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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 15-32 protein denotes adenylate cyclase
T2 37-51 protein denotes p70(S6)-kinase
T3 66-71 protein denotes IL-10
T4 89-104 cell_type denotes human monocytes
T5 108-129 protein denotes gp41 envelope protein
T6 201-217 protein denotes recombinant gp41
T7 219-228 protein denotes aa565-647
T8 235-255 protein denotes extracellular domain
T9 259-291 protein denotes HIV-1 transmembrane glycoprotein
T10 304-318 protein denotes interleukin-10
T11 320-325 protein denotes IL-10
T12 341-356 cell_type denotes human monocytes
T13 454-458 protein denotes gp41
T14 467-472 protein denotes IL-10
T15 562-571 protein denotes NF-kappaB
T16 582-586 protein denotes gp41
T17 616-625 cell_type denotes monocytes
T18 680-697 protein denotes adenylate cyclase
T19 728-732 protein denotes gp41
T20 741-746 protein denotes IL-10
T21 761-770 cell_type denotes monocytes
T22 785-789 protein denotes gp41
T23 810-819 protein denotes NF-kappaB
T24 854-863 protein denotes NF-kappaB
T25 877-904 DNA denotes main NF-kappaB-binding site
T26 914-928 DNA denotes IL-10 promoter
T27 947-951 protein denotes gp41
T28 1048-1062 protein denotes p70(S6)-kinase
T29 1080-1090 protein denotes Gi protein
T30 1092-1107 protein denotes pertussis toxin
T31 1133-1138 protein denotes IL-10
T32 1153-1157 protein denotes gp41
T33 1161-1170 cell_type denotes monocytes
T34 1196-1225 protein denotes phosphatidylinositol 3-kinase
T35 1227-1238 protein denotes PI 3-kinase
T36 1291-1295 protein denotes MAPK
T37 1336-1340 protein denotes gp41
T38 1349-1354 protein denotes IL-10
T39 1372-1381 cell_type denotes monocytes
T40 1398-1407 protein denotes NF-kappaB
T41 1409-1413 protein denotes MAPK
T42 1418-1429 protein denotes PI 3-kinase
T43 1487-1504 protein denotes adenylate cyclase
T44 1509-1548 protein denotes pertussis-toxin-sensitive Gi/Go protein
T45 1559-1573 protein denotes p70(S6)-kinase

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 15-32 NP denotes adenylate cyclase
C2 37-62 NP denotes p70(S6)-kinase activation
C3 89-104 NP denotes human monocytes
C4 108-168 NP denotes gp41 envelope protein of human immunodeficiency virus type 1
C5 201-229 NP denotes recombinant gp41 (aa565-647)
C6 231-291 NP denotes the extracellular domain of HIV-1 transmembrane glycoprotein
C7 341-356 NP denotes human monocytes
C8 582-586 NP denotes gp41
C9 616-625 NP denotes monocytes
C10 761-770 NP denotes monocytes
C11 785-789 NP denotes gp41
C12 947-951 NP denotes gp41
C13 1153-1157 NP denotes gp41
C14 1161-1170 NP denotes monocytes
C15 1372-1381 NP denotes monocytes
C16 1487-1504 NP denotes adenylate cyclase
C17 1559-1584 NP denotes p70(S6)-kinase activation
R1 C6 C5 coref-appos the extracellular domain of HIV-1 transmembrane glycoprotein,recombinant gp41 (aa565-647)
R2 C7 C3 coref-ident human monocytes,human monocytes
R3 C8 C4 coref-ident gp41,gp41 envelope protein of human immunodeficiency virus type 1
R4 C9 C7 coref-ident monocytes,human monocytes
R5 C10 C9 coref-ident monocytes,monocytes
R6 C11 C8 coref-ident gp41,gp41
R7 C12 C11 coref-ident gp41,gp41
R8 C13 C12 coref-ident gp41,gp41
R9 C14 C10 coref-ident monocytes,monocytes
R10 C15 C14 coref-ident monocytes,monocytes
R11 C16 C1 coref-ident adenylate cyclase,adenylate cyclase
R12 C17 C2 coref-ident p70(S6)-kinase activation,p70(S6)-kinase activation

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-169 Sentence denotes Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.
S2 170-357 Sentence denotes Our previous results show that recombinant gp41 (aa565-647), the extracellular domain of HIV-1 transmembrane glycoprotein, stimulates interleukin-10 (IL-10) production in human monocytes.
S3 358-418 Sentence denotes The signal cascade transducing this effect is not yet clear.
S4 419-581 Sentence denotes In this study, we examined whether gp41-induced IL-10 up-regulation is mediated by the previously described synergistic activation of cAMP and NF-kappaB pathways.
