PubMed:10090947
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 27-36 | protein | denotes | NF-kappaB |
| T2 | 40-75 | cell_type | denotes | primary adult T-cell leukemia cells |
| T3 | 179-192 | protein | denotes | viral protein |
| T4 | 193-196 | protein | denotes | Tax |
| T5 | 253-273 | protein | denotes | transcription factor |
| T6 | 274-283 | protein | denotes | NF-kappaB |
| T7 | 351-358 | cell_type | denotes | T cells |
| T8 | 383-395 | DNA | denotes | HTLV-I genes |
| T9 | 406-409 | protein | denotes | Tax |
| T10 | 445-467 | cell_type | denotes | primary leukemic cells |
| T11 | 528-537 | protein | denotes | NF-kappaB |
| T12 | 552-583 | cell_type | denotes | freshly isolated leukemic cells |
| T13 | 617-631 | cell_type | denotes | leukemic cells |
| T14 | 656-684 | cell_line | denotes | HTLV-I-infected T-cell lines |
| T15 | 707-716 | protein | denotes | NF-kappaB |
| T16 | 767-779 | protein | denotes | IkappaBalpha |
| T17 | 797-806 | protein | denotes | NF-kappaB |
| T18 | 821-830 | protein | denotes | NF-kappaB |
| T19 | 851-878 | cell_line | denotes | Tax-expressing T-cell lines |
| T20 | 899-908 | protein | denotes | p50/c-Rel |
| T21 | 938-970 | protein | denotes | p50/p50 and p50/p65 heterodimers |
| T22 | 976-987 | cell_line | denotes | T-cell line |
| T23 | 1005-1019 | cell_type | denotes | leukemic cells |
| T24 | 1052-1061 | protein | denotes | NF-kappaB |
| T25 | 1107-1119 | protein | denotes | IkappaBalpha |
| T26 | 1152-1155 | protein | denotes | Tax |
| T27 | 1187-1196 | protein | denotes | NF-kappaB |
| T28 | 1219-1226 | protein | denotes | p50/p50 |
| T29 | 1231-1238 | protein | denotes | p50/p65 |
| T30 | 1258-1280 | cell_type | denotes | primary leukemic cells |
| T31 | 1321-1330 | protein | denotes | NF-kappaB |
| T32 | 1348-1351 | protein | denotes | Tax |
| T33 | 1377-1391 | cell_type | denotes | leukemic cells |
| T34 | 1438-1447 | protein | denotes | NF-kappaB |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-76 | Sentence | denotes | Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells. |
| S2 | 77-174 | Sentence | denotes | Human T-cell leukemia virus type I (HTLV-I) is an etiologic agent of adult T-cell leukemia (ATL). |
| S3 | 175-369 | Sentence | denotes | The viral protein Tax induces the activation and nuclear translocalization of transcription factor NF-kappaB, which is proposed to play a crucial role in the transformation of T cells by HTLV-I. |
| S4 | 370-486 | Sentence | denotes | However, the HTLV-I genes including Tax are not expressed significantly in primary leukemic cells from ATL patients. |
| S5 | 487-602 | Sentence | denotes | In this study, we examined the basis for NF-kappaB activation in freshly isolated leukemic cells from ATL patients. |
| S6 | 603-808 | Sentence | denotes | We found that leukemic cells from ATL patients, like HTLV-I-infected T-cell lines, display constitutive NF-kappaB DNA binding activity and increased degradation of IkappaBalpha (an inhibitor of NF-kappaB). |
| S7 | 809-971 | Sentence | denotes | Whereas the NF-kappaB binding activity in Tax-expressing T-cell lines consisted mostly of p50/c-Rel, fresh ATL samples contained p50/p50 and p50/p65 heterodimers. |
