PubMed:10201929 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10201929","sourcedb":"PubMed","sourceid":"10201929","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10201929","text":"Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line.\nNK cell cytotoxicity is a fast and efficient mechanism of target cell lysis. Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos. In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity. Interaction between immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity. Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":262,"end":282},"obj":"NP"},{"id":"C2","span":{"begin":355,"end":446},"obj":"NP"},{"id":"C3","span":{"begin":584,"end":604},"obj":"NP"},{"id":"C4","span":{"begin":738,"end":779},"obj":"NP"},{"id":"C5","span":{"begin":781,"end":786},"obj":"NP"},{"id":"C6","span":{"begin":879,"end":884},"obj":"NP"},{"id":"C7","span":{"begin":987,"end":1012},"obj":"NP"},{"id":"C8","span":{"begin":1194,"end":1198},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C3","obj":"C1"},{"id":"R2","pred":"coref-relat","subj":"C5","obj":"C4"},{"id":"R3","pred":"coref-pron","subj":"C6","obj":"C2"},{"id":"R4","pred":"coref-ident","subj":"C8","obj":"C7"}],"attributes":[{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"}]},{"project":"metamap-sample","denotations":[{"id":"T1","span":{"begin":88,"end":90},"obj":"C0022688"},{"id":"T2","span":{"begin":55,"end":59},"obj":"C0085828"},{"id":"T3","span":{"begin":1071,"end":1079},"obj":"C0376691"},{"id":"T4","span":{"begin":36,"end":44},"obj":"C0376691"},{"id":"T5","span":{"begin":760,"end":767},"obj":"C0205296"},{"id":"T6","span":{"begin":585,"end":592},"obj":"C0205296"},{"id":"T7","span":{"begin":263,"end":270},"obj":"C0205296"},{"id":"T8","span":{"begin":15,"end":22},"obj":"C0205296"},{"id":"T9","span":{"begin":768,"end":780},"obj":"C0596402"},{"id":"T10","span":{"begin":593,"end":605},"obj":"C0596402"},{"id":"T11","span":{"begin":271,"end":283},"obj":"C0596402"},{"id":"T12","span":{"begin":23,"end":35},"obj":"C0596402"},{"id":"T13","span":{"begin":1089,"end":1099},"obj":"C0425152"},{"id":"T14","span":{"begin":1,"end":11},"obj":"C0425152"},{"id":"T15","span":{"begin":60,"end":70},"obj":"C0185117"},{"id":"T16","span":{"begin":840,"end":853},"obj":"C0040649"},{"id":"T17","span":{"begin":185,"end":198},"obj":"C0040649"},{"id":"T18","span":{"begin":1136,"end":1157},"obj":"C0019629"},{"id":"T19","span":{"begin":670,"end":672},"obj":"C0021027"},{"id":"T20","span":{"begin":128,"end":132},"obj":"C0015663"},{"id":"T21","span":{"begin":199,"end":207},"obj":"C1524024"},{"id":"T22","span":{"begin":526,"end":563},"obj":"C0949632"},{"id":"T23","span":{"begin":335,"end":338},"obj":"C0035696"},{"id":"T24","span":{"begin":1111,"end":1120},"obj":"C3463820"},{"id":"T25","span":{"begin":660,"end":669},"obj":"C0023516"},{"id":"T26","span":{"begin":1061,"end":1070},"obj":"C1536403"},{"id":"T27","span":{"begin":981,"end":986},"obj":"C1536403"},{"id":"T28","span":{"begin":172,"end":177},"obj":"C1536403"},{"id":"T29","span":{"begin":993,"end":1013},"obj":"C0040648"},{"id":"T30","span":{"begin":886,"end":889},"obj":"C0012854"},{"id":"T31","span":{"begin":834,"end":839},"obj":"C0087140"},{"id":"T32","span":{"begin":442,"end":447},"obj":"C0087140"},{"id":"T33","span":{"begin":1017,"end":1026},"obj":"C1879547"},{"id":"T34","span":{"begin":1181,"end":1191},"obj":"C1879547"},{"id":"T35","span":{"begin":1175,"end":1180},"obj":"C1279919"},{"id":"T36","span":{"begin":361,"end":366},"obj":"C1279919"},{"id":"T37","span":{"begin":1170,"end":1174},"obj":"C0442824"},{"id":"T38","span":{"begin":356,"end":360},"obj":"C0442824"},{"id":"T39","span":{"begin":886,"end":897},"obj":"C1148673"},{"id":"T40","span":{"begin":462,"end":473},"obj":"C1148673"},{"id":"T41","span":{"begin":452,"end":460},"obj":"C1883712"},{"id":"T42","span":{"begin":575,"end":581},"obj":"C0750729"},{"id":"T43","span":{"begin":102,"end":122},"obj":"C2984255"},{"id":"T44","span":{"begin":248,"end":252},"obj":"C1547282"},{"id":"T45","span":{"begin":179,"end":184},"obj":"C1524063"},{"id":"T46","span":{"begin":952,"end":960},"obj":"C0439831"},{"id":"T47","span":{"begin":696,"end":701},"obj":"C0007634"},{"id":"T48","span":{"begin":912,"end":919},"obj":"C0947630"},{"id":"T49","span":{"begin":678,"end":686},"obj":"C0597357"},{"id":"T50","span":{"begin":237,"end":243},"obj":"C0243073"},{"id":"T51","span":{"begin":392,"end":417},"obj":"C0812327"},{"id":"T52","span":{"begin":147,"end":156},"obj":"C0441712"},{"id":"T53","span":{"begin":514,"end":522},"obj":"C1441672"},{"id":"T54","span":{"begin":474,"end":484},"obj":"C0441655"},{"id":"T55","span":{"begin":284,"end":291},"obj":"C0015264"},{"id":"T56","span":{"begin":730,"end":735},"obj":"C2348269"},{"id":"T57","span":{"begin":742,"end":752},"obj":"C0684336"},{"id":"T58","span":{"begin":607,"end":618},"obj":"C1704675"},{"id":"T59","span":{"begin":227,"end":236},"obj":"C0169911"},{"id":"T60","span":{"begin":972,"end":980},"obj":"C0127400"},{"id":"T61","span":{"begin":160,"end":171},"obj":"C0221284"},{"id":"T62","span":{"begin":890,"end":906},"obj":"C2266866"},{"id":"T63","span":{"begin":717,"end":722},"obj":"C1521840"},{"id":"T64","span":{"begin":137,"end":146},"obj":"C0442799"},{"id":"T65","span":{"begin":898,"end":906},"obj":"C1561536"},{"id":"T66","span":{"begin":488,"end":491},"obj":"C3536909"}],"attributes":[{"subj":"T1","pred":"source","obj":"metamap-sample"},{"subj":"T2","pred":"source","obj":"metamap-sample"},{"subj":"T3","pred":"source","obj":"metamap-sample"},{"subj":"T4","pred":"source","obj":"metamap-sample"},{"subj":"T5","pred":"source","obj":"metamap-sample"},{"subj":"T6","pred":"source","obj":"metamap-sample"},{"subj":"T7","pred":"source","obj":"metamap-sample"},{"subj":"T8","pred":"source","obj":"metamap-sample"},{"subj":"T9","pred":"source","obj":"metamap-sample"},{"subj":"T10","pred":"source","obj":"metamap-sample"},{"subj":"T11","pred":"source","obj":"metamap-sample"},{"subj":"T12","pred":"source","obj":"metamap-sample"},{"subj":"T13","pred":"source","obj":"metamap-sample"},{"subj":"T14","pred":"source","obj":"metamap-sample"},{"subj":"T15","pred":"source","obj":"metamap-sample"},{"subj":"T16","pred":"source","obj":"metamap-sample"},{"subj":"T17","pred":"source","obj":"metamap-sample"},{"subj":"T18","pred":"source","obj":"metamap-sample"},{"subj":"T19","pred":"source","obj":"metamap-sample"},{"subj":"T20","pred":"source","obj":"metamap-sample"},{"subj":"T21","pred":"source","obj":"metamap-sample"},{"subj":"T22","