PubMed:10208590 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10208590","sourcedb":"PubMed","sourceid":"10208590","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10208590","text":"Isolation of human delta-catenin and its binding specificity with presenilin 1.\nWe screened proteins for interaction with presenilin (PS) 1, and cloned the full-length cDNA of human delta-catenin, which encoded 1225 amino acids. Yeast two-hybrid assay, GST binding assay and immunoprecipitation demonstrated that delta-catenin interacted with a hydrophilic loop region in the endoproteolytic C-terminal fragment of PS1, but not with that of PS-2. These results suggest that PS1 and PS2 partly differ in function. PS1 loop fragment containing the pathogenic mutation retained the binding ability. We also found another armadillo-protein, p0071, interacted with PS1.","tracks":[{"project":"FSU-PRGE","denotations":[{"id":"T1","span":{"begin":19,"end":32},"obj":"protein"},{"id":"T2","span":{"begin":66,"end":78},"obj":"protein"},{"id":"T3","span":{"begin":122,"end":139},"obj":"protein"},{"id":"T4","span":{"begin":182,"end":195},"obj":"protein"},{"id":"T5","span":{"begin":253,"end":256},"obj":"protein"},{"id":"T6","span":{"begin":313,"end":326},"obj":"protein"},{"id":"T7","span":{"begin":415,"end":418},"obj":"protein"},{"id":"T8","span":{"begin":441,"end":445},"obj":"protein"},{"id":"T9","span":{"begin":474,"end":477},"obj":"protein"},{"id":"T10","span":{"begin":482,"end":485},"obj":"protein"},{"id":"T11","span":{"begin":513,"end":516},"obj":"protein"},{"id":"T12","span":{"begin":618,"end":627},"obj":"protein"},{"id":"T13","span":{"begin":637,"end":642},"obj":"protein"},{"id":"T14","span":{"begin":660,"end":663},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"FSU-PRGE"},{"subj":"T2","pred":"source","obj":"FSU-PRGE"},{"subj":"T3","pred":"source","obj":"FSU-PRGE"},{"subj":"T4","pred":"source","obj":"FSU-PRGE"},{"subj":"T5","pred":"source","obj":"FSU-PRGE"},{"subj":"T6","pred":"source","obj":"FSU-PRGE"},{"subj":"T7","pred":"source","obj":"FSU-PRGE"},{"subj":"T8","pred":"source","obj":"FSU-PRGE"},{"subj":"T9","pred":"source","obj":"FSU-PRGE"},{"subj":"T10","pred":"source","obj":"FSU-PRGE"},{"subj":"T11","pred":"source","obj":"FSU-PRGE"},{"subj":"T12","pred":"source","obj":"FSU-PRGE"},{"subj":"T13","pred":"source","obj":"FSU-PRGE"},{"subj":"T14","pred":"source","obj":"FSU-PRGE"}]},{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":19,"end":32},"obj":"protein"},{"id":"T2","span":{"begin":66,"end":78},"obj":"protein"},{"id":"T3","span":{"begin":122,"end":139},"obj":"protein"},{"id":"T4","span":{"begin":182,"end":195},"obj":"protein"},{"id":"T5","span":{"begin":313,"end":326},"obj":"protein"},{"id":"T6","span":{"begin":415,"end":418},"obj":"protein"},{"id":"T7","span":{"begin":441,"end":445},"obj":"protein"},{"id":"T8","span":{"begin":474,"end":477},"obj":"protein"},{"id":"T9","span":{"begin":482,"end":485},"obj":"protein"},{"id":"T10","span":{"begin":513,"end":516},"obj":"protein"},{"id":"T11","span":{"begin":618,"end":635},"obj":"protein"},{"id":"T12","span":{"begin":637,"end":642},"obj":"protein"},{"id":"T13","span":{"begin":660,"end":663},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"AIMed"},{"subj":"T2","pred":"source","obj":"AIMed"},{"subj":"T3","pred":"source","obj":"AIMed"},{"subj":"T4","pred":"source","obj":"AIMed"},{"subj":"T5","pred":"source","obj":"AIMed"},{"subj":"T6","pred":"source","obj":"AIMed"},{"subj":"T7","pred":"source","obj":"AIMed"},{"subj":"T8","pred":"source","obj":"AIMed"},{"subj":"T9","pred":"source","obj":"AIMed"},{"subj":"T10","pred":"source","obj":"AIMed"},{"subj":"T11","pred":"source","obj":"AIMed"},{"subj":"T12","pred":"source","obj":"AIMed"},{"subj":"T13","pred":"source","obj":"AIMed"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"FSU-PRGE","color":"#ec93c1","default":true},{"id":"AIMed","color":"#93dbec"}]}]}}