PubMed:10201929
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 54-58 | protein | denotes | AP-1 |
| T2 | 77-99 | cell_line | denotes | NKL human NK cell line |
| T3 | 298-317 | cell_line | denotes | human NKL cell line |
| T4 | 355-390 | protein | denotes | very early activator protein (AP)-1 |
| T5 | 391-417 | DNA | denotes | transcription factor genes |
| T6 | 426-430 | DNA | denotes | JunB |
| T7 | 432-436 | DNA | denotes | FosB |
| T8 | 441-446 | DNA | denotes | c-Fos |
| T9 | 487-507 | protein | denotes | Jun-Fos heterodimers |
| T10 | 626-687 | protein | denotes | immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 |
| T11 | 691-700 | cell_type | denotes | NKL cells |
| T12 | 705-712 | protein | denotes | HLA-B27 |
| T13 | 716-728 | cell_type | denotes | target cells |
| T14 | 987-1012 | protein | denotes | AP-1 transcription factor |
| T15 | 1102-1130 | protein | denotes | NK cell inhibitory receptors |
| T16 | 1135-1156 | protein | denotes | MHC class I molecules |
| T17 | 1194-1198 | protein | denotes | AP-1 |
semrep-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| E1-ti-1 | 0-10 | cui:C0425152 | denotes | Engagement |
| E2-ti-1 | 14-21 | cui:C0205296 | denotes | natural |
| E3-ti-1 | 22-34 | cui:C0596402 | denotes | cytotoxicity |
| E4-ti-1 | 54-58 | cui:C0085828 | denotes | AP-1 |
| E5-ti-1 | 59-69 | cui:C0185117 | denotes | expression |
| E6-ti-1 | 77-80 | entrez:84662 | denotes | NKL |
| E7-ti-1 | 81-99 | cui:C0682523 | denotes | human NK cell line |
| T1 | 59-69 | PART_OF | denotes | expression |
| E1-ab-1 | 101-108 | cui:C0022688 | denotes | NK cell |
| E2-ab-1 | 109-121 | cui:C0596402 | denotes | cytotoxicity |
| E3-ab-1 | 127-131 | cui:C0456962 | denotes | fast |
| E4-ab-1 | 136-145 | cui:C0442799 | denotes | efficient |
| E5-ab-1 | 146-155 | cui:C0441712 | denotes | mechanism |
| E6-ab-1 | 159-170 | cui:C0221284 | denotes | target cell |
| E7-ab-1 | 171-176 | cui:C1260960 | denotes | lysis |
| T2 | 146-155 | MANIFESTATION_OF | denotes | mechanism |
| E1-ab-2 | 184-197 | cui:C0040649 | denotes | transcription |
| E2-ab-2 | 198-206 | cui:C0936012 | denotes | analysis |
| E3-ab-2 | 226-235 | cui:C0169911 | denotes | messenger |
| E4-ab-2 | 236-242 | cui:C1510438 | denotes | assays |
| E5-ab-2 | 262-269 | cui:C0205296 | denotes | natural |
| E6-ab-2 | 270-282 | cui:C0596402 | denotes | cytotoxicity |
| E7-ab-2 | 304-307 | entrez:84662 | denotes | NKL |
| E8-ab-2 | 298-317 | cui:C0682523 | denotes | human NKL cell line |
| E9-ab-2 | 334-338 | cui:C0035696 | denotes | mRNA |
| E10-ab-2 | 355-359 | cui:C0442824 | denotes | very |
| E11-ab-2 | 360-365 | cui:C1279919 | denotes | early |
| E12-ab-2 | 366-390 | cui:C0085828 | denotes | activator protein (AP)-1 |
| E13-ab-2 | 391-417 | cui:C0812327 | denotes | transcription factor genes |
| E14-ab-2 | 426-430 | cui:C0812313 | denotes | JunB |
| E15-ab-2 | 432-436 | cui:C1333571 | denotes | FosB |
| E16-ab-2 | 441-446 | cui:C0085301 | denotes | c-Fos |
| T3 | 391-430 | ISA | denotes | transcription factor genes such as JunB |