pred":"source","obj":"metamap-sample"},{"subj":"T23","pred":"source","obj":"metamap-sample"},{"subj":"T24","pred":"source","obj":"metamap-sample"},{"subj":"T25","pred":"source","obj":"metamap-sample"},{"subj":"T26","pred":"source","obj":"metamap-sample"},{"subj":"T27","pred":"source","obj":"metamap-sample"},{"subj":"T28","pred":"source","obj":"metamap-sample"},{"subj":"T29","pred":"source","obj":"metamap-sample"},{"subj":"T30","pred":"source","obj":"metamap-sample"},{"subj":"T31","pred":"source","obj":"metamap-sample"},{"subj":"T32","pred":"source","obj":"metamap-sample"},{"subj":"T33","pred":"source","obj":"metamap-sample"},{"subj":"T34","pred":"source","obj":"metamap-sample"},{"subj":"T35","pred":"source","obj":"metamap-sample"},{"subj":"T36","pred":"source","obj":"metamap-sample"},{"subj":"T37","pred":"source","obj":"metamap-sample"},{"subj":"T38","pred":"source","obj":"metamap-sample"},{"subj":"T39","pred":"source","obj":"metamap-sample"},{"subj":"T40","pred":"source","obj":"metamap-sample"},{"subj":"T41","pred":"source","obj":"metamap-sample"},{"subj":"T42","pred":"source","obj":"metamap-sample"},{"subj":"T43","pred":"source","obj":"metamap-sample"},{"subj":"T44","pred":"source","obj":"metamap-sample"},{"subj":"T45","pred":"source","obj":"metamap-sample"},{"subj":"T46","pred":"source","obj":"metamap-sample"},{"subj":"T47","pred":"source","obj":"metamap-sample"},{"subj":"T48","pred":"source","obj":"metamap-sample"},{"subj":"T49","pred":"source","obj":"metamap-sample"},{"subj":"T50","pred":"source","obj":"metamap-sample"},{"subj":"T51","pred":"source","obj":"metamap-sample"},{"subj":"T52","pred":"source","obj":"metamap-sample"},{"subj":"T53","pred":"source","obj":"metamap-sample"},{"subj":"T54","pred":"source","obj":"metamap-sample"},{"subj":"T55","pred":"source","obj":"metamap-sample"},{"subj":"T56","pred":"source","obj":"metamap-sample"},{"subj":"T57","pred":"source","obj":"metamap-sample"},{"subj":"T58","pred":"source","obj":"metamap-sample"},{"subj":"T59","pred":"source","obj":"metamap-sample"},{"subj":"T60","pred":"source","obj":"metamap-sample"},{"subj":"T61","pred":"source","obj":"metamap-sample"},{"subj":"T62","pred":"source","obj":"metamap-sample"},{"subj":"T63","pred":"source","obj":"metamap-sample"},{"subj":"T64","pred":"source","obj":"metamap-sample"},{"subj":"T65","pred":"source","obj":"metamap-sample"},{"subj":"T66","pred":"source","obj":"metamap-sample"}]},{"project":"semrep-sample","denotations":[{"id":"E1-ti-1","span":{"begin":0,"end":10},"obj":"cui:C0425152"},{"id":"E2-ti-1","span":{"begin":14,"end":21},"obj":"cui:C0205296"},{"id":"E3-ti-1","span":{"begin":22,"end":34},"obj":"cui:C0596402"},{"id":"E4-ti-1","span":{"begin":54,"end":58},"obj":"cui:C0085828"},{"id":"E5-ti-1","span":{"begin":59,"end":69},"obj":"cui:C0185117"},{"id":"E6-ti-1","span":{"begin":77,"end":80},"obj":"entrez:84662"},{"id":"E7-ti-1","span":{"begin":81,"end":99},"obj":"cui:C0682523"},{"id":"T1","span":{"begin":59,"end":69},"obj":"PART_OF"},{"id":"E1-ab-1","span":{"begin":101,"end":108},"obj":"cui:C0022688"},{"id":"E2-ab-1","span":{"begin":109,"end":121},"obj":"cui:C0596402"},{"id":"E3-ab-1","span":{"begin":127,"end":131},"obj":"cui:C0456962"},{"id":"E4-ab-1","span":{"begin":136,"end":145},"obj":"cui:C0442