PubMed:10089212 JSON TXT

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GlyCosmos6-UBERON

{"project":"GlyCosmos6-UBERON","denotations":[{"id":"T1","span":{"begin":119,"end":128},"obj":"Body_part"},{"id":"T2","span":{"begin":276,"end":285},"obj":"Body_part"},{"id":"T3","span":{"begin":351,"end":357},"obj":"Body_part"},{"id":"T4","span":{"begin":439,"end":443},"obj":"Body_part"},{"id":"T5","span":{"begin":851,"end":855},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0004529"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0004529"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

NCBITAXON

sentences

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":55},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":56,"end":170},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":171,"end":449},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":450,"end":618},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":619,"end":743},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":744,"end":862},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":863,"end":1024},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":1025,"end":1192},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":55},"obj":"Sentence"},{"id":"T2","span":{"begin":56,"end":170},"obj":"Sentence"},{"id":"T3","span":{"begin":171,"end":449},"obj":"Sentence"},{"id":"T4","span":{"begin":450,"end":618},"obj":"Sentence"},{"id":"T5","span":{"begin":619,"end":743},"obj":"Sentence"},{"id":"T6","span":{"begin":744,"end":862},"obj":"Sentence"},{"id":"T7","span":{"begin":863,"end":1024},"obj":"Sentence"},{"id":"T8","span":{"begin":1025,"end":1192},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":55},"obj":"Sentence"},{"id":"T2","span":{"begin":56,"end":170},"obj":"Sentence"},{"id":"T3","span":{"begin":171,"end":449},"obj":"Sentence"},{"id":"T4","span":{"begin":450,"end":618},"obj":"Sentence"},{"id":"T5","span":{"begin":619,"end":743},"obj":"Sentence"},{"id":"T6","span":{"begin":744,"end":862},"obj":"Sentence"},{"id":"T7","span":{"begin":863,"end":1024},"obj":"Sentence"},{"id":"T8","span":{"begin":1025,"end":1192},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

GlyCosmos6-CLO

{"project":"GlyCosmos6-CLO","denotations":[{"id":"T1","span":{"begin":351,"end":357},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T2","span":{"begin":353,"end":357},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3","span":{"begin":432,"end":443},"obj":"http://purl.obolibrary.org/obo/CLO_0007824"},{"id":"T4","span":{"begin":439,"end":443},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T5","span":{"begin":478,"end":483},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T6","span":{"begin":845,"end":861},"obj":"http://www.ebi.ac.uk/cellline#human_cell_line"},{"id":"T7","span":{"begin":845,"end":855},"obj":"http://purl.obolibrary.org/obo/CLO_0053065"},{"id":"T8","span":{"begin":851,"end":855},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T9","span":{"begin":1140,"end":1150},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

mondo_disease

{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":332,"end":341},"obj":"Disease"},{"id":"T2","span":{"begin":374,"end":390},"obj":"Disease"},{"id":"T3","span":{"begin":397,"end":412},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0021094"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005109"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

GlycoBiology-PACDB

{"project":"GlycoBiology-PACDB","denotations":[{"id":"_T1","span":{"begin":368,"end":401},"obj":"http://acgg.asia/db/diseases/pacdb/lec?ids=LEC512"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

ICD10

{"project":"ICD10","denotations":[{"id":"T1","span":{"begin":368,"end":401},"obj":"http://purl.bioontology.org/ontology/ICD10/B24"},{"id":"T2","span":{"begin":368,"end":401},"obj":"http://purl.bioontology.org/ontology/ICD10/Z71.7"},{"id":"T3","span":{"begin":368,"end":401},"obj":"http://purl.bioontology.org/ontology/ICD10/B20-B24.9"},{"id":"T4","span":{"begin":374,"end":390},"obj":"http://purl.bioontology.org/ontology/ICD10/D84.9"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

