PubMed:10212389 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":319,"end":359},"obj":"cell_line"},{"id":"T2","span":{"begin":413,"end":435},"obj":"protein"},{"id":"T3","span":{"begin":437,"end":440},"obj":"protein"}],"text":"Dicarba-closo-dodecaboranes as a pharmacophore. Retinoidal antagonists and potential agonists.\nSynthesis and biological evaluation of the first dicarba-closo-dodecaborane (carborane) derivatives of retinoids are described. Their retinoidal activity were examined in terms of the differentiation-inducing ability toward human promyelocytic leukemia HL-60 cells. High retinoidal activity (agonist or antagonist for retinoic acid receptor (RAR) requires a carboxylic acid moiety and an appropriate hydrophobic group located at a suitable position on the molecule. The 4-carboranyl-substituted compounds (7, 11) showed antagonistic activity but no agonistic activity even in the presence of the potent synergist HX630. On the other hand, the 3-carboranyl-substituted compounds (8, 12) showed potential agonistic activity, but no antagonistic activity. The results indicates that carboranes are applicable as the hydrophobic moiety of biologically active molecules."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":47},"obj":"Sentence"},{"id":"S2","span":{"begin":48,"end":94},"obj":"Sentence"},{"id":"S3","span":{"begin":95,"end":222},"obj":"Sentence"},{"id":"S4","span":{"begin":223,"end":360},"obj":"Sentence"},{"id":"S5","span":{"begin":361,"end":560},"obj":"Sentence"},{"id":"S6","span":{"begin":561,"end":714},"obj":"Sentence"},{"id":"S7","span":{"begin":715,"end":847},"obj":"Sentence"},{"id":"S8","span":{"begin":848,"end":960},"obj":"Sentence"}],"text":"Dicarba-closo-dodecaboranes as a pharmacophore. Retinoidal antagonists and potential agonists.\nSynthesis and biological evaluation of the first dicarba-closo-dodecaborane (carborane) derivatives of retinoids are described. Their retinoidal activity were examined in terms of the differentiation-inducing ability toward human promyelocytic leukemia HL-60 cells. High retinoidal activity (agonist or antagonist for retinoic acid receptor (RAR) requires a carboxylic acid moiety and an appropriate hydrophobic group located at a suitable position on the molecule. The 4-carboranyl-substituted compounds (7, 11) showed antagonistic activity but no agonistic activity even in the presence of the potent synergist HX630. On the other hand, the 3-carboranyl-substituted compounds (8, 12) showed potential agonistic activity, but no antagonistic activity. The results indicates that carboranes are applicable as the hydrophobic moiety of biologically active molecules."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":27},"obj":"NP"},{"id":"C2","span":{"begin":134,"end":207},"obj":"NP"},{"id":"C3","span":{"begin":223,"end":228},"obj":"NP"},{"id":"C4","span":{"begin":875,"end":885},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-pron","subj":"C3","obj":"C2"},{"id":"R2","pred":"coref-ident","subj":"C4","obj":"C1"}],"text":"Dicarba-closo-dodecaboranes as a pharmacophore. Retinoidal antagonists and potential agonists.\nSynthesis and biological evaluation of the first dicarba-closo-dodecaborane (carborane) derivatives of retinoids are described. Their retinoidal activity were examined in terms of the differentiation-inducing ability toward human promyelocytic leukemia HL-60 cells. High retinoidal activity (agonist or antagonist for retinoic acid receptor (RAR) requires a carboxylic acid moiety and an appropriate hydrophobic group located at a suitable position on the molecule. The 4-carboranyl-substituted compounds (7, 11) showed antagonistic activity but no agonistic activity even in the presence of the potent synergist HX630. On the other hand, the 3-carboranyl-substituted compounds (8, 12) showed potential agonistic activity, but no antagonistic activity. The results indicates that carboranes are applicable as the hydrophobic moiety of biologically active molecules."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":27},"obj":"other_organic_compound"},{"id":"T2","span":{"begin":33,"end":46},"obj":"other_name"},{"id":"T3","span":{"begin":48,"end":70},"obj":"other_organic_compound"},{"id":"T4","span":{"begin":75,"end":93},"obj":"other_organic_compound"},{"id":"T5","span":{"begin":144,"end":170},"obj":"other_organic_compound"},{"id":"T6","span":{"begin":172,"end":181},"obj":"other_organic_compound"},{"id":"T7","span":{"begin":198,"end":207},"obj":"other_organic_compound"},{"id":"T8","span":{"begin":319,"end":359},"obj":"cell_line"},{"id":"T9","span":{"begin":413,"end":435},"obj":"protein_family_or_group"},{"id":"T10","span":{"begin":437,"end":440},"obj":"protein_family_or_group"},{"id":"T11","span":{"begin":453,"end":475},"obj":"other_organic_compound"},{"id":"T12","span":{"begin":483,"end":512},"obj":"other_organic_compound"},{"id":"T13","span":{"begin":565,"end":599},"obj":"other_organic_compound"},{"id":"T14","span":{"begin":601,"end":602},"obj":"other_organic_compound"},{"id":"T15","span":{"begin":604,"end":606},"obj":"other_organic_compound"},{"id":"T16","span":{"begin":691,"end":707},"obj":"other_name"},{"id":"T17","span":{"begin":708,"end":713},"obj":"other_organic_compound"},{"id":"T18","span":{"begin":738,"end":772},"obj":"other_organic_compound"},{"id":"T19","span":{"begin":774,"end":775},"obj":"other_organic_compound"},{"id":"T20","span":{"begin":777,"end":779},"obj":"other_organic_compound"},{"id":"T21","span":{"begin":798,"end":816},"obj":"other_name"},{"id":"T22","span":{"begin":825,"end":846},"obj":"other_name"},{"id":"T23","span":{"begin":908,"end":926},"obj":"other_organic_compound"}],"text":"Dicarba-closo-dodecaboranes as a pharmacophore. Retinoidal antagonists and potential agonists.\nSynthesis and biological evaluation of the first dicarba-closo-dodecaborane (carborane) derivatives of retinoids are described. Their retinoidal activity were examined in terms of the differentiation-inducing ability toward human promyelocytic leukemia HL-60 cells. High retinoidal activity (agonist or antagonist for retinoic acid receptor (RAR) requires a carboxylic acid moiety and an appropriate hydrophobic group located at a suitable position on the molecule. The 4-carboranyl-substituted compounds (7, 11) showed antagonistic activity but no agonistic activity even in the presence of the potent synergist HX630. On the other hand, the 3-carboranyl-substituted compounds (8, 12) showed potential agonistic activity, but no antagonistic activity. The results indicates that carboranes are applicable as the hydrophobic moiety of biologically active molecules."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":339,"end":347},"obj":"HP_0001909"}],"text":"Dicarba-closo-dodecaboranes as a pharmacophore. Retinoidal antagonists and potential agonists.\nSynthesis and biological evaluation of the first dicarba-closo-dodecaborane (carborane) derivatives of retinoids are described. Their retinoidal activity were examined in terms of the differentiation-inducing ability toward human promyelocytic leukemia HL-60 cells. High retinoidal activity (agonist or antagonist for retinoic acid receptor (RAR) requires a carboxylic acid moiety and an appropriate hydrophobic group located at a suitable position on the molecule. The 4-carboranyl-substituted compounds (7, 11) showed antagonistic activity but no agonistic activity even in the presence of the potent synergist HX630. On the other hand, the 3-carboranyl-substituted compounds (8, 12) showed potential agonistic activity, but no antagonistic activity. The results indicates that carboranes are applicable as the hydrophobic moiety of biologically active molecules."}