PubMed:10026210 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10026210","sourcedb":"PubMed","sourceid":"10026210","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10026210","text":"A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho.\nSmall GTP-binding proteins of the Rho family play a critical role in signal transduction. However, there is still very limited information on how they are activated by cell surface receptors. Here, we used a consensus sequence for Dbl domains of Rho guanine nucleotide exchange factors (GEFs) to search DNA data bases, and identified a novel human GEF for Rho-related GTPases harboring structural features indicative of its possible regulatory mechanism(s). This protein contained a tandem DH/PH domain closely related to those of Rho-specific GEFs, a PDZ domain, a proline-rich domain, and an area of homology to Lsc, p115-RhoGEF, and a Drosophila RhoGEF that was termed Lsc-homology (LH) domain. This novel molecule, designated PDZ-RhoGEF, activated biological and biochemical pathways specific for Rho, and activation of these pathways required an intact DH and PH domain. However, the PDZ domain was dispensable for these functions, and mutants lacking the LH domain were more active, suggesting a negative regulatory role for the LH domain. A search for additional molecules exhibiting an LH domain revealed a limited homology with the catalytic region of a newly identified GTPase-activating protein for heterotrimeric G proteins, RGS14. This prompted us to investigate whether PDZ-RhoGEF could interact with representative members of each G protein family. We found that PDZ-RhoGEF was able to form, in vivo, stable complexes with two members of the Galpha12 family, Galpha12 and Galpha13, and that this interaction was mediated by the LH domain. Furthermore, we obtained evidence to suggest that PDZ-RhoGEF mediates the activation of Rho by Galpha12 and Galpha13. Together, these findings suggest the existence of a novel mechanism whereby the large family of cell surface receptors that transmit signals through heterotrimeric G proteins activate Rho-dependent pathways: by stimulating the activity of members of the Galpha12 family which, in turn, activate an exchange factor acting on Rho.","tracks":[{"project":"bionlp-st-gro-2013-training","denotations":[{"id":"T1","span":{"begin":8,"end":18},"obj":"ProteinDomain"},{"id":"T4","span":{"begin":71,"end":96},"obj":"Protein"},{"id":"T5","span":{"begin":100,"end":103},"obj":"Protein"},{"id":"T9","span":{"begin":139,"end":142},"obj":"Protein"},{"id":"T12","span":{"begin":273,"end":285},"obj":"CellComponent"},{"id":"T13","span":{"begin":286,"end":295},"obj":"Protein"},{"id":"T14","span":{"begin":336,"end":347},"obj":"ProteinDomain"},{"id":"T15","span":{"begin":351,"end":390},"obj":"Protein"},{"id":"T16","span":{"begin":392,"end":396},"obj":"Protein"},{"id":"T17","span":{"begin":408,"end":411},"obj":"DNA"},{"id":"T18","span":{"begin":447,"end":452},"obj":"Eukaryote"},{"id":"T19","span":{"begin":453,"end":456},"obj":"Protein"},{"id":"T20","span":{"begin":461,"end":464},"obj":"Protein"},{"id":"T21","span":{"begin":473,"end":480},"obj":"Enzyme"},{"id":"T22","span":{"begin":568,"end":575},"obj":"Protein"},{"id":"T23","span":{"begin":595,"end":607},"obj":"ProteinDomain"},{"id":"T24","span":{"begin":636,"end":639},"obj":"Protein"},{"id":"T25","span":{"begin":649,"end":653},"obj":"Protein"},{"id":"T26","span":{"begin":657,"end":667},"obj":"ProteinDomain"},{"id":"T27","span":{"begin":671,"end":690},"obj":"ProteinDomain"},{"id":"T28","span":{"begin":719,"end":722},"obj":"Protein"},{"id":"T29","span":{"begin":724,"end":735},"obj":"Protein"},{"id":"T30","span":{"begin":743,"end":753},"obj":"Eukaryote"},{"id":"T31","span":{"begin":754,"end":760},"obj":"Protein"},{"id":"T32","span":{"begin":791,"end":793},"obj":"ProteinDomain"},{"id":"T33","span":