PubMed:10208590 JSONTXT

{"project":"FSU-PRGE","denotations":[{"id":"T1","span":{"begin":19,"end":32},"obj":"protein"},{"id":"T2","span":{"begin":66,"end":78},"obj":"protein"},{"id":"T3","span":{"begin":122,"end":139},"obj":"protein"},{"id":"T4","span":{"begin":182,"end":195},"obj":"protein"},{"id":"T5","span":{"begin":253,"end":256},"obj":"protein"},{"id":"T6","span":{"begin":313,"end":326},"obj":"protein"},{"id":"T7","span":{"begin":415,"end":418},"obj":"protein"},{"id":"T8","span":{"begin":441,"end":445},"obj":"protein"},{"id":"T9","span":{"begin":474,"end":477},"obj":"protein"},{"id":"T10","span":{"begin":482,"end":485},"obj":"protein"},{"id":"T11","span":{"begin":513,"end":516},"obj":"protein"},{"id":"T12","span":{"begin":618,"end":627},"obj":"protein"},{"id":"T13","span":{"begin":637,"end":642},"obj":"protein"},{"id":"T14","span":{"begin":660,"end":663},"obj":"protein"}],"text":"Isolation of human delta-catenin and its binding specificity with presenilin 1.\nWe screened proteins for interaction with presenilin (PS) 1, and cloned the full-length cDNA of human delta-catenin, which encoded 1225 amino acids. Yeast two-hybrid assay, GST binding assay and immunoprecipitation demonstrated that delta-catenin interacted with a hydrophilic loop region in the endoproteolytic C-terminal fragment of PS1, but not with that of PS-2. These results suggest that PS1 and PS2 partly differ in function. PS1 loop fragment containing the pathogenic mutation retained the binding ability. We also found another armadillo-protein, p0071, interacted with PS1."}

{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":19,"end":32},"obj":"protein"},{"id":"T2","span":{"begin":66,"end":78},"obj":"protein"},{"id":"T3","span":{"begin":122,"end":139},"obj":"protein"},{"id":"T4","span":{"begin":182,"end":195},"obj":"protein"},{"id":"T5","span":{"begin":313,"end":326},"obj":"protein"},{"id":"T6","span":{"begin":415,"end":418},"obj":"protein"},{"id":"T7","span":{"begin":441,"end":445},"obj":"protein"},{"id":"T8","span":{"begin":474,"end":477},"obj":"protein"},{"id":"T9","span":{"begin":482,"end":485},"obj":"protein"},{"id":"T10","span":{"begin":513,"end":516},"obj":"protein"},{"id":"T11","span":{"begin":618,"end":635},"obj":"protein"},{"id":"T12","span":{"begin":637,"end":642},"obj":"protein"},{"id":"T13","span":{"begin":660,"end":663},"obj":"protein"}],"text":"Isolation of human delta-catenin and its binding specificity with presenilin 1.\nWe screened proteins for interaction with presenilin (PS) 1, and cloned the full-length cDNA of human delta-catenin, which encoded 1225 amino acids. Yeast two-hybrid assay, GST binding assay and immunoprecipitation demonstrated that delta-catenin interacted with a hydrophilic loop region in the endoproteolytic C-terminal fragment of PS1, but not with that of PS-2. These results suggest that PS1 and PS2 partly differ in function. PS1 loop fragment containing the pathogenic mutation retained the binding ability. We also found another armadillo-protein, p0071, interacted with PS1."}