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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-71 Sentence denotes Interferon-beta mediates stromal cell rescue of T cells from apoptosis.
T2 72-168 Sentence denotes The resolution of immune responses is characterized by extensive apoptosis of activated T cells.
T3 169-304 Sentence denotes However, to generate and maintain immunological memory, some antigen-specific T cells must survive and revert to a resting G0/G1 state.
T4 305-441 Sentence denotes Cytokines that bind to the common gamma chain of the IL-2 receptor promote the survival of T cell blasts, but also induce proliferation.
T5 442-544 Sentence denotes In contrast, soluble factors secreted by stromal cells induce Tcell survival in a resting G0/G1 state.
T6 545-659 Sentence denotes We now report that interferon-beta is the principal mediator of stromal cell-mediated Tcell rescue from apoptosis.
T7 660-864 Sentence denotes Interferon-alpha and -beta promote the reversion of blast Tcells to a resting G0/G1 configuration with all the characteristic features of stromal cell rescue; such as high Bcl-XL expression and low Bcl-2.
T8 865-982 Sentence denotes Type I interferons and stromal cells stimulate apparently identical signaling pathways, leading to STAT-1 activation.
T9 983-1196 Sentence denotes We also show that this mechanism may play a fundamental role in the persistence of T cells at sites of chronic inflammation; suggesting that chronic inflammation is an aberrant consequence of immunological memory.
T1 0-71 Sentence denotes Interferon-beta mediates stromal cell rescue of T cells from apoptosis.
T2 72-168 Sentence denotes The resolution of immune responses is characterized by extensive apoptosis of activated T cells.
T3 169-304 Sentence denotes However, to generate and maintain immunological memory, some antigen-specific T cells must survive and revert to a resting G0/G1 state.
T4 305-441 Sentence denotes Cytokines that bind to the common gamma chain of the IL-2 receptor promote the survival of T cell blasts, but also induce proliferation.
T5 442-544 Sentence denotes In contrast, soluble factors secreted by stromal cells induce Tcell survival in a resting G0/G1 state.
T6 545-659 Sentence denotes We now report that interferon-beta is the principal mediator of stromal cell-mediated Tcell rescue from apoptosis.
T7 660-864 Sentence denotes Interferon-alpha and -beta promote the reversion of blast Tcells to a resting G0/G1 configuration with all the characteristic features of stromal cell rescue; such as high Bcl-XL expression and low Bcl-2.
T8 865-982 Sentence denotes Type I interferons and stromal cells stimulate apparently identical signaling pathways, leading to STAT-1 activation.
T9 983-1196 Sentence denotes We also show that this mechanism may play a fundamental role in the persistence of T cells at sites of chronic inflammation; suggesting that chronic inflammation is an aberrant consequence of immunological memory.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-15 protein denotes Interferon-beta
T2 48-55 cell_type denotes T cells
T3 160-167 cell_type denotes T cells
T4 230-254 cell_type denotes antigen-specific T cells
T5 305-314 protein denotes Cytokines
T6 339-350 protein denotes gamma chain
T7 358-362 protein denotes IL-2
T8 396-409 cell_type denotes T cell blasts
T9 455-470 protein denotes soluble factors
T10 483-496 cell_type denotes stromal cells
T11 660-686 protein denotes Interferon-alpha and -beta
T12 712-724 cell_type denotes blast Tcells
T13 832-838 protein denotes Bcl-XL
T14 858-863 protein denotes Bcl-2
T15 865-883 protein denotes Type I interferons
T16 888-901 cell_type denotes stromal cells
T17 964-970 protein denotes STAT-1
T18 1066-1073 cell_type denotes T cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-71 Sentence denotes Interferon-beta mediates stromal cell rescue of T cells from apoptosis.
S2 72-168 Sentence denotes The resolution of immune responses is characterized by extensive apoptosis of activated T cells.
S3 169-304 Sentence denotes However, to generate and maintain immunological memory, some antigen-specific T cells must survive and revert to a resting G0/G1 state.
S4 305-441 Sentence denotes Cytokines that bind to the common gamma chain of the IL-2 receptor promote the survival of T cell blasts, but also induce proliferation.
S5 442-544 Sentence denotes In contrast, soluble factors secreted by stromal cells induce Tcell survival in a resting G0/G1 state.
S6 545-659 Sentence denotes We now report that interferon-beta is the principal mediator of stromal cell-mediated Tcell rescue from apoptosis.
S7 660-864 Sentence denotes Interferon-alpha and -beta promote the reversion of blast Tcells to a resting G0/G1 configuration with all the characteristic features of stromal cell rescue; such as high Bcl-XL expression and low Bcl-2.
S8 865-982 Sentence denotes Type I interferons and stromal cells stimulate apparently identical signaling pathways, leading to STAT-1 activation.
S9 983-1196 Sentence denotes We also show that this mechanism may play a fundamental role in the persistence of T cells at sites of chronic inflammation; suggesting that chronic inflammation is an aberrant consequence of immunological memory.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-15 NP denotes Interferon-beta
C2 61-70 NP denotes apoptosis
C3 203-223 NP denotes immunological memory
C4 282-303 NP denotes a resting G0/G1 state
C5 305-314 NP denotes Cytokines
C6 315-319 NP denotes that
C7 483-496 NP denotes stromal cells
C8 522-543 NP denotes a resting G0/G1 state
C9 564-579 NP denotes interferon-beta
C10 649-658 NP denotes apoptosis
C11 888-901 NP denotes stromal cells
C12 1086-1107 NP denotes chronic inflammation;
C13 1124-1144 NP denotes chronic inflammation
C14 1175-1195 NP denotes immunological memory
R1 C6 C5 coref-relat that,Cytokines
R2 C8 C4 coref-ident a resting G0/G1 state,a resting G0/G1 state
R3 C9 C1 coref-ident interferon-beta,Interferon-beta
R4 C10 C2 coref-ident apoptosis,apoptosis
R5 C11 C7 coref-ident stromal cells,stromal cells
R6 C13 C12 coref-ident chronic inflammation,chronic inflammation;
R7 C14 C3 coref-ident immunological memory,immunological memory

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-15 protein_molecule denotes Interferon-beta
T2 25-44 other_name denotes stromal cell rescue
T3 48-55 cell_type denotes T cells
T4 61-70 other_name denotes apoptosis
T5 90-106 other_name denotes immune responses
T6 137-146 other_name denotes apoptosis
T7 160-167 cell_type denotes T cells
T8 203-223 other_name denotes immunological memory
T9 230-254 cell_type denotes antigen-specific T cells
T10 284-303 other_name denotes resting G0/G1 state
T11 305-314 protein_family_or_group denotes Cytokines
T12 339-350 protein_subunit denotes gamma chain
T13 358-362 protein_molecule denotes IL-2
T14 396-409 cell_type denotes T cell blasts
T15 455-470 protein_family_or_group denotes soluble factors
T16 483-496 cell_type denotes stromal cells
T17 504-518 other_name denotes Tcell survival
T18 524-543 other_name denotes resting G0/G1 state
T19 609-643 other_name denotes stromal cell-mediated Tcell rescue
T20 649-658 other_name denotes apoptosis
T21 712-724 cell_type denotes blast Tcells
T22 730-757 other_name denotes resting G0/G1 configuration
T23 798-817 other_name denotes stromal cell rescue
T24 832-838 protein_molecule denotes Bcl-XL
T25 858-863 protein_molecule denotes Bcl-2
T26 865-883 protein_family_or_group denotes Type I interferons
T27 888-901 cell_type denotes stromal cells
T28 964-970 protein_molecule denotes STAT-1
T29 1066-1073 cell_type denotes T cells
T30 1086-1106 other_name denotes chronic inflammation
T31 1175-1195 other_name denotes immunological memory