PubMed:10079106 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10079106","sourcedb":"PubMed","sourceid":"10079106","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10079106","text":"Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils.\nActivation of leukocytes by proinflammatory stimuli selectively initiates intracellular signal transduction via sequential phosphorylation of kinases. Lipopolysaccharide (LPS) stimulation of human neutrophils is known to result in activation of p38 mitogen-activated protein kinase (MAPk); however, the upstream activator(s) of p38 MAPk is unknown, and consequences of p38 MAPk activation remain largely undefined. We investigated the MAPk kinase (MKK) that activates p38 MAPk in response to LPS, the p38 MAPk isoforms that are activated as part of this pathway, and the functional responses affected by p38 MAPk activation. Although MKK3, MKK4, and MKK6 all activated p38 MAPk in experimental models, only MKK3 was found to activate recombinant p38 MAPk in LPS-treated neutrophils. Of p38 MAPk isoforms studied, only p38alpha and p38delta were detected in neutrophils. LPS stimulation selectively activated p38alpha. Specific inhibitors of p38alpha MAPk blocked LPS-induced adhesion, nuclear factor-kappa B (NF-kappaB) activation, and synthesis of tumor necrosis factor-alpha (TNF-alpha). Inhibition of p38alpha MAPk resulted in a transient decrease in TNF-alpha mRNA accumulation but persistent loss of TNF-alpha synthesis. These findings support a pathway by which LPS stimulation of neutrophils results in activation of MKK3, which in turn activates p38alpha MAPk, ultimately regulating adhesion, NF-kappaB activation, enhanced gene expression of TNF-alpha, and regulation of TNF-alpha synthesis.","tracks":[{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":311,"end":314},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":632,"end":635},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":898,"end":901},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1010,"end":1013},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1103,"end":1106},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":1189,"end":1194},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":1408,"end":1411},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0019508"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0019508"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0019508"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0019508"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0019508"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0005070"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0019508"},{"subj":"T1","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T2","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T3","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T4","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T5","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T6","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T7","pred":"source","obj":"PMID_GLOBAL"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":52,"end":93},"obj":"protein"},{"id":"T2","span":{"begin":97,"end":138},"obj":"cell_line"},{"id":"T3","span":{"begin":154,"end":164},"obj":"cell_type"},{"id":"T4","span":{"begin":282,"end":289},"obj":"protein"},{"id":"T5","span":{"begin":331,"end":348},"obj":"cell_type"},{"id":"T6","span":{"begin":385,"end":421},"obj":"protein"},{"id":"T7","span":{"begin":423,"end":427},"obj":"protein"},{"id":"T8","span":{"begin":443,"end":461},"obj":"protein"},{"id":"T9","span":{"begin":468,"end":476},"obj":"protein"},{"id":"T10","span":{"begin":509,"end":517},"obj":"protein"},{"id":"T11","span":{"begin":575,"end":586},"obj":"protein"},{"id":"T12","span":{"begin":588,"end":591},"obj":"protein"},{"id":"T13","span":{"begin":608,"end":616},"obj":"protein"},{"id":"T14","span":{"begin":641,"end":658},"obj":"protein"},{"id":"T15","span":{"begin":744,"end":752},"obj":"protein"},{"id":"T16","span":{"begin":774,"end":778},"obj":"protein"},{"id":"T17","span":{"begin":780,"end":784},"obj":"protein"},{"id":"T18","span":{"begin":790,"end":794},"obj":"protein"},{"id":"T19","span":{"begin":809,"end":817},"obj":"protein"},{"id":"T20","span":{"begin":847,"end":851},"obj":"protein"},{"id":"T21","span":{"begin":886,"end":894},"obj":"protein"},{"id":"T22","span":{"begin":926,"end":943},"obj":"protein"},{"id":"T23","span":{"begin":958,"end":966},"obj":"protein"},{"id":"T24","span":{"begin":971,"end":979},"obj":"protein"},{"id":"T25","span":{"begin":997,"end":1008},"obj":"cell_type"},{"id":"T26","span":{"begin":1048,"end":1056},"obj":"protein"},{"id":"T27","span":{"begin":1081,"end":1094},"obj":"protein"},{"id":"T28","span":{"begin":1149,"end":1158},"obj":"protein"},{"id":"T29","span":{"begin":1189,"end":1216},"obj":"protein"},{"id":"T30","span":{"begin":1218,"end":1227},"obj":"protein"},{"id":"T31","span":{"begin":1244,"end":1257},"obj":"protein"},{"id":"T32","span":{"begin":1294,"end":1308},"obj":"RNA"},{"id":"T33","span":{"begin":1345,"end":1354},"obj":"protein"},{"id":"T34","span":{"begin":1427,"end":1438},"obj":"cell_type"},{"id":"T35","span":{"begin":1464,"end":1468},"obj":"protein"},{"id":"T36","span":{"begin":1494,"end":1507},"obj":"protein"},{"id":"T37","span":{"begin":1541,"end":1550},"obj":"protein"},{"id":"T38","span":{"begin":1591,"end":1600},"obj":"protein"},{"id":"T39","span":{"begin":1620,"end":1629},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"},{"subj":"T5","pred":"source","obj":"jnlpba-st-training"},{"subj":"T6","pred":"source","obj":"jnlpba-st-training"},{"subj":"T7","pred":"source","obj":"jnlpba-st-training"},{"subj":"T8","pred":"source","obj":"jnlpba-st-training"},{"subj":"T9","pred":"source","obj":"jnlpba-st-training"},{"subj":"T10","pred":"source","obj":"jnlpba-st-training"},{"subj":"T11","pred":"source","obj":"jnlpba-st-training"},{"subj":"T12","pred":"source","obj":"jnlpba-st-training"},{"subj":"T13","pred":"source","obj":"jnlpba-st-training"},{"subj":"T14","pred":"source","obj":"jnlpba-st-training"},{"subj":"T15","pred":"source","obj":"jnlpba-st-training"},{"subj":"T16","pred":"source","obj":"jnlpba-st-training"},{"subj":"T17","pred":"source","obj":"jnlpba-st-training"},{"subj":"T18","pred":"source","obj":"jnlpba-st-training"},{"subj":"T19","pred":"source","obj":"jnlpba-st-training"},{"subj":"T20","pred":"source","obj":"jnlpba-st-training"},{"subj":"T21","pred":"source","obj":"jnlpba-st-training"},{"subj":"T22","pred":"source","obj":"jnlpba-st-training"},{"subj":"T23","pred":"source","obj":"jnlpba-st-training"},{"subj":"T24","pred":"source","obj":"jnlpba-st-training"},{"subj":"T25","pred":"source","obj":"jnlpba-st-training"},{"subj":"T26","pred":"source","obj":"jnlpba-st-training"},{"subj":"T27","pred":"source","obj":"jnlpba-st-training"},{"subj":"T28","pred":"source","obj":"jnlpba-st-training"},{"subj":"T29","pred":"source","obj":"jnlpba-st-training"},{"subj":"T30","pred":"source","obj":"jnlpba-st-training"},{"subj":"T31","pred":"source","obj":"jnlpba-st-training"},{"subj":"T32","pred":"source","obj":"jnlpba-st-training"},{"subj":"T33","pred":"source","obj":"jnlpba-st-training"},{"subj":"T34","pred":"source","obj":"jnlpba-st-training"},{"subj":"T35","pred":"source","obj":"jnlpba-st-training"},{"subj":"T36","pred":"source","obj":"jnlpba-st-training"},{"subj":"T37","pred":"source","obj":"jnlpba-st-training"},{"subj":"T38","pred":"source","obj":"jnlpba-st-training"},{"subj":"T39","pred":"source","obj":"jnlpba-st-training"}]},{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":52,"end":93},"obj":"NP"},{"id":"C3","span":{"begin":331,"end":348},"obj":"NP"},{"id":"C2","span":{"begin":291,"end":348},"obj":"NP"},{"id":"C5","span":{"begin":385,"end":429},"obj":"NP"},{"id":"C4","span":{"begin":371,"end":429},"obj":"NP"},{"id":"C6","span":{"begin":468,"end":476},"obj":"NP"},{"id":"C7","span":{"begin":509,"end":528},"obj":"NP"},{"id":"C8","span":{"begin":571,"end":592},"obj":"NP"},{"id":"C9","span":{"begin":593,"end":597},"obj":"NP"},{"id":"C10","span":{"begin":608,"end":616},"obj":"NP"},{"id":"C12","span":{"begin":637,"end":658},"obj":"NP"},{"id":"C13","span":{"begin":659,"end":663},"obj":"NP"},{"id":"C11","span":{"begin":637,"end":701},"obj":"NP"},{"id":"C14","span":{"begin":744,"end":763},"obj":"NP"},{"id":"C15","span":{"begin":809,"end":817},"obj":"NP"},{"id":"C16","span":{"begin":926,"end":951},"obj":"NP"},{"id":"C17","span":{"begin":997,"end":1008},"obj":"NP"},{"id":"C18","span":{"begin":1081,"end":1094},"obj":"NP"},{"id":"C19","span":{"begin":1125,"end":1170},"obj":"NP"},{"id":"C21","span":{"begin":1189,"end":1228},"obj":"NP"},{"id":"C20","span":{"begin":1176,"end":1228},"obj":"NP"},{"id":"C22","span":{"begin":1244,"end":1257},"obj":"NP"},{"id":"C23","span":{"begin":1345,"end":1364},"obj":"NP"},{"id":"C24","span":{"begin":1389,"end":1398},"obj":"NP"},{"id":"C25","span":{"begin":1402,"end":1407},"obj":"NP"},{"id":"C27","span":{"begin":1427,"end":1438},"obj":"NP"},{"id":"C26","span":{"begin":1408,"end":1438},"obj":"NP"},{"id":"C28","span":{"begin":1464,"end":1468},"obj":"NP"},{"id":"C29","span":{"begin":1470,"end":1475},"obj":"NP"},{"id":"C30","span":{"begin":1494,"end":1507},"obj":"NP"},{"id":"C31","span":{"begin":1541,"end":1561},"obj":"NP"},{"id":"C32","span":{"begin":1591,"end":1600},"obj":"NP"},{"id":"C33","span":{"begin":1620,"end":1639},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C6","obj":"C5"},{"id":"R2","pred":"coref-ident","subj":"C7","obj":"C4"},{"id":"R3","pred":"coref-relat","subj":"C9","obj":"C8"},{"id":"R4","pred":"coref-ident","subj":"C10","obj":"C6"},{"id":"R5","pred":"coref-relat","subj":"C13","obj":"C12"},{"id":"R6","pred":"coref-ident","subj":"C14","obj":"C7"},{"id":"R7","pred":"coref-ident","subj":"C15","obj":"C10"},{"id":"R8","pred":"coref-ident","subj":"C16","obj":"C11"},{"id":"R9","pred":"coref-ident","subj":"C17","obj":"C3"},{"id":"R10","pred":"coref-ident","subj":"C18","obj":"C1"},{"id":"R11","pred":"coref-ident","subj":"C22","obj":"C18"},{"id":"R12","pred":"coref-ident","subj":"C23","obj":"C20"},{"id":"R13","pred":"coref-relat","subj":"C25","obj":"C24"},{"id":"R14","pred":"coref-ident","subj":"C27","obj":"C17"},{"id":"R15","pred":"coref-ident","subj":"C26","obj":"C2"},{"id":"R16","pred":"coref-relat","subj":"C29","obj":"C28"},{"id":"R17","pred":"coref-ident","subj":"C30","obj":"C22"},{"id":"R18","pred":"coref-ident","subj":"C31","obj":"C19"},{"id":"R19","pred":"coref-ident","subj":"C32","obj":"C21"},{"id":"R20","pred":"coref-ident","subj":"C33","obj":"C23"}],"attributes":[{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"},{"subj":"C8","pred":"source","obj":"genia-medco-coref"},{"subj":"C9","pred":"source","obj":"genia-medco-coref"},{"subj":"C10","pred