{"begin":835,"end":845},"obj":"Protein"},{"id":"T35","span":{"begin":906,"end":909},"obj":"Protein"},{"id":"T37","span":{"begin":963,"end":965},"obj":"ProteinDomain"},{"id":"T38","span":{"begin":970,"end":979},"obj":"ProteinDomain"},{"id":"T39","span":{"begin":994,"end":1004},"obj":"ProteinDomain"},{"id":"T40","span":{"begin":1046,"end":1053},"obj":"MutantProtein"},{"id":"T41","span":{"begin":1066,"end":1075},"obj":"ProteinDomain"},{"id":"T44","span":{"begin":1140,"end":1149},"obj":"ProteinDomain"},{"id":"T45","span":{"begin":1199,"end":1208},"obj":"ProteinDomain"},{"id":"T49","span":{"begin":1315,"end":1340},"obj":"Protein"},{"id":"T50","span":{"begin":1342,"end":1347},"obj":"Protein"},{"id":"T51","span":{"begin":1389,"end":1399},"obj":"Protein"},{"id":"T53","span":{"begin":1451,"end":1460},"obj":"Protein"},{"id":"T54","span":{"begin":1483,"end":1493},"obj":"Protein"},{"id":"T55","span":{"begin":1562,"end":1570},"obj":"Protein"},{"id":"T56","span":{"begin":1579,"end":1587},"obj":"Protein"},{"id":"T57","span":{"begin":1592,"end":1600},"obj":"Protein"},{"id":"T60","span":{"begin":1648,"end":1657},"obj":"ProteinDomain"},{"id":"T61","span":{"begin":1709,"end":1719},"obj":"Protein"},{"id":"T64","span":{"begin":1747,"end":1750},"obj":"Protein"},{"id":"T65","span":{"begin":1754,"end":1762},"obj":"Protein"},{"id":"T66","span":{"begin":1767,"end":1775},"obj":"Protein"},{"id":"T67","span":{"begin":1873,"end":1885},"obj":"CellComponent"},{"id":"T68","span":{"begin":1886,"end":1895},"obj":"Protein"},{"id":"T69","span":{"begin":1926,"end":1951},"obj":"Protein"},{"id":"T73","span":{"begin":2031,"end":2039},"obj":"Protein"},{"id":"T76","span":{"begin":2101,"end":2104},"obj":"Protein"},{"id":"T2","span":{"begin":30,"end":64},"obj":"Protein"},{"id":"T3","span":{"begin":105,"end":131},"obj":"Protein"},{"id":"T6","span":{"begin":699,"end":703},"obj":"ProteinDomain"},{"id":"T43","span":{"begin":1285,"end":1310},"obj":"Protein"},{"id":"T46","span":{"begin":1528,"end":1537},"obj":"ProteinComplex"},{"id":"T71","span":{"begin":2075,"end":2090},"obj":"Protein"},{"id":"E2","span":{"begin":174,"end":193},"obj":"SignalingPathway"},{"id":"E3","span":{"begin":260,"end":269},"obj":"PositiveRegulation"},{"id":"E4","span":{"begin":847,"end":856},"obj":"PositiveRegulation"},{"id":"E5","span":{"begin":915,"end":925},"obj":"PositiveRegulation"},{"id":"E8","span":{"begin":1406,"end":1414},"obj":"BindingToProtein"},{"id":"E9","span":{"begin":1616,"end":1627},"obj":"BindingToProtein"},{"id":"E10","span":{"begin":1632,"end":1640},"obj":"RegulatoryProcess"},{"id":"E11","span":{"begin":1720,"end":1728},"obj":"RegulatoryProcess"},{"id":"E12","span":{"begin":1733,"end":1743},"obj":"PositiveRegulation"},{"id":"E13","span":{"begin":1952,"end":1960},"obj":"PositiveRegulation"},{"id":"E14","span":{"begin":1988,"end":1999},"obj":"Increase"},{"id":"E15","span":{"begin":2063,"end":2071},"obj":"PositiveRegulation"},{"id":"E1","span":{"begin":857,"end":892},"obj":"Pathway"},{"id":"E6","span":{"begin":1107,"end":1126},"obj":"NegativeRegulation"},{"id":"E16","span":{"begin":935,"end":943},"obj":"Pathway"},{"id":"E7","span":{"begin":1901,"end":1917},"obj":"SignalingPathway"},{"id":"E17","span":{"begin":1961,"end":1983},"obj":"SignalingPathway"},{"id":"E18","span":{"begin":1733,"end":1743},"obj":"PositiveRegulation"},{"id":"E19","span":{"begin":1720,"end":1728},"obj":"RegulatoryProcess"}],"relations":[{"id":"R1","pred":"locatedIn","subj":"T13","obj":"T12"},{"id":"R3","pred":"fromSpecies","subj":"T19","obj":"T18"},{"id":"R6","pred":"hasPart","subj":"T22","obj":"T23"},{"id":"R7","pred":"hasPart","subj":"T22","obj":"T26"},{"id":"R8","pred":"hasPart","subj":"T22","obj":"T27"},{"id":"R9","pred":"fromSpecies","subj":"T31","obj":"T30"},{"id":"R10","pred":"locatedIn","subj":"T68","obj":"T67"},{"id":"R13","pred":"hasPart","subj":"T2","obj":"T1"},{"id":"R2","pred