| S8 | 972-1167 | Sentence | denotes | One T-cell line derived from ATL leukemic cells, TL-Om1, displayed constitutive NF-kappaB activity, as well as enhanced degradation of IkappaBalpha, despite the lack of detectable Tax expression. |
| S9 | 1168-1281 | Sentence | denotes | Interestingly, the NF-kappaB in TL-Om1 consists of p50/p50 and p50/p65 like that in fresh primary leukemic cells. |
| S10 | 1282-1467 | Sentence | denotes | Our results suggest that activation of NF-kappaB occurs through a Tax-independent mechanism in leukemic cells of ATL patients, possibly due to differential NF-kappaB subunit activation. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 27-36 | NP | denotes | NF-kappaB |
| C2 | 77-120 | NP | denotes | Human T-cell leukemia virus type I (HTLV-I) |
| C3 | 175-196 | NP | denotes | The viral protein Tax |
| C5 | 253-283 | NP | denotes | transcription factor NF-kappaB |
| C6 | 285-290 | NP | denotes | which |
| C7 | 362-368 | NP | denotes | HTLV-I |
| C4 | 253-368 | NP | denotes | transcription factor NF-kappaB, which is proposed to play a crucial role in the transformation of T cells by HTLV-I |
| C8 | 406-409 | NP | denotes | Tax |
| C9 | 473-485 | NP | denotes | ATL patients |
| C10 | 589-601 | NP | denotes | ATL patients |
| C11 | 637-649 | NP | denotes | ATL patients |
| C13 | 767-807 | NP | denotes | IkappaBalpha (an inhibitor of NF-kappaB) |
| C12 | 752-807 | NP | denotes | degradation of IkappaBalpha (an inhibitor of NF-kappaB) |
| C14 | 938-970 | NP | denotes | p50/p50 and p50/p65 heterodimers |
| C15 | 1001-1019 | NP | denotes | ATL leukemic cells |
| C16 | 1021-1027 | NP | denotes | TL-Om1 |
| C18 | 1107-1119 | NP | denotes | IkappaBalpha |
| C17 | 1092-1119 | NP | denotes | degradation of IkappaBalpha |
| C19 | 1183-1196 | NP | denotes | the NF-kappaB |
| C20 | 1200-1206 | NP | denotes | TL-Om1 |
| C21 | 1219-1238 | NP | denotes | p50/p50 and p50/p65 |
| C22 | 1244-1248 | NP | denotes | that |
| C23 | 1321-1330 | NP | denotes | NF-kappaB |
| C24 | 1395-1407 | NP | denotes | ATL patients |
| R1 | C6 | C5 | coref-relat | which,transcription factor NF-kappaB |
| R2 | C7 | C2 | coref-ident | HTLV-I,Human T-cell leukemia virus type I (HTLV-I) |
| R3 | C4 | C1 | coref-ident | "transcription factor NF-kappaB, which is proposed to play a crucial role in the transformation of T cells by HTLV-I",NF-kappaB |
| R4 | C8 | C3 | coref-ident | Tax,The viral protein Tax |
| R5 | C10 | C9 | coref-ident | ATL patients,ATL patients |
| R6 | C11 | C10 | coref-ident | ATL patients,ATL patients |
| R7 | C16 | C15 | coref-appos | TL-Om1,ATL leukemic cells |
| R8 | C18 | C13 | coref-ident | IkappaBalpha,IkappaBalpha (an inhibitor of NF-kappaB) |
| R9 | C17 | C12 | coref-ident | degradation of IkappaBalpha,degradation of IkappaBalpha (an inhibitor of NF-kappaB) |
| R10 | C20 | C15 | coref-ident | TL-Om1,ATL leukemic cells |
| R11 | C21 | C14 | coref-ident | p50/p50 and p50/p65,p50/p50 and p50/p65 heterodimers |
| R12 | C22 | C19 | coref-pron | that,the NF-kappaB |
| R13 | C23 | C4 | coref-ident | NF-kappaB,"transcription factor NF-kappaB, which is proposed to play a crucial role in the transformation of T cells by HTLV-I" |
