell-receptor-induced FasL upregulation and cell death.
S5	474-569	Sentence	denotes	Overexpression of full-length ALG-4 induced transcription of FasL and, consequently, apoptosis.
S6	570-652	Sentence	denotes	These results indicate that ALG-4 is necessary and sufficient for FasL expression.
S7	653-800	Sentence	denotes	Fas/FasL interaction initiates cell death in many other systems, and its dysregulation is a mechanism by which several pathologic conditions arise.
S8	801-971	Sentence	denotes	Understanding the molecular mechanisms of FasL regulation could be very useful in elucidating how these diseases develop and in identifying potential therapeutic targets.

Id	Subject	Object	Predicate	Lexical cue
C2	14-35	NP	denotes	Fas ligand expression
C1	0-35	NP	denotes	Regulation of Fas ligand expression
C3	40-50	NP	denotes	cell death
C4	255-288	NP	denotes	Fas/Fas ligand (FasL) interaction
C5	371-377	NP	denotes	ALG-4F
C7	379-401	NP	denotes	a truncated transcript
C8	402-406	NP	denotes	that
C9	462-472	NP	denotes	cell death
C6	379-472	NP	denotes	a truncated transcript that prevents T cell-receptor-induced FasL upregulation and cell death
C10	598-603	NP	denotes	ALG-4
C11	636-651	NP	denotes	FasL expression
C12	653-673	NP	denotes	Fas/FasL interaction
C13	722-725	NP	denotes	its
C14	743-754	NP	denotes	a mechanism
C15	758-763	NP	denotes	which
C16	843-858	NP	denotes	FasL regulation
R1	C8	C7	coref-relat	that,a truncated transcript
R2	C9	C3	coref-ident	cell death,cell death
R3	C6	C5	coref-appos	a truncated transcript that prevents T cell-receptor-induced FasL upregulation and cell death,ALG-4F
R4	C10	C5	coref-ident	ALG-4,ALG-4F
R5	C11	C2	coref-ident	FasL expression,Fas ligand expression
R6	C12	C4	coref-ident	Fas/FasL interaction,Fas/Fas ligand (FasL) interaction
R7	C13	C12	coref-pron	its,Fas/FasL interaction
R8	C15	C14	coref-relat	which,a mechanism
R9	C16	C1	coref-ident	FasL regulation,Regulation of Fas ligand expression

Id	Subject	Object	Predicate	Lexical cue
T1	14-24	protein_molecule	denotes	Fas ligand
T2	40-50	other_name	denotes	cell death
T3	54-77	DNA_domain_or_region	denotes	apoptosis-linked gene 4
T4	90-100	other_name	denotes	cell death
T5	131-149	other_name	denotes	normal development
T6	193-211	other_name	denotes	apoptotic pathways
T7	222-235	cell_type	denotes	T lymphocytes
T8	255-258	protein_molecule	denotes	Fas
T9	258-269	protein_molecule	denotes	/Fas ligand
T10	271-275	protein_molecule	denotes	FasL
T11	308-317	other_name	denotes	apoptosis
T12	329-355	other_name	denotes	T cell-receptor engagement
T13	371-377	protein_molecule	denotes	ALG-4F
T14	381-401	protein_molecule	denotes	truncated transcript
T15	416-439	other_name	denotes	T cell-receptor-induced
T16	440-444	protein_molecule	denotes	FasL
T17	462-472	other_name	denotes	cell death
T18	492-509	protein_molecule	denotes	full-length ALG-4
T19	518-531	other_name	denotes	transcription
T20	535-539	protein_molecule	denotes	FasL
T21	559-568	other_name	denotes	apoptosis
T22	598-603	protein_molecule	denotes	ALG-4
T23	636-640	protein_molecule	denotes	FasL
T24	653-657	other_name	denotes	Fas/
T25	657-661	protein_molecule	denotes	FasL
T26	684-694	other_name	denotes	cell death
T27	819-839	other_name	denotes	molecular mechanisms
T28	843-847	protein_molecule	denotes	FasL
T29	941-970	other_name	denotes	potential therapeutic targets