":"hasPart","subj":"T15","obj":"T14"},{"id":"R4","pred":"hasPart","subj":"T22","obj":"T6"},{"id":"R5","pred":"hasPart","subj":"T46","obj":"T54"},{"id":"R14","pred":"hasPart","subj":"T46","obj":"T56"},{"id":"R15","pred":"hasPart","subj":"T46","obj":"T57"},{"id":"R17","pred":"hasAgent","subj":"T13","obj":"E3"},{"id":"R18","pred":"hasAgent","subj":"T33","obj":"E4"},{"id":"R19","pred":"hasPatient","subj":"E1","obj":"E4"},{"id":"R20","pred":"hasPatient","subj":"E16","obj":"E5"},{"id":"R21","pred":"hasPatient","subj":"T53","obj":"E8"},{"id":"R22","pred":"hasPatient","subj":"T51","obj":"E8"},{"id":"R23","pred":"hasAgent","subj":"T60","obj":"E10"},{"id":"R24","pred":"hasPatient","subj":"E9","obj":"E10"},{"id":"R25","pred":"hasAgent","subj":"T61","obj":"E11"},{"id":"R26","pred":"hasPatient","subj":"E12","obj":"E11"},{"id":"R27","pred":"hasAgent","subj":"T65","obj":"E12"},{"id":"R28","pred":"hasPatient","subj":"T64","obj":"E12"},{"id":"R29","pred":"hasAgent","subj":"T68","obj":"E13"},{"id":"R30","pred":"hasPatient","subj":"E17","obj":"E13"},{"id":"R31","pred":"hasPatient","subj":"T73","obj":"E14"},{"id":"R32","pred":"hasPatient","subj":"T71","obj":"E15"},{"id":"R33","pred":"hasPatient","subj":"T35","obj":"E1"},{"id":"R34","pred":"hasAgent","subj":"T44","obj":"E6"},{"id":"R35","pred":"hasAgent","subj":"T69","obj":"E7"},{"id":"R36","pred":"hasAgent","subj":"T66","obj":"E18"},{"id":"R37","pred":"hasPatient","subj":"T64","obj":"E18"},{"id":"R38","pred":"hasAgent","subj":"T61","obj":"E19"},{"id":"R39","pred":"hasPatient","subj":"E18","obj":"E19"}],"attributes":[{"subj":"T1","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T4","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T5","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T9","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T12","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T13","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T14","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T15","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T16","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T17","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T18","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T19","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T20","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T21","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T22","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T23","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T24","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T25","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T26","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T27","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T28","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T29","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T30","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T31","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T32","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T33","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T35","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T37","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T38","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T39","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T40","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T41","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T44","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T45","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T49","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T50","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T51","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T53","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T54","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