GlycoBiology-FMA

{"project":"GlycoBiology-FMA","denotations":[{"id":"_T1","span":{"begin":8,"end":15},"obj":"FMAID:67257"},{"id":"_T2","span":{"begin":8,"end":15},"obj":"FMAID:165447"},{"id":"_T3","span":{"begin":154,"end":169},"obj":"FMAID:82782"},{"id":"_T4","span":{"begin":154,"end":169},"obj":"FMAID:196776"},{"id":"_T5","span":{"begin":416,"end":431},"obj":"FMAID:83031"},{"id":"_T6","span":{"begin":416,"end":431},"obj":"FMAID:197293"},{"id":"_T7","span":{"begin":416,"end":431},"obj":"FMAID:197292"},{"id":"_T8","span":{"begin":416,"end":431},"obj":"FMAID:83032"},{"id":"_T9","span":{"begin":418,"end":431},"obj":"FMAID:83030"},{"id":"_T10","span":{"begin":418,"end":431},"obj":"FMAID:197290"},{"id":"_T11","span":{"begin":478,"end":483},"obj":"FMAID:68646"},{"id":"_T12","span":{"begin":478,"end":483},"obj":"FMAID:169002"},{"id":"_T13","span":{"begin":609,"end":613},"obj":"FMAID:198663"},{"id":"_T14","span":{"begin":777,"end":784},"obj":"FMAID:67257"},{"id":"_T15","span":{"begin":777,"end":784},"obj":"FMAID:165447"},{"id":"_T16","span":{"begin":902,"end":922},"obj":"FMAID:198077"},{"id":"_T17","span":{"begin":902,"end":922},"obj":"FMAID:84122"},{"id":"_T18","span":{"begin":941,"end":945},"obj":"FMAID:198663"},{"id":"_T19","span":{"begin":1016,"end":1023},"obj":"FMAID:67257"},{"id":"_T20","span":{"begin":1016,"end":1023},"obj":"FMAID:165447"},{"id":"_T21","span":{"begin":1052,"end":1080},"obj":"FMAID:198077"},{"id":"_T22","span":{"begin":1052,"end":1080},"obj":"FMAID:84122"}],"namespaces":[{"prefix":"FMAID","uri":"http://purl.org/sig/ont/fma/fma"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

uniprot-human

{"project":"uniprot-human","denotations":[{"id":"T1","span":{"begin":33,"end":43},"obj":"http://www.uniprot.org/uniprot/P17931"},{"id":"T2","span":{"begin":528,"end":538},"obj":"http://www.uniprot.org/uniprot/P17931"},{"id":"T3","span":{"begin":706,"end":716},"obj":"http://www.uniprot.org/uniprot/P17931"},{"id":"T4","span":{"begin":823,"end":833},"obj":"http://www.uniprot.org/uniprot/P17931"},{"id":"T5","span":{"begin":930,"end":940},"obj":"http://www.uniprot.org/uniprot/P17931"},{"id":"T6","span":{"begin":1096,"end":1106},"obj":"http://www.uniprot.org/uniprot/P17931"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

uniprot-mouse

{"project":"uniprot-mouse","denotations":[{"id":"T1","span":{"begin":4,"end":7},"obj":"http://www.uniprot.org/uniprot/Q8QZR1"},{"id":"T2","span":{"begin":614,"end":617},"obj":"http://www.uniprot.org/uniprot/Q8QZR1"},{"id":"T3","span":{"begin":727,"end":730},"obj":"http://www.uniprot.org/uniprot/Q8QZR1"},{"id":"T4","span":{"begin":773,"end":776},"obj":"http://www.uniprot.org/uniprot/Q8QZR1"},{"id":"T5","span":{"begin":1012,"end":1015},"obj":"http://www.uniprot.org/uniprot/Q8QZR1"},{"id":"T6","span":{"begin":1120,"end":1123},"obj":"http://www.uniprot.org/uniprot/Q8QZR1"},{"id":"T7","span":{"begin":33,"end":43},"obj":"http://www.uniprot.org/uniprot/P16110"},{"id":"T8","span":{"begin":528,"end":538},"obj":"http://www.uniprot.org/uniprot/P16110"},{"id":"T9","span":{"begin":706,"end":716},"obj":"http://www.uniprot.org/uniprot/P16110"},{"id":"T10","span":{"begin":823,"end":833},"obj":"http://www.uniprot.org/uniprot/P16110"},{"id":"T11","span":{"begin":930,"end":940},"obj":"http://www.uniprot.org/uniprot/P16110"},{"id":"T12","span":{"begin":1096,"end":1106},"obj":"http://www.uniprot.org/uniprot/P16110"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