799"},{"id":"E5-ab-1","span":{"begin":146,"end":155},"obj":"cui:C0441712"},{"id":"E6-ab-1","span":{"begin":159,"end":170},"obj":"cui:C0221284"},{"id":"E7-ab-1","span":{"begin":171,"end":176},"obj":"cui:C1260960"},{"id":"T2","span":{"begin":146,"end":155},"obj":"MANIFESTATION_OF"},{"id":"E1-ab-2","span":{"begin":184,"end":197},"obj":"cui:C0040649"},{"id":"E2-ab-2","span":{"begin":198,"end":206},"obj":"cui:C0936012"},{"id":"E3-ab-2","span":{"begin":226,"end":235},"obj":"cui:C0169911"},{"id":"E4-ab-2","span":{"begin":236,"end":242},"obj":"cui:C1510438"},{"id":"E5-ab-2","span":{"begin":262,"end":269},"obj":"cui:C0205296"},{"id":"E6-ab-2","span":{"begin":270,"end":282},"obj":"cui:C0596402"},{"id":"E7-ab-2","span":{"begin":304,"end":307},"obj":"entrez:84662"},{"id":"E8-ab-2","span":{"begin":298,"end":317},"obj":"cui:C0682523"},{"id":"E9-ab-2","span":{"begin":334,"end":338},"obj":"cui:C0035696"},{"id":"E10-ab-2","span":{"begin":355,"end":359},"obj":"cui:C0442824"},{"id":"E11-ab-2","span":{"begin":360,"end":365},"obj":"cui:C1279919"},{"id":"E12-ab-2","span":{"begin":366,"end":390},"obj":"cui:C0085828"},{"id":"E13-ab-2","span":{"begin":391,"end":417},"obj":"cui:C0812327"},{"id":"E14-ab-2","span":{"begin":426,"end":430},"obj":"cui:C0812313"},{"id":"E15-ab-2","span":{"begin":432,"end":436},"obj":"cui:C1333571"},{"id":"E16-ab-2","span":{"begin":441,"end":446},"obj":"cui:C0085301"},{"id":"T3","span":{"begin":391,"end":430},"obj":"ISA"},{"id":"T4","span":{"begin":391,"end":430},"obj":"ISA"},{"id":"T5","span":{"begin":226,"end":242},"obj":"USES"},{"id":"E1-ab-3","span":{"begin":451,"end":459},"obj":"cui:C0442796"},{"id":"E2-ab-3","span":{"begin":461,"end":472},"obj":"cui:C1148673"},{"id":"E3-ab-3","span":{"begin":473,"end":483},"obj":"cui:C0441655"},{"id":"E4-ab-3","span":{"begin":487,"end":490},"obj":"cui:C0085296"},{"id":"E5-ab-3","span":{"begin":491,"end":494},"obj":"cui:C0085940"},{"id":"E6-ab-3","span":{"begin":525,"end":562},"obj":"cui:C0949632"},{"id":"E7-ab-3","span":{"begin":574,"end":580},"obj":"cui:C0750729"},{"id":"E8-ab-3","span":{"begin":584,"end":591},"obj":"cui:C0205296"},{"id":"E9-ab-3","span":{"begin":592,"end":604},"obj":"cui:C0596402"},{"id":"E1-ab-4","span":{"begin":606,"end":617},"obj":"cui:C0687133"},{"id":"E2-ab-4","span":{"begin":626,"end":640},"obj":"cui:C0021027"},{"id":"E3-ab-4","span":{"begin":646,"end":656},"obj":"cui:C1519595"},{"id":"E4-ab-4","span":{"begin":659,"end":668},"obj":"cui:C0023516"},{"id":"E5-ab-4","span":{"begin":677,"end":685},"obj":"cui:C0597357"},{"id":"E6-ab-4","span":{"begin":691,"end":694},"obj":"entrez:84662"},{"id":"E7-ab-4","span":{"begin":695,"end":700},"obj":"cui:C0007634"},{"id":"E8-ab-4","span":{"begin":705,"end":712},"obj":"entrez:3106"},{"id":"E9-ab-4","span":{"begin":716,"end":728},"obj":"cui:C0221284"},{"id":"E10-ab-4","span":{"begin":755,"end":758},"obj":"entrez:84662"},{"id":"E11-ab-4","span":{"begin":759,"end":766},"obj":"cui:C0205296"},{"id":"E12-ab-4","span":{"begin":767,"end":779},"obj":"cui:C0596402"},{"id":"E13-ab-4","span":{"begin":817,"end":821},"obj":"cui:C0812313"},{"id":"E14-ab-4","span":{"begin":823,"end":827},"obj":"cui:C1333571"},{"id":"E15-ab-4","span":{"begin":833,"end":838},"obj":"cui:C0085301"},{"id":"E16-ab-4","span":{"begin