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PubMed:10026226 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-96 Sentence denotes Skeletal muscle type ryanodine receptor is involved in calcium signaling in human B lymphocytes.
T2 97-362 Sentence denotes The regulation of intracellular free Ca2+ concentration ([Ca2+]i) in B cells remains poorly understood and is presently explained almost solely by inositol 1,4,5-triphosphate (IP3)-mediated Ca2+ release, followed by activation of a store-operated channel mechanism.
T3 363-482 Sentence denotes In fact, there are reports indicating that IP3 production does not always correlate with the magnitude of Ca2+ release.
T4 483-673 Sentence denotes We demonstrate here that human B cells express a ryanodine receptor (RYR) that functions as a Ca2+ release channel during the B cell antigen receptor (BCR)-stimulated Ca2+ signaling process.
T5 674-874 Sentence denotes Immunoblotting studies showed that both human primary CD19(+) B and DAKIKI cells express a 565-kDa immunoreactive protein that is indistinguishable in molecular size and immunoreactivity from the RYR.
T6 875-1146 Sentence denotes Selective reverse transcription-polymerase chain reaction, restriction fragment length polymorphism, and sequencing of cloned cDNA indicated that the major isoform of the RYR expressed in primary CD19(+) B and DAKIKI cells is identical to the skeletal muscle type (RYR1).
T7 1147-1262 Sentence denotes Saturation analysis of [3H]ryanodine binding yielded Bmax = 150 fmol/mg of protein and Kd = 110 nM in DAKIKI cells.
T8 1263-1493 Sentence denotes In fluo-3-loaded CD19(+) B and DAKIKI cells, 4-chloro-m-cresol, a potent activator of Ca2+ release mediated by the ryanodine-sensitive Ca2+ release channel, induced Ca2+ release in a dose-dependent and ryanodine-sensitive fashion.
T9 1494-1613 Sentence denotes Furthermore, BCR-mediated Ca2+ release in CD19(+) B cells was significantly altered by 4-chloro-m-cresol and ryanodine.
T10 1614-1867 Sentence denotes These results indicate that RYR1 functions as a Ca2+ release channel during BCR-stimulated Ca2+ signaling and suggest that complex Ca2+ signals that control the cellular activities of B cells may be generated by cooperation of the IP3 receptor and RYR1.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 0-15 http://purl.obolibrary.org/obo/MAT_0000302 denotes Skeletal muscle
T2 9-15 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T3 1118-1133 http://purl.obolibrary.org/obo/MAT_0000302 denotes skeletal muscle
T4 1127-1133 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 0-39 protein denotes Skeletal muscle type ryanodine receptor
T2 532-550 protein denotes ryanodine receptor
T3 552-555 protein denotes RYR
T4 609-632 protein denotes B cell antigen receptor
T5 634-637 protein denotes BCR
T6 728-732 protein denotes CD19
T7 870-873 protein denotes RYR
T8 1046-1049 protein denotes RYR
T9 1071-1075 protein denotes CD19
T10 1118-1138 protein denotes skeletal muscle type
T11 1140-1144 protein denotes RYR1
T12 1280-1284 protein denotes CD19
T13 1507-1510 protein denotes BCR
T14 1536-1540 protein denotes CD19
T15 1642-1646 protein denotes RYR1
T16 1690-1693 protein denotes BCR
T17 1845-1857 protein denotes IP3 receptor
T18 1862-1866 protein denotes RYR1