GlycoBiology-NCBITAXON

{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T1","span":{"begin":56,"end":62},"obj":"http://purl.bioontology.org/ontology/STY/T008"},{"id":"T2","span":{"begin":187,"end":191},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T3","span":{"begin":187,"end":191},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T4","span":{"begin":296,"end":322},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/318275"},{"id":"T5","span":{"begin":317,"end":322},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/184751"},{"id":"T6","span":{"begin":368,"end":396},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/12721"},{"id":"T7","span":{"begin":368,"end":396},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/11723"},{"id":"T8","span":{"begin":368,"end":396},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/11709"},{"id":"T9","span":{"begin":368,"end":396},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/11676"},{"id":"T10","span":{"begin":374,"end":396},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/11673"},{"id":"T11","span":{"begin":391,"end":396},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/184751"},{"id":"T12","span":{"begin":478,"end":483},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T13","span":{"begin":559,"end":566},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/353209"},{"id":"T14","span":{"begin":866,"end":868},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/13893"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

GO-BP

{"project":"GO-BP","denotations":[{"id":"T1","span":{"begin":1171,"end":1184},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

GO-MF

{"project":"GO-MF","denotations":[{"id":"T1","span":{"begin":192,"end":211},"obj":"http://purl.obolibrary.org/obo/GO_0016936"},{"id":"T2","span":{"begin":204,"end":211},"obj":"http://purl.obolibrary.org/obo/GO_0070026"},{"id":"T3","span":{"begin":1163,"end":1170},"obj":"http://purl.obolibrary.org/obo/GO_0070026"},{"id":"T4","span":{"begin":204,"end":211},"obj":"http://purl.obolibrary.org/obo/GO_0003680"},{"id":"T5","span":{"begin":1163,"end":1170},"obj":"http://purl.obolibrary.org/obo/GO_0003680"},{"id":"T6","span":{"begin":204,"end":211},"obj":"http://purl.obolibrary.org/obo/GO_0017091"},{"id":"T7","span":{"begin":1163,"end":1170},"obj":"http://purl.obolibrary.org/obo/GO_0017091"},{"id":"T8","span":{"begin":204,"end":211},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T9","span":{"begin":1163,"end":1170},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T10","span":{"begin":1163,"end":1191},"obj":"http://purl.obolibrary.org/obo/GO_0033613"},{"id":"T11","span":{"begin":1163,"end":1191},"obj":"http://purl.obolibrary.org/obo/GO_0043425"},{"id":"T12","span":{"begin":1163,"end":1191},"obj":"http://purl.obolibrary.org/obo/GO_0070491"},{"id":"T13","span":{"begin":1163,"end":1191},"obj":"http://purl.obolibrary.org/obo/GO_0008134"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

GO-CC

{"project":"GO-CC","denotations":[{"id":"T1","span":{"begin":353,"end":357},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2","span":{"begin":439,"end":443},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3","span":{"begin":478,"end":483},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

UBERON-AE

{"project":"UBERON-AE","denotations":[{"id":"T1","span":{"begin":659,"end":668},"obj":"http://purl.obolibrary.org/obo/UBERON_2000106"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

EDAM-topics

{"project":"EDAM-topics","denotations":[{"id":"T1","span":{"begin":8,"end":15},"obj":"http://edamontology.org/topic_0078"},{"id":"T2","span":{"begin":56,"end":62},"obj":"http://edamontology.org/topic_3500"},{"id":"T3","span":{"begin":263,"end":275},"obj":"http://edamontology.org/topic_0634"},{"id":"T4","span":{"begin":296,"end":301},"obj":"http://edamontology.org/topic_2815"},{"id":"T5","span":{"begin":345,"end":350},"obj":"http://edamontology.org/topic_2815"},{"id":"T6","span":{"begin":368,"end":373},"obj":"http://edamontology.org/topic_2815"},{"id":"T7","span":{"begin":598,"end":613},"obj":"http://edamontology.org/topic_0204"},{"id":"T8","span":{"begin":752,"end":757},"obj":"http://edamontology.org/topic_3678"},{"id":"T9","span":{"begin":777,"end":784},"obj":"http://edamontology.org/topic_0078"},{"id":"T10","span":{"begin":777,"end":795},"obj":"http://edamontology.org/topic_0121"},{"id":"T11","span":{"begin":777,"end":795},"obj":"http://edamontology.org/topic_0108"},{"id":"T12","span":{"begin":845,"end":850},"obj":"http://edamontology.org/topic_2815"},{"id":"T13","span":{"begin":913,"end":922},"obj":"http://edamontology.org/topic_0080"},{"id":"T14","span":{"begin":913,"end":922},"obj":"http://edamontology.org/topic_3168"},{"id":"T15","span":{"begin":1016,"end":1023},"obj":"http://edamontology.org/topic_0078"},{"id":"T16","span":{"begin":1071,"end":1080},"obj":"http://edamontology.org/topic_3168"},{"id":"T17","span":{"begin":1071,"end":1080},"obj":"http://edamontology.org/topic_0080"},{"id":"T18","span":{"begin":1171,"end":1184},"obj":"http://edamontology.org/topic_0110"},{"id":"T19","span":{"begin":1171,"end":1184},"obj":"http://edamontology.org/topic_0203"},{"id":"T20","span":{"begin":1171,"end":1184},"obj":"http://edamontology.org/topic_3512"},{"id":"T21","span":{"begin":1171,"end":1184},"obj":"http://edamontology.org/topic_3308"},{"id":"T22","span":{"begin":1171,"end":1191},"obj":"http://edamontology.org/topic_0749"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

