PMC:7799378 / 21832-22448 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7799378","sourcedb":"PMC","sourceid":"7799378","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7799378","text":"The severity of COVID-19 is influenced by genetic variants of G6PD in humans, which is related to an impaired immune response [111]. It has been predicted that COVID-19 will spread more widely in areas or countries with a high prevalence of G6PD deficiency. This concern poses a serious challenge to treat COVID-19 in G6PD-deficient patients. Severe G6PD deficiency is associated with an altered immune response, including NET formation, inflammasome activation, and bactericidal activity as well as an antiviral response [9–11,42,85,95,110]. Hence, G6PD deficiency presents a challenge during the COVID-19 pandemic.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"877","span":{"begin":62,"end":66},"obj":"Gene"},{"id":"878","span":{"begin":70,"end":76},"obj":"Species"},{"id":"879","span":{"begin":333,"end":341},"obj":"Species"},{"id":"880","span":{"begin":16,"end":24},"obj":"Disease"},{"id":"881","span":{"begin":160,"end":168},"obj":"Disease"},{"id":"882","span":{"begin":241,"end":256},"obj":"Disease"},{"id":"883","span":{"begin":306,"end":314},"obj":"Disease"},{"id":"884","span":{"begin":318,"end":332},"obj":"Disease"},{"id":"885","span":{"begin":350,"end":365},"obj":"Disease"},{"id":"886","span":{"begin":550,"end":565},"obj":"Disease"},{"id":"887","span":{"begin":598,"end":606},"obj":"Disease"}],"attributes":[{"id":"A877","pred":"tao:has_database_id","subj":"877","obj":"Gene:2539"},{"id":"A878","pred":"tao:has_database_id","subj":"878","obj":"Tax:9606"},{"id":"A879","pred":"tao:has_database_id","subj":"879","obj":"Tax:9606"},{"id":"A880","pred":"tao:has_database_id","subj":"880","obj":"MESH:C000657245"},{"id":"A881","pred":"tao:has_database_id","subj":"881","obj":"MESH:C000657245"},{"id":"A882","pred":"tao:has_database_id","subj":"882","obj":"MESH:D005955"},{"id":"A883","pred":"tao:has_database_id","subj":"883","obj":"MESH:C000657245"},{"id":"A884","pred":"tao:has_database_id","subj":"884","obj":"MESH:D005955"},{"id":"A885","pred":"tao:has_database_id","subj":"885","obj":"MESH:D005955"},{"id":"A886","pred":"tao:has_database_id","subj":"886","obj":"MESH:D005955"},{"id":"A887","pred":"tao:has_database_id","subj":"887","obj":"MESH:C000657245"},{"subj":"877","pred":"source","obj":"LitCovid-PubTator"},{"subj":"878","pred":"source","obj":"LitCovid-PubTator"},{"subj":"879","pred":"source","obj":"LitCovid-PubTator"},{"subj":"880","pred":"source","obj":"LitCovid-PubTator"},{"subj":"881","pred":"source","obj":"LitCovid-PubTator"},{"subj":"882","pred":"source","obj":"LitCovid-PubTator"},{"subj":"883","pred":"source","obj":"LitCovid-PubTator"},{"subj":"884","pred":"source","obj":"LitCovid-PubTator"},{"subj":"885","pred":"source","obj":"LitCovid-PubTator"},{"subj":"886","pred":"source","obj":"LitCovid-PubTator"},{"subj":"887","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T175","span":{"begin":0,"end":132},"obj":"Sentence"},{"id":"T176","span":{"begin":133,"end":257},"obj":"Sentence"},{"id":"T177","span":{"begin":258,"end":342},"obj":"Sentence"},{"id":"T178","span":{"begin":343,"end":542},"obj":"Sentence"},{"id":"T179","span":{"begin":543,"end":616},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T175","pred":"source","obj":"LitCovid-sentences"},{"subj":"T176","pred":"source","obj":"LitCovid-sentences"},{"subj":"T177","pred":"source","obj":"LitCovid-sentences"},{"subj":"T178","pred":"source","obj":"LitCovid-sentences"},{"subj":"T179","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#e0ec93","default":true},{"id":"LitCovid-sentences","color":"#de93ec"}]}]}}