| R14 | C24 | C11 | coref-ident | ATL patients,ATL patients |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 27-36 | protein_complex | denotes | NF-kappaB |
| T2 | 40-75 | cell_type | denotes | primary adult T-cell leukemia cells |
| T3 | 77-111 | virus | denotes | Human T-cell leukemia virus type I |
| T4 | 113-119 | virus | denotes | HTLV-I |
| T5 | 146-167 | other_name | denotes | adult T-cell leukemia |
| T6 | 169-172 | other_name | denotes | ATL |
| T7 | 179-192 | protein_family_or_group | denotes | viral protein |
| T8 | 193-196 | protein_molecule | denotes | Tax |
| T9 | 253-273 | protein_family_or_group | denotes | transcription factor |
| T10 | 274-283 | protein_complex | denotes | NF-kappaB |
| T11 | 351-358 | cell_type | denotes | T cells |
| T12 | 362-368 | virus | denotes | HTLV-I |
| T13 | 383-389 | virus | denotes | HTLV-I |
| T14 | 406-409 | protein_molecule | denotes | Tax |
| T15 | 445-467 | cell_type | denotes | primary leukemic cells |
| T16 | 473-476 | other_name | denotes | ATL |
| T17 | 477-485 | multi_cell | denotes | patients |
| T18 | 528-537 | protein_complex | denotes | NF-kappaB |
| T19 | 552-583 | cell_type | denotes | freshly isolated leukemic cells |
| T20 | 589-592 | other_name | denotes | ATL |
| T21 | 593-601 | multi_cell | denotes | patients |
| T22 | 617-631 | cell_type | denotes | leukemic cells |
| T23 | 637-640 | other_name | denotes | ATL |
| T24 | 641-649 | multi_cell | denotes | patients |
| T25 | 656-662 | virus | denotes | HTLV-I |
| T26 | 707-716 | protein_complex | denotes | NF-kappaB |
| T27 | 717-737 | other_name | denotes | DNA binding activity |
| T28 | 767-779 | protein_molecule | denotes | IkappaBalpha |
| T29 | 797-806 | protein_complex | denotes | NF-kappaB |
| T30 | 821-830 | protein_complex | denotes | NF-kappaB |
| T31 | 851-854 | protein_molecule | denotes | Tax |
| T32 | 899-908 | protein_complex | denotes | p50/c-Rel |
| T33 | 916-919 | other_name | denotes | ATL |
| T34 | 976-987 | cell_line | denotes | T-cell line |
| T35 | 1001-1004 | other_name | denotes | ATL |
| T36 | 1005-1019 | cell_type | denotes | leukemic cells |
| T37 | 1039-1051 | other_name | denotes | constitutive |
| T38 | 1052-1061 | protein_complex | denotes | NF-kappaB |
| T39 | 1107-1119 | protein_molecule | denotes | IkappaBalpha |
| T40 | 1152-1155 | protein_molecule | denotes | Tax |
| T41 | 1187-1196 | protein_complex | denotes | NF-kappaB |
| T42 | 1219-1226 | protein_complex | denotes | p50/p50 |
| T43 | 1231-1238 | protein_complex | denotes | p50/p65 |
| T44 | 1258-1265 | cell_type | denotes | primary |
| T45 | 1266-1280 | cell_type | denotes | leukemic cells |
| T46 | 1321-1330 | protein_complex | denotes | NF-kappaB |
| T47 | 1348-1351 | protein_molecule | denotes | Tax |
| T48 | 1377-1391 | cell_type | denotes | leukemic cells |
| T49 | 1395-1398 | other_name | denotes | ATL |
| T50 | 1399-1407 | multi_cell | denotes | patients |
| T51 | 1438-1447 | protein_complex | denotes | NF-kappaB |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 90-98 | HP_0001909 | denotes | leukemia |
| T2 | 159-167 | HP_0001909 | denotes | leukemia |