":839,"end":852},"obj":"cui:C0040649"},{"id":"E17-ab-4","span":{"begin":885,"end":896},"obj":"cui:C1148673"},{"id":"E18-ab-4","span":{"begin":897,"end":905},"obj":"cui:C0439167"},{"id":"T6","span":{"begin":606,"end":617},"obj":"INTERACTS_WITH"},{"id":"T7","span":{"begin":606,"end":617},"obj":"INTERACTS_WITH"},{"id":"T8","span":{"begin":606,"end":617},"obj":"INTERACTS_WITH"},{"id":"T9","span":{"begin":688,"end":690},"obj":"LOCATION_OF"},{"id":"T10","span":{"begin":713,"end":715},"obj":"LOCATION_OF"},{"id":"E1-ab-5","span":{"begin":911,"end":918},"obj":"cui:C0008972"},{"id":"E2-ab-5","span":{"begin":951,"end":959},"obj":"cui:C0439831"},{"id":"E3-ab-5","span":{"begin":963,"end":970},"obj":"cui:C0022688"},{"id":"E4-ab-5","span":{"begin":971,"end":979},"obj":"cui:C0086597"},{"id":"E5-ab-5","span":{"begin":980,"end":985},"obj":"cui:C1260960"},{"id":"E6-ab-5","span":{"begin":987,"end":991},"obj":"cui:C0085828"},{"id":"E7-ab-5","span":{"begin":992,"end":1012},"obj":"cui:C0040648"},{"id":"E8-ab-5","span":{"begin":1037,"end":1042},"obj":"cui:C1279919"},{"id":"E9-ab-5","span":{"begin":1043,"end":1048},"obj":"cui:C1306673"},{"id":"E10-ab-5","span":{"begin":1052,"end":1059},"obj":"cui:C0022688"},{"id":"E11-ab-5","span":{"begin":1060,"end":1069},"obj":"cui:C1260960"},{"id":"E12-ab-5","span":{"begin":1088,"end":1098},"obj":"cui:C0425152"},{"id":"E13-ab-5","span":{"begin":1110,"end":1120},"obj":"cui:C0243077"},{"id":"E14-ab-5","span":{"begin":1102,"end":1130},"obj":"cui:C0382839"},{"id":"E15-ab-5","span":{"begin":1135,"end":1138},"obj":"entrez:3133"},{"id":"E16-ab-5","span":{"begin":1139,"end":1144},"obj":"cui:C0456387"},{"id":"E17-ab-5","span":{"begin":1147,"end":1156},"obj":"cui:C0567416"},{"id":"E18-ab-5","span":{"begin":1169,"end":1173},"obj":"cui:C0442824"},{"id":"E19-ab-5","span":{"begin":1174,"end":1179},"obj":"cui:C1279919"},{"id":"E20-ab-5","span":{"begin":1194,"end":1198},"obj":"cui:C0085828"},{"id":"T11","span":{"begin":1180,"end":1190},"obj":"STIMULATES"}],"relations":[{"id":"R1","pred":"subjectOf","subj":"E4-ti-1","obj":"T1"},{"id":"R2","pred":"objectOf","subj":"E7-ti-1","obj":"T1"},{"id":"R3","pred":"subjectOf","subj":"E2-ab-1","obj":"T2"},{"id":"R4","pred":"objectOf","subj":"E7-ab-1","obj":"T2"},{"id":"R5","pred":"subjectOf","subj":"E14-ab-2","obj":"T3"},{"id":"R6","pred":"objectOf","subj":"E13-ab-2","obj":"T3"},{"id":"R7","pred":"subjectOf","subj":"E15-ab-2","obj":"T4"},{"id":"R8","pred":"objectOf","subj":"E13-ab-2","obj":"T4"},{"id":"R9","pred":"subjectOf","subj":"E4-ab-2","obj":"T5"},{"id":"R10","pred":"objectOf","subj":"E3-ab-2","obj":"T5"},{"id":"R11","pred":"subjectOf","subj":"E14-ab-4","obj":"T6"},{"id":"R12","pred":"objectOf","subj":"E2-ab-4","obj":"T6"},{"id":"R13","pred":"subjectOf","subj":"E15-ab-4","obj":"T7"},{"id":"R14","pred":"objectOf","subj":"E2-ab-4","obj":"T7"},{"id":"R15","pred":"subjectOf","subj":"E13-ab-4","obj":"T8"},{"id":"R16","pred":"objectOf","subj":"E2-ab-4","obj":"T8"},{"id":"R17","pred":"subjectOf","subj":"E7-ab-4","obj":"T9"},{"id":"R18","pred":"objectOf","subj":"E2-ab-4","obj":"T9"},{"id":"R19","pred":"subjectOf","subj":"E9-ab-4","obj":"T10"},{"id":"R20","pred":"objectOf","subj":"E8-ab-4","obj":"T10"},{"id":"R21","pred":"subjectOf","subj":"E7-ab-5","obj":"T11"},{"id":"R22","pred":"objectOf","subj":"E20-ab-5","obj":"T11"}],"attributes":[{"subj":"E1-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E2-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E3-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E4-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E5-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E6-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E7-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"T1","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"T2","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E10-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E11-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E12-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E13-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E14-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E15-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E16-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"T3","pred":"source","obj":"semrep-sample"},{"subj":"T4","pred":"source","obj":"semrep-sample"},{"subj":"T5","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E10-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E11-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E12-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E13-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E14-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E15-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E16-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E17-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E18-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"T6","pred":"source","obj":"semrep-sample"},{"subj":"T7","pred":"source","obj":"semrep-sample"},{"subj":"T8","pred":"source","obj":"semrep-sample"},{"subj":"T9","pred":"source","obj":"semrep-sample"},{"subj":"T10","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E10-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E11-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E12-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E13-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E14-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E15-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E16-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E17-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E18-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E19-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E20-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"T11","pred":"source","obj":"semrep-sample"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":54,"end":58},"obj":"protein"},{"id":"T2","span":{"begin":77,"end":99},"obj":"cell_line"},{"id":"T3","span":{"begin":298,"end":317},"obj":"cell_line"},{"id":"T4","span":{"begin":355,"end":390},"obj":"protein"},{"id":"T5","span":{"begin":391,"end":417},"obj":"DNA"},{"id":"T6","span":{"begin":426,"end":430},"obj":"DNA"},{"id":"T7","span":{"begin":432,"end":436},"obj":"DNA"},{"id":"T8","span":{"begin":441,"end":446},"obj":"DNA"},{"id":"T9","span":{"begin":487,"end":507},"obj":"protein"},{"id":"T10","span":{"begin":626,"end":687},"obj":"protein"},{"id":"T11","span":{"begin":691,"end":700},