PubMed:10051632 JSON TXT

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PMID_GLOBAL

{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":173,"end":191},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":466,"end":469},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":1394,"end":1397},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":1612,"end":1630},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0007179"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0012833"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0012833"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0007179"}],"text":"Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: implications for molecular mimicry in autoimmune disease.\nThe immunodominant, CD8(+) cytotoxic T lymphocyte (CTL) response to the HLA-B8-restricted peptide, RAKFKQLL, located in the Epstein-Barr virus immediate-early antigen, BZLF1, is characterized by a diverse T cell receptor (TCR) repertoire. Here, we show that this diversity can be partitioned on the basis of crossreactive cytotoxicity patterns involving the recognition of a self peptide-RSKFRQIV-located in a serine/threonine kinase and a bacterial peptide-RRKYKQII-located in Staphylococcus aureus replication initiation protein. Thus CTL clones that recognized the viral, self, and bacterial peptides expressed a highly restricted alphabeta TCR phenotype. The CTL clones that recognized viral and self peptides were more oligoclonal, whereas clones that strictly recognized the viral peptide displayed a diverse TCR profile. Interestingly, the self and bacterial peptides equally were substantially less effective than the cognate viral peptide in sensitizing target cell lysis, and also resulted only in a weak reactivation of memory CTLs in limiting dilution assays, whereas the cognate peptide was highly immunogenic. The described crossreactions show that human antiviral, CD8(+) CTL responses can be shaped by peptide ligands derived from autoantigens and environmental bacterial antigens, thereby providing a firm structural basis for molecular mimicry involving class I-restricted CTLs in the pathogenesis of autoimmune disease."}

jnlpba-st-training

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":75,"end":134},"obj":"cell_type"},{"id":"T2","span":{"begin":213,"end":242},"obj":"cell_type"},{"id":"T3","span":{"begin":317,"end":359},"obj":"protein"},{"id":"T4","span":{"begin":361,"end":366},"obj":"protein"},{"id":"T5","span":{"begin":398,"end":430},"obj":"protein"},{"id":"T6","span":{"begin":603,"end":626},"obj":"protein"},{"id":"T7","span":{"begin":671,"end":723},"obj":"protein"},{"id":"T8","span":{"begin":730,"end":740},"obj":"cell_line"},{"id":"T9","span":{"begin":837,"end":840},"obj":"protein"},{"id":"T10","span":{"begin":856,"end":866},"obj":"cell_line"},{"id":"T11","span":{"begin":1008,"end":1011},"obj":"protein"},{"id":"T12","span":{"begin":1224,"end":1235},"obj":"cell_type"},{"id":"T13","span":{"begin":1571,"end":1588},"obj":"cell_line"}],"text":"Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: implications for molecular mimicry in autoimmune disease.\nThe immunodominant, CD8(+) cytotoxic T lymphocyte (CTL) response to the HLA-B8-restricted peptide, RAKFKQLL, located in the Epstein-Barr virus immediate-early antigen, BZLF1, is characterized by a diverse T cell receptor (TCR) repertoire. Here, we show that this diversity can be partitioned on the basis of crossreactive cytotoxicity patterns involving the recognition of a self peptide-RSKFRQIV-located in a serine/threonine kinase and a bacterial peptide-RRKYKQII-located in Staphylococcus aureus replication initiation protein. Thus CTL clones that recognized the viral, self, and bacterial peptides expressed a highly restricted alphabeta TCR phenotype. The CTL clones that recognized viral and self peptides were more oligoclonal, whereas clones that strictly recognized the viral peptide displayed a diverse TCR profile. Interestingly, the self and bacterial peptides equally were substantially less effective than the cognate viral peptide in sensitizing target cell lysis, and also resulted only in a weak reactivation of memory CTLs in limiting dilution assays, whereas the cognate peptide was highly immunogenic. The described crossreactions show that human antiviral, CD8(+) CTL responses can be shaped by peptide ligands derived from autoantigens and environmental bacterial antigens, thereby providing a firm structural basis for molecular mimicry involving class I-restricted CTLs in the pathogenesis of autoimmune disease."}

