PubMed:10090942 JSON TXT

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jnlpba-st-training

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":71,"end":99},"obj":"cell_type"},{"id":"T2","span":{"begin":349,"end":374},"obj":"cell_line"},{"id":"T3","span":{"begin":541,"end":546},"obj":"protein"},{"id":"T4","span":{"begin":550,"end":570},"obj":"protein"},{"id":"T5","span":{"begin":584,"end":612},"obj":"cell_line"},{"id":"T6","span":{"begin":621,"end":637},"obj":"protein"},{"id":"T7","span":{"begin":639,"end":644},"obj":"protein"},{"id":"T8","span":{"begin":696,"end":702},"obj":"cell_type"},{"id":"T9","span":{"begin":906,"end":914},"obj":"cell_line"},{"id":"T10","span":{"begin":979,"end":984},"obj":"protein"},{"id":"T11","span":{"begin":1024,"end":1039},"obj":"cell_line"},{"id":"T12","span":{"begin":1050,"end":1055},"obj":"protein"},{"id":"T13","span":{"begin":1068,"end":1076},"obj":"cell_line"},{"id":"T14","span":{"begin":1095,"end":1099},"obj":"protein"},{"id":"T15","span":{"begin":1128,"end":1180},"obj":"cell_type"},{"id":"T16","span":{"begin":1276,"end":1280},"obj":"protein"},{"id":"T17","span":{"begin":1280,"end":1286},"obj":"protein"},{"id":"T18","span":{"begin":1313,"end":1321},"obj":"cell_line"},{"id":"T19","span":{"begin":1358,"end":1395},"obj":"protein"},{"id":"T20","span":{"begin":1397,"end":1401},"obj":"protein"},{"id":"T21","span":{"begin":1444,"end":1448},"obj":"protein"}],"text":"Human immunodeficiency virus-associated Hodgkin's disease derives from post-germinal center B cells.\nHuman immunodeficiency virus-associated Hodgkin's disease (HIV-HD) displays several peculiarities when compared with HD of the general population. These include overrepresentation of clinically aggressive histologic types and frequent infection of Reed-Sternberg (RS) cells by Epstein-Barr virus (EBV). Recently, we have reported that the histogenesis of HD of the general population may be assessed by monitoring the expression pattern of BCL-6, a transcription factor expressed in germinal center (GC) B cells, and of CD138/syndecan-1 (syn-1), a proteoglycan associated with post-GC, terminal B-cell differentiation. In this study, we have applied these two markers to the study of HIV-HD histogenesis and correlated their expression status to the virologic features of this disease. We have found that RS cells of all histologic categories of HIV-HD consistently display the BCL-6(-)/syn-1(+) phenotype and thus reflect post-GC B cells. Although BCL-6(-)/syn-1(+) RS cells of HIV-HD express CD40, they are not surrounded by CD40 ligand-positive (CD40L+) reactive T lymphocytes, which, in HD of the general population, are thought to regulate the disease phenotype through CD40/CD40L interactions. Conversely, RS cells of virtually all HIV-HD express the EBV-encoded latent membrane protein 1 (LMP1), which, being functionally homologous to CD40, may contribute, at least in part, to the modulation of the HIV-HD phenotype."}

pubmed-sentences-benchmark

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":100},"obj":"Sentence"},{"id":"S2","span":{"begin":101,"end":247},"obj":"Sentence"},{"id":"S3","span":{"begin":248,"end":403},"obj":"Sentence"},{"id":"S4","span":{"begin":404,"end":719},"obj":"Sentence"},{"id":"S5","span":{"begin":720,"end":886},"obj":"Sentence"},{"id":"S6","span":{"begin":887,"end":1040},"obj":"Sentence"},{"id":"S7","span":{"begin":1041,"end":1300},"obj":"Sentence"},{"id":"S8","span":{"begin":1301,"end":1526},"obj":"Sentence"}],"text":"Human immunodeficiency virus-associated Hodgkin's disease derives from post-germinal center B cells.\nHuman immunodeficiency virus-associated Hodgkin's disease (HIV-HD) displays several peculiarities when compared with HD of the general population. These include overrepresentation of clinically aggressive histologic types and frequent infection of Reed-Sternberg (RS) cells by Epstein-Barr virus (EBV). Recently, we have reported that the histogenesis of HD of the general population may be assessed by monitoring the expression pattern of BCL-6, a transcription factor expressed in germinal center (GC) B cells, and of CD138/syndecan-1 (syn-1), a proteoglycan associated with post-GC, terminal B-cell differentiation. In this study, we have applied these two markers to the study of HIV-HD histogenesis and correlated their expression status to the virologic features of this disease. We have found that RS cells of all histologic categories of HIV-HD consistently display the BCL-6(-)/syn-1(+) phenotype and thus reflect post-GC B cells. Although BCL-6(-)/syn-1(+) RS cells of HIV-HD express CD40, they are not surrounded by CD40 ligand-positive (CD40L+) reactive T lymphocytes, which, in HD of the general population, are thought to regulate the disease phenotype through CD40/CD40L interactions. Conversely, RS cells of virtually all HIV-HD express the EBV-encoded latent membrane protein 1 (LMP1), which, being functionally homologous to CD40, may contribute, at least in part, to the modulation of the HIV-HD phenotype."}

genia-medco-coref

GENIAcorpus

PubmedHPO

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":107,"end":123},"obj":"HP_0002721"},{"id":"T2","span":{"begin":141,"end":158},"obj":"HP_0012189"},{"id":"T3","span":{"begin":295,"end":305},"obj":"HP_0000718"},{"id":"T4","span":{"begin":327,"end":345},"obj":"HP_0002719"}],"text":"Human immunodeficiency virus-associated Hodgkin's disease derives from post-germinal center B cells.\nHuman immunodeficiency virus-associated Hodgkin's disease (HIV-HD) displays several peculiarities when compared with HD of the general population. These include overrepresentation of clinically aggressive histologic types and frequent infection of Reed-Sternberg (RS) cells by Epstein-Barr virus (EBV). Recently, we have reported that the histogenesis of HD of the general population may be assessed by monitoring the expression pattern of BCL-6, a transcription factor expressed in germinal center (GC) B cells, and of CD138/syndecan-1 (syn-1), a proteoglycan associated with post-GC, terminal B-cell differentiation. In this study, we have applied these two markers to the study of HIV-HD histogenesis and correlated their expression status to the virologic features of this disease. We have found that RS cells of all histologic categories of HIV-HD consistently display the BCL-6(-)/syn-1(+) phenotype and thus reflect post-GC B cells. Although BCL-6(-)/syn-1(+) RS cells of HIV-HD express CD40, they are not surrounded by CD40 ligand-positive (CD40L+) reactive T lymphocytes, which, in HD of the general population, are thought to regulate the disease phenotype through CD40/CD40L interactions. Conversely, RS cells of virtually all HIV-HD express the EBV-encoded latent membrane protein 1 (LMP1), which, being functionally homologous to CD40, may contribute, at least in part, to the modulation of the HIV-HD phenotype."}