"obj":"cell_type"},{"id":"T12","span":{"begin":705,"end":712},"obj":"protein"},{"id":"T13","span":{"begin":716,"end":728},"obj":"cell_type"},{"id":"T14","span":{"begin":987,"end":1012},"obj":"protein"},{"id":"T15","span":{"begin":1102,"end":1130},"obj":"protein"},{"id":"T16","span":{"begin":1135,"end":1156},"obj":"protein"},{"id":"T17","span":{"begin":1194,"end":1198},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":100},"obj":"Sentence"},{"id":"S2","span":{"begin":101,"end":177},"obj":"Sentence"},{"id":"S3","span":{"begin":178,"end":447},"obj":"Sentence"},{"id":"S4","span":{"begin":448,"end":605},"obj":"Sentence"},{"id":"S5","span":{"begin":606,"end":906},"obj":"Sentence"},{"id":"S6","span":{"begin":907,"end":1199},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":14,"end":43},"obj":"other_name"},{"id":"T2","span":{"begin":54,"end":58},"obj":"protein_molecule"},{"id":"T3","span":{"begin":77,"end":99},"obj":"cell_line"},{"id":"T4","span":{"begin":101,"end":121},"obj":"other_name"},{"id":"T5","span":{"begin":159,"end":176},"obj":"other_name"},{"id":"T6","span":{"begin":184,"end":206},"obj":"other_name"},{"id":"T7","span":{"begin":216,"end":242},"obj":"other_name"},{"id":"T8","span":{"begin":262,"end":282},"obj":"other_name"},{"id":"T9","span":{"begin":298,"end":317},"obj":"cell_line"},{"id":"T10","span":{"begin":334,"end":351},"obj":"other_name"},{"id":"T11","span":{"begin":355,"end":390},"obj":"protein_molecule"},{"id":"T12","span":{"begin":391,"end":417},"obj":"DNA_family_or_group"},{"id":"T13","span":{"begin":426,"end":430},"obj":"DNA_domain_or_region"},{"id":"T14","span":{"begin":432,"end":436},"obj":"DNA_domain_or_region"},{"id":"T15","span":{"begin":441,"end":446},"obj":"DNA_domain_or_region"},{"id":"T16","span":{"begin":461,"end":483},"obj":"other_name"},{"id":"T17","span":{"begin":487,"end":507},"obj":"protein_complex"},{"id":"T18","span":{"begin":525,"end":562},"obj":"other_name"},{"id":"T19","span":{"begin":584,"end":604},"obj":"other_name"},{"id":"T20","span":{"begin":626,"end":687},"obj":"protein_complex"},{"id":"T21","span":{"begin":691,"end":700},"obj":"cell_type"},{"id":"T22","span":{"begin":705,"end":712},"obj":"protein_molecule"},{"id":"T23","span":{"begin":716,"end":728},"obj":"cell_type"},{"id":"T24","span":{"begin":759,"end":779},"obj":"other_name"},{"id":"T25","span":{"begin":963,"end":985},"obj":"other_name"},{"id":"T26","span":{"begin":987,"end":1012},"obj":"protein_molecule"},{"id":"T27","span":{"begin":1052,"end":1078},"obj":"other_name"},{"id":"T28","span":{"begin":1102,"end":1130},"obj":"protein_family_or_group"},{"id":"T29","span":{"begin":1135,"end":1156},"obj":"protein_family_or_group"},{"id":"T30","span":{"begin":1194,"end":1198},"obj":"protein_molecule"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"},{"subj":"T28","pred":"source","obj":"GENIAcorpus"},{"subj":"T29","pred":"source","obj":"GENIAcorpus"},{"subj":"T30","pred":"source","obj":"GENIAcorpus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#9393ec","default":true},{"id":"metamap-sample","color":"#adec93"},{"id":"semrep-sample","color":"#ec93c7"},{"id":"jnlpba-st-training","color":"#93e1ec"},{"id":"pubmed-sentences-benchmark","color":"#ecdc93"},{"id":"GENIAcorpus","color":"#c293ec"}]}]}}