genia-medco-coref

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":173,"end":191},"obj":"NP"},{"id":"C2","span":{"begin":261,"end":290},"obj":"NP"},{"id":"C3","span":{"begin":292,"end":300},"obj":"NP"},{"id":"C4","span":{"begin":313,"end":359},"obj":"NP"},{"id":"C5","span":{"begin":361,"end":366},"obj":"NP"},{"id":"C6","span":{"begin":730,"end":740},"obj":"NP"},{"id":"C7","span":{"begin":741,"end":745},"obj":"NP"},{"id":"C8","span":{"begin":852,"end":866},"obj":"NP"},{"id":"C9","span":{"begin":867,"end":871},"obj":"NP"},{"id":"C10","span":{"begin":938,"end":944},"obj":"NP"},{"id":"C11","span":{"begin":945,"end":949},"obj":"NP"},{"id":"C12","span":{"begin":1612,"end":1630},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-appos","subj":"C3","obj":"C2"},{"id":"R2","pred":"coref-appos","subj":"C5","obj":"C4"},{"id":"R3","pred":"coref-relat","subj":"C7","obj":"C6"},{"id":"R4","pred":"coref-relat","subj":"C9","obj":"C8"},{"id":"R5","pred":"coref-relat","subj":"C11","obj":"C10"},{"id":"R6","pred":"coref-ident","subj":"C12","obj":"C1"}],"text":"Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: implications for molecular mimicry in autoimmune disease.\nThe immunodominant, CD8(+) cytotoxic T lymphocyte (CTL) response to the HLA-B8-restricted peptide, RAKFKQLL, located in the Epstein-Barr virus immediate-early antigen, BZLF1, is characterized by a diverse T cell receptor (TCR) repertoire. Here, we show that this diversity can be partitioned on the basis of crossreactive cytotoxicity patterns involving the recognition of a self peptide-RSKFRQIV-located in a serine/threonine kinase and a bacterial peptide-RRKYKQII-located in Staphylococcus aureus replication initiation protein. Thus CTL clones that recognized the viral, self, and bacterial peptides expressed a highly restricted alphabeta TCR phenotype. The CTL clones that recognized viral and self peptides were more oligoclonal, whereas clones that strictly recognized the viral peptide displayed a diverse TCR profile. Interestingly, the self and bacterial peptides equally were substantially less effective than the cognate viral peptide in sensitizing target cell lysis, and also resulted only in a weak reactivation of memory CTLs in limiting dilution assays, whereas the cognate peptide was highly immunogenic. The described crossreactions show that human antiviral, CD8(+) CTL responses can be shaped by peptide ligands derived from autoantigens and environmental bacterial antigens, thereby providing a firm structural basis for molecular mimicry involving class I-restricted CTLs in the pathogenesis of autoimmune disease."}

pubmed-sentences-benchmark

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":192},"obj":"Sentence"},{"id":"S2","span":{"begin":193,"end":431},"obj":"Sentence"},{"id":"S3","span":{"begin":432,"end":724},"obj":"Sentence"},{"id":"S4","span":{"begin":725,"end":851},"obj":"Sentence"},{"id":"S5","span":{"begin":852,"end":1020},"obj":"Sentence"},{"id":"S6","span":{"begin":1021,"end":1316},"obj":"Sentence"},{"id":"S7","span":{"begin":1317,"end":1631},"obj":"Sentence"}],"text":"Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: implications for molecular mimicry in autoimmune disease.\nThe immunodominant, CD8(+) cytotoxic T lymphocyte (CTL) response to the HLA-B8-restricted peptide, RAKFKQLL, located in the Epstein-Barr virus immediate-early antigen, BZLF1, is characterized by a diverse T cell receptor (TCR) repertoire. Here, we show that this diversity can be partitioned on the basis of crossreactive cytotoxicity patterns involving the recognition of a self peptide-RSKFRQIV-located in a serine/threonine kinase and a bacterial peptide-RRKYKQII-located in Staphylococcus aureus replication initiation protein. Thus CTL clones that recognized the viral, self, and bacterial peptides expressed a highly restricted alphabeta TCR phenotype. The CTL clones that recognized viral and self peptides were more oligoclonal, whereas clones that strictly recognized the viral peptide displayed a diverse TCR profile. Interestingly, the self and bacterial peptides equally were substantially less effective than the cognate viral peptide in sensitizing target cell lysis, and also resulted only in a weak reactivation of memory CTLs in limiting dilution assays, whereas the cognate peptide was highly immunogenic. The described crossreactions show that human antiviral, CD8(+) CTL responses can be shaped by peptide ligands derived from autoantigens and environmental bacterial antigens, thereby providing a firm structural basis for molecular mimicry involving class I-restricted CTLs in the pathogenesis of autoimmune disease."}

GENIAcorpus

PubmedHPO

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":1612,"end":1630},"obj":"HP_0002960"},{"id":"T2","span":{"begin":1612,"end":1622},"obj":"HP_0002960"}],"text":"Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: implications for molecular mimicry in autoimmune disease.\nThe immunodominant, CD8(+) cytotoxic T lymphocyte (CTL) response to the HLA-B8-restricted peptide, RAKFKQLL, located in the Epstein-Barr virus immediate-early antigen, BZLF1, is characterized by a diverse T cell receptor (TCR) repertoire. Here, we show that this diversity can be partitioned on the basis of crossreactive cytotoxicity patterns involving the recognition of a self peptide-RSKFRQIV-located in a serine/threonine kinase and a bacterial peptide-RRKYKQII-located in Staphylococcus aureus replication initiation protein. Thus CTL clones that recognized the viral, self, and bacterial peptides expressed a highly restricted alphabeta TCR phenotype. The CTL clones that recognized viral and self peptides were more oligoclonal, whereas clones that strictly recognized the viral peptide displayed a diverse TCR profile. Interestingly, the self and bacterial peptides equally were substantially less effective than the cognate viral peptide in sensitizing target cell lysis, and also resulted only in a weak reactivation of memory CTLs in limiting dilution assays, whereas the cognate peptide was highly immunogenic. The described crossreactions show that human antiviral, CD8(+) CTL responses can be shaped by peptide ligands derived from autoantigens and environmental bacterial antigens, thereby providing a firm structural basis for molecular mimicry involving class I-restricted CTLs in the pathogenesis of autoimmune disease."}