PubMed:10029571 JSONTXT

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    jnlpba-st-training

    {"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":0,"end":14},"obj":"protein"},{"id":"T2","span":{"begin":43,"end":96},"obj":"DNA"},{"id":"T3","span":{"begin":140,"end":145},"obj":"protein"},{"id":"T4","span":{"begin":147,"end":161},"obj":"protein"},{"id":"T5","span":{"begin":163,"end":168},"obj":"protein"},{"id":"T6","span":{"begin":185,"end":209},"obj":"cell_type"},{"id":"T7","span":{"begin":215,"end":252},"obj":"cell_type"},{"id":"T8","span":{"begin":321,"end":330},"obj":"cell_type"},{"id":"T9","span":{"begin":362,"end":378},"obj":"protein"},{"id":"T10","span":{"begin":380,"end":388},"obj":"protein"},{"id":"T11","span":{"begin":413,"end":422},"obj":"cell_type"},{"id":"T12","span":{"begin":470,"end":479},"obj":"cell_type"},{"id":"T13","span":{"begin":608,"end":613},"obj":"protein"},{"id":"T14","span":{"begin":730,"end":739},"obj":"cell_type"},{"id":"T15","span":{"begin":760,"end":765},"obj":"protein"},{"id":"T16","span":{"begin":810,"end":818},"obj":"protein"},{"id":"T17","span":{"begin":822,"end":830},"obj":"protein"},{"id":"T18","span":{"begin":832,"end":837},"obj":"protein"},{"id":"T19","span":{"begin":910,"end":927},"obj":"DNA"},{"id":"T20","span":{"begin":937,"end":942},"obj":"protein"},{"id":"T21","span":{"begin":944,"end":949},"obj":"protein"},{"id":"T22","span":{"begin":955,"end":988},"obj":"protein"},{"id":"T23","span":{"begin":1052,"end":1057},"obj":"protein"},{"id":"T24","span":{"begin":1070,"end":1073},"obj":"protein"},{"id":"T25","span":{"begin":1094,"end":1157},"obj":"protein"},{"id":"T26","span":{"begin":1161,"end":1185},"obj":"DNA"},{"id":"T27","span":{"begin":1189,"end":1227},"obj":"DNA"},{"id":"T28","span":{"begin":1309,"end":1314},"obj":"protein"},{"id":"T29","span":{"begin":1336,"end":1388},"obj":"protein"},{"id":"T30","span":{"begin":1401,"end":1406},"obj":"protein"},{"id":"T31","span":{"begin":1428,"end":1462},"obj":"DNA"},{"id":"T32","span":{"begin":1490,"end":1498},"obj":"protein"},{"id":"T33","span":{"begin":1503,"end":1511},"obj":"protein"},{"id":"T34","span":{"begin":1515,"end":1524},"obj":"cell_type"},{"id":"T35","span":{"begin":1572,"end":1577},"obj":"protein"},{"id":"T36","span":{"begin":1617,"end":1622},"obj":"protein"},{"id":"T37","span":{"begin":1671,"end":1691},"obj":"protein"},{"id":"T38","span":{"begin":1693,"end":1698},"obj":"protein"}],"text":"Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.\nInterleukin-10 (IL-10) helps maintain polarized T-helper cells in a T-helper lymphocyte 2 (Th2) phenotype. Part of this process involves the prevention of the development of Th1 cells, which are a primary source of interferon gamma (IFNgamma), a potent activator of monocytes and an inhibitor of Th2 proliferation. Because monocytes and macrophages are important mediators of Th1-type responses, such as delayed-type hypersensitivity, we sought to determine if IL-10 could directly mediate inhibition of IFNgamma- and IFNalpha-induced gene expression in these cells. Highly purified monocytes were incubated with IL-10 for 60 to 90 minutes before the addition of IFNgamma or IFNalpha. IL-10 preincubation resulted in the inhibition of gene expression for several IFN-induced genes, such as IP-10, ISG54, and intercellular adhesion molecule-1. The reduction in gene expression resulted from the ability of IL-10 to suppress IFN-induced assembly of signal transducer and activator of transcription (STAT) factors to specific promoter motifs on IFNalpha- and IFNgamma-inducible genes. This was accomplished by preventing the IFN-induced tyrosine phosphorylation of STAT1, a component of both IFNalpha- and IFNgamma-induced DNA binding complexes. Therefore, IL-10 can directly inhibit STAT-dependent early response gene expression induced by both IFNalpha and IFNgamma in monocytes by suppressing the tyrosine phosphorylation of STAT1. This may occur through the ability of IL-10 to induce expression of the gene, suppressor of cytokine signaling 3 (SOCS3)."}

