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PubMed:10029571 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-14 protein denotes Interleukin-10
T2 43-96 DNA denotes interferon alpha- and interferon gamma- induced genes
T3 140-145 protein denotes STAT1
T4 147-161 protein denotes Interleukin-10
T5 163-168 protein denotes IL-10
T6 185-209 cell_type denotes polarized T-helper cells
T7 215-252 cell_type denotes T-helper lymphocyte 2 (Th2) phenotype
T8 321-330 cell_type denotes Th1 cells
T9 362-378 protein denotes interferon gamma
T10 380-388 protein denotes IFNgamma
T11 413-422 cell_type denotes monocytes
T12 470-479 cell_type denotes monocytes
T13 608-613 protein denotes IL-10
T14 730-739 cell_type denotes monocytes
T15 760-765 protein denotes IL-10
T16 810-818 protein denotes IFNgamma
T17 822-830 protein denotes IFNalpha
T18 832-837 protein denotes IL-10
T19 910-927 DNA denotes IFN-induced genes
T20 937-942 protein denotes IP-10
T21 944-949 protein denotes ISG54
T22 955-988 protein denotes intercellular adhesion molecule-1
T23 1052-1057 protein denotes IL-10
T24 1070-1073 protein denotes IFN
T25 1094-1157 protein denotes signal transducer and activator of transcription (STAT) factors
T26 1161-1185 DNA denotes specific promoter motifs
T27 1189-1227 DNA denotes IFNalpha- and IFNgamma-inducible genes
T28 1309-1314 protein denotes STAT1
T29 1336-1388 protein denotes IFNalpha- and IFNgamma-induced DNA binding complexes
T30 1401-1406 protein denotes IL-10
T31 1428-1462 DNA denotes STAT-dependent early response gene
T32 1490-1498 protein denotes IFNalpha
T33 1503-1511 protein denotes IFNgamma
T34 1515-1524 cell_type denotes monocytes
T35 1572-1577 protein denotes STAT1
T36 1617-1622 protein denotes IL-10
T37 1671-1691 protein denotes cytokine signaling 3
T38 1693-1698 protein denotes SOCS3

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-14 NP denotes Interleukin-10
C2 38-96 NP denotes both interferon alpha- and interferon gamma- induced genes
C4 140-145 NP denotes STAT1
C3 112-145 NP denotes tyrosine phosphorylation of STAT1
C5 147-169 NP denotes Interleukin-10 (IL-10)
C6 321-330 NP denotes Th1 cells
C7 332-337 NP denotes which
C8 362-389 NP denotes interferon gamma (IFNgamma)
C9 413-422 NP denotes monocytes
C11 470-479 NP denotes monocytes
C10 470-495 NP denotes monocytes and macrophages
C12 608-613 NP denotes IL-10
C13 701-712 NP denotes these cells
C14 760-765 NP denotes IL-10
C15 810-818 NP denotes IFNgamma
C16 882-897 NP denotes gene expression
C17 1007-1022 NP denotes gene expression
C18 1052-1057 NP denotes IL-10
C19 1189-1227 NP denotes IFNalpha- and IFNgamma-inducible genes
C20 1309-1314 NP denotes STAT1
C21 1316-1388 NP denotes a component of both IFNalpha- and IFNgamma-induced DNA binding complexes
C22 1401-1406 NP denotes IL-10
C23 1515-1524 NP denotes monocytes
C25 1572-1577 NP denotes STAT1
C24 1540-1577 NP denotes the tyrosine phosphorylation of STAT1
C26 1617-1622 NP denotes IL-10
C27 1647-1655 NP denotes the gene
C28 1657-1699 NP denotes suppressor of cytokine signaling 3 (SOCS3)
R1 C5 C1 coref-ident Interleukin-10 (IL-10),Interleukin-10
R2 C7 C6 coref-relat which,Th1 cells
R3 C11 C9 coref-ident monocytes,monocytes
R4 C12 C5 coref-ident IL-10,Interleukin-10 (IL-10)
R5 C13 C10 coref-ident these cells,monocytes and macrophages
R6 C14 C12 coref-ident IL-10,IL-10
R7 C15 C8 coref-ident IFNgamma,interferon gamma (IFNgamma)
R8 C17 C16 coref-ident gene expression,gene expression
R9 C18 C14 coref-ident IL-10,IL-10
R10 C19 C2 coref-ident IFNalpha- and IFNgamma-inducible genes,both interferon alpha- and interferon gamma- induced genes
R11 C20 C4 coref-ident STAT1,STAT1
R12 C21 C20 coref-appos a component of both IFNalpha- and IFNgamma-induced DNA binding complexes,STAT1
R13 C22 C18 coref-ident IL-10,IL-10
R14 C23 C11 coref-ident monocytes,monocytes
R15 C25 C20 coref-ident STAT1,STAT1
R16 C24 C3 coref-ident the tyrosine phosphorylation of STAT1,tyrosine phosphorylation of STAT1
R17 C26 C22 coref-ident IL-10,IL-10
R18 C28 C27 coref-appos suppressor of cytokine signaling 3 (SOCS3),the gene

