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sentences

Id Subject Object Predicate Lexical cue
T1 0-104 Sentence denotes A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho.
T2 105-194 Sentence denotes Small GTP-binding proteins of the Rho family play a critical role in signal transduction.
T3 195-296 Sentence denotes However, there is still very limited information on how they are activated by cell surface receptors.
T4 297-562 Sentence denotes Here, we used a consensus sequence for Dbl domains of Rho guanine nucleotide exchange factors (GEFs) to search DNA data bases, and identified a novel human GEF for Rho-related GTPases harboring structural features indicative of its possible regulatory mechanism(s).
T5 563-802 Sentence denotes This protein contained a tandem DH/PH domain closely related to those of Rho-specific GEFs, a PDZ domain, a proline-rich domain, and an area of homology to Lsc, p115-RhoGEF, and a Drosophila RhoGEF that was termed Lsc-homology (LH) domain.
T6 803-980 Sentence denotes This novel molecule, designated PDZ-RhoGEF, activated biological and biochemical pathways specific for Rho, and activation of these pathways required an intact DH and PH domain.
T7 981-1150 Sentence denotes However, the PDZ domain was dispensable for these functions, and mutants lacking the LH domain were more active, suggesting a negative regulatory role for the LH domain.
T8 1151-1348 Sentence denotes A search for additional molecules exhibiting an LH domain revealed a limited homology with the catalytic region of a newly identified GTPase-activating protein for heterotrimeric G proteins, RGS14.
T9 1349-1468 Sentence denotes This prompted us to investigate whether PDZ-RhoGEF could interact with representative members of each G protein family.
T10 1469-1658 Sentence denotes We found that PDZ-RhoGEF was able to form, in vivo, stable complexes with two members of the Galpha12 family, Galpha12 and Galpha13, and that this interaction was mediated by the LH domain.
T11 1659-1776 Sentence denotes Furthermore, we obtained evidence to suggest that PDZ-RhoGEF mediates the activation of Rho by Galpha12 and Galpha13.
T12 1777-2105 Sentence denotes Together, these findings suggest the existence of a novel mechanism whereby the large family of cell surface receptors that transmit signals through heterotrimeric G proteins activate Rho-dependent pathways: by stimulating the activity of members of the Galpha12 family which, in turn, activate an exchange factor acting on Rho.

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 30-64 protein denotes guanine nucleotide exchange factor
T2 71-96 protein denotes heterotrimeric G proteins
T3 100-103 protein denotes Rho
T4 105-149 protein denotes Small GTP-binding proteins of the Rho family
T5 336-339 protein denotes Dbl
T6 351-390 protein denotes Rho guanine nucleotide exchange factors
T7 392-396 protein denotes GEFs
T8 453-456 protein denotes GEF
T9 461-464 protein denotes Rho
T10 473-480 protein denotes GTPases
T11 636-653 protein denotes Rho-specific GEFs
T12 719-722 protein denotes Lsc
T13 724-735 protein denotes p115-RhoGEF
T14 754-760 protein denotes RhoGEF
T15 777-780 protein denotes Lsc
T16 835-845 protein denotes PDZ-RhoGEF
T17 906-909 protein denotes Rho
T18 1285-1310 protein denotes GTPase-activating protein
T19 1315-1340 protein denotes heterotrimeric G proteins
T20 1342-1347 protein denotes RGS14
T21 1389-1399 protein denotes PDZ-RhoGEF
T22 1451-1467 protein denotes G protein family
T23 1483-1493 protein denotes PDZ-RhoGEF
T24 1562-1577 protein denotes Galpha12 family
T25 1579-1587 protein denotes Galpha12
T26 1592-1600 protein denotes Galpha13
T27 1709-1719 protein denotes PDZ-RhoGEF
T28 1747-1750 protein denotes Rho
T29 1754-1762 protein denotes Galpha12
T30 1767-1775 protein denotes Galpha13
T31 1926-1951 protein denotes heterotrimeric G proteins
T32 1961-1964 protein denotes Rho
T33 2031-2046 protein denotes Galpha12 family
T34 2075-2090 protein denotes exchange factor
T35 2101-2104 protein denotes Rho

bionlp-st-gro-2013-training

Id Subject Object Predicate Lexical cue
T1 8-18 ProteinDomain denotes PDZ domain
T4 71-96 Protein denotes heterotrimeric G proteins
T5 100-103 Protein denotes Rho
T9 139-142 Protein denotes Rho
T12 273-285 CellComponent denotes cell surface
T13 286-295 Protein denotes receptors
T14 336-347 ProteinDomain denotes Dbl domains
T15 351-390 Protein denotes Rho guanine nucleotide exchange factors
T16 392-396 Protein denotes GEFs
T17 408-411 DNA denotes DNA
T18 447-452 Eukaryote denotes human
T19 453-456 Protein denotes GEF
T20 461-464 Protein denotes Rho
T21 473-480 Enzyme denotes GTPases
T22 568-575 Protein denotes protein
T23 595-607 ProteinDomain denotes DH/PH domain
T24 636-639 Protein denotes Rho
T25 649-653 Protein denotes GEFs
T26 657-667 ProteinDomain denotes PDZ domain
T27 671-690 ProteinDomain denotes proline-rich domain
T28 719-722 Protein denotes Lsc
T29 724-735 Protein denotes p115-RhoGEF
T30 743-753 Eukaryote denotes Drosophila
T31 754-760 Protein denotes RhoGEF
T32 791-793 ProteinDomain denotes LH
T33 835-845 Protein denotes PDZ-RhoGEF
T35 906-909 Protein denotes Rho
T37 963-965 ProteinDomain denotes DH
T38 970-979 ProteinDomain denotes PH domain
T39 994-1004 ProteinDomain denotes PDZ domain
T40 1046-1053 MutantProtein denotes mutants
T41 1066-1075 ProteinDomain denotes LH domain
T44 1140-1149 ProteinDomain denotes LH domain
T45 1199-1208 ProteinDomain denotes LH domain
T49 1315-1340 Protein denotes heterotrimeric G proteins
T50 1342-1347 Protein denotes RGS14
T51 1389-1399 Protein denotes PDZ-RhoGEF
T53 1451-1460 Protein denotes G protein
T54 1483-1493 Protein denotes PDZ-RhoGEF
T55 1562-1570 Protein denotes Galpha12
T56 1579-1587 Protein denotes Galpha12
T57 1592-1600 Protein denotes Galpha13
T60 1648-1657 ProteinDomain denotes LH domain
T61 1709-1719 Protein denotes PDZ-RhoGEF
T64 1747-1750 Protein denotes Rho
T65 1754-1762 Protein denotes Galpha12
T66 1767-1775 Protein denotes Galpha13
T67 1873-1885 CellComponent denotes cell surface
T68 1886-1895 Protein denotes receptors
T69 1926-1951 Protein denotes heterotrimeric G proteins
T73 2031-2039 Protein denotes Galpha12
T76 2101-2104 Protein denotes Rho
T2 30-64 Protein denotes guanine nucleotide exchange factor
T3 105-131 Protein denotes Small GTP-binding proteins
T6 699-703 ProteinDomain denotes area
T43 1285-1310 Protein denotes GTPase-activating protein
T46 1528-1537 ProteinComplex denotes complexes
T71 2075-2090 Protein denotes exchange factor
E2 174-193 SignalingPathway denotes signal transduction
E3 260-269 PositiveRegulation denotes activated
E4 847-856 PositiveRegulation denotes activated
E5 915-925 PositiveRegulation denotes activation
E8 1406-1414 BindingToProtein denotes interact
E9 1616-1627 BindingToProtein denotes interaction
E10 1632-1640 RegulatoryProcess denotes mediated
E11 1720-1728 RegulatoryProcess denotes mediates
E12 1733-1743 PositiveRegulation denotes activation
E13 1952-1960 PositiveRegulation denotes activate
E14 1988-1999 Increase denotes stimulating
E15 2063-2071 PositiveRegulation denotes activate
E1 857-892 Pathway denotes biological and biochemical pathways
E6 1107-1126 NegativeRegulation denotes negative regulatory
E16 935-943 Pathway denotes pathways
E7 1901-1917 SignalingPathway denotes transmit signals
E17 1961-1983 SignalingPathway denotes Rho-dependent pathways
E18 1733-1743 PositiveRegulation denotes activation
E19 1720-1728 RegulatoryProcess denotes mediates
R1 T13 T12 locatedIn receptors,cell surface
R3 T19 T18 fromSpecies GEF,human
R6 T22 T23 hasPart protein,DH/PH domain
R7 T22 T26 hasPart protein,PDZ domain
R8 T22 T27 hasPart protein,proline-rich domain
R9 T31 T30 fromSpecies RhoGEF,Drosophila
R10 T68 T67 locatedIn receptors,cell surface
R13 T2 T1 hasPart guanine nucleotide exchange factor,PDZ domain
R2 T15 T14 hasPart Rho guanine nucleotide exchange factors,Dbl domains
R4 T22 T6 hasPart protein,area
R5 T46 T54 hasPart complexes,PDZ-RhoGEF
R14 T46 T56 hasPart complexes,Galpha12
R15 T46 T57 hasPart complexes,Galpha13
R17 T13 E3 hasAgent receptors,activated
R18 T33 E4 hasAgent PDZ-RhoGEF,activated
R19 E1 E4 hasPatient biological and biochemical pathways,activated
R20 E16 E5 hasPatient pathways,activation
R21 T53 E8 hasPatient G protein,interact
R22 T51 E8 hasPatient PDZ-RhoGEF,interact
R23 T60 E10 hasAgent LH domain,mediated
R24 E9 E10 hasPatient interaction,mediated
R25 T61 E11 hasAgent PDZ-RhoGEF,mediates
R26 E12 E11 hasPatient activation,mediates
R27 T65 E12 hasAgent Galpha12,activation
R28 T64 E12 hasPatient Rho,activation
R29 T68 E13 hasAgent receptors,activate
R30 E17 E13 hasPatient Rho-dependent pathways,activate
R31 T73 E14 hasPatient Galpha12,stimulating
R32 T71 E15 hasPatient exchange factor,activate
R33 T35 E1 hasPatient Rho,biological and biochemical pathways
R34 T44 E6 hasAgent LH domain,negative regulatory
R35 T69 E7 hasAgent heterotrimeric G proteins,transmit signals
R36 T66 E18 hasAgent Galpha13,activation
R37 T64 E18 hasPatient Rho,activation
R38 T61 E19 hasAgent PDZ-RhoGEF,mediates
R39 E18 E19 hasPatient activation,mediates

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 392-396 Disease denotes GEFs http://purl.obolibrary.org/obo/MONDO_0018214
T2 649-653 Disease denotes GEFs http://purl.obolibrary.org/obo/MONDO_0018214

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 447-452 OrganismTaxon denotes human 9606
T2 743-753 OrganismTaxon denotes Drosophila 2081351|32281|7215