    genia-medco-coref

    {"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":0,"end":14},"obj":"NP"},{"id":"C2","span":{"begin":38,"end":96},"obj":"NP"},{"id":"C4","span":{"begin":140,"end":145},"obj":"NP"},{"id":"C3","span":{"begin":112,"end":145},"obj":"NP"},{"id":"C5","span":{"begin":147,"end":169},"obj":"NP"},{"id":"C6","span":{"begin":321,"end":330},"obj":"NP"},{"id":"C7","span":{"begin":332,"end":337},"obj":"NP"},{"id":"C8","span":{"begin":362,"end":389},"obj":"NP"},{"id":"C9","span":{"begin":413,"end":422},"obj":"NP"},{"id":"C11","span":{"begin":470,"end":479},"obj":"NP"},{"id":"C10","span":{"begin":470,"end":495},"obj":"NP"},{"id":"C12","span":{"begin":608,"end":613},"obj":"NP"},{"id":"C13","span":{"begin":701,"end":712},"obj":"NP"},{"id":"C14","span":{"begin":760,"end":765},"obj":"NP"},{"id":"C15","span":{"begin":810,"end":818},"obj":"NP"},{"id":"C16","span":{"begin":882,"end":897},"obj":"NP"},{"id":"C17","span":{"begin":1007,"end":1022},"obj":"NP"},{"id":"C18","span":{"begin":1052,"end":1057},"obj":"NP"},{"id":"C19","span":{"begin":1189,"end":1227},"obj":"NP"},{"id":"C20","span":{"begin":1309,"end":1314},"obj":"NP"},{"id":"C21","span":{"begin":1316,"end":1388},"obj":"NP"},{"id":"C22","span":{"begin":1401,"end":1406},"obj":"NP"},{"id":"C23","span":{"begin":1515,"end":1524},"obj":"NP"},{"id":"C25","span":{"begin":1572,"end":1577},"obj":"NP"},{"id":"C24","span":{"begin":1540,"end":1577},"obj":"NP"},{"id":"C26","span":{"begin":1617,"end":1622},"obj":"NP"},{"id":"C27","span":{"begin":1647,"end":1655},"obj":"NP"},{"id":"C28","span":{"begin":1657,"end":1699},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C5","obj":"C1"},{"id":"R2","pred":"coref-relat","subj":"C7","obj":"C6"},{"id":"R3","pred":"coref-ident","subj":"C11","obj":"C9"},{"id":"R4","pred":"coref-ident","subj":"C12","obj":"C5"},{"id":"R5","pred":"coref-ident","subj":"C13","obj":"C10"},{"id":"R6","pred":"coref-ident","subj":"C14","obj":"C12"},{"id":"R7","pred":"coref-ident","subj":"C15","obj":"C8"},{"id":"R8","pred":"coref-ident","subj":"C17","obj":"C16"},{"id":"R9","pred":"coref-ident","subj":"C18","obj":"C14"},{"id":"R10","pred":"coref-ident","subj":"C19","obj":"C2"},{"id":"R11","pred":"coref-ident","subj":"C20","obj":"C4"},{"id":"R12","pred":"coref-appos","subj":"C21","obj":"C20"},{"id":"R13","pred":"coref-ident","subj":"C22","obj":"C18"},{"id":"R14","pred":"coref-ident","subj":"C23","obj":"C11"},{"id":"R15","pred":"coref-ident","subj":"C25","obj":"C20"},{"id":"R16","pred":"coref-ident","subj":"C24","obj":"C3"},{"id":"R17","pred":"coref-ident","subj":"C26","obj":"C22"},{"id":"R18","pred":"coref-appos","subj":"C28","obj":"C27"}],"text":"Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.\nInterleukin-10 (IL-10) helps maintain polarized T-helper cells in a T-helper lymphocyte 2 (Th2) phenotype. Part of this process involves the prevention of the development of Th1 cells, which are a primary source of interferon gamma (IFNgamma), a potent activator of monocytes and an inhibitor of Th2 proliferation. Because monocytes and macrophages are important mediators of Th1-type responses, such as delayed-type hypersensitivity, we sought to determine if IL-10 could directly mediate inhibition of IFNgamma- and IFNalpha-induced gene expression in these cells. Highly purified monocytes were incubated with IL-10 for 60 to 90 minutes before the addition of IFNgamma or IFNalpha. IL-10 preincubation resulted in the inhibition of gene expression for several IFN-induced genes, such as IP-10, ISG54, and intercellular adhesion molecule-1. The reduction in gene expression resulted from the ability of IL-10 to suppress IFN-induced assembly of signal transducer and activator of transcription (STAT) factors to specific promoter motifs on IFNalpha- and IFNgamma-inducible genes. This was accomplished by preventing the IFN-induced tyrosine phosphorylation of STAT1, a component of both IFNalpha- and IFNgamma-induced DNA binding complexes. Therefore, IL-10 can directly inhibit STAT-dependent early response gene expression induced by both IFNalpha and IFNgamma in monocytes by suppressing the tyrosine phosphorylation of STAT1. This may occur through the ability of IL-10 to induce expression of the gene, suppressor of cytokine signaling 3 (SOCS3)."}