":"source","obj":"genia-medco-coref"},{"subj":"C12","pred":"source","obj":"genia-medco-coref"},{"subj":"C13","pred":"source","obj":"genia-medco-coref"},{"subj":"C11","pred":"source","obj":"genia-medco-coref"},{"subj":"C14","pred":"source","obj":"genia-medco-coref"},{"subj":"C15","pred":"source","obj":"genia-medco-coref"},{"subj":"C16","pred":"source","obj":"genia-medco-coref"},{"subj":"C17","pred":"source","obj":"genia-medco-coref"},{"subj":"C18","pred":"source","obj":"genia-medco-coref"},{"subj":"C19","pred":"source","obj":"genia-medco-coref"},{"subj":"C21","pred":"source","obj":"genia-medco-coref"},{"subj":"C20","pred":"source","obj":"genia-medco-coref"},{"subj":"C22","pred":"source","obj":"genia-medco-coref"},{"subj":"C23","pred":"source","obj":"genia-medco-coref"},{"subj":"C24","pred":"source","obj":"genia-medco-coref"},{"subj":"C25","pred":"source","obj":"genia-medco-coref"},{"subj":"C27","pred":"source","obj":"genia-medco-coref"},{"subj":"C26","pred":"source","obj":"genia-medco-coref"},{"subj":"C28","pred":"source","obj":"genia-medco-coref"},{"subj":"C29","pred":"source","obj":"genia-medco-coref"},{"subj":"C30","pred":"source","obj":"genia-medco-coref"},{"subj":"C31","pred":"source","obj":"genia-medco-coref"},{"subj":"C32","pred":"source","obj":"genia-medco-coref"},{"subj":"C33","pred":"source","obj":"genia-medco-coref"}]},{"project":"semrep-sample","denotations":[{"id":"E1-ti-1","span":{"begin":25,"end":35},"obj":"cui:C0205245"},{"id":"E2-ti-1","span":{"begin":36,"end":48},"obj":"cui:C0750502"},{"id":"E3-ti-1","span":{"begin":52,"end":93},"obj":"cui:C0257535"},{"id":"E4-ti-1","span":{"begin":97,"end":115},"obj":"cui:C0023810"},{"id":"E5-ti-1","span":{"begin":127,"end":138},"obj":"cui:C0027950"},{"id":"T1","span":{"begin":94,"end":96},"obj":"LOCATION_OF"},{"id":"E1-ab-1","span":{"begin":154,"end":164},"obj":"cui:C0023516"},{"id":"E2-ab-1","span":{"begin":184,"end":191},"obj":"cui:C0234402"},{"id":"E3-ab-1","span":{"begin":214,"end":227},"obj":"cui:C0175996"},{"id":"E4-ab-1","span":{"begin":228,"end":247},"obj":"cui:C0037083"},{"id":"E5-ab-1","span":{"begin":248,"end":251},"obj":"cui:C1550513"},{"id":"E6-ab-1","span":{"begin":252,"end":262},"obj":"cui:C1548958"},{"id":"E7-ab-1","span":{"begin":263,"end":278},"obj":"cui:C0031715"},{"id":"E8-ab-1","span":{"begin":282,"end":289},"obj":"cui:C0031727"},{"id":"E1-ab-2","span":{"begin":291,"end":309},"obj":"cui:C0023810"},{"id":"E2-ab-2","span":{"begin":316,"end":327},"obj":"cui:C1292856"},{"id":"E3-ab-2","span":{"begin":331,"end":336},"obj":"cui:C0020114"},{"id":"E4-ab-2","span":{"begin":337,"end":348},"obj":"cui:C0027950"},{"id":"E5-ab-2","span":{"begin":385,"end":421},"obj":"cui:C1456380"},{"id":"T2","span":{"begin":316,"end":327},"obj":"AUGMENTS"},{"id":"T3","span":{"begin":331,"end":348},"obj":"PART_OF"},{"id":"E1-ab-3","span":{"begin":443,"end":451},"obj":"cui:C0522505"},{"id":"E2-ab-3","span":{"begin":468,"end":476},"obj":"cui:C1456380"},{"id":"E3-ab-3","span":{"begin":480,"end":487},"obj":"cui:C0439673"},{"id":"E4-ab-3","span":{"begin":509,"end":512},"obj":"cui:C1451465"},{"id":"E5-ab-3","span":{"begin":513,"end":517},"obj":"cui:C0018284"},{"id":"E6-ab-3","span":{"begin":513,"end":517},"obj":"cui:C1515877"},{"id":"E7-ab-3","span":{"begin":513,"end":517},"obj":"cui:C0031727"},{"id":"E8-ab-3","span":{"begin":513,"end":528},"obj":"cui:C0599177"},{"id":"E9-ab-3","span":{"begin":544,"end":553},"obj":"cui:C0750600"},{"id":"E1-ab-4","span":{"begin":575,"end":579},"obj":"cui:C0169101"},{"id":"E2-ab-4","span":{"begin":608,"end":616},"obj":"cui:C1456380"},{"id":"E3-ab-4","span":{"begin":620,"end":628},"obj":"cui:C0871261"},{"id":"E4-ab-4","span":{"begin":632,"end":635},"obj":"cui:C0023810"},{"id":"E5-ab-4","span":{"begin":641,"end":644},"obj":"cui:C1451465"},{"id":"E6-ab-4","span":{"begin":645,"end":649},"obj":"cui:C0018284"},{"id":"E7-ab-4","span":{"begin":645,"end":649},"obj":"cui:C1515877"},{"id":"E8-ab-4","span":{"begin":645,"end":649},"obj":"cui:C0031727"},{"id":"E9-ab-4","span":{"begin":645,"end":658},"obj":"cui:C0597298"},{"id":"E10-ab-4","span":{"begin":681,"end":685},"obj":"cui:C0449719"},{"id":"E11-ab-4","span":{"begin":694,"end":701},"obj":"cui:C0243123"},{"id":"E12-ab-4","span":{"begin":711,"end":721},"obj":"cui:C0205245"},{"id":"E13-ab-4","span":{"begin":722,"end":731},"obj":"cui:C0871261"},{"id":"E14-ab-4","span":{"begin":744,"end":747},"obj":"cui:C1451465"},{"id":"E15-ab-4","span":{"begin":748,"end":752},"obj":"cui:C0018284"},{"id":"E16-ab-4","span":{"begin":748,"end":752},"obj":"cui:C1515877"},{"id":"E17-ab-4","span":{"begin":748,"end":752},"obj":"cui:C0031727"},{"id":"E18-ab-4","span":{"begin":748,"end":763},"obj":"cui:C0599177"},{"id":"T4","span":{"begin":598,"end":607},"obj":"STIMULATES"},{"id":"E1-ab-5","span":{"begin":790,"end":794},"obj":"cui:C1334475"},{"id":"E2-ab-5","span":{"begin":799,"end":808},"obj":"cui:C1515877"},{"id":"E3-ab-5","span":{"begin":809,"end":817},"obj":"cui:C1456380"},{"id":"E4-ab-5","span":{"begin":821,"end":840},"obj":"cui:C0086272"},{"id":"E5-ab-5","span":{"begin":874,"end":885},"obj":"cui:C1514798"},{"id":"E6-ab-5","span":{"begin":886,"end":894},"obj":"cui:C1456380"},{"id":"E7-ab-5","span":{"begin":898,"end":901},"obj":"cui:C0023810"},{"id":"E8-ab-5","span":{"begin":902,"end":909},"obj":"cui:C1522326"},{"id":"E9-ab-5","span":{"begin":910,"end":921},"obj":"cui:C0027950"},{"id":"T5","span":{"begin":799,"end":808},"obj":"STIMULATES"},{"id":"T6","span":{"begin":874,"end":894},"obj":"PART_OF"},{"id":"T7","span":{"begin":895,"end":897},"obj":"LOCATION_OF"},{"id":"E1-ab-6","span":{"begin":926,"end":929},"obj":"cui:C1451465"},{"id":"E2-ab-6","span":{"begin":930,"end":934},"obj":"cui:C0018284"},{"id":"E3-ab-6","span":{"begin":930,"end":934},"obj":"cui:C1515877"},{"id":"E4-ab-6","span":{"begin":930,"end":934},"obj":"cui:C0031727"},{"id":"E5-ab-6","span":{"begin":930,"end":943},"obj":"cui:C0597298"},{"id":"E6-ab-6","span":{"begin":958,"end":966},"obj":"cui:C1366876"},{"id":"E7-ab-6","span":{"begin":971,"end":979},"obj":"cui:C0541265"},{"id":"E8-ab-6","span":{"begin":997,"end":1008},"obj":"cui:C0027950"},{"id":"T8","span":{"begin":994,"end":996},"obj":"LOCATION_OF"},{"id":"E1-ab-7","span":{"begin":1010,"end":1013},"obj":"cui:C0023810"},{"id":"E2-ab-7","span":{"begin":1014,"end":1025},"obj":"cui:C1292856"},{"id":"E3-ab-7","span":{"begin":1038,"end":1047},"obj":"cui:C1515877"},{"id":"E4-ab-7","span":{"begin":1048,"end":1056},"obj":"cui:C1366876"},{"id":"E1-ab-8","span":{"begin":1067,"end":1077},"obj":"cui:C0243077"},{"id":"E2-ab-8","span":{"begin":1081,"end":1094},"obj":"cui:C0257535"},{"id":"E3-ab-8","span":{"begin":1103,"end":1106},"obj":"cui:C0023810"},{"id":"E4-ab-8","span":{"begin":1107,"end":1114},"obj":"cui:C0205263"},{"id":"E5-ab-8","span":{"begin":1115,"end":1123},"obj":"cui:C0001511"},{"id":"E6-ab-8","span":{"begin":1125,"end":1147},"obj":"cui:C0079904"},{"id":"E7-ab-8","span":{"begin":1176,"end":1185},"obj":"cui:C0869032"},{"id":"E8-ab-8","span":{"begin":1189,"end":1216},"obj":"cui:C1448177"},{"id":"T9","span":{"begin":1095,"end":1102},"obj":"AFFECTS"},{"id":"T10","span":{"begin":1160,"end":1170},"obj":"STIMULATES"},{"id":"E1-ab-9","span":{"begin":1244,"end":1257},"obj":"cui:C0257535"},{"id":"E2-ab-9","span":{"begin":1272,"end":1281},"obj":"cui:C0205374"},{"id":"E3-ab-9","span":{"begin":1282,"end":1290},"obj":"cui:C0547047"},{"id":"E4-ab-9","span":{"begin":1294,"end":1303},"obj":"cui:C1448177"},{"id":"E5-ab-9","span":{"begin":1304,"end":1308},"obj":"cui:C0035696"},{"id":"E6-ab-9","span":{"begin":1326,"end":1336},"obj":"cui:C0205322"},{"id":"E7-ab-9","span":{"begin":1337,"end":1341},"obj":"cui:C1517945"},{"id":"E8-ab-9","span":{"begin":1345,"end":1354},"obj":"cui:C1448177"},{"id":"E9-ab-9","span":{"begin":1355,"end":1364},"obj":"cui:C0869032"},{"id":"E1-ab-10","span":{"begin":1372,"end":1380},"obj":"cui:C0243095"},{"id":"E2-ab-10","span":{"begin":1391,"end":1398},"obj":"cui:C0243123"},{"id":"E3-ab-10","span":{"begin":1408,"end":1411},"obj":"cui:C0023810"},{"id":"E4-ab-10","span":{"begin":1412,"end":1423},"obj":"cui:C1292856"},{"id":"E5-ab-10","span":{"begin":1427,"end":1438},"obj":"cui:C0027950"},{"id":"E6-ab-10","span":{"begin":1494,"end":1507},"obj":"cui:C0257535"},{"id":"E7-ab-10","span":{"begin":1531,"end":1539},"obj":"cui:C0001511"},{"id":"E8-ab-10","span":{"begin":1541,"end":1550},"obj":"cui:C0079904"},{"id":"E9-ab-10","span":{"begin":1572,"end":1587},"obj":"cui:C0017262"},{"id":"E10-ab-10","span":{"begin":1591,"end":1600},"obj":"cui:C1448177"},{"id":"E11-ab-10","span":{"begin":1606,"end":1616},"obj":"cui:C0851285"},{"id":"E12-ab-10","span":{"begin":1620,"end":1629},"obj":"cui:C1448177"},{"id":"E13-ab-10","span":{"begin":1630,"end":1639},"obj":"cui:C0869032"},{"id":"T11","span":{"begin":1412,"end":1423},"obj":"STIMULATES"},{"id":"T12","span":{"begin":1551,"end":1561},"obj":"STIMULATES"}],"relations":[{"id":"R1","pred":"subjectOf","subj":"E5-ti-1","obj":"T1"},{"id":"R2","pred":"objectOf","subj":"E3-ti-1","obj":"T1"},{"id":"R3","pred":"subjectOf","subj":"E1-ab-2","obj":"T2"},{"id":"R4","pred":"objectOf","subj":"E4-ab-2","obj":"T2"},{"id":"R5","pred":"subjectOf","subj":"E4-ab-2","obj":"T3"},{"id":"R6","pred":"objectOf","subj":"E3-ab-2","obj":"T3"},{"id":"R7","pred":"subjectOf","subj":"E1-ab-4","obj":"T4"},{"id":"R8","pred":"objectOf","subj":"E2-ab-4","obj":"T4"},{"id":"R9","pred":"subjectOf","subj":"E1-ab-5","obj":"T5"},{"id":"R10","pred":"objectOf","subj":"E6-ab-5","obj":"T5"},{"id":"R11","pred":"subjectOf","subj":"E6-ab-5","obj":"T6"},{"id":"R12","pred":"objectOf","subj":"E5-ab-5","obj":"T6"},{"id":"R13","pred":"subjectOf","subj":"E9-ab-5","obj":"T7"},{"id":"R14","pred":"objectOf","subj":"E6-ab-5","obj":"T7"},{"id":"R15","pred":"subjectOf","subj":"E8-ab-6","obj":"T8"},{"id":"R16","pred":"objectOf","subj":"E7-ab-6","obj":"T8"},{"id":"R17","pred":"subjectOf","subj":"E2-ab-8","obj":"T9"},{"id":"R18","pred":"objectOf","subj":"E5-ab-8","obj":"T9"},{"id":"R19","pred":"subjectOf","subj":"E8-ab-8","obj":"T10"},{"id":"R20","pred":"objectOf","subj":"E6-ab-8","obj":"T10"},{"id":"R21","pred":"subjectOf","subj":"E6-ab-10","obj":"T11"},{"id":"R22","pred":"objectOf","subj":"E3-ab-10","obj":"T11"},{"id":"R23","pred":"subjectOf","subj":"E10-ab-10","obj":"T12"},{"id":"R24","pred":"objectOf","subj":"E8-ab-10","obj":"T12"}],"attributes":[{"subj":"E1-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E2-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E3-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E4-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"E5-ti-1","pred":"source","obj":"semrep-sample"},{"subj":"T1","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-1","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-2","pred":"source","obj":"semrep-sample"},{"subj":"T2","pred":"source","obj":"semrep-sample"},{"subj":"T3","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-3","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E10-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E11-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E12-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E13-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E14-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E15-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E16-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E17-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"E18-ab-4","pred":"source","obj":"semrep-sample"},{"subj":"T4","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-5","pred":"source","obj":"semrep-sample"},{"subj":"T5","pred":"source","obj":"semrep-sample"},{"subj":"T6","pred":"source","obj":"semrep-sample"},{"subj":"T7","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-6","pred":"source","obj":"semrep-sample"},{"subj":"T8","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-7","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-8","pred":"source","obj":"semrep-sample"},{"subj":"T9","pred":"source","obj":"semrep-sample"},{"subj":"T10","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-9","pred":"source","obj":"semrep-sample"},{"subj":"E1-ab-10","pred":"source","obj":"semrep-sample"},{"subj":"E2-ab-10","pred":"source","obj":"semrep-sample"},{"subj":"E3-ab-10","pred":"source","obj":"semrep-sample"},{"subj":"E4-ab-10","pred":"source","obj":"semrep-sample"},{"subj":"E5-ab-10","pred":"source","obj":"semrep-sample"},{"subj":"E6-ab-10","pred":"source","obj":"semrep-sample"},{"subj":"E7-ab-10","pred":"source","obj":"semrep-sample"},{"subj":"E8-ab-10","pred":"source","obj":"semrep-sample"},{"subj":"E9-ab-10","pred":"source","obj":"semrep-sample"},{"subj":"E10-ab-10","pred":"source","obj":"semrep-sample"},{"subj":"E11-ab-10","pred":"source","obj":"semrep-sample"},{"subj":"E12-ab-10","pred":"source","obj":"semrep-sample"},{"subj":"E13-ab-10","pred":"source","obj":"semrep-sample"},{"subj":"T11","pred":"source","obj":"semrep-sample"},{"subj":"T12","pred":"source","obj":"semrep-sample"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":139},"obj":"Sentence"},{"id":"S2","span":{"begin":140,"end":290},"obj":"Sentence"},{"id":"S3","span":{"begin":291,"end":554},"obj":"Sentence"},{"id":"S4","span":{"begin":555,"end":764},"obj":"Sentence"},{"id":"S5","span":{"begin":765,"end":922},"obj":"Sentence"},{"id":"S6","span":{"begin":923,"end":1009},"obj":"Sentence"},{"id":"S7","span":{"begin":1010,"end":1057},"obj":"Sentence"},{"id":"S8","span":{"begin":1058,"end":1229},"obj":"Sentence"},{"id":"S9","span":{"begin":1230,"end":1365},"obj":"Sentence"},{"id":"S10","span":{"begin":1366,"end":1640},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S7","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S8","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S9","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S10","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":52,"end":93},"obj":"protein_molecule"},{"id":"T2","span":{"begin":97,"end":115},"obj":"lipid"},{"id":"T3","span":{"begin":154,"end":164},"obj":"cell_type"},{"id":"T4","span":{"begin":168,"end":191},"obj":"other_name"},{"id":"T5","span":{"begin":214,"end":247},"obj":"other_name"},{"id":"T6","span":{"begin":282,"end":289},"obj":"protein_family_or_group"},{"id":"T7","span":{"begin":291,"end":309},"obj":"lipid"},{"id":"T8","span":{"begin":311,"end":314},"obj":"lipid"},{"id":"T9","span":{"begin":331,"end":348},"obj":"cell_type"},{"id":"T10","span":{"begin":385,"end":421},"obj":"protein_molecule"},{"id":"T11","span":{"begin":423,"end":427},"obj":"protein_family_or_group"},{"id":"T12","span":{"begin":443,"end":461},"obj":"protein_family_or_group"},{"id":"T13","span":{"begin":468,"end":476},"obj":"protein_molecule"},{"id":"T14","span":{"begin":509,"end":517},"obj":"protein_molecule"},{"id":"T15","span":{"begin":575,"end":586},"obj":"protein_family_or_group"},{"id":"T16","span":{"begin":588,"end":591},"obj":"protein_family_or_group"},{"id":"T17","span":{"begin":608,"end":616},"obj":"protein_molecule"},{"id":"T18","span":{"begin":632,"end":635},"obj":"lipid"},{"id":"T19","span":{"begin":641,"end":649},"obj":"protein_molecule"},{"id":"T20","span":{"begin":744,"end":752},"obj":"protein_molecule"},{"id":"T21","span":{"begin":774,"end":778},"obj":"protein_molecule"},{"id":"T22","span":{"begin":780,"end":784},"obj":"protein_molecule"},{"id":"T23","span":{"begin":790,"end":794},"obj":"protein_molecule"},{"id":"T24","span":{"begin":809,"end":817},"obj":"protein_molecule"},{"id":"T25","span":{"begin":821,"end":840},"obj":"other_name"},{"id":"T26","span":{"begin":847,"end":851},"obj":"protein_molecule"},{"id":"T27","span":{"begin":886,"end":894},"obj":"protein_molecule"},{"id":"T28","span":{"begin":898,"end":901},"obj":"lipid"},{"id":"T29","span":{"begin":926,"end":934},"obj":"protein_molecule"},{"id":"T30","span":{"begin":958,"end":966},"obj":"protein_molecule"},{"id":"T31","span":{"begin":971,"end":979},"obj":"protein_molecule"},{"id":"T32","span":{"begin":997,"end":1008},"obj":"cell_type"},{"id":"T33","span":{"begin":1010,"end":1013},"obj":"lipid"},{"id":"T34","span":{"begin":1048,"end":1056},"obj":"protein_molecule"},{"id":"T35","span":{"begin":1081,"end":1089},"obj":"protein_molecule"},{"id":"T36","span":{"begin":1103,"end":1106},"obj":"lipid"},{"id":"T37","span":{"begin":1125,"end":1149},"obj":"other_name"},{"id":"T38","span":{"begin":1149,"end":1158},"obj":"protein_complex"},{"id":"T39","span":{"begin":1189,"end":1216},"obj":"protein_molecule"},{"id":"T40","span":{"begin":1218,"end":1227},"obj":"protein_molecule"},{"id":"T41","span":{"begin":1244,"end":1252},"obj":"protein_molecule"},{"id":"T42","span":{"begin":1294,"end":1308},"obj":"RNA_molecule"},{"id":"T43","span":{"begin":1345,"end":1354},"obj":"protein_molecule"},{"id":"T44","span":{"begin":1408,"end":1411},"obj":"lipid"},{"id":"T45","span":{"begin":1427,"end":1438},"obj":"cell_type"},{"id":"T46","span":{"begin":1464,"end":1468},"obj":"protein_molecule"},{"id":"T47","span":{"begin":1494,"end":1502},"obj":"protein_molecule"},{"id":"T48","span":{"begin":1541,"end":1550},"obj":"protein_complex"},{"id":"T49","span":{"begin":1563,"end":1587},"obj":"other_name"},{"id":"T50","span":{"begin":1591,"end":1600},"obj":"protein_molecule"},{"id":"T51","span":{"begin":1606,"end":1616},"obj":"other_name"},{"id":"T52","span":{"begin":1620,"end":1629},"obj":"protein_molecule"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"},{"subj":"T16","pred":"source","obj":"GENIAcorpus"},{"subj":"T17","pred":"source","obj":"GENIAcorpus"},{"subj":"T18","pred":"source","obj":"GENIAcorpus"},{"subj":"T19","pred":"source","obj":"GENIAcorpus"},{"subj":"T20","pred":"source","obj":"GENIAcorpus"},{"subj":"T21","pred":"source","obj":"GENIAcorpus"},{"subj":"T22","pred":"source","obj":"GENIAcorpus"},{"subj":"T23","pred":"source","obj":"GENIAcorpus"},{"subj":"T24","pred":"source","obj":"GENIAcorpus"},{"subj":"T25","pred":"source","obj":"GENIAcorpus"},{"subj":"T26","pred":"source","obj":"GENIAcorpus"},{"subj":"T27","pred":"source","obj":"GENIAcorpus"},{"subj":"T28","pred":"source","obj":"GENIAcorpus"},{"subj":"T29","pred":"source","obj":"GENIAcorpus"},{"subj":"T30","pred":"source","obj":"GENIAcorpus"},{"subj":"T31","pred":"source","obj":"GENIAcorpus"},{"subj":"T32","pred":"source","obj":"GENIAcorpus"},{"subj":"T33","pred":"source","obj":"GENIAcorpus"},{"subj":"T34","pred":"source","obj":"GENIAcorpus"},{"subj":"T35","pred":"source","obj":"GENIAcorpus"},{"subj":"T36","pred":"source","obj":"GENIAcorpus"},{"subj":"T37","pred":"source","obj":"GENIAcorpus"},{"subj":"T38","pred":"source","obj":"GENIAcorpus"},{"subj":"T39","pred":"source","obj":"GENIAcorpus"},{"subj":"T40","pred":"source","obj":"GENIAcorpus"},{"subj":"T41","pred":"source","obj":"GENIAcorpus"},{"subj":"T42","pred":"source","obj":"GENIAcorpus"},{"subj":"T43","pred":"source","obj":"GENIAcorpus"},{"subj":"T44","pred":"source","obj":"GENIAcorpus"},{"subj":"T45","pred":"source","obj":"GENIAcorpus"},{"subj":"T46","pred":"source","obj":"GENIAcorpus"},{"subj":"T47","pred":"source","obj":"GENIAcorpus"},{"subj":"T48","pred":"source","obj":"GENIAcorpus"},{"subj":"T49","pred":"source","obj":"GENIAcorpus"},{"subj":"T50","pred":"source","obj":"GENIAcorpus"},{"subj":"T51","pred":"source","obj":"GENIAcorpus"},{"subj":"T52","pred":"source","obj":"GENIAcorpus"}]},{"project":"metamap-sample","denotations":[{"id":"T1","span":{"begin":1495,"end":1508},"obj":"C0257535"},{"id":"T2","span":{"begin":1245,"end":1258},"obj":"C0257535"},{"id":"T3","span":{"begin":1082,"end":1095},"obj":"C0257535"},{"id":"T4","span":{"begin":1428,"end":1439},"obj":"C0027950"},{"id":"T5","span":{"begin":998,"end":1009},"obj":"C0027950"},{"id":"T6","span":{"begin":911,"end":922},"obj":"C0027950"},{"id":"T7","span":{"begin":338,"end":349},"obj":"C0027950"},{"id":"T8","span":{"begin":128,"end":139},"obj":"C0027950"},{"id":"T9","span":{"begin":1409,"end":1412},"obj":"C0023810"},{"id":"T10","span":{"begin":1104,"end":1107},"obj":"C0023810"},{"id":"T11","span":{"begin":1011,"end":1014},"obj":"C0023810"},{"id":"T12","span":{"begin":899,"end":902},"obj":"C0023810"},{"id":"T13","span":{"begin":633,"end":636},"obj":"C0023810"},{"id":"T14","span":{"begin":292,"end":310},"obj":"C0023810"},{"id":"T15","span":{"begin":98,"end":116},"obj":"C0023810"},{"id":"T16","span":{"begin":37,"end":49},"obj":"C0750502"},{"id":"T17","span":{"begin":1161,"end":1171},"obj":"C1879547"},{"id":"T18","span":{"begin":1039,"end":1048},"obj":"C1879547"},{"id":"T19","span":{"begin":800,"end":809},"obj":"C1879547"},{"id":"T20","span":{"begin":669,"end":678},"obj":"C1879547"},{"id":"T21","span":{"begin":754,"end":764},"obj":"C1879547"},{"id":"T22","span":{"begin":519,"end":528},"obj":"C1879547"},{"id":"T23","span":{"begin":372,"end":382},"obj":"C1879547"},{"id":"T24","span":{"begin":11,"end":21},"obj":"C1879547"},{"id":"T25","span":{"begin":117,"end":127},"obj":"C1948023"},{"id":"T26","span":{"begin":712,"end":722},"obj":"C2700217"},{"id":"T27","span":{"begin":26,"end":36},"obj":"C2700217"},{"id":"T28","span":{"begin":1592,"end":1601},"obj":"C1456820"},{"id":"T29","span":{"begin":1190,"end":1217},"obj":"C1456820"},{"id":"T30","span":{"begin":927,"end":935},"obj":"C1456380"},{"id":"T31","span":{"begin":800,"end":818},"obj":"C1456380"},{"id":"T32","span":{"begin":887,"end":895},"obj":"C1456380"},{"id":"T33","span":{"begin":386,"end":422},"obj":"C1456380"},{"id":"T34","span":{"begin":1532,"end":1540},"obj":"C0001511"},{"id":"T35","span":{"begin":1116,"end":1124},"obj":"C0001511"},{"id":"T36","span":{"begin":332,"end":337},"obj":"C0086418"},{"id":"T37","span":{