bionlp-st-gro-2013-training

Id Subject Object Predicate Lexical cue
T3 55-62 Ion denotes calcium
T5 76-81 Eukaryote denotes human
T6 82-95 Cell denotes B lymphocytes
T8 134-138 Ion denotes Ca2+
T9 166-173 Cell denotes B cells
T11 273-276 Chemical denotes IP3
T13 287-291 Ion denotes Ca2+
T17 508-513 Eukaryote denotes human
T18 514-521 Cell denotes B cells
T21 552-555 Protein denotes RYR
T22 577-581 Ion denotes Ca2+
T24 590-597 Protein denotes channel
T26 634-637 Protein denotes BCR
T28 650-654 Ion denotes Ca2+
T30 714-719 Eukaryote denotes human
T31 720-737 Cell denotes primary CD19(+) B
T32 742-754 Cell denotes DAKIKI cells
T34 788-795 Protein denotes protein
T35 870-873 Protein denotes RYR
T36 1046-1049 Protein denotes RYR
T38 1063-1080 Cell denotes primary CD19(+) B
T39 1085-1097 Cell denotes DAKIKI cells
T40 1118-1138 Tissue denotes skeletal muscle type
T41 1140-1144 Protein denotes RYR1
T42 1170-1183 Chemical denotes [3H]ryanodine
T43 1222-1229 Protein denotes protein
T44 1249-1261 Cell denotes DAKIKI cells
T45 1280-1289 Cell denotes CD19(+) B
T46 1294-1306 Cell denotes DAKIKI cells
T47 1308-1325 Chemical denotes 4-chloro-m-cresol
T49 1349-1353 Ion denotes Ca2+
T52 1378-1387 Chemical denotes ryanodine
T53 1398-1402 Ion denotes Ca2+
T55 1411-1418 Protein denotes channel
T57 1428-1432 Ion denotes Ca2+
T59 1465-1474 Chemical denotes ryanodine
T60 1507-1510 Protein denotes BCR
T62 1520-1524 Ion denotes Ca2+
T64 1536-1551 Cell denotes CD19(+) B cells
T66 1581-1598 Chemical denotes 4-chloro-m-cresol
T67 1603-1612 Chemical denotes ryanodine
T68 1642-1646 Protein denotes RYR1
T69 1662-1666 Ion denotes Ca2+
T71 1675-1682 Protein denotes channel
T72 1690-1693 Protein denotes BCR
T74 1705-1709 Ion denotes Ca2+
T76 1745-1749 Ion denotes Ca2+
T78 1798-1805 Cell denotes B cells
T80 1845-1857 Protein denotes IP3 receptor
T81 1862-1866 Protein denotes RYR1
T1 0-39 Protein denotes Skeletal muscle type ryanodine receptor
T10 406-409 Chemical denotes IP3
T82 469-473 Ion denotes Ca2+
E1 63-72 SignalingPathway denotes signaling
E2 278-286 RegulatoryProcess denotes mediated
E3 292-299 Transport denotes release
E4 313-323 PositiveRegulation denotes activation
E5 329-361 Transport denotes store-operated channel mechanism
E6 522-529 GeneExpression denotes express
E7 582-589 Transport denotes release
E8 639-649 Increase denotes stimulated
E9 655-672 SignalingPathway denotes signaling process
E10 755-762 GeneExpression denotes express
E11 1050-1059 GeneExpression denotes expressed
E12 1336-1345 PositiveRegulation denotes activator
E13 1354-1361 Transport denotes release
E14 1362-1370 RegulatoryProcess denotes mediated
E15 1403-1410 Transport denotes release
E16 1420-1427 PositiveRegulation denotes induced
E17 1433-1440 Transport denotes release
E18 1511-1519 RegulatoryProcess denotes mediated
E19 1525-1532 Transport denotes release
E20 1570-1577 Affecting denotes altered
E21 1667-1674 Transport denotes release
E22 1694-1704 Increase denotes stimulated
E23 1710-1719 SignalingPathway denotes signaling
E24 1763-1770 RegulatoryProcess denotes control
E26 101-111 RegulatoryProcess denotes regulation
E27 474-481 Transport denotes release
E25 1570-1577 Affecting denotes altered
E28 1763-1770 RegulatoryProcess denotes control
R2 E1 T6 locatedIn signaling,B lymphocytes
R3 T6 T5 fromSpecies B lymphocytes,human
R5 E3 E4 precedes release,activation
R6 T18 T17 fromSpecies B cells,human
R7 E6 T18 locatedIn express,B cells
R8 T31 T30 fromSpecies primary CD19(+) B,human
R9 E10 T31 locatedIn express,primary CD19(+) B
R10 E10 T32 locatedIn express,DAKIKI cells
R11 E11 T38 locatedIn expressed,primary CD19(+) B
R12 E11 T39 locatedIn expressed,DAKIKI cells
R14 E19 T64 locatedIn release,CD19(+) B cells
R1 T8 T9 locatedIn Ca2+,B cells
R4 T41 T40 locatedIn RYR1,skeletal muscle type
R13 T43 T44 locatedIn protein,DAKIKI cells
R15 T11 E2 hasAgent IP3,mediated
R16 E3 E2 hasPatient release,mediated
R17 T13 E3 hasPatient Ca2+,release
R18 E5 E4 hasPatient store-operated channel mechanism,activation
R19 T21 E6 hasPatient RYR,express
R20 T24 E7 hasAgent channel,release
R21 T22 E7 hasPatient Ca2+,release
R22 T26 E8 hasAgent BCR,stimulated
R23 E9 E8 hasPatient signaling process,stimulated
R24 T34 E10 hasPatient protein,express
R25 T36 E11 hasPatient RYR,expressed
R26 T47 E12 hasAgent 4-chloro-m-cresol,activator
R27 E13 E12 hasPatient release,activator
R28 T49 E13 hasPatient Ca2+,release
R29 T55 E14 hasAgent channel,mediated
R30 E13 E14 hasPatient release,mediated
R31 T55 E15 hasAgent channel,release
R32 T53 E15 hasPatient Ca2+,release
R33 E17 E16 hasPatient release,induced
R34 T57 E17 hasPatient Ca2+,release
R35 T60 E18 hasAgent BCR,mediated
R36 E19 E18 hasPatient release,mediated
R37 T62 E19 hasPatient Ca2+,release
R38 T66 E20 hasAgent 4-chloro-m-cresol,altered
R39 E19 E20 hasPatient release,altered
R40 T71 E21 hasAgent channel,release
R41 T69 E21 hasPatient Ca2+,release
R42 T72 E22 hasAgent BCR,stimulated
R43 E23 E22 hasPatient signaling,stimulated
R44 T74 E23 hasPatient Ca2+,signaling
R45 T80 E24 hasAgent IP3 receptor,control
R46 T82 E27 hasPatient Ca2+,release
R47 T67 E25 hasAgent ryanodine,altered
R48 E19 E25 hasPatient release,altered
R49 T81 E28 hasAgent RYR1,control

