PubMed:10209041
Annnotations
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 702-706 | DiseaseOrPhenotypicFeature | denotes | rich | 0015404 |
| T2 | 720-723 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
| T3 | 830-833 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-4 | protein | denotes | GrpL |
| T2 | 8-12 | protein | denotes | Grb2 |
| T3 | 21-36 | protein | denotes | adaptor protein |
| T4 | 53-59 | protein | denotes | SLP-76 |
| T5 | 72-106 | protein | denotes | nuclear factor of activated T cell |
| T6 | 151-174 | protein | denotes | T cell antigen receptor |
| T7 | 176-179 | protein | denotes | TCR |
| T8 | 221-253 | protein | denotes | SH2 domain-containing protein 76 |
| T9 | 255-261 | protein | denotes | SLP-76 |
| T10 | 282-316 | protein | denotes | guanine nucleotide exchange factor |
| T11 | 317-320 | protein | denotes | Vav |
| T12 | 337-370 | protein | denotes | nuclear factor of activated cells |
| T13 | 372-377 | protein | denotes | NF-AT |
| T14 | 422-428 | cell_type | denotes | T cell |
| T15 | 496-522 | protein | denotes | Grb2-like adaptor molecule |
| T16 | 537-580 | protein | denotes | Grb2-related protein of the lymphoid system |
| T17 | 582-586 | protein | denotes | GrpL |
| T18 | 603-607 | protein | denotes | GrpL |
| T19 | 677-681 | protein | denotes | Grb2 |
| T20 | 694-713 | protein | denotes | proline-rich region |
| T21 | 715-719 | protein | denotes | GrpL |
| T22 | 753-759 | protein | denotes | SLP-76 |
| T23 | 773-777 | protein | denotes | Sos1 |
| T24 | 781-785 | protein | denotes | Sos2 |
| T25 | 791-802 | cell_line | denotes | Jurkat cell |
| T26 | 825-829 | protein | denotes | Grb2 |
| T27 | 863-867 | protein | denotes | Sos1 |
| T28 | 872-876 | protein | denotes | Sos2 |
| T29 | 890-896 | protein | denotes | SLP-76 |
| T30 | 908-943 | protein | denotes | tyrosine-phosphorylated LAT/pp36/38 |
| T31 | 979-1006 | cell_type | denotes | anti-CD3 stimulated T cells |
| T32 | 1023-1027 | protein | denotes | Grb2 |
| T33 | 1036-1040 | protein | denotes | GrpL |
| T34 | 1105-1109 | protein | denotes | GrpL |
| T35 | 1114-1118 | protein | denotes | Grb2 |
| T36 | 1122-1129 | cell_type | denotes | T cells |
| T37 | 1156-1175 | protein | denotes | GrpL-SLP-76 complex |
| T38 | 1207-1211 | protein | denotes | GrpL |
| T39 | 1244-1250 | protein | denotes | SLP-76 |
| T40 | 1262-1267 | protein | denotes | NF-AT |
| T41 | 1282-1288 | cell_line | denotes | Jurkat |
| T42 | 1289-1296 | cell_type | denotes | T cells |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-118 | Sentence | denotes | GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation. |
| S2 | 119-220 | Sentence | denotes | Propagation of signals from the T cell antigen receptor (TCR) involves a number of adaptor molecules. |
| S3 | 221-441 | Sentence | denotes | SH2 domain-containing protein 76 (SLP-76) interacts with the guanine nucleotide exchange factor Vav to activate the nuclear factor of activated cells (NF-AT), and its expression is required for normal T cell development. |
| S4 | 442-588 | Sentence | denotes | We report the cloning and characterization of a novel Grb2-like adaptor molecule designated as Grb2-related protein of the lymphoid system (GrpL). |
| S5 | 589-714 | Sentence | denotes | Expression of GrpL is restricted to hematopoietic tissues, and it is distinguished from Grb2 by having a proline-rich region. |
| S6 | 715-811 | Sentence | denotes | GrpL can be coimmunoprecipitated with SLP-76 but not with Sos1 or Sos2 from Jurkat cell lysates. |
| S7 | 812-897 | Sentence | denotes | In contrast, Grb2 can be coimmunoprecipitated with Sos1 and Sos2 but not with SLP-76. |
| S8 | 898-1041 | Sentence | denotes | Moreover, tyrosine-phosphorylated LAT/pp36/38 in detergent lysates prepared from anti-CD3 stimulated T cells associated with Grb2 but not GrpL. |
| S9 | 1042-1130 | Sentence | denotes | These data reveal the presence of distinct complexes involving GrpL and Grb2 in T cells. |
| S10 | 1131-1297 | Sentence | denotes | A functional role of the GrpL-SLP-76 complex is suggested by the ability of GrpL to act alone or in concert with SLP-76 to augment NF-AT activation in Jurkat T cells. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 0-4 | NP | denotes | GrpL |
| C2 | 6-36 | NP | denotes | a Grb2-related adaptor protein |
| C3 | 53-59 | NP | denotes | SLP-76 |
| C4 | 221-262 | NP | denotes | SH2 domain-containing protein 76 (SLP-76) |
| C5 | 333-378 | NP | denotes | the nuclear factor of activated cells (NF-AT) |
| C6 | 384-387 | NP | denotes | its |
