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PubMed:10080875 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 15-44 protein denotes NF-kappaB p50/p65 heterodimer
T2 66-98 DNA denotes human pro-interleukin-1beta gene
T3 124-149 DNA denotes upstream enhancer element
T4 204-222 DNA denotes transcription site
T5 230-276 DNA denotes human pro-interleukin 1beta (proIL-1beta) gene
T6 298-329 DNA denotes LPS-responsive enhancer element
T7 385-408 DNA denotes between -3134 and -2987
T8 448-464 DNA denotes proIL-1beta gene
T9 468-498 cell_line denotes LPS-stimulated Raw 264.7 cells
T10 577-592 DNA denotes -CAT constructs
T11 608-636 DNA denotes serial 5'-deletion mutations
T12 779-805 DNA denotes synthetic oligonucleotides
T13 923-944 DNA denotes protein binding sites
T14 1125-1146 protein denotes transcription factors
T15 1199-1219 protein denotes NF-kappaB components
T16 1220-1223 protein denotes p50
T17 1228-1231 protein denotes p65
T18 1259-1277 protein denotes NF-kappaB proteins
T19 1279-1282 protein denotes p52
T20 1284-1289 protein denotes c-Rel
T21 1291-1296 protein denotes Rel B
T22 1299-1312 protein denotes AP-1 proteins
T23 1314-1319 protein denotes c-Fos
T24 1321-1326 protein denotes C-Jun
T25 1329-1333 protein denotes CREB
T26 1337-1346 protein denotes C/EBPbeta
T27 1348-1354 protein denotes NF-IL6
T28 1392-1415 DNA denotes NF-kappaB-binding sites
T29 1525-1548 DNA denotes NF-kappaB-binding sites
T30 1576-1591 DNA denotes -3134 and -3059
T31 1628-1644 DNA denotes proIL-1beta gene

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 15-32 protein denotes NF-kappaB p50/p65
T2 72-93 protein denotes pro-interleukin-1beta
T3 240-257 protein denotes interleukin 1beta
T4 259-270 protein denotes proIL-1beta
T5 448-459 protein denotes proIL-1beta
T6 573-576 protein denotes fos
T7 578-581 protein denotes CAT
T8 1125-1146 protein denotes transcription factors
T9 1199-1208 protein denotes NF-kappaB
T10 1220-1223 protein denotes p50
T11 1228-1231 protein denotes p65
T12 1259-1268 protein denotes NF-kappaB
T13 1279-1282 protein denotes p52
T14 1284-1289 protein denotes c-Rel
T15 1291-1296 protein denotes Rel B
T16 1299-1303 protein denotes AP-1
T17 1314-1319 protein denotes c-Fos
T18 1321-1326 protein denotes C-Jun
T19 1329-1333 protein denotes CREB
T20 1337-1346 protein denotes C/EBPbeta
T21 1348-1354 protein denotes NF-IL6
T22 1392-1401 protein denotes NF-kappaB
T23 1525-1534 protein denotes NF-kappaB
T24 1628-1639 protein denotes proIL-1beta

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 62-98 NP denotes the human pro-interleukin-1beta gene
C2 226-276 NP denotes the human pro-interleukin 1beta (proIL-1beta) gene
C3 444-464 NP denotes the proIL-1beta gene
C4 547-592 NP denotes transient transfection of fos -CAT constructs
C5 593-597 NP denotes that
C7 668-683 NP denotes -3134 and -3059
C6 649-683 NP denotes the region between -3134 and -3059
C8 844-861 NP denotes the latter region
C9 1521-1548 NP denotes two NF-kappaB-binding sites
C10 1550-1555 NP denotes which
C11 1576-1591 NP denotes -3134 and -3059
R1 C2 C1 coref-ident the human pro-interleukin 1beta (proIL-1beta) gene,the human pro-interleukin-1beta gene
R2 C3 C2 coref-ident the proIL-1beta gene,the human pro-interleukin 1beta (proIL-1beta) gene
R3 C5 C4 coref-relat that,transient transfection of fos -CAT constructs
R4 C8 C6 coref-ident the latter region,the region between -3134 and -3059
R5 C10 C9 coref-relat which,two NF-kappaB-binding sites
R6 C11 C7 coref-ident -3134 and -3059,-3134 and -3059

