PubMed:10209041 JSONTXT

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    PMID_GLOBAL

    {"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":702,"end":706},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":720,"end":723},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":830,"end":833},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0015404"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0012833"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0012833"}],"text":"GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation.\nPropagation of signals from the T cell antigen receptor (TCR) involves a number of adaptor molecules. SH2 domain-containing protein 76 (SLP-76) interacts with the guanine nucleotide exchange factor Vav to activate the nuclear factor of activated cells (NF-AT), and its expression is required for normal T cell development. We report the cloning and characterization of a novel Grb2-like adaptor molecule designated as Grb2-related protein of the lymphoid system (GrpL). Expression of GrpL is restricted to hematopoietic tissues, and it is distinguished from Grb2 by having a proline-rich region. GrpL can be coimmunoprecipitated with SLP-76 but not with Sos1 or Sos2 from Jurkat cell lysates. In contrast, Grb2 can be coimmunoprecipitated with Sos1 and Sos2 but not with SLP-76. Moreover, tyrosine-phosphorylated LAT/pp36/38 in detergent lysates prepared from anti-CD3 stimulated T cells associated with Grb2 but not GrpL. These data reveal the presence of distinct complexes involving GrpL and Grb2 in T cells. A functional role of the GrpL-SLP-76 complex is suggested by the ability of GrpL to act alone or in concert with SLP-76 to augment NF-AT activation in Jurkat T cells."}

    jnlpba-st-training

    {"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":0,"end":4},"obj":"protein"},{"id":"T2","span":{"begin":8,"end":12},"obj":"protein"},{"id":"T3","span":{"begin":21,"end":36},"obj":"protein"},{"id":"T4","span":{"begin":53,"end":59},"obj":"protein"},{"id":"T5","span":{"begin":72,"end":106},"obj":"protein"},{"id":"T6","span":{"begin":151,"end":174},"obj":"protein"},{"id":"T7","span":{"begin":176,"end":179},"obj":"protein"},{"id":"T8","span":{"begin":221,"end":253},"obj":"protein"},{"id":"T9","span":{"begin":255,"end":261},"obj":"protein"},{"id":"T10","span":{"begin":282,"end":316},"obj":"protein"},{"id":"T11","span":{"begin":317,"end":320},"obj":"protein"},{"id":"T12","span":{"begin":337,"end":370},"obj":"protein"},{"id":"T13","span":{"begin":372,"end":377},"obj":"protein"},{"id":"T14","span":{"begin":422,"end":428},"obj":"cell_type"},{"id":"T15","span":{"begin":496,"end":522},"obj":"protein"},{"id":"T16","span":{"begin":537,"end":580},"obj":"protein"},{"id":"T17","span":{"begin":582,"end":586},"obj":"protein"},{"id":"T18","span":{"begin":603,"end":607},"obj":"protein"},{"id":"T19","span":{"begin":677,"end":681},"obj":"protein"},{"id":"T20","span":{"begin":694,"end":713},"obj":"protein"},{"id":"T21","span":{"begin":715,"end":719},"obj":"protein"},{"id":"T22","span":{"begin":753,"end":759},"obj":"protein"},{"id":"T23","span":{"begin":773,"end":777},"obj":"protein"},{"id":"T24","span":{"begin":781,"end":785},"obj":"protein"},{"id":"T25","span":{"begin":791,"end":802},"obj":"cell_line"},{"id":"T26","span":{"begin":825,"end":829},"obj":"protein"},{"id":"T27","span":{"begin":863,"end":867},"obj":"protein"},{"id":"T28","span":{"begin":872,"end":876},"obj":"protein"},{"id":"T29","span":{"begin":890,"end":896},"obj":"protein"},{"id":"T30","span":{"begin":908,"end":943},"obj":"protein"},{"id":"T31","span":{"begin":979,"end":1006},"obj":"cell_type"},{"id":"T32","span":{"begin":1023,"end":1027},"obj":"protein"},{"id":"T33","span":{"begin":1036,"end":1040},"obj":"protein"},{"id":"T34","span":{"begin":1105,"end":1109},"obj":"protein"},{"id":"T35","span":{"begin":1114,"end":1118},"obj":"protein"},{"id":"T36","span":{"begin":1122,"end":1129},"obj":"cell_type"},{"id":"T37","span":{"begin":1156,"end":1175},"obj":"protein"},{"id":"T38","span":{"begin":1207,"end":1211},"obj":"protein"},{"id":"T39","span":{"begin":1244,"end":1250},"obj":"protein"},{"id":"T40","span":{"begin":1262,"end":1267},"obj":"protein"},{"id":"T41","span":{"begin":1282,"end":1288},"obj":"cell_line"},{"id":"T42","span":{"begin":1289,"end":1296},"obj":"cell_type"}],"text":"GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation.\nPropagation of signals from the T cell antigen receptor (TCR) involves a number of adaptor molecules. SH2 domain-containing protein 76 (SLP-76) interacts with the guanine nucleotide exchange factor Vav to activate the nuclear factor of activated cells (NF-AT), and its expression is required for normal T cell development. We report the cloning and characterization of a novel Grb2-like adaptor molecule designated as Grb2-related protein of the lymphoid system (GrpL). Expression of GrpL is restricted to hematopoietic tissues, and it is distinguished from Grb2 by having a proline-rich region. GrpL can be coimmunoprecipitated with SLP-76 but not with Sos1 or Sos2 from Jurkat cell lysates. In contrast, Grb2 can be coimmunoprecipitated with Sos1 and Sos2 but not with SLP-76. Moreover, tyrosine-phosphorylated LAT/pp36/38 in detergent lysates prepared from anti-CD3 stimulated T cells associated with Grb2 but not GrpL. These data reveal the presence of distinct complexes involving GrpL and Grb2 in T cells. A functional role of the GrpL-SLP-76 complex is suggested by the ability of GrpL to act alone or in concert with SLP-76 to augment NF-AT activation in Jurkat T cells."}