"begin":1542,"end":1551},"obj":"C0079904"},{"id":"T38","span":{"begin":1126,"end":1148},"obj":"C0079904"},{"id":"T39","span":{"begin":576,"end":587},"obj":"C0169101"},{"id":"T40","span":{"begin":936,"end":944},"obj":"C0597298"},{"id":"T41","span":{"begin":651,"end":659},"obj":"C0597298"},{"id":"T42","span":{"begin":1485,"end":1494},"obj":"C1515877"},{"id":"T43","span":{"begin":866,"end":874},"obj":"C1515877"},{"id":"T44","span":{"begin":599,"end":607},"obj":"C1515877"},{"id":"T45","span":{"begin":1231,"end":1241},"obj":"C0021467"},{"id":"T46","span":{"begin":1305,"end":1309},"obj":"C0035696"},{"id":"T47","span":{"begin":264,"end":279},"obj":"C0031715"},{"id":"T48","span":{"begin":283,"end":290},"obj":"C0031727"},{"id":"T49","span":{"begin":1465,"end":1469},"obj":"C1456386"},{"id":"T50","span":{"begin":1440,"end":1447},"obj":"C2825142"},{"id":"T51","span":{"begin":1259,"end":1267},"obj":"C2825142"},{"id":"T52","span":{"begin":362,"end":368},"obj":"C2825142"},{"id":"T53","span":{"begin":1413,"end":1424},"obj":"C1292856"},{"id":"T54","span":{"begin":1015,"end":1026},"obj":"C1292856"},{"id":"T55","span":{"begin":317,"end":328},"obj":"C1292856"},{"id":"T56","span":{"begin":1621,"end":1630},"obj":"C2003941"},{"id":"T57","span":{"begin":1346,"end":1355},"obj":"C2003941"},{"id":"T58","span":{"begin":1212,"end":1217},"obj":"C2003941"},{"id":"T59","span":{"begin":781,"end":785},"obj":"C1150604"},{"id":"T60","span":{"begin":589,"end":592},"obj":"C1150604"},{"id":"T61","span":{"begin":863,"end":865},"obj":"C1883351"},{"id":"T62","span":{"begin":359,"end":361},"obj":"C1883351"},{"id":"T63","span":{"begin":1573,"end":1588},"obj":"C0017262"},{"id":"T64","span":{"begin":1049,"end":1057},"obj":"C1705633"},{"id":"T65","span":{"begin":959,"end":967},"obj":"C1705633"},{"id":"T66","span":{"begin":1346,"end":1365},"obj":"C1155227"},{"id":"T67","span":{"begin":1392,"end":1399},"obj":"C1704259"},{"id":"T68","span":{"begin":695,"end":702},"obj":"C1704259"},{"id":"T69","span":{"begin":621,"end":629},"obj":"C0871261"},{"id":"T70","span":{"begin":723,"end":732},"obj":"C0871261"},{"id":"T71","span":{"begin":954,"end":958},"obj":"C0205171"},{"id":"T72","span":{"begin":843,"end":846},"obj":"C0205171"},{"id":"T73","span":{"begin":1356,"end":1365},"obj":"C1883254"},{"id":"T74","span":{"begin":1177,"end":1186},"obj":"C1883254"},{"id":"T75","span":{"begin":822,"end":841},"obj":"C0086272"},{"id":"T76","span":{"begin":1096,"end":1103},"obj":"C0332206"},{"id":"T77","span":{"begin":205,"end":213},"obj":"C1704686"},{"id":"T78","span":{"begin":559,"end":571},"obj":"C1292732"},{"id":"T79","span":{"begin":353,"end":358},"obj":"C0205309"},{"id":"T80","span":{"begin":791,"end":795},"obj":"C1706267"},{"id":"T81","span":{"begin":857,"end":862},"obj":"C0150312"},{"id":"T82","span":{"begin":1373,"end":1381},"obj":"C2926606"},{"id":"T83","span":{"begin":1382,"end":1389},"obj":"C0183683"},{"id":"T84","span":{"begin":481,"end":488},"obj":"C0439673"},{"id":"T85","span":{"begin":945,"end":952},"obj":"C2603343"},{"id":"T86","span":{"begin":1607,"end":1640},"obj":"C1155222"},{"id":"T87","span":{"begin":1480,"end":1483},"obj":"C1709743"},{"id":"T88","span":{"begin":545,"end":554},"obj":"C0750600"},{"id":"T89","span":{"begin":185,"end":192},"obj":"C0234402"},{"id":"T90","span":{"begin":215,"end":248},"obj":"C1155494"},{"id":"T91","span":{"begin":986,"end":994},"obj":"C0442726"},{"id":"T92","span":{"begin":682,"end":689},"obj":"C1292711"},{"id":"T93","span":{"begin":1283,"end":1291},"obj":"C0392756"},{"id":"T94","span":{"begin":1273,"end":1282},"obj":"C0205374"},{"id":"T95","span":{"begin":494,"end":509},"obj":"C0686907"},{"id":"T96","span":{"begin":463,"end":464},"obj":"C2603362"},{"id":"T97","span":{"begin":733,"end":741},"obj":"C1314939"},{"id":"T98","span":{"begin":1338,"end":1342},"obj":"C1517945"},{"id":"T99","span":{"begin":1068,"end":1078},"obj":"C0243077"},{"id":"T100","span":{"begin":444,"end":452},"obj":"C0522505"},{"id":"T101","span":{"begin":1108,"end":1115},"obj":"C0205263"},{"id":"T102","span":{"begin":1564,"end":1572},"obj":"C2349975"},{"id":"T103","span":{"begin":1327,"end":1337},"obj":"C0205322"},{"id":"T104","span":{"begin":253,"end":263},"obj":"C1548958"},{"id":"T105","span":{"begin":1059,"end":1067},"obj":"C0205369"},{"id":"T106","span":{"begin":796,"end":799},"obj":"C0444868"},{"id":"T107","span":{"begin":875,"end":886},"obj":"C1514798"},{"id":"T108","span":{"begin":903,"end":910},"obj":"C1522326"}],"attributes":[{"subj":"T1","pred":"source","obj":"metamap-sample"},{"subj":"T2","pred":"source","obj":"metamap-sample"},{"subj":"T3","pred":"source","obj":"metamap-sample"},{"subj":"T4","pred":"source","obj":"metamap-sample"},{"subj":"T5","pred":"source","obj":"metamap-sample"},{"subj":"T6","pred":"source","obj":"metamap-sample"},{"subj":"T7","pred":"source","obj":"metamap-sample"},{"subj":"T8","pred":"source","obj":"metamap-sample"},{"subj":"T9","pred":"source","obj":"metamap-sample"},{"subj":"T10","pred":"source","obj":"metamap-sample"},{"subj":"T11","pred":"source","obj":"metamap-sample"},{"subj":"T12","pred":"source","obj":"metamap-sample"},{"subj":"T13","pred":"source","obj":"metamap-sample"},{"subj":"T14","pred":"source","obj":"metamap-sample"},{"subj":"T15","pred":"source","obj":"metamap-sample"},{"subj":"T16","pred":"source","obj":"metamap-sample"},{"subj":"T17","pred":"source","obj":"metamap-sample"},{"subj":"T18","pred":"source","obj":"metamap-sample"},{"subj":"T19","pred":"source","obj":"metamap-sample"},{"subj":"T20","pred":"source","obj":"metamap-sample"},{"subj":"T21","pred":"source","obj":"metamap-sample"},{"subj":"T22","pred":"source","obj":"metamap-sample"},{"subj":"T23","pred":"source","obj":"metamap-sample"},{"subj":"T24","pred":"source","obj":"metamap-sample"},{"subj":"T25","pred":"source","obj":"metamap-sample"},{"subj":"T26","pred":"source","obj":"metamap-sample"},{"subj":"T27","pred":"source","obj":"metamap-sample"},{"subj":"T28","pred":"source","obj":"metamap-sample"},{"subj":"T29","pred":"source","obj":"metamap-sample"},{"subj":"T30","pred":"source","obj":"metamap-sample"},{"subj":"T31","pred":"source","obj":"metamap-sample"},{"subj":"T32","pred":"source","obj":"metamap-sample"},{"subj":"T33","pred":"source","obj":"metamap-sample"},{"subj":"T34","pred":"source","obj":"metamap-sample"},{"subj":"T35","pred":"source","obj":"metamap-sample"},{"subj":"T36","pred":"source","obj":"metamap-sample"},{"subj":"T37","pred":"source","obj":"metamap-sample"},{"subj":"T38","pred":"source","obj":"metamap-sample"},{"subj":"T39","pred":"source","obj":"metamap-sample"},{"subj":"T40","pred":"source","obj":"metamap-sample"},{"subj":"T41","pred":"source","obj":"metamap-sample"},{"subj":"T42","pred":"source","obj":"metamap-sample"},{"subj":"T43","pred":"source","obj":"metamap-sample"},{"subj":"T44","pred":"source","obj":"metamap-sample"},{"subj":"T45","pred":"source","obj":"metamap-sample"},{"subj":"T46","pred":"source","obj":"metamap-sample"},{"subj":"T47","pred":"source","obj":"metamap-sample"},{"subj":"T48","pred":"source","obj":"metamap-sample"},{"subj":"T49","pred":"source","obj":"metamap-sample"},{"subj":"T50","pred":"source","obj":"metamap-sample"},{"subj":"T51","pred":"source","obj":"metamap-sample"},{"subj":"T52","pred":"source","obj":"metamap-sample"},{"subj":"T53","pred":"source","obj":"metamap-sample"},{"subj":"T54","pred":"source","obj":"metamap-sample"},{"subj":"T55","pred":"source","obj":"metamap-sample"},{"subj":"T56","pred":"source","obj":"metamap-sample"},{"subj":"T57","pred":"source","obj":"metamap-sample"},{"subj":"T58","pred":"source","obj":"metamap-sample"},{"subj":"T59","pred":"source","obj":"metamap-sample"},{"subj":"T60","pred":"source","obj":"metamap-sample"},{"subj":"T61","pred":"source","obj":"metamap-sample"},{"subj":"T62","pred":"source","obj":"metamap-sample"},{"subj":"T63","pred":"source","obj":"metamap-sample"},{"subj":"T64","pred":"source","obj":"metamap-sample"},{"subj":"T65","pred":"source","obj":"metamap-sample"},{"subj":"T66","pred":"source","obj":"metamap-sample"},{"subj":"T67","pred":"source","obj":"metamap-sample"},{"subj":"T68","pred":"source","obj":"metamap-sample"},{"subj":"T69","pred":"source","obj":"metamap-sample"},{"subj":"T70","pred":"source","obj":"metamap-sample"},{"subj":"T71","pred":"source","obj":"metamap-sample"},{"subj":"T72","pred":"source","obj":"metamap-sample"},{"subj":"T73","pred":"source","obj":"metamap-sample"},{"subj":"T74","pred":"source","obj":"metamap-sample"},{"subj":"T75","pred":"source","obj":"metamap-sample"},{"subj":"T76","pred":"source","obj":"metamap-sample"},{"subj":"T77","pred":"source","obj":"metamap-sample"},{"subj":"T78","pred":"source","obj":"metamap-sample"},{"subj":"T79","pred":"source","obj":"metamap-sample"},{"subj":"T80","pred":"source","obj":"metamap-sample"},{"subj":"T81","pred":"source","obj":"metamap-sample"},{"subj":"T82","pred":"source","obj":"metamap-sample"},{"subj":"T83","pred":"source","obj":"metamap-sample"},{"subj":"T84","pred":"source","obj":"metamap-sample"},{"subj":"T85","pred":"source","obj":"metamap-sample"},{"subj":"T86","pred":"source","obj":"metamap-sample"},{"subj":"T87","pred":"source","obj":"metamap-sample"},{"subj":"T88","pred":"source","obj":"metamap-sample"},{"subj":"T89","pred":"source","obj":"metamap-sample"},{"subj":"T90","pred":"source","obj":"metamap-sample"},{"subj":"T91","pred":"source","obj":"metamap-sample"},{"subj":"T92","pred":"source","obj":"metamap-sample"},{"subj":"T93","pred":"source","obj":"metamap-sample"},{"subj":"T94","pred":"source","obj":"metamap-sample"},{"subj":"T95","pred":"source","obj":"metamap-sample"},{"subj":"T96","pred":"source","obj":"metamap-sample"},{"subj":"T97","pred":"source","obj":"metamap-sample"},{"subj":"T98","pred":"source","obj":"metamap-sample"},{"subj":"T99","pred":"source","obj":"metamap-sample"},{"subj":"T100","pred":"source","obj":"metamap-sample"},{"subj":"T101","pred":"source","obj":"metamap-sample"},{"subj":"T102","pred":"source","obj":"metamap-sample"},{"subj":"T103","pred":"source","obj":"metamap-sample"},{"subj":"T104","pred":"source","obj":"metamap-sample"},{"subj":"T105","pred":"source","obj":"metamap-sample"},{"subj":"T106","pred":"source","obj":"metamap-sample"},{"subj":"T107","pred":"source","obj":"metamap-sample"},{"subj":"T108","pred":"source","obj":"metamap-sample"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":1189,"end":1194},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PMID_GLOBAL","color":"#93a3ec","default":true},{"id":"jnlpba-st-training","color":"#bdec93"},{"id":"genia-medco-coref","color":"#ec93d7"},{"id":"semrep-sample","color":"#93ece6"},{"id":"pubmed-sentences-benchmark","color":"#eccc93"},{"id":"GENIAcorpus","color":"#b293ec"},{"id":"metamap-sample","color":"#93ec98"},{"id":"PubmedHPO","color":"#ec93a7"}]}]}}