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PubMed:10090942 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 71-99 cell_type denotes post-germinal center B cells
T2 349-374 cell_line denotes Reed-Sternberg (RS) cells
T3 541-546 protein denotes BCL-6
T4 550-570 protein denotes transcription factor
T5 584-612 cell_line denotes germinal center (GC) B cells
T6 621-637 protein denotes CD138/syndecan-1
T7 639-644 protein denotes syn-1
T8 696-702 cell_type denotes B-cell
T9 906-914 cell_line denotes RS cells
T10 979-984 protein denotes BCL-6
T11 1024-1039 cell_line denotes post-GC B cells
T12 1050-1055 protein denotes BCL-6
T13 1068-1076 cell_line denotes RS cells
T14 1095-1099 protein denotes CD40
T15 1128-1180 cell_type denotes CD40 ligand-positive (CD40L+) reactive T lymphocytes
T16 1276-1280 protein denotes CD40
T17 1280-1286 protein denotes /CD40L
T18 1313-1321 cell_line denotes RS cells
T19 1358-1395 protein denotes EBV-encoded latent membrane protein 1
T20 1397-1401 protein denotes LMP1
T21 1444-1448 protein denotes CD40

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-100 Sentence denotes Human immunodeficiency virus-associated Hodgkin's disease derives from post-germinal center B cells.
S2 101-247 Sentence denotes Human immunodeficiency virus-associated Hodgkin's disease (HIV-HD) displays several peculiarities when compared with HD of the general population.
S3 248-403 Sentence denotes These include overrepresentation of clinically aggressive histologic types and frequent infection of Reed-Sternberg (RS) cells by Epstein-Barr virus (EBV).
S4 404-719 Sentence denotes Recently, we have reported that the histogenesis of HD of the general population may be assessed by monitoring the expression pattern of BCL-6, a transcription factor expressed in germinal center (GC) B cells, and of CD138/syndecan-1 (syn-1), a proteoglycan associated with post-GC, terminal B-cell differentiation.
S5 720-886 Sentence denotes In this study, we have applied these two markers to the study of HIV-HD histogenesis and correlated their expression status to the virologic features of this disease.
S6 887-1040 Sentence denotes We have found that RS cells of all histologic categories of HIV-HD consistently display the BCL-6(-)/syn-1(+) phenotype and thus reflect post-GC B cells.
S7 1041-1300 Sentence denotes Although BCL-6(-)/syn-1(+) RS cells of HIV-HD express CD40, they are not surrounded by CD40 ligand-positive (CD40L+) reactive T lymphocytes, which, in HD of the general population, are thought to regulate the disease phenotype through CD40/CD40L interactions.
S8 1301-1526 Sentence denotes Conversely, RS cells of virtually all HIV-HD express the EBV-encoded latent membrane protein 1 (LMP1), which, being functionally homologous to CD40, may contribute, at least in part, to the modulation of the HIV-HD phenotype.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-57 NP denotes Human immunodeficiency virus-associated Hodgkin's disease
C2 71-99 NP denotes post-germinal center B cells
C3 101-167 NP denotes Human immunodeficiency virus-associated Hodgkin's disease (HIV-HD)
C4 177-198 NP denotes several peculiarities
C5 218-246 NP denotes HD of the general population
C6 248-253 NP denotes These
C7 456-484 NP denotes HD of the general population
C8 541-546 NP denotes BCL-6
C9 548-612 NP denotes a transcription factor expressed in germinal center (GC) B cells
C10 621-645 NP denotes CD138/syndecan-1 (syn-1)
C11 647-718 NP denotes a proteoglycan associated with post-GC, terminal B-cell differentiation
C12 751-768 NP denotes these two markers
C13 820-825 NP denotes their
C14 873-885 NP denotes this disease
C15 947-953 NP denotes HIV-HD
C16 1024-1039 NP denotes post-GC B cells
C18 1080-1086 NP denotes HIV-HD
C17 1050-1086 NP denotes BCL-6(-)/syn-1(+) RS cells of HIV-HD
C19 1095-1099 NP denotes CD40
C20 1101-1105 NP denotes they
C21 1128-1180 NP denotes CD40 ligand-positive (CD40L+) reactive T lymphocytes
C22 1182-1187 NP denotes which
C23 1192-1220 NP denotes HD of the general population
C24 1246-1267 NP denotes the disease phenotype
C25 1354-1402 NP denotes the EBV-encoded latent membrane protein 1 (LMP1)
C26 1404-1409 NP denotes which
C27 1444-1448 NP denotes CD40
C28 1505-1525 NP denotes the HIV-HD phenotype
R1 C3 C1 coref-ident Human immunodeficiency virus-associated Hodgkin's disease (HIV-HD),Human immunodeficiency virus-associated Hodgkin's disease
R2 C6 C4 coref-pron These,several peculiarities
R3 C7 C5 coref-ident HD of the general population,HD of the general population
R4 C9 C8 coref-appos a transcription factor expressed in germinal center (GC) B cells,BCL-6
R5 C11 C10 coref-appos "a proteoglycan associated with post-GC, terminal B-cell differentiation",CD138/syndecan-1 (syn-1)
R6 C13 C12 coref-pron their,these two markers
R7 C14 C3 coref-ident this disease,Human immunodeficiency virus-associated Hodgkin's disease (HIV-HD)
R8 C15 C14 coref-ident HIV-HD,this disease
R9 C16 C2 coref-ident post-GC B cells,post-germinal center B cells
R10 C18 C15 coref-ident HIV-HD,HIV-HD
R11 C20 C17 coref-pron they,BCL-6(-)/syn-1(+) RS cells of HIV-HD
R12 C22 C21 coref-relat which,CD40 ligand-positive (CD40L+) reactive T lymphocytes
R13 C23 C7 coref-ident HD of the general population,HD of the general population
R14 C26 C25 coref-relat which,the EBV-encoded latent membrane protein 1 (LMP1)
R15 C27 C19 coref-ident CD40,CD40
R16 C28 C24 coref-ident the HIV-HD phenotype,the disease phenotype

