PMC:8275828 / 36128-37162 JSONTXT

{"project":"TEST0","denotations":[{"id":"34268331-238-243-887419","span":{"begin":515,"end":516},"obj":"[\"25770254\"]"},{"id":"34268331-230-236-887420","span":{"begin":518,"end":520},"obj":"[\"23670794\"]"},{"id":"34268331-234-240-887421","span":{"begin":522,"end":524},"obj":"[\"20305128\"]"},{"id":"34268331-233-239-887422","span":{"begin":832,"end":834},"obj":"[\"26195103\", \"11124739\", \"27375409\"]"}],"text":"In summary, this report is the first to adopt a multivariate analysis approach to address the co-existence of nutrients and dietary compounds in the brain when investigating the relationship between nutrition and cognitive function in an aging population. Our findings support beneficial effects of a NP higher in carotenoids potentially derived from a diet rich in fruits and vegetables similar to the MeDi and DASH diets, on lowering the risk of age-related cognitive impairment and dementia previously reported (2, 93, 94). As compared to symptoms of nutritional deficiency which could be caused by an inadequate intake of one single nutrient and manifest within a short period of time, we are aware of the need to assess diet as a dietary pattern or NP in a context of complex outcomes such as age-related cognitive impairment (20–22). The synergistic and cumulative effect of nutrients on a person's risk of chronic diseases have recently been highlighted in the Dietary Guidelines for Americans 2015–2020 and 2020–2025 (96, 97)."}