    pubmed-sentences-benchmark

    {"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":146},"obj":"Sentence"},{"id":"S2","span":{"begin":147,"end":253},"obj":"Sentence"},{"id":"S3","span":{"begin":254,"end":461},"obj":"Sentence"},{"id":"S4","span":{"begin":462,"end":713},"obj":"Sentence"},{"id":"S5","span":{"begin":714,"end":831},"obj":"Sentence"},{"id":"S6","span":{"begin":832,"end":989},"obj":"Sentence"},{"id":"S7","span":{"begin":990,"end":1228},"obj":"Sentence"},{"id":"S8","span":{"begin":1229,"end":1389},"obj":"Sentence"},{"id":"S9","span":{"begin":1390,"end":1578},"obj":"Sentence"},{"id":"S10","span":{"begin":1579,"end":1700},"obj":"Sentence"}],"text":"Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.\nInterleukin-10 (IL-10) helps maintain polarized T-helper cells in a T-helper lymphocyte 2 (Th2) phenotype. Part of this process involves the prevention of the development of Th1 cells, which are a primary source of interferon gamma (IFNgamma), a potent activator of monocytes and an inhibitor of Th2 proliferation. Because monocytes and macrophages are important mediators of Th1-type responses, such as delayed-type hypersensitivity, we sought to determine if IL-10 could directly mediate inhibition of IFNgamma- and IFNalpha-induced gene expression in these cells. Highly purified monocytes were incubated with IL-10 for 60 to 90 minutes before the addition of IFNgamma or IFNalpha. IL-10 preincubation resulted in the inhibition of gene expression for several IFN-induced genes, such as IP-10, ISG54, and intercellular adhesion molecule-1. The reduction in gene expression resulted from the ability of IL-10 to suppress IFN-induced assembly of signal transducer and activator of transcription (STAT) factors to specific promoter motifs on IFNalpha- and IFNgamma-inducible genes. This was accomplished by preventing the IFN-induced tyrosine phosphorylation of STAT1, a component of both IFNalpha- and IFNgamma-induced DNA binding complexes. Therefore, IL-10 can directly inhibit STAT-dependent early response gene expression induced by both IFNalpha and IFNgamma in monocytes by suppressing the tyrosine phosphorylation of STAT1. This may occur through the ability of IL-10 to induce expression of the gene, suppressor of cytokine signaling 3 (SOCS3)."}