| C7 | 488-587 | NP | denotes | a novel Grb2-like adaptor molecule designated as Grb2-related protein of the lymphoid system (GrpL) |
| C8 | 603-607 | NP | denotes | GrpL |
| C9 | 652-654 | NP | denotes | it |
| C10 | 677-681 | NP | denotes | Grb2 |
| C11 | 715-719 | NP | denotes | GrpL |
| C12 | 753-759 | NP | denotes | SLP-76 |
| C13 | 825-829 | NP | denotes | Grb2 |
| C14 | 890-896 | NP | denotes | SLP-76 |
| C15 | 1023-1027 | NP | denotes | Grb2 |
| C16 | 1122-1129 | NP | denotes | T cells |
| C17 | 1207-1211 | NP | denotes | GrpL |
| C18 | 1244-1250 | NP | denotes | SLP-76 |
| C19 | 1282-1296 | NP | denotes | Jurkat T cells |
| R1 | C2 | C1 | coref-appos | a Grb2-related adaptor protein,GrpL |
| R2 | C4 | C3 | coref-ident | SH2 domain-containing protein 76 (SLP-76),SLP-76 |
| R3 | C6 | C5 | coref-pron | its,the nuclear factor of activated cells (NF-AT) |
| R4 | C7 | C1 | coref-ident | a novel Grb2-like adaptor molecule designated as Grb2-related protein of the lymphoid system (GrpL),GrpL |
| R5 | C8 | C7 | coref-ident | GrpL,a novel Grb2-like adaptor molecule designated as Grb2-related protein of the lymphoid system (GrpL) |
| R6 | C9 | C8 | coref-pron | it,GrpL |
| R7 | C11 | C8 | coref-ident | GrpL,GrpL |
| R8 | C12 | C4 | coref-ident | SLP-76,SH2 domain-containing protein 76 (SLP-76) |
| R9 | C13 | C10 | coref-ident | Grb2,Grb2 |
| R10 | C14 | C12 | coref-ident | SLP-76,SLP-76 |
| R11 | C15 | C13 | coref-ident | Grb2,Grb2 |
| R12 | C17 | C11 | coref-ident | GrpL,GrpL |
| R13 | C18 | C14 | coref-ident | SLP-76,SLP-76 |
| R14 | C19 | C16 | coref-ident | Jurkat T cells,T cells |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-4 | protein_molecule | denotes | GrpL |
| T2 | 8-12 | protein_molecule | denotes | Grb2 |
| T3 | 21-36 | protein_family_or_group | denotes | adaptor protein |
| T4 | 53-59 | protein_molecule | denotes | SLP-76 |
| T5 | 72-89 | protein_molecule | denotes | nuclear factor of |
| T6 | 90-106 | cell_type | denotes | activated T cell |
| T7 | 151-157 | cell_type | denotes | T cell |
| T8 | 176-179 | protein_complex | denotes | TCR |
| T9 | 221-253 | protein_molecule | denotes | SH2 domain-containing protein 76 |
| T10 | 255-261 | protein_molecule | denotes | SLP-76 |
| T11 | 282-316 | protein_family_or_group | denotes | guanine nucleotide exchange factor |
| T12 | 317-320 | protein_molecule | denotes | Vav |
| T13 | 337-370 | protein_molecule | denotes | nuclear factor of activated cells |
| T14 | 372-377 | protein_molecule | denotes | NF-AT |
| T15 | 422-428 | cell_type | denotes | T cell |
| T16 | 496-522 | protein_molecule | denotes | Grb2-like adaptor molecule |
| T17 | 537-580 | protein_molecule | denotes | Grb2-related protein of the lymphoid system |
| T18 | 582-586 | protein_molecule | denotes | GrpL |
| T19 | 603-607 | protein_molecule | denotes | GrpL |
| T20 | 625-646 | tissue | denotes | hematopoietic tissues |
| T21 | 677-681 | protein_molecule | denotes | Grb2 |
| T22 | 694-701 | amino_acid_monomer | denotes | proline |
| T23 | 715-719 | protein_molecule | denotes | GrpL |
| T24 | 727-747 | other_name | denotes | coimmunoprecipitated |
| T25 | 753-759 | protein_molecule | denotes | SLP-76 |
| T26 | 773-777 | protein_molecule | denotes | Sos1 |
| T27 | 781-785 | protein_molecule | denotes | Sos2 |
| T28 | 791-802 | cell_line | denotes | Jurkat cell |
| T29 | 825-829 | protein_molecule | denotes | Grb2 |
| T30 | 837-857 | other_name | denotes | coimmunoprecipitated |
| T31 | 863-867 | protein_molecule | denotes | Sos1 |
| T32 | 872-876 | protein_molecule | denotes | Sos2 |
| T33 | 890-896 | protein_molecule | denotes | SLP-76 |
| T34 | 908-916 | amino_acid_monomer | denotes | tyrosine |
| T35 | 932-935 | protein_molecule | denotes | LAT |
| T36 | 936-940 | protein_molecule | denotes | pp36 |
| T37 | 941-943 | protein_molecule | denotes | 38 |
| T38 | 979-1006 | cell_type | denotes | anti-CD3 stimulated T cells |
| T39 | 1023-1027 | protein_molecule | denotes | Grb2 |
| T40 | 1036-1040 | protein_molecule | denotes | GrpL |
| T41 | 1105-1109 | protein_molecule | denotes | GrpL |
| T42 | 1114-1118 | protein_molecule | denotes | Grb2 |
| T43 | 1122-1129 | cell_type | denotes | T cells |
| T44 | 1156-1160 | protein_molecule | denotes | GrpL |
| T45 | 1160-1167 | protein_molecule | denotes | -SLP-76 |
| T46 | 1207-1211 | protein_molecule | denotes | GrpL |
| T47 | 1244-1250 | protein_molecule | denotes | SLP-76 |
| T48 | 1262-1267 | protein_molecule | denotes | NF-AT |
| T49 | 1282-1288 | cell_line | denotes | Jurkat |
| T50 | 1289-1296 | cell_type | denotes | T cells |