EDAM-DFO

{"project":"EDAM-DFO","denotations":[{"id":"T1","span":{"begin":8,"end":15},"obj":"http://edamontology.org/format_1208"},{"id":"T2","span":{"begin":8,"end":15},"obj":"http://edamontology.org/data_1467"},{"id":"T3","span":{"begin":119,"end":128},"obj":"http://edamontology.org/operation_2409"},{"id":"T4","span":{"begin":119,"end":128},"obj":"http://edamontology.org/operation_0004"},{"id":"T5","span":{"begin":139,"end":150},"obj":"http://edamontology.org/operation_2423"},{"id":"T6","span":{"begin":276,"end":285},"obj":"http://edamontology.org/operation_0004"},{"id":"T7","span":{"begin":276,"end":285},"obj":"http://edamontology.org/operation_2409"},{"id":"T8","span":{"begin":353,"end":367},"obj":"http://edamontology.org/data_0963"},{"id":"T9","span":{"begin":777,"end":784},"obj":"http://edamontology.org/data_1467"},{"id":"T10","span":{"begin":777,"end":784},"obj":"http://edamontology.org/format_1208"},{"id":"T11","span":{"begin":913,"end":922},"obj":"http://edamontology.org/data_2044"},{"id":"T12","span":{"begin":913,"end":922},"obj":"http://edamontology.org/operation_3218"},{"id":"T13","span":{"begin":1016,"end":1023},"obj":"http://edamontology.org/format_1208"},{"id":"T14","span":{"begin":1016,"end":1023},"obj":"http://edamontology.org/data_1467"},{"id":"T15","span":{"begin":1016,"end":1033},"obj":"http://edamontology.org/operation_2502"},{"id":"T16","span":{"begin":1016,"end":1033},"obj":"http://edamontology.org/operation_2415"},{"id":"T17","span":{"begin":1025,"end":1033},"obj":"http://edamontology.org/operation_2945"},{"id":"T18","span":{"begin":1071,"end":1080},"obj":"http://edamontology.org/data_2044"},{"id":"T19","span":{"begin":1071,"end":1080},"obj":"http://edamontology.org/operation_3218"},{"id":"T20","span":{"begin":1171,"end":1191},"obj":"http://edamontology.org/data_2911"},{"id":"T21","span":{"begin":1171,"end":1191},"obj":"http://edamontology.org/data_2755"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

Lectin

{"project":"Lectin","denotations":[{"id":"Lectin_T1","span":{"begin":171,"end":179},"obj":"https://acgg.asia/db/lfdb/LfDB0270"},{"id":"Lectin_T2","span":{"begin":171,"end":179},"obj":"https://acgg.asia/db/lfdb/LfDB0272"},{"id":"Lectin_T3","span":{"begin":171,"end":179},"obj":"https://acgg.asia/db/lfdb/LfDB0274"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

performance-test

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":659,"end":668},"obj":"http://purl.obolibrary.org/obo/UBERON_2000106"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}

PubmedHPO

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":374,"end":390},"obj":"HP_0002721"}],"text":"The tat protein of HIV-1 induces galectin-3 expression.\nAnimal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human immunodeficiency virus (HIV) infection of T-lymphoblastic Molt-3 cell line. In the case of HIV-infected cells, it has been suggested that the increase in galectin-3 expression could be related to the expression of the viral regulatory gene tat. These results prompt us to perform more extensive analyses of the relationship between galectin-3 and HIV-1 Tat expressions. In this study, we found that Tat protein expression induces an upregulation of galectin-3 in several human cell lines. In co-transfection experiments, the 5'-regulatory sequences of the galectin-3 gene were significantly upregulated by expression vectors encoding the Tat protein. Analysis performed with 5'-regulatory deleted sequences suggested that galectin-3 induction by Tat is dependent on activation of the Sp-1 binding transcription factor."}