S5 582-771 Sentence denotes gp41 induced cAMP accumulation in monocytes in a time- and concentration-dependent manner and the adenylate cyclase inhibitor SQ 22536 suppressed gp41-induced IL-10 production in monocytes.
S6 772-952 Sentence denotes In contrast, gp41 failed to stimulate NF-kappaB binding activity in as much as no NF-kappaB bound to the main NF-kappaB-binding site 2 of the IL-10 promoter after addition of gp41.
S7 953-1024 Sentence denotes We also examined the involvement of other signal transduction pathways.
S8 1025-1324 Sentence denotes Specific inhibitors of p70(S6)-kinase (rapamycin), and Gi protein (pertussis toxin), prevented induction of IL-10 production by gp41 in monocytes, while inhibitors of the phosphatidylinositol 3-kinase (PI 3-kinase) (wortmannin) and mitogen-activated protein kinase (MAPK) pathway (PD 98059) did not.
S9 1325-1585 Sentence denotes Thus HIV-1 gp41-induced IL-10 up-regulation in monocytes may not involve NF-kappaB, MAPK, or PI 3-kinase activation, but rather may operate through activation of adenylate cyclase and pertussis-toxin-sensitive Gi/Go protein to effect p70(S6)-kinase activation.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 15-32 protein_complex denotes adenylate cyclase
T2 37-51 protein_molecule denotes p70(S6)-kinase
T3 66-71 protein_molecule denotes IL-10
T4 89-104 cell_type denotes human monocytes
T5 108-129 protein_molecule denotes gp41 envelope protein
T6 133-168 virus denotes human immunodeficiency virus type 1
T7 201-217 protein_molecule denotes recombinant gp41
T8 219-228 protein_molecule denotes aa565-647
T9 235-255 protein_domain_or_region denotes extracellular domain
T10 259-291 protein_family_or_group denotes HIV-1 transmembrane glycoprotein
T11 304-318 protein_molecule denotes interleukin-10
T12 320-325 protein_molecule denotes IL-10
T13 341-356 cell_type denotes human monocytes
T14 454-458 protein_molecule denotes gp41
T15 467-472 protein_molecule denotes IL-10
T16 553-557 nucleotide denotes cAMP
T17 562-571 protein_complex denotes NF-kappaB
T18 582-586 protein_molecule denotes gp41
T19 595-599 nucleotide denotes cAMP
T20 616-625 cell_type denotes monocytes
T21 680-697 protein_complex denotes adenylate cyclase
T22 708-716 other_organic_compound denotes SQ 22536
T23 728-732 protein_molecule denotes gp41
T24 741-746 protein_molecule denotes IL-10
T25 761-770 cell_type denotes monocytes
T26 785-789 protein_molecule denotes gp41
T27 810-819 protein_complex denotes NF-kappaB
T28 854-863 protein_complex denotes NF-kappaB
T29 877-881 DNA_domain_or_region denotes main
T30 882-891 protein_complex denotes NF-kappaB
T31 914-919 protein_molecule denotes IL-10
T32 947-951 protein_molecule denotes gp41
T33 995-1023 other_name denotes signal transduction pathways
T34 1048-1062 protein_molecule denotes p70(S6)-kinase
T35 1064-1073 other_organic_compound denotes rapamycin
T36 1080-1090 protein_molecule denotes Gi protein
T37 1092-1107 protein_molecule denotes pertussis toxin
T38 1133-1138 protein_molecule denotes IL-10
T39 1153-1157 protein_molecule denotes gp41
T40 1161-1170 cell_type denotes monocytes
T41 1196-1225 protein_molecule denotes phosphatidylinositol 3-kinase
T42 1227-1238 protein_molecule denotes PI 3-kinase
T43 1241-1251 other_organic_compound denotes wortmannin
T44 1257-1291 other_name denotes mitogen-activated protein kinase (
T45 1291-1295 protein_family_or_group denotes MAPK
T46 1306-1314 other_organic_compound denotes PD 98059
T47 1330-1335 virus denotes HIV-1
T48 1336-1340 protein_molecule denotes gp41
T49 1349-1354 protein_molecule denotes IL-10
T50 1372-1381 cell_type denotes monocytes
T51 1398-1407 protein_complex denotes NF-kappaB
T52 1409-1413 protein_family_or_group denotes MAPK
T53 1418-1429 protein_molecule denotes PI 3-kinase
T54 1487-1504 protein_complex denotes adenylate cyclase
T55 1509-1548 protein_molecule denotes pertussis-toxin-sensitive Gi/Go protein
T56 1559-1573 protein_molecule denotes p70(S6)-kinase