T55","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T56","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T57","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T60","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T61","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T64","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T65","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T66","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T67","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T68","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T69","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T73","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T76","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T2","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T3","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T6","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T43","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T46","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"T71","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E2","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E3","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E4","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E5","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E8","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E9","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E10","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E11","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E12","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E13","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E14","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E15","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E1","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E6","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E16","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E7","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E17","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E18","pred":"source","obj":"bionlp-st-gro-2013-training"},{"subj":"E19","pred":"source","obj":"bionlp-st-gro-2013-training"}]},{"project":"FSU-PRGE","denotations":[{"id":"T1","span":{"begin":30,"end":64},"obj":"protein"},{"id":"T2","span":{"begin":71,"end":96},"obj":"protein"},{"id":"T3","span":{"begin":100,"end":103},"obj":"protein"},{"id":"T4","span":{"begin":105,"end":149},"obj":"protein"},{"id":"T5","span":{"begin":336,"end":339},"obj":"protein"},{"id":"T6","span":{"begin":351,"end":390},"obj":"protein"},{"id":"T7","span":{"begin":392,"end":396},"obj":"protein"},{"id":"T8","span":{"begin":453,"end":456},"obj":"protein"},{"id":"T9","span":{"begin":461,"end":464},"obj":"protein"},{"id":"T10","span":{"begin":473,"end":480},"obj":"protein"},{"id":"T11","span":{"begin":636,"end":653},"obj":"protein"},{"id":"T12","span":{"begin":719,"end":722},"obj":"protein"},{"id":"T13","span":{"begin":724,"end":735},"obj":"protein"},{"id":"T14","span":{"begin":754,"end":760},"obj":"protein"},{"id":"T15","span":{"begin":777,"end":780},"obj":"protein"},{"id":"T16","span":{"begin":835,"end":845},"obj":"protein"},{"id":"T17","span":{"begin":906,"end":909},"obj":"protein"},{"id":"T18","span":{"begin":1285,"end":1310},"obj":"protein"},{"id":"T19","span":{"begin":1315,"end":1340},"obj":"protein"},{"id":"T20","span":{"begin":1342,"end":1347},"obj":"protein"},{"id":"T21","span":{"begin":1389,"end":1399},"obj":"protein"},{"id":"T22","span":{"begin":1451,"end":1467},"obj":"protein"},{"id":"T23","span":{"begin":1483,"end":1493},"obj":"protein"},{"id":"T24","span":{"begin":1562,"end":1577},"obj":"protein"},{"id":"T25","span":{"begin":1579,"end":1587},"obj":"protein"},{"id":"T26","span":{"begin":1592,"end":1600},"obj":"protein"},{"id":"T27","span