    pubmed-sentences-benchmark

    {"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":118},"obj":"Sentence"},{"id":"S2","span":{"begin":119,"end":220},"obj":"Sentence"},{"id":"S3","span":{"begin":221,"end":441},"obj":"Sentence"},{"id":"S4","span":{"begin":442,"end":588},"obj":"Sentence"},{"id":"S5","span":{"begin":589,"end":714},"obj":"Sentence"},{"id":"S6","span":{"begin":715,"end":811},"obj":"Sentence"},{"id":"S7","span":{"begin":812,"end":897},"obj":"Sentence"},{"id":"S8","span":{"begin":898,"end":1041},"obj":"Sentence"},{"id":"S9","span":{"begin":1042,"end":1130},"obj":"Sentence"},{"id":"S10","span":{"begin":1131,"end":1297},"obj":"Sentence"}],"text":"GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation.\nPropagation of signals from the T cell antigen receptor (TCR) involves a number of adaptor molecules. SH2 domain-containing protein 76 (SLP-76) interacts with the guanine nucleotide exchange factor Vav to activate the nuclear factor of activated cells (NF-AT), and its expression is required for normal T cell development. We report the cloning and characterization of a novel Grb2-like adaptor molecule designated as Grb2-related protein of the lymphoid system (GrpL). Expression of GrpL is restricted to hematopoietic tissues, and it is distinguished from Grb2 by having a proline-rich region. GrpL can be coimmunoprecipitated with SLP-76 but not with Sos1 or Sos2 from Jurkat cell lysates. In contrast, Grb2 can be coimmunoprecipitated with Sos1 and Sos2 but not with SLP-76. Moreover, tyrosine-phosphorylated LAT/pp36/38 in detergent lysates prepared from anti-CD3 stimulated T cells associated with Grb2 but not GrpL. These data reveal the presence of distinct complexes involving GrpL and Grb2 in T cells. A functional role of the GrpL-SLP-76 complex is suggested by the ability of GrpL to act alone or in concert with SLP-76 to augment NF-AT activation in Jurkat T cells."}

    genia-medco-coref

    {"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":4},"obj":"NP"},{"id":"C2","span":{"begin":6,"end":36},"obj":"NP"},{"id":"C3","span":{"begin":53,"end":59},"obj":"NP"},{"id":"C4","span":{"begin":221,"end":262},"obj":"NP"},{"id":"C5","span":{"begin":333,"end":378},"obj":"NP"},{"id":"C6","span":{"begin":384,"end":387},"obj":"NP"},{"id":"C7","span":{"begin":488,"end":587},"obj":"NP"},{"id":"C8","span":{"begin":603,"end":607},"obj":"NP"},{"id":"C9","span":{"begin":652,"end":654},"obj":"NP"},{"id":"C10","span":{"begin":677,"end":681},"obj":"NP"},{"id":"C11","span":{"begin":715,"end":719},"obj":"NP"},{"id":"C12","span":{"begin":753,"end":759},"obj":"NP"},{"id":"C13","span":{"begin":825,"end":829},"obj":"NP"},{"id":"C14","span":{"begin":890,"end":896},"obj":"NP"},{"id":"C15","span":{"begin":1023,"end":1027},"obj":"NP"},{"id":"C16","span":{"begin":1122,"end":1129},"obj":"NP"},{"id":"C17","span":{"begin":1207,"end":1211},"obj":"NP"},{"id":"C18","span":{"begin":1244,"end":1250},"obj":"NP"},{"id":"C19","span":{"begin":1282,"end":1296},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-appos","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C4","obj":"C3"},{"id":"R3","pred":"coref-pron","subj":"C6","obj":"C5"},{"id":"R4","pred":"coref-ident","subj":"C7","obj":"C1"},{"id":"R5","pred":"coref-ident","subj":"C8","obj":"C7"},{"id":"R6","pred":"coref-pron","subj":"C9","obj":"C8"},{"id":"R7","pred":"coref-ident","subj":"C11","obj":"C8"},{"id":"R8","pred":"coref-ident","subj":"C12","obj":"C4"},{"id":"R9","pred":"coref-ident","subj":"C13","obj":"C10"},{"id":"R10","pred":"coref-ident","subj":"C14","obj":"C12"},{"id":"R11","pred":"coref-ident","subj":"C15","obj":"C13"},{"id":"R12","pred":"coref-ident","subj":"C17","obj":"C11"},{"id":"R13","pred":"coref-ident","subj":"C18","obj":"C14"},{"id":"R14","pred":"coref-ident","subj":"C19","obj":"C16"}],"text":"GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation.\nPropagation of signals from the T cell antigen receptor (TCR) involves a number of adaptor molecules. SH2 domain-containing protein 76 (SLP-76) interacts with the guanine nucleotide exchange factor Vav to activate the nuclear factor of activated cells (NF-AT), and its expression is required for normal T cell development. We report the cloning and characterization of a novel Grb2-like adaptor molecule designated as Grb2-related protein of the lymphoid system (GrpL). Expression of GrpL is restricted to hematopoietic tissues, and it is distinguished from Grb2 by having a proline-rich region. GrpL can be coimmunoprecipitated with SLP-76 but not with Sos1 or Sos2 from Jurkat cell lysates. In contrast, Grb2 can be coimmunoprecipitated with Sos1 and Sos2 but not with SLP-76. Moreover, tyrosine-phosphorylated LAT/pp36/38 in detergent lysates prepared from anti-CD3 stimulated T cells associated with Grb2 but not GrpL. These data reveal the presence of distinct complexes involving GrpL and Grb2 in T cells. A functional role of the GrpL-SLP-76 complex is suggested by the ability of GrpL to act alone or in concert with SLP-76 to augment NF-AT activation in Jurkat T cells."}

