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Extragonadal germ cell tumor of the prostate associated with Klinefelter's syndrome.
PURPOSE: We report on a case of extragonadal germ cell tumor of the prostate associated with Klinefelter's syndrome.
METHODS/RESULTS: The patient was a 33-year-old man. A transrectal prostate biopsy suggested combined germ cell tumor (yolk sac tumor + teratoma). Because there was no tumor except from the prostate, we considered this case to be a primary extragonadal germ cell tumor of the prostate. The prostate tumor responded to systemic chemotherapy with cisplatin, vinblastine and bleomycin and elevated lactate dehydrogenase and alpha-fetoprotein levels normalized. In addition to chemotherapy, the patient also underwent radiation therapy.
CONCLUSION: The patient has survived for approximately 4 years since the diagnosis.
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