":{"begin":1709,"end":1719},"obj":"protein"},{"id":"T28","span":{"begin":1747,"end":1750},"obj":"protein"},{"id":"T29","span":{"begin":1754,"end":1762},"obj":"protein"},{"id":"T30","span":{"begin":1767,"end":1775},"obj":"protein"},{"id":"T31","span":{"begin":1926,"end":1951},"obj":"protein"},{"id":"T32","span":{"begin":1961,"end":1964},"obj":"protein"},{"id":"T33","span":{"begin":2031,"end":2046},"obj":"protein"},{"id":"T34","span":{"begin":2075,"end":2090},"obj":"protein"},{"id":"T35","span":{"begin":2101,"end":2104},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"FSU-PRGE"},{"subj":"T2","pred":"source","obj":"FSU-PRGE"},{"subj":"T3","pred":"source","obj":"FSU-PRGE"},{"subj":"T4","pred":"source","obj":"FSU-PRGE"},{"subj":"T5","pred":"source","obj":"FSU-PRGE"},{"subj":"T6","pred":"source","obj":"FSU-PRGE"},{"subj":"T7","pred":"source","obj":"FSU-PRGE"},{"subj":"T8","pred":"source","obj":"FSU-PRGE"},{"subj":"T9","pred":"source","obj":"FSU-PRGE"},{"subj":"T10","pred":"source","obj":"FSU-PRGE"},{"subj":"T11","pred":"source","obj":"FSU-PRGE"},{"subj":"T12","pred":"source","obj":"FSU-PRGE"},{"subj":"T13","pred":"source","obj":"FSU-PRGE"},{"subj":"T14","pred":"source","obj":"FSU-PRGE"},{"subj":"T15","pred":"source","obj":"FSU-PRGE"},{"subj":"T16","pred":"source","obj":"FSU-PRGE"},{"subj":"T17","pred":"source","obj":"FSU-PRGE"},{"subj":"T18","pred":"source","obj":"FSU-PRGE"},{"subj":"T19","pred":"source","obj":"FSU-PRGE"},{"subj":"T20","pred":"source","obj":"FSU-PRGE"},{"subj":"T21","pred":"source","obj":"FSU-PRGE"},{"subj":"T22","pred":"source","obj":"FSU-PRGE"},{"subj":"T23","pred":"source","obj":"FSU-PRGE"},{"subj":"T24","pred":"source","obj":"FSU-PRGE"},{"subj":"T25","pred":"source","obj":"FSU-PRGE"},{"subj":"T26","pred":"source","obj":"FSU-PRGE"},{"subj":"T27","pred":"source","obj":"FSU-PRGE"},{"subj":"T28","pred":"source","obj":"FSU-PRGE"},{"subj":"T29","pred":"source","obj":"FSU-PRGE"},{"subj":"T30","pred":"source","obj":"FSU-PRGE"},{"subj":"T31","pred":"source","obj":"FSU-PRGE"},{"subj":"T32","pred":"source","obj":"FSU-PRGE"},{"subj":"T33","pred":"source","obj":"FSU-PRGE"},{"subj":"T34","pred":"source","obj":"FSU-PRGE"},{"subj":"T35","pred":"source","obj":"FSU-PRGE"}]},{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":104},"obj":"Sentence"},{"id":"T2","span":{"begin":105,"end":194},"obj":"Sentence"},{"id":"T3","span":{"begin":195,"end":296},"obj":"Sentence"},{"id":"T4","span":{"begin":297,"end":562},"obj":"Sentence"},{"id":"T5","span":{"begin":563,"end":802},"obj":"Sentence"},{"id":"T6","span":{"begin":803,"end":980},"obj":"Sentence"},{"id":"T7","span":{"begin":981,"end":1150},"obj":"Sentence"},{"id":"T8","span":{"begin":1151,"end":1348},"obj":"Sentence"},{"id":"T9","span":{"begin":1349,"end":1468},"obj":"Sentence"},{"id":"T10","span":{"begin":1469,"end":1658},"obj":"Sentence"},{"id":"T11","span":{"begin":1659,"end":1776},"obj":"Sentence"},{"id":"T12","span":{"begin":1777,"end":2105},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":447,"end":452},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":743,"end":753},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"2081351"},{"id":"A3","pred":"db_id","subj":"T2","obj":"32281"},{"id":"A4","pred":"db_id","subj":"T2","obj":"7215"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T2","pred":"source","obj":"NCBITAXON"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":392,"end":396},"obj":"Disease"},{"id":"T2","span":{"begin":649,"end":653},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0018214"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0018214"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"bionlp-st-gro-2013-training","color":"#9893ec","default":true},{"id":"FSU-PRGE","color":"#a7ec93"},{"id":"sentences","color":"#ec93c1"},{"id":"NCBITAXON","color":"#93dbec"},{"id":"mondo_disease","color":"#ece393"}]}]}}