PubMed:10212389 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	319-359	cell_line	denotes	human promyelocytic leukemia HL-60 cells
T2	413-435	protein	denotes	retinoic acid receptor
T3	437-440	protein	denotes	RAR

Id	Subject	Object	Predicate	Lexical cue
S1	0-47	Sentence	denotes	Dicarba-closo-dodecaboranes as a pharmacophore.
S2	48-94	Sentence	denotes	Retinoidal antagonists and potential agonists.
S3	95-222	Sentence	denotes	Synthesis and biological evaluation of the first dicarba-closo-dodecaborane (carborane) derivatives of retinoids are described.
S4	223-360	Sentence	denotes	Their retinoidal activity were examined in terms of the differentiation-inducing ability toward human promyelocytic leukemia HL-60 cells.
S5	361-560	Sentence	denotes	High retinoidal activity (agonist or antagonist for retinoic acid receptor (RAR) requires a carboxylic acid moiety and an appropriate hydrophobic group located at a suitable position on the molecule.
S6	561-714	Sentence	denotes	The 4-carboranyl-substituted compounds (7, 11) showed antagonistic activity but no agonistic activity even in the presence of the potent synergist HX630.
S7	715-847	Sentence	denotes	On the other hand, the 3-carboranyl-substituted compounds (8, 12) showed potential agonistic activity, but no antagonistic activity.
S8	848-960	Sentence	denotes	The results indicates that carboranes are applicable as the hydrophobic moiety of biologically active molecules.

Id	Subject	Object	Predicate	Lexical cue
C1	0-27	NP	denotes	Dicarba-closo-dodecaboranes
C2	134-207	NP	denotes	the first dicarba-closo-dodecaborane (carborane) derivatives of retinoids
C3	223-228	NP	denotes	Their
C4	875-885	NP	denotes	carboranes
R1	C3	C2	coref-pron	Their,the first dicarba-closo-dodecaborane (carborane) derivatives of retinoids
R2	C4	C1	coref-ident	carboranes,Dicarba-closo-dodecaboranes

Id	Subject	Object	Predicate	Lexical cue
T1	0-27	other_organic_compound	denotes	Dicarba-closo-dodecaboranes
T2	33-46	other_name	denotes	pharmacophore
T3	48-70	other_organic_compound	denotes	Retinoidal antagonists
T4	75-93	other_organic_compound	denotes	potential agonists
T5	144-170	other_organic_compound	denotes	dicarba-closo-dodecaborane
T6	172-181	other_organic_compound	denotes	carborane
T7	198-207	other_organic_compound	denotes	retinoids
T8	319-359	cell_line	denotes	human promyelocytic leukemia HL-60 cells
T9	413-435	protein_family_or_group	denotes	retinoic acid receptor
T10	437-440	protein_family_or_group	denotes	RAR
T11	453-475	other_organic_compound	denotes	carboxylic acid moiety
T12	483-512	other_organic_compound	denotes	appropriate hydrophobic group
T13	565-599	other_organic_compound	denotes	4-carboranyl-substituted compounds
T14	601-602	other_organic_compound	denotes	7
T15	604-606	other_organic_compound	denotes	11
T16	691-707	other_name	denotes	potent synergist
T17	708-713	other_organic_compound	denotes	HX630
T18	738-772	other_organic_compound	denotes	3-carboranyl-substituted compounds
T19	774-775	other_organic_compound	denotes	8
T20	777-779	other_organic_compound	denotes	12
T21	798-816	other_name	denotes	agonistic activity
T22	825-846	other_name	denotes	antagonistic activity
T23	908-926	other_organic_compound	denotes	hydrophobic moiety

Id	Subject	Object	Predicate	Lexical cue
T1	339-347	HP_0001909	denotes	leukemia