    GENIAcorpus

    {"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":4},"obj":"protein_molecule"},{"id":"T2","span":{"begin":8,"end":12},"obj":"protein_molecule"},{"id":"T3","span":{"begin":21,"end":36},"obj":"protein_family_or_group"},{"id":"T4","span":{"begin":53,"end":59},"obj":"protein_molecule"},{"id":"T5","span":{"begin":72,"end":89},"obj":"protein_molecule"},{"id":"T6","span":{"begin":90,"end":106},"obj":"cell_type"},{"id":"T7","span":{"begin":151,"end":157},"obj":"cell_type"},{"id":"T8","span":{"begin":176,"end":179},"obj":"protein_complex"},{"id":"T9","span":{"begin":221,"end":253},"obj":"protein_molecule"},{"id":"T10","span":{"begin":255,"end":261},"obj":"protein_molecule"},{"id":"T11","span":{"begin":282,"end":316},"obj":"protein_family_or_group"},{"id":"T12","span":{"begin":317,"end":320},"obj":"protein_molecule"},{"id":"T13","span":{"begin":337,"end":370},"obj":"protein_molecule"},{"id":"T14","span":{"begin":372,"end":377},"obj":"protein_molecule"},{"id":"T15","span":{"begin":422,"end":428},"obj":"cell_type"},{"id":"T16","span":{"begin":496,"end":522},"obj":"protein_molecule"},{"id":"T17","span":{"begin":537,"end":580},"obj":"protein_molecule"},{"id":"T18","span":{"begin":582,"end":586},"obj":"protein_molecule"},{"id":"T19","span":{"begin":603,"end":607},"obj":"protein_molecule"},{"id":"T20","span":{"begin":625,"end":646},"obj":"tissue"},{"id":"T21","span":{"begin":677,"end":681},"obj":"protein_molecule"},{"id":"T22","span":{"begin":694,"end":701},"obj":"amino_acid_monomer"},{"id":"T23","span":{"begin":715,"end":719},"obj":"protein_molecule"},{"id":"T24","span":{"begin":727,"end":747},"obj":"other_name"},{"id":"T25","span":{"begin":753,"end":759},"obj":"protein_molecule"},{"id":"T26","span":{"begin":773,"end":777},"obj":"protein_molecule"},{"id":"T27","span":{"begin":781,"end":785},"obj":"protein_molecule"},{"id":"T28","span":{"begin":791,"end":802},"obj":"cell_line"},{"id":"T29","span":{"begin":825,"end":829},"obj":"protein_molecule"},{"id":"T30","span":{"begin":837,"end":857},"obj":"other_name"},{"id":"T31","span":{"begin":863,"end":867},"obj":"protein_molecule"},{"id":"T32","span":{"begin":872,"end":876},"obj":"protein_molecule"},{"id":"T33","span":{"begin":890,"end":896},"obj":"protein_molecule"},{"id":"T34","span":{"begin":908,"end":916},"obj":"amino_acid_monomer"},{"id":"T35","span":{"begin":932,"end":935},"obj":"protein_molecule"},{"id":"T36","span":{"begin":936,"end":940},"obj":"protein_molecule"},{"id":"T37","span":{"begin":941,"end":943},"obj":"protein_molecule"},{"id":"T38","span":{"begin":979,"end":1006},"obj":"cell_type"},{"id":"T39","span":{"begin":1023,"end":1027},"obj":"protein_molecule"},{"id":"T40","span":{"begin":1036,"end":1040},"obj":"protein_molecule"},{"id":"T41","span":{"begin":1105,"end":1109},"obj":"protein_molecule"},{"id":"T42","span":{"begin":1114,"end":1118},"obj":"protein_molecule"},{"id":"T43","span":{"begin":1122,"end":1129},"obj":"cell_type"},{"id":"T44","span":{"begin":1156,"end":1160},"obj":"protein_molecule"},{"id":"T45","span":{"begin":1160,"end":1167},"obj":"protein_molecule"},{"id":"T46","span":{"begin":1207,"end":1211},"obj":"protein_molecule"},{"id":"T47","span":{"begin":1244,"end":1250},"obj":"protein_molecule"},{"id":"T48","span":{"begin":1262,"end":1267},"obj":"protein_molecule"},{"id":"T49","span":{"begin":1282,"end":1288},"obj":"cell_line"},{"id":"T50","span":{"begin":1289,"end":1296},"obj":"cell_type"}],"text":"GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation.\nPropagation of signals from the T cell antigen receptor (TCR) involves a number of adaptor molecules. SH2 domain-containing protein 76 (SLP-76) interacts with the guanine nucleotide exchange factor Vav to activate the nuclear factor of activated cells (NF-AT), and its expression is required for normal T cell development. We report the cloning and characterization of a novel Grb2-like adaptor molecule designated as Grb2-related protein of the lymphoid system (GrpL). Expression of GrpL is restricted to hematopoietic tissues, and it is distinguished from Grb2 by having a proline-rich region. GrpL can be coimmunoprecipitated with SLP-76 but not with Sos1 or Sos2 from Jurkat cell lysates. In contrast, Grb2 can be coimmunoprecipitated with Sos1 and Sos2 but not with SLP-76. Moreover, tyrosine-phosphorylated LAT/pp36/38 in detergent lysates prepared from anti-CD3 stimulated T cells associated with Grb2 but not GrpL. These data reveal the presence of distinct complexes involving GrpL and Grb2 in T cells. A functional role of the GrpL-SLP-76 complex is suggested by the ability of GrpL to act alone or in concert with SLP-76 to augment NF-AT activation in Jurkat T cells."}