PMC:8275828 / 23139-24350 JSONTXT

{"project":"TEST0","denotations":[{"id":"34268331-159-165-887376","span":{"begin":548,"end":550},"obj":"[\"23421635\"]"}],"text":"The time interval between the cognitive assessment at the time point closest to death and the autopsy was \u003c1 year for all subjects with an average of 156 (93) days for those whose data could be accurately calculated (81%). Subjects with GDS 1–3 had significantly higher MMSE scores than those with GDS 4–7 (p \u003c 0.001). Similarly, SIB score was higher in subjects with GDS 1–3 (p \u003c 0.001). Therefore, GDS effectively separated subjects based on their performance on global cognition as also previously reported in the original GCS cohort (n = 244) (56). Further, the composite scores for cognitive domains, depression, and activities of daily living had been calculated (Supplementary Table 3). Subjects with GDS 1–3 had significantly higher composite scores on all six cognitive domains and activities of daily living, and significantly lower scores on depression (less depression). Of note, while composite scores for other cognitive domains were available for all subjects, visuospatial function score was available for 87% of participants without dementia and 50% of participants with dementia, and attention score was available for 70% of participants without demented and 46% of participants with dementia."}