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 0-15 Body_part denotes Skeletal muscle http://purl.obolibrary.org/obo/MAT_0000302
T2 1118-1133 Body_part denotes skeletal muscle http://purl.obolibrary.org/obo/MAT_0000302

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 76-81 OrganismTaxon denotes human 9606
T2 508-513 OrganismTaxon denotes human 9606
T3 714-719 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-15 Body_part denotes Skeletal muscle http://purl.obolibrary.org/obo/UBERON_0001134|http://purl.obolibrary.org/obo/UBERON_0014892|http://purl.obolibrary.org/obo/UBERON_0014895
T4 82-95 Body_part denotes B lymphocytes http://purl.obolibrary.org/obo/CL_0000236
T5 115-128 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T6 609-615 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T7 1118-1133 Body_part denotes skeletal muscle http://purl.obolibrary.org/obo/UBERON_0001134|http://purl.obolibrary.org/obo/UBERON_0014892|http://purl.obolibrary.org/obo/UBERON_0014895

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 82-95 Cell denotes B lymphocytes http://purl.obolibrary.org/obo/CL:0000236
T2 166-173 Cell denotes B cells http://purl.obolibrary.org/obo/CL:0000236
T3 514-521 Cell denotes B cells http://purl.obolibrary.org/obo/CL:0000236
T4 609-615 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T5 1536-1551 Cell denotes CD19(+) B cells http://purl.obolibrary.org/obo/CL:0001201
T6 1798-1805 Cell denotes B cells http://purl.obolibrary.org/obo/CL:0000236