PMC:7799377 / 36441-37392 JSONTXT

{"project":"LitCovid-sentences","denotations":[{"id":"T245","span":{"begin":0,"end":220},"obj":"Sentence"},{"id":"T246","span":{"begin":221,"end":348},"obj":"Sentence"},{"id":"T247","span":{"begin":349,"end":490},"obj":"Sentence"},{"id":"T248","span":{"begin":491,"end":643},"obj":"Sentence"},{"id":"T249","span":{"begin":644,"end":773},"obj":"Sentence"},{"id":"T250","span":{"begin":774,"end":951},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"It has been postulated that the neuroinvasion of the brain’s medulla oblongata region by the SARS-CoV-2 virus might impair cardiorespiratory control centers and, in that way, lead to respiratory distress and failure [4]. The literature reports a COVID-19 patient who lost the involuntary process of breathing and suffered respiratory failure [115]. ACE-2 receptors are expressed abundantly in the body, even in the brain, and particularly in the brain stem which controls respiration [116]. In the event that the SARS-CoV-2 virus might enