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PubMed:10187864 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-90 Sentence denotes Cloning, characterization, and chromosomal location of a novel human K+-Cl- cotransporter.
T2 91-281 Sentence denotes Differential display polymerase chain reaction has been used to isolate genes regulated in vascular endothelial cells by the angiogenic factor vascular endothelial cell growth factor (VEGF).
T3 282-501 Sentence denotes Analysis of one of the bands consistently up-regulated by VEGF led us to the identification of a cDNA from a human umbilical vein endothelial cell library that is 77% identical to the human K+-Cl- cotransporter1 (KCC1).
T4 502-577 Sentence denotes We have referred to the predicted protein as K+-Cl- cotransporter 3 (KCC3).
T5 578-827 Sentence denotes Hydrophobicity analysis of the KCC3 amino acid sequence showed an almost identical pattern to KCC1, suggesting 12 membrane-spanning segments, a large extracellular loop with potential N-glycosylation sites, and cytoplasmic N- and C-terminal regions.
T6 828-964 Sentence denotes The KCC3 mRNA was highly expressed in brain, heart, skeletal muscle, and kidney, showing a distinct pattern and size from KCC1 and KCC2.
T7 965-1160 Sentence denotes The KCC3 mRNA level in endothelial cells increased on treatment with VEGF and decreased with the proinflammatory cytokine tumor necrosis factor alpha, whereas KCC1 mRNA levels remained unchanged.
T8 1161-1316 Sentence denotes Stable overexpression of KCC3 cDNA in HEK293 cells produced a glycoprotein of approximately 150 kDa, which was reduced to 120 kDa by glycosidase digestion.
T9 1317-1515 Sentence denotes An increased initial uptake rate of 86Rb was seen in clones with high KCC3 expression, which was dependent on extracellular Cl- but not Na+ and was inhibitable by the loop diuretic agent furosemide.
T10 1516-1606 Sentence denotes The KCC3 genomic localization was shown to be 15q13 by fluorescence in situ hybridization.
T11 1607-1704 Sentence denotes Radiation hybrid analysis placed KCC3 within an area associated with juvenile myoclonic epilepsy.
T12 1705-1810 Sentence denotes These results suggest KCC3 is a new member of the KCC family that is under distinct regulation from KCC1.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 407-411 http://purl.obolibrary.org/obo/MAT_0000037 denotes vein
T2 866-871 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T3 873-878 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T4 880-895 http://purl.obolibrary.org/obo/MAT_0000302 denotes skeletal muscle
T5 889-895 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T6 901-907 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 69-89 protein denotes K+-Cl- cotransporter
T2 234-273 protein denotes vascular endothelial cell growth factor
T3 275-279 protein denotes VEGF
T4 340-344 protein denotes VEGF
T5 472-493 protein denotes K+-Cl- cotransporter1
T6 495-499 protein denotes KCC1
T7 547-569 protein denotes K+-Cl- cotransporter 3
T8 571-575 protein denotes KCC3
T9 609-613 protein denotes KCC3
T10 672-676 protein denotes KCC1
T11 832-836 protein denotes KCC3
T12 950-954 protein denotes KCC1
T13 959-963 protein denotes KCC2
T14 969-973 protein denotes KCC3
T15 1034-1038 protein denotes VEGF
T16 1078-1086 protein denotes cytokine
T17 1087-1114 protein denotes tumor necrosis factor alpha
T18 1124-1128 protein denotes KCC1
T19 1186-1190 protein denotes KCC3
T20 1294-1305 protein denotes glycosidase
T21 1387-1391 protein denotes KCC3
T22 1520-1524 protein denotes KCC3
T23 1640-1644 protein denotes KCC3
T24 1727-1731 protein denotes KCC3
T25 1755-1765 protein denotes KCC family
T26 1805-1809 protein denotes KCC1

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10187864-10#33#37#gene9990 1640-1644 gene9990 denotes KCC3
10187864-10#69#96#diseaseC0270853 1676-1703 diseaseC0270853 denotes juvenile myoclonic epilepsy
33#37#gene999069#96#diseaseC0270853 10187864-10#33#37#gene9990 10187864-10#69#96#diseaseC0270853 associated_with KCC3,juvenile myoclonic epilepsy

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1640-1644 gene:9990 denotes KCC3
T1 1676-1703 disease:C0270853 denotes juvenile myoclonic epilepsy
R1 T0 T1 associated_with KCC3,juvenile myoclonic epilepsy

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1087-1092 HP_0002664 denotes tumor
T2 1685-1694 HP_0001336 denotes myoclonic

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1087-1092 Phenotype denotes tumor HP:0002664
T2 1695-1703 Phenotype denotes epilepsy HP:0001250

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1087-1092 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 1676-1703 Disease denotes juvenile myoclonic epilepsy http://purl.obolibrary.org/obo/MONDO_0009696

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 63-68 OrganismTaxon denotes human 9606
T2 391-396 OrganismTaxon denotes human 9606
T3 466-471 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 182-208 Body_part denotes vascular endothelial cells http://purl.obolibrary.org/obo/CL_0002139
T2 234-259 Body_part denotes vascular endothelial cell http://purl.obolibrary.org/obo/CL_0002139
T3 397-411 Body_part denotes umbilical vein http://purl.obolibrary.org/obo/UBERON_0002066
T4 412-428 Body_part denotes endothelial cell http://purl.obolibrary.org/obo/CL_0000115
T5 692-700 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T8 710-718 Body_part denotes segments http://purl.obolibrary.org/obo/UBERON_0000914
T9 728-741 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T10 789-800 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T11 866-871 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T13 873-878 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T17 880-895 Body_part denotes skeletal muscle http://purl.obolibrary.org/obo/UBERON_0001134|http://purl.obolibrary.org/obo/UBERON_0014892|http://purl.obolibrary.org/obo/UBERON_0014895
T20 901-907 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T21 988-1005 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T22 1427-1440 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T23 1676-1684 Body_part denotes juvenile http://purl.obolibrary.org/obo/UBERON_0007021

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 407-411 Body_part denotes vein http://purl.obolibrary.org/obo/MAT_0000037
T2 866-871 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T3 873-878 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T4 880-895 Body_part denotes skeletal muscle http://purl.obolibrary.org/obo/MAT_0000302
T5 901-907 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 182-208 Cell denotes vascular endothelial cells http://purl.obolibrary.org/obo/CL:0002139
T2 234-259 Cell denotes vascular endothelial cell http://purl.obolibrary.org/obo/CL:0002139
T3 243-259 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115
T4 407-428 Cell denotes vein endothelial cell http://purl.obolibrary.org/obo/CL:0002543
T5 412-428 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115
T6 988-1005 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115