| T4 | 391-430 | ISA | denotes | transcription factor genes such as JunB |
| T5 | 226-242 | USES | denotes | messenger assays |
| E1-ab-3 | 451-459 | cui:C0442796 | denotes | addition |
| E2-ab-3 | 461-472 | cui:C1148673 | denotes | DNA-binding |
| E3-ab-3 | 473-483 | cui:C0441655 | denotes | activities |
| E4-ab-3 | 487-490 | cui:C0085296 | denotes | Jun |
| E5-ab-3 | 491-494 | cui:C0085940 | denotes | Fos |
| E6-ab-3 | 525-562 | cui:C0949632 | denotes | electrophoretic mobility shift assays |
| E7-ab-3 | 574-580 | cui:C0750729 | denotes | course |
| E8-ab-3 | 584-591 | cui:C0205296 | denotes | natural |
| E9-ab-3 | 592-604 | cui:C0596402 | denotes | cytotoxicity |
| E1-ab-4 | 606-617 | cui:C0687133 | denotes | Interaction |
| E2-ab-4 | 626-640 | cui:C0021027 | denotes | immunoglobulin |
| E3-ab-4 | 646-656 | cui:C1519595 | denotes | transcript |
| E4-ab-4 | 659-668 | cui:C0023516 | denotes | leukocyte |
| E5-ab-4 | 677-685 | cui:C0597357 | denotes | receptor |
| E6-ab-4 | 691-694 | entrez:84662 | denotes | NKL |
| E7-ab-4 | 695-700 | cui:C0007634 | denotes | cells |
| E8-ab-4 | 705-712 | entrez:3106 | denotes | HLA-B27 |
| E9-ab-4 | 716-728 | cui:C0221284 | denotes | target cells |
| E10-ab-4 | 755-758 | entrez:84662 | denotes | NKL |
| E11-ab-4 | 759-766 | cui:C0205296 | denotes | natural |
| E12-ab-4 | 767-779 | cui:C0596402 | denotes | cytotoxicity |
| E13-ab-4 | 817-821 | cui:C0812313 | denotes | JunB |
| E14-ab-4 | 823-827 | cui:C1333571 | denotes | FosB |
| E15-ab-4 | 833-838 | cui:C0085301 | denotes | c-Fos |
| E16-ab-4 | 839-852 | cui:C0040649 | denotes | transcription |
| E17-ab-4 | 885-896 | cui:C1148673 | denotes | DNA-binding |
| E18-ab-4 | 897-905 | cui:C0439167 | denotes | activity |
| T6 | 606-617 | INTERACTS_WITH | denotes | Interaction |
| T7 | 606-617 | INTERACTS_WITH | denotes | Interaction |
| T8 | 606-617 | INTERACTS_WITH | denotes | Interaction |
| T9 | 688-690 | LOCATION_OF | denotes | on |
| T10 | 713-715 | LOCATION_OF | denotes | on |
| E1-ab-5 | 911-918 | cui:C0008972 | denotes | studies |
| E2-ab-5 | 951-959 | cui:C0439831 | denotes | rapidity |
| E3-ab-5 | 963-970 | cui:C0022688 | denotes | NK cell |
| E4-ab-5 | 971-979 | cui:C0086597 | denotes | mediated |
| E5-ab-5 | 980-985 | cui:C1260960 | denotes | lysis |
| E6-ab-5 | 987-991 | cui:C0085828 | denotes | AP-1 |
| E7-ab-5 | 992-1012 | cui:C0040648 | denotes | transcription factor |
| E8-ab-5 | 1037-1042 | cui:C1279919 | denotes | early |
| E9-ab-5 | 1043-1048 | cui:C1306673 | denotes | stage |
| E10-ab-5 | 1052-1059 | cui:C0022688 | denotes | NK cell |
| E11-ab-5 | 1060-1069 | cui:C1260960 | denotes | cytolytic |
| E12-ab-5 | 1088-1098 | cui:C0425152 | denotes | engagement |
| E13-ab-5 | 1110-1120 | cui:C0243077 | denotes | inhibitory |
| E14-ab-5 | 1102-1130 | cui:C0382839 | denotes | NK cell inhibitory receptors |
| E15-ab-5 | 1135-1138 | entrez:3133 | denotes | MHC |
| E16-ab-5 | 1139-1144 | cui:C0456387 | denotes | class |
| E17-ab-5 | 1147-1156 | cui:C0567416 | denotes | molecules |
| E18-ab-5 | 1169-1173 | cui:C0442824 | denotes | very |
| E19-ab-5 | 1174-1179 | cui:C1279919 | denotes | early |
| E20-ab-5 | 1194-1198 | cui:C0085828 | denotes | AP-1 |
| T11 | 1180-1190 | STIMULATES | denotes | activation |
| R1 | E4-ti-1 | T1 | subjectOf | AP-1,expression |
| R2 | E7-ti-1 | T1 | objectOf | human NK cell line,expression |
| R3 | E2-ab-1 | T2 | subjectOf | cytotoxicity,mechanism |
| R4 | E7-ab-1 | T2 | objectOf | lysis,mechanism |
| R5 | E14-ab-2 | T3 | subjectOf | JunB,transcription factor genes such as JunB |
| R6 | E13-ab-2 | T3 | objectOf | transcription factor genes,transcription factor genes such as JunB |
| R7 | E15-ab-2 | T4 | subjectOf | FosB,transcription factor genes such as JunB |
| R8 | E13-ab-2 | T4 | objectOf | transcription factor genes,transcription factor genes such as JunB |
| R9 | E4-ab-2 | T5 | subjectOf | assays,messenger assays |
| R10 | E3-ab-2 | T5 | objectOf | messenger,messenger assays |
| R11 | E14-ab-4 | T6 | subjectOf | FosB,Interaction |
| R12 | E2-ab-4 | T6 | objectOf | immunoglobulin,Interaction |
| R13 | E15-ab-4 | T7 | subjectOf | c-Fos,Interaction |
| R14 | E2-ab-4 | T7 | objectOf | immunoglobulin,Interaction |
| R15 | E13-ab-4 | T8 | subjectOf | JunB,Interaction |
| R16 | E2-ab-4 | T8 | objectOf | immunoglobulin,Interaction |
| R17 | E7-ab-4 | T9 | subjectOf | cells,on |
| R18 | E2-ab-4 | T9 | objectOf | immunoglobulin,on |
| R19 | E9-ab-4 | T10 | subjectOf | target cells,on |
| R20 | E8-ab-4 | T10 | objectOf | HLA-B27,on |
| R21 | E7-ab-5 | T11 | subjectOf | transcription factor,activation |
| R22 | E20-ab-5 | T11 | objectOf | AP-1,activation |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-100 | Sentence | denotes | Engagement of natural cytotoxicity programs regulates AP-1 expression in the NKL human NK cell line. |
| S2 | 101-177 | Sentence | denotes | NK cell cytotoxicity is a fast and efficient mechanism of target cell lysis. |
| S3 | 178-447 | Sentence | denotes | Using transcription analysis, such as multiplex messenger assays, we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos. |
| S4 | 448-605 | Sentence | denotes | In addition, DNA-binding activities of Jun-Fos heterodimers were observed by electrophoretic mobility shift assays during the course of natural cytotoxicity. |
| S5 | 606-906 | Sentence | denotes | Interaction between immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 on NKL cells and HLA-B27 on target cells leads to an impairment of NKL natural cytotoxicity, which correlates with an absence of JunB, FosB, and c-Fos transcription, as well as an absence of their DNA-binding activity. |
| S6 | 907-1199 | Sentence | denotes | Our studies thus indicate that, despite the rapidity of NK cell-mediated lysis, AP-1 transcription factor is activated during the early stage of NK cell cytolytic programs and that engagement of NK cell inhibitory receptors for MHC class I molecules impairs the very early activation of AP-1. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 262-282 | NP | denotes | natural cytotoxicity |
| C2 | 355-446 | NP | denotes | very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos |
| C3 | 584-604 | NP | denotes | natural cytotoxicity |
| C4 | 738-779 | NP | denotes | an impairment of NKL natural cytotoxicity |
| C5 | 781-786 | NP | denotes | which |
| C6 | 879-884 | NP | denotes | their |
| C7 | 987-1012 | NP | denotes | AP-1 transcription factor |
| C8 | 1194-1198 | NP | denotes | AP-1 |
| R1 | C3 | C1 | coref-ident | natural cytotoxicity,natural cytotoxicity |
| R2 | C5 | C4 | coref-relat | which,an impairment of NKL natural cytotoxicity |
| R3 | C6 | C2 | coref-pron | their,"very early activator protein (AP)-1 transcription factor genes such as JunB, FosB and c-Fos" |
| R4 | C8 | C7 | coref-ident | AP-1,AP-1 transcription factor |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 14-43 | other_name | denotes | natural cytotoxicity programs |
| T2 | 54-58 | protein_molecule | denotes | AP-1 |
| T3 | 77-99 | cell_line | denotes | NKL human NK cell line |
| T4 | 101-121 | other_name | denotes | NK cell cytotoxicity |
| T5 | 159-176 | other_name | denotes | target cell lysis |
| T6 | 184-206 | other_name | denotes | transcription analysis |
| T7 | 216-242 | other_name | denotes | multiplex messenger assays |
| T8 | 262-282 | other_name | denotes | natural cytotoxicity |
| T9 | 298-317 | cell_line | denotes | human NKL cell line |
| T10 | 334-351 | other_name | denotes | mRNA accumulation |
| T11 | 355-390 | protein_molecule | denotes | very early activator protein (AP)-1 |
| T12 | 391-417 | DNA_family_or_group | denotes | transcription factor genes |
| T13 | 426-430 | DNA_domain_or_region | denotes | JunB |
| T14 | 432-436 | DNA_domain_or_region | denotes | FosB |
| T15 | 441-446 | DNA_domain_or_region | denotes | c-Fos |
| T16 | 461-483 | other_name | denotes | DNA-binding activities |
| T17 | 487-507 | protein_complex | denotes | Jun-Fos heterodimers |
| T18 | 525-562 | other_name | denotes | electrophoretic mobility shift assays |
| T19 | 584-604 | other_name | denotes | natural cytotoxicity |
| T20 | 626-687 | protein_complex | denotes | immunoglobulin-like transcript-2/leukocyte Ig-like receptor 1 |
| T21 | 691-700 | cell_type | denotes | NKL cells |
| T22 | 705-712 | protein_molecule | denotes | HLA-B27 |
| T23 | 716-728 | cell_type | denotes | target cells |
| T24 | 759-779 | other_name | denotes | natural cytotoxicity |
| T25 | 963-985 | other_name | denotes | NK cell-mediated lysis |
| T26 | 987-1012 | protein_molecule | denotes | AP-1 transcription factor |
| T27 | 1052-1078 | other_name | denotes | NK cell cytolytic programs |
| T28 | 1102-1130 | protein_family_or_group | denotes | NK cell inhibitory receptors |
| T29 | 1135-1156 | protein_family_or_group | denotes | MHC class I molecules |
| T30 | 1194-1198 | protein_molecule | denotes | AP-1 |
metamap-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 88-90 | C0022688 | denotes | K |
| T2 | 55-59 | C0085828 | denotes | P-1 |
| T3 | 1071-1079 | C0376691 | denotes | rograms |
| T4 | 36-44 | C0376691 | denotes | rograms |
| T5 | 760-767 | C0205296 | denotes | atural |
| T6 | 585-592 | C0205296 | denotes | atural |
| T7 | 263-270 | C0205296 | denotes | atural |
| T8 | 15-22 | C0205296 | denotes | atural |
| T9 | 768-780 | C0596402 | denotes | ytotoxicity, |
| T10 | 593-605 | C0596402 | denotes | ytotoxicity. |
| T11 | 271-283 | C0596402 | denotes | ytotoxicity |
| T12 | 23-35 | C0596402 | denotes | ytotoxicity |
| T13 | 1089-1099 | C0425152 | denotes | ngagement |
| T14 | 1-11 | C0425152 | denotes | ngagement |
| T15 | 60-70 | C0185117 | denotes | xpression |
| T16 | 840-853 | C0040649 | denotes | ranscription, |
| T17 | 185-198 | C0040649 | denotes | ranscription |
| T18 | 1136-1157 | C0019629 | denotes | HC class I molecules |
| T19 | 670-672 | C0021027 | denotes | g- |
| T20 | 128-132 | C0015663 | denotes | ast |
| T21 | 199-207 | C1524024 | denotes | nalysis, |
| T22 | 526-563 | C0949632 | denotes | lectrophoretic mobility shift assays |
| T23 | 335-338 | C0035696 | denotes | RNA |
| T24 | 1111-1120 | C3463820 | denotes | nhibitory |
| T25 | 660-669 | C0023516 | denotes | eukocyte |
| T26 | 1061-1070 | C1536403 | denotes | ytolytic |
| T27 | 981-986 | C1536403 | denotes | ysis, |
| T28 | 172-177 | C1536403 | denotes | ysis. |
| T29 | 993-1013 | C0040648 | denotes | ranscription factor |
| T30 | 886-889 | C0012854 | denotes | NA- |
| T31 | 834-839 | C0087140 | denotes | -Fos |
| T32 | 442-447 | C0087140 | denotes | -Fos. |
| T33 | 1017-1026 | C1879547 | denotes | ctivated |
| T34 | 1181-1191 | C1879547 | denotes | ctivation |
| T35 | 1175-1180 | C1279919 | denotes | arly |
| T36 | 361-366 | C1279919 | denotes | arly |
| T37 | 1170-1174 | C0442824 | denotes | ery |
| T38 | 356-360 | C0442824 | denotes | ery |
| T39 | 886-897 | C1148673 | denotes | NA-binding |
| T40 | 462-473 | C1148673 | denotes | NA-binding |
| T41 | 452-460 | C1883712 | denotes | ddition, |
| T42 | 575-581 | C0750729 | denotes | ourse |
| T43 | 102-122 | C2984255 | denotes | K cell cytotoxicity |
| T44 | 248-252 | C1547282 | denotes | how |
| T45 | 179-184 | C1524063 | denotes | sing |
| T46 | 952-960 | C0439831 | denotes | apidity |
| T47 | 696-701 | C0007634 | denotes | ells |
| T48 | 912-919 | C0947630 | denotes | tudies |
| T49 | 678-686 | C0597357 | denotes | eceptor |
| T50 | 237-243 | C0243073 | denotes | ssays, |
| T51 | 392-417 | C0812327 | denotes | ranscription factor genes |
| T52 | 147-156 | C0441712 | denotes | echanism |
| T53 | 514-522 | C1441672 | denotes | bserved |
| T54 | 474-484 | C0441655 | denotes | ctivities |
| T55 | 284-291 | C0015264 | denotes | xerted |
| T56 | 730-735 | C2348269 | denotes | eads |
| T57 | 742-752 | C0684336 | denotes | mpairment |
| T58 | 607-618 | C1704675 | denotes | nteraction |
| T59 | 227-236 | C0169911 | denotes | essenger |
| T60 | 972-980 | C0127400 | denotes | ediated |
| T61 | 160-171 | C0221284 | denotes | arget cell |
| T62 | 890-906 | C2266866 | denotes | inding activity. |
| T63 | 717-722 | C1521840 | denotes | arget |
| T64 | 137-146 | C0442799 | denotes | fficient |
| T65 | 898-906 | C1561536 | denotes | ctivity. |
| T66 | 488-491 | C3536909 | denotes | un- |