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-28 virus denotes Human immunodeficiency virus
T2 71-99 cell_type denotes post-germinal center B cells
T3 101-129 virus denotes Human immunodeficiency virus
T4 160-166 other_name denotes HIV-HD
T5 218-220 other_name denotes HD
T6 349-374 cell_line denotes Reed-Sternberg (RS) cells
T7 378-396 virus denotes Epstein-Barr virus
T8 398-401 virus denotes EBV
T9 440-452 other_name denotes histogenesis
T10 456-458 other_name denotes HD
T11 541-546 protein_molecule denotes BCL-6
T12 550-570 protein_family_or_group denotes transcription factor
T13 584-612 cell_line denotes germinal center (GC) B cells
T14 621-637 protein_molecule denotes CD138/syndecan-1
T15 639-644 protein_molecule denotes syn-1
T16 687-695 other_name denotes terminal
T17 696-702 cell_type denotes B-cell
T18 785-789 other_name denotes HIV-
T19 789-791 other_name denotes HD
T20 851-869 other_name denotes virologic features
T21 906-914 cell_line denotes RS cells
T22 947-951 other_name denotes HIV-
T23 951-953 other_name denotes HD
T24 979-984 protein_molecule denotes BCL-6
T25 1024-1039 cell_line denotes post-GC B cells
T26 1050-1055 protein_molecule denotes BCL-6
T27 1068-1076 cell_line denotes RS cells
T28 1080-1086 other_name denotes HIV-HD
T29 1095-1099 protein_molecule denotes CD40
T30 1128-1132 protein_molecule denotes CD40
T31 1150-1155 protein_molecule denotes CD40L
T32 1192-1194 other_name denotes HD
T33 1276-1280 protein_molecule denotes CD40
T34 1280-1286 protein_molecule denotes /CD40L
T35 1313-1321 cell_line denotes RS cells
T36 1339-1343 other_name denotes HIV-
T37 1343-1345 other_name denotes HD
T38 1358-1361 virus denotes EBV
T39 1397-1401 protein_molecule denotes LMP1
T40 1444-1448 protein_molecule denotes CD40
T41 1509-1513 other_name denotes HIV-
T42 1513-1515 other_name denotes HD

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 107-123 HP_0002721 denotes immunodeficiency
T2 141-158 HP_0012189 denotes Hodgkin's disease
T3 295-305 HP_0000718 denotes aggressive
T4 327-345 HP_0002719 denotes frequent infection