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-146 Sentence denotes Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1.
S2 147-253 Sentence denotes Interleukin-10 (IL-10) helps maintain polarized T-helper cells in a T-helper lymphocyte 2 (Th2) phenotype.
S3 254-461 Sentence denotes Part of this process involves the prevention of the development of Th1 cells, which are a primary source of interferon gamma (IFNgamma), a potent activator of monocytes and an inhibitor of Th2 proliferation.
S4 462-713 Sentence denotes Because monocytes and macrophages are important mediators of Th1-type responses, such as delayed-type hypersensitivity, we sought to determine if IL-10 could directly mediate inhibition of IFNgamma- and IFNalpha-induced gene expression in these cells.
S5 714-831 Sentence denotes Highly purified monocytes were incubated with IL-10 for 60 to 90 minutes before the addition of IFNgamma or IFNalpha.
S6 832-989 Sentence denotes IL-10 preincubation resulted in the inhibition of gene expression for several IFN-induced genes, such as IP-10, ISG54, and intercellular adhesion molecule-1.
S7 990-1228 Sentence denotes The reduction in gene expression resulted from the ability of IL-10 to suppress IFN-induced assembly of signal transducer and activator of transcription (STAT) factors to specific promoter motifs on IFNalpha- and IFNgamma-inducible genes.
S8 1229-1389 Sentence denotes This was accomplished by preventing the IFN-induced tyrosine phosphorylation of STAT1, a component of both IFNalpha- and IFNgamma-induced DNA binding complexes.
S9 1390-1578 Sentence denotes Therefore, IL-10 can directly inhibit STAT-dependent early response gene expression induced by both IFNalpha and IFNgamma in monocytes by suppressing the tyrosine phosphorylation of STAT1.
S10 1579-1700 Sentence denotes This may occur through the ability of IL-10 to induce expression of the gene, suppressor of cytokine signaling 3 (SOCS3).

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-14 protein_molecule denotes Interleukin-10
T2 140-145 protein_molecule denotes STAT1
T3 147-161 protein_molecule denotes Interleukin-10
T4 163-168 protein_molecule denotes IL-10
T5 185-209 cell_type denotes polarized T-helper cells
T6 215-252 cell_type denotes T-helper lymphocyte 2 (Th2) phenotype
T7 321-330 cell_type denotes Th1 cells
T8 362-378 protein_molecule denotes interferon gamma
T9 380-388 protein_molecule denotes IFNgamma
T10 413-422 cell_type denotes monocytes
T11 443-460 other_name denotes Th2 proliferation
T12 470-479 cell_type denotes monocytes
T13 523-541 other_name denotes Th1-type responses
T14 551-580 other_name denotes delayed-type hypersensitivity
T15 608-613 protein_molecule denotes IL-10
T16 730-739 cell_type denotes monocytes
T17 760-765 protein_molecule denotes IL-10
T18 810-818 protein_molecule denotes IFNgamma
T19 822-830 protein_molecule denotes IFNalpha
T20 832-837 protein_molecule denotes IL-10
T21 882-897 other_name denotes gene expression
T22 910-927 DNA_family_or_group denotes IFN-induced genes
T23 937-942 protein_molecule denotes IP-10
T24 944-949 protein_molecule denotes ISG54
T25 955-988 protein_molecule denotes intercellular adhesion molecule-1
T26 1007-1022 other_name denotes gene expression
T27 1052-1057 protein_molecule denotes IL-10
T28 1070-1073 protein_family_or_group denotes IFN
T29 1094-1157 protein_family_or_group denotes signal transducer and activator of transcription (STAT) factors
T30 1161-1185 DNA_family_or_group denotes specific promoter motifs
T31 1269-1280 other_name denotes IFN-induced
T32 1281-1289 amino_acid_monomer denotes tyrosine
T33 1309-1314 protein_molecule denotes STAT1
T34 1401-1406 protein_molecule denotes IL-10
T35 1428-1462 DNA_domain_or_region denotes STAT-dependent early response gene
T36 1490-1498 protein_molecule denotes IFNalpha
T37 1503-1511 protein_molecule denotes IFNgamma
T38 1515-1524 cell_type denotes monocytes
T39 1544-1552 amino_acid_monomer denotes tyrosine
T40 1572-1577 protein_molecule denotes STAT1
T41 1617-1622 protein_molecule denotes IL-10
T42 1671-1691 protein_molecule denotes cytokine signaling 3
T43 1693-1698 protein_molecule denotes SOCS3