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-150 Sentence denotes Involvement of NF-kappaB p50/p65 heterodimer in activation of the human pro-interleukin-1beta gene at two subregions of the upstream enhancer element.
S2 151-330 Sentence denotes A region between-3134 and -2729 bp upstream from the transcription site of the human pro-interleukin 1beta (proIL-1beta) gene was identified as an LPS-responsive enhancer element.
S3 331-522 Sentence denotes In this study, the influence of the sequences located between -3134 and -2987 on the transcriptional activity of the proIL-1beta gene in LPS-stimulated Raw 264.7 cells was examined in detail.
S4 523-749 Sentence denotes The results obtained by transient transfection of fos -CAT constructs that contained serial 5'-deletion mutations showed that the region between -3134 and -3059 appears to be required for the induction of transcription by LPS.
S5 750-997 Sentence denotes Gel shift assay studies with synthetic oligonucleotides corresponding to partial sequences of the latter region and nuclear extracts from stimulated cells revealed specific protein binding sites between -3110 and -3090 and between -3079 and -3059.
S6 998-1055 Sentence denotes These specific bindings were time and LPS dose dependent.
S7 1056-1356 Sentence denotes The results of supershift analysis using specific antibodies against transcription factors suggested that both binding complexes contained the NF-kappaB components p50 and p65, and did not contain other NF-kappaB proteins (p52, c-Rel, Rel B), AP-1 proteins (c-Fos, C-Jun), CREB or C/EBPbeta (NF-IL6).
S8 1357-1494 Sentence denotes Mutation of either of the putative NF-kappaB-binding sites in the enhancer element decreased the LPS-stimulated transcriptional activity.
S9 1495-1659 Sentence denotes These data indicated that two NF-kappaB-binding sites, which are located between -3134 and -3059, are critical for the activation of proIL-1beta gene transcription.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 15-24 protein_complex denotes NF-kappaB
T2 66-98 DNA_domain_or_region denotes human pro-interleukin-1beta gene
T3 124-149 DNA_domain_or_region denotes upstream enhancer element
T4 204-222 DNA_domain_or_region denotes transcription site
T5 230-257 protein_molecule denotes human pro-interleukin 1beta
T6 259-270 protein_molecule denotes proIL-1beta
T7 298-329 DNA_domain_or_region denotes LPS-responsive enhancer element
T8 385-408 DNA_domain_or_region denotes between -3134 and -2987
T9 416-440 other_name denotes transcriptional activity
T10 448-464 DNA_domain_or_region denotes proIL-1beta gene
T11 468-498 cell_line denotes LPS-stimulated Raw 264.7 cells
T12 577-592 DNA_family_or_group denotes -CAT constructs
T13 608-636 DNA_domain_or_region denotes serial 5'-deletion mutations
T14 745-748 lipid denotes LPS
T15 779-805 DNA_family_or_group denotes synthetic oligonucleotides
T16 866-882 cell_component denotes nuclear extracts
T17 923-944 DNA_domain_or_region denotes protein binding sites
T18 1036-1039 lipid denotes LPS
T19 1125-1146 protein_family_or_group denotes transcription factors
T20 1199-1208 protein_complex denotes NF-kappaB
T21 1220-1223 protein_subunit denotes p50
T22 1228-1231 protein_subunit denotes p65
T23 1259-1268 protein_complex denotes NF-kappaB
T24 1279-1282 protein_subunit denotes p52
T25 1284-1289 protein_subunit denotes c-Rel
T26 1291-1296 protein_subunit denotes Rel B
T27 1299-1312 protein_family_or_group denotes AP-1 proteins
T28 1314-1319 protein_molecule denotes c-Fos
T29 1321-1326 protein_molecule denotes C-Jun
T30 1329-1333 protein_family_or_group denotes CREB
T31 1337-1346 protein_molecule denotes C/EBPbeta
T32 1348-1354 protein_molecule denotes NF-IL6
T33 1392-1415 DNA_domain_or_region denotes NF-kappaB-binding sites
T34 1454-1457 lipid denotes LPS
T35 1469-1493 other_name denotes transcriptional activity
T36 1525-1548 DNA_domain_or_region denotes NF-kappaB-binding sites
T37 1576-1591 DNA_domain_or_region denotes -3134 and -3059
T38 1628-1644 DNA_domain_or_region denotes proIL-1beta gene