    GENIAcorpus

    {"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":0,"end":14},"obj":"protein_molecule"},{"id":"T2","span":{"begin":140,"end":145},"obj":"protein_molecule"},{"id":"T3","span":{"begin":147,"end":161},"obj":"protein_molecule"},{"id":"T4","span":{"begin":163,"end":168},"obj":"protein_molecule"},{"id":"T5","span":{"begin":185,"end":209},"obj":"cell_type"},{"id":"T6","span":{"begin":215,"end":252},"obj":"cell_type"},{"id":"T7","span":{"begin":321,"end":330},"obj":"cell_type"},{"id":"T8","span":{"begin":362,"end":378},"obj":"protein_molecule"},{"id":"T9","span":{"begin":380,"end":388},"obj":"protein_molecule"},{"id":"T10","span":{"begin":413,"end":422},"obj":"cell_type"},{"id":"T11","span":{"begin":443,"end":460},"obj":"other_name"},{"id":"T12","span":{"begin":470,"end":479},"obj":"cell_type"},{"id":"T13","span":{"begin":523,"end":541},"obj":"other_name"},{"id":"T14","span":{"begin":551,"end":580},"obj":"other_name"},{"id":"T15","span":{"begin":608,"end":613},"obj":"protein_molecule"},{"id":"T16","span":{"begin":730,"end":739},"obj":"cell_type"},{"id":"T17","span":{"begin":760,"end":765},"obj":"protein_molecule"},{"id":"T18","span":{"begin":810,"end":818},"obj":"protein_molecule"},{"id":"T19","span":{"begin":822,"end":830},"obj":"protein_molecule"},{"id":"T20","span":{"begin":832,"end":837},"obj":"protein_molecule"},{"id":"T21","span":{"begin":882,"end":897},"obj":"other_name"},{"id":"T22","span":{"begin":910,"end":927},"obj":"DNA_family_or_group"},{"id":"T23","span":{"begin":937,"end":942},"obj":"protein_molecule"},{"id":"T24","span":{"begin":944,"end":949},"obj":"protein_molecule"},{"id":"T25","span":{"begin":955,"end":988},"obj":"protein_molecule"},{"id":"T26","span":{"begin":1007,"end":1022},"obj":"other_name"},{"id":"T27","span":{"begin":1052,"end":1057},"obj":"protein_molecule"},{"id":"T28","span":{"begin":1070,"end":1073},"obj":"protein_family_or_group"},{"id":"T29","span":{"begin":1094,"end":1157},"obj":"protein_family_or_group"},{"id":"T30","span":{"begin":1161,"end":1185},"obj":"DNA_family_or_group"},{"id":"T31","span":{"begin":1269,"end":1280},"obj":"other_name"},{"id":"T32","span":{"begin":1281,"end":1289},"obj":"amino_acid_monomer"},{"id":"T33","span":{"begin":1309,"end":1314},"obj":"protein_molecule"},{"id":"T34","span":{"begin":1401,"end":1406},"obj":"protein_molecule"},{"id":"T35","span":{"begin":1428,"end":1462},"obj":"DNA_domain_or_region"},{"id":"T36","span":{"begin":1490,"end":1498},"obj":"protein_molecule"},{"id":"T37","span":{"begin":1503,"end":1511},"obj":"protein_molecule"},{"id":"T38","span":{"begin":1515,"end":1524},"obj":"cell_type"},{"id":"T39","span":{"begin":1544,"end":1552},"obj":"amino_acid_monomer"},{"id":"T40","span":{"begin":1572,"end":1577},"obj":"protein_molecule"},{"id":"T41","span":{"begin":1617,"end":1622},"obj":"protein_molecule"},{"id":"T42","span":{"begin":1671,"end":1691},"obj":"protein_molecule"},{"id":"T43","span":{"begin":1693,"end":1698},"obj":"protein_molecule"}],"text":"Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.\nInterleukin-10 (IL-10) helps maintain polarized T-helper cells in a T-helper lymphocyte 2 (Th2) phenotype. Part of this process involves the prevention of the development of Th1 cells, which are a primary source of interferon gamma (IFNgamma), a potent activator of monocytes and an inhibitor of Th2 proliferation. Because monocytes and macrophages are important mediators of Th1-type responses, such as delayed-type hypersensitivity, we sought to determine if IL-10 could directly mediate inhibition of IFNgamma- and IFNalpha-induced gene expression in these cells. Highly purified monocytes were incubated with IL-10 for 60 to 90 minutes before the addition of IFNgamma or IFNalpha. IL-10 preincubation resulted in the inhibition of gene expression for several IFN-induced genes, such as IP-10, ISG54, and intercellular adhesion molecule-1. The reduction in gene expression resulted from the ability of IL-10 to suppress IFN-induced assembly of signal transducer and activator of transcription (STAT) factors to specific promoter motifs on IFNalpha- and IFNgamma-inducible genes. This was accomplished by preventing the IFN-induced tyrosine phosphorylation of STAT1, a component of both IFNalpha- and IFNgamma-induced DNA binding complexes. Therefore, IL-10 can directly inhibit STAT-dependent early response gene expression induced by both IFNalpha and IFNgamma in monocytes by suppressing the tyrosine phosphorylation of STAT1. This may occur through the ability of IL-10 to induce expression of the gene, suppressor of cytokine signaling 3 (SOCS3)."}