PubMed:10026206
Annnotations
Inflammaging
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-95 | Sentence | denotes | CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway. |
| T2 | 96-162 | Sentence | denotes | A target of interleukin (il)-4 and il-10 anti-inflammatory action. |
| T3 | 163-418 | Sentence | denotes | Ligation of CD40 on monocytes through its interaction with CD40 ligand (CD154) present on activated T helper cells, results in activation of monocyte inflammatory cytokine synthesis and rescue of monocytes from apoptosis induced through serum deprivation. |
| T4 | 419-551 | Sentence | denotes | Both of these consequences of CD40 stimulation have been shown to be dependent on the induction of protein tyrosine kinase activity. |
| T5 | 552-784 | Sentence | denotes | CD40-mediated activation of protein tyrosine kinase activity and subsequent inflammatory cytokine production are abrogated by treatment of monocytes with the T helper type 2 cytokines interleukin 4 (IL-4) and interleukin 10 (IL-10). |
| T6 | 785-1192 | Sentence | denotes | In the current study we demonstrate that stimulation of monocytes through CD40 resulted in the phosphorylation and activation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) mitogen-activated protein kinases, whereas phosphorylation of mitogen-activated protein kinases family members p38 and c-Jun N-terminal kinase was not observed in response to this stimuli over the time course examined. |
| T7 | 1193-1370 | Sentence | denotes | PD98059, an inhibitor of the upstream activator of ERK1/2, the MAP/ERK kinase MEK1/2, suppressed IL-1beta and tumor necrosis factor-alpha production in a dose-dependent fashion. |
| T8 | 1371-1561 | Sentence | denotes | Pretreatment of monocytes with IL-4 and IL-10 inhibited CD40-mediated activation of ERK1/2 kinase activity when used individually, and are enhanced in effectiveness when used in combination. |
| T9 | 1562-1788 | Sentence | denotes | Together, the data demonstrate that CD40-mediated induction of IL-1beta and tumor necrosis factor-alpha synthesis is dependent on a MEK/ERK pathway which is obstructed by signals generated through the action of IL-4 and IL-10. |
| T1 | 0-95 | Sentence | denotes | CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway. |
| T2 | 96-162 | Sentence | denotes | A target of interleukin (il)-4 and il-10 anti-inflammatory action. |
| T3 | 163-418 | Sentence | denotes | Ligation of CD40 on monocytes through its interaction with CD40 ligand (CD154) present on activated T helper cells, results in activation of monocyte inflammatory cytokine synthesis and rescue of monocytes from apoptosis induced through serum deprivation. |
| T4 | 419-551 | Sentence | denotes | Both of these consequences of CD40 stimulation have been shown to be dependent on the induction of protein tyrosine kinase activity. |
| T5 | 552-784 | Sentence | denotes | CD40-mediated activation of protein tyrosine kinase activity and subsequent inflammatory cytokine production are abrogated by treatment of monocytes with the T helper type 2 cytokines interleukin 4 (IL-4) and interleukin 10 (IL-10). |
| T6 | 785-1192 | Sentence | denotes | In the current study we demonstrate that stimulation of monocytes through CD40 resulted in the phosphorylation and activation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) mitogen-activated protein kinases, whereas phosphorylation of mitogen-activated protein kinases family members p38 and c-Jun N-terminal kinase was not observed in response to this stimuli over the time course examined. |
| T7 | 1193-1370 | Sentence | denotes | PD98059, an inhibitor of the upstream activator of ERK1/2, the MAP/ERK kinase MEK1/2, suppressed IL-1beta and tumor necrosis factor-alpha production in a dose-dependent fashion. |
| T8 | 1371-1561 | Sentence | denotes | Pretreatment of monocytes with IL-4 and IL-10 inhibited CD40-mediated activation of ERK1/2 kinase activity when used individually, and are enhanced in effectiveness when used in combination. |
| T9 | 1562-1788 | Sentence | denotes | Together, the data demonstrate that CD40-mediated induction of IL-1beta and tumor necrosis factor-alpha synthesis is dependent on a MEK/ERK pathway which is obstructed by signals generated through the action of IL-4 and IL-10. |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-95 | Sentence | denotes | CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway. |
| T2 | 96-162 | Sentence | denotes | A target of interleukin (il)-4 and il-10 anti-inflammatory action. |
| T3 | 163-418 | Sentence | denotes | Ligation of CD40 on monocytes through its interaction with CD40 ligand (CD154) present on activated T helper cells, results in activation of monocyte inflammatory cytokine synthesis and rescue of monocytes from apoptosis induced through serum deprivation. |
| T4 | 419-551 | Sentence | denotes | Both of these consequences of CD40 stimulation have been shown to be dependent on the induction of protein tyrosine kinase activity. |
| T5 | 552-784 | Sentence | denotes | CD40-mediated activation of protein tyrosine kinase activity and subsequent inflammatory cytokine production are abrogated by treatment of monocytes with the T helper type 2 cytokines interleukin 4 (IL-4) and interleukin 10 (IL-10). |
| T6 | 785-1192 | Sentence | denotes | In the current study we demonstrate that stimulation of monocytes through CD40 resulted in the phosphorylation and activation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) mitogen-activated protein kinases, whereas phosphorylation of mitogen-activated protein kinases family members p38 and c-Jun N-terminal kinase was not observed in response to this stimuli over the time course examined. |
| T7 | 1193-1370 | Sentence | denotes | PD98059, an inhibitor of the upstream activator of ERK1/2, the MAP/ERK kinase MEK1/2, suppressed IL-1beta and tumor necrosis factor-alpha production in a dose-dependent fashion. |
| T8 | 1371-1561 | Sentence | denotes | Pretreatment of monocytes with IL-4 and IL-10 inhibited CD40-mediated activation of ERK1/2 kinase activity when used individually, and are enhanced in effectiveness when used in combination. |
| T9 | 1562-1788 | Sentence | denotes | Together, the data demonstrate that CD40-mediated induction of IL-1beta and tumor necrosis factor-alpha synthesis is dependent on a MEK/ERK pathway which is obstructed by signals generated through the action of IL-4 and IL-10. |
2015-BEL-Sample-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| BEL:20040926 | 1572-1786 | p(HGNC:CD40) increases p(HGNC:IL1B) | denotes | the data demonstrate that CD40-mediated induction of IL-1beta and tumor necrosis factor-alpha synthesis is dependent on a MEK/ERK pathway which is obstructed by signals generated through the action of IL-4 and IL-1 |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1303-1308 | HP_0002664 | denotes | tumor |
| T2 | 1638-1643 | HP_0002664 | denotes | tumor |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1303-1308 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T2 | 1638-1643 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 1303-1308 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 1638-1643 | Phenotype | denotes | tumor | HP:0002664 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 18-26 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T3 | 183-192 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T5 | 304-312 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T7 | 359-368 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T9 | 691-700 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T11 | 841-850 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T13 | 918-931 | Body_part | denotes | extracellular | http://purl.obolibrary.org/obo/GO_0005576 |
| T14 | 1387-1396 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
Glycosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 18-26 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T3 | 183-192 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T5 | 263-277 | Cell | denotes | T helper cells | http://purl.obolibrary.org/obo/CL:0000912 |
| T6 | 304-312 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T8 | 359-368 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T10 | 691-700 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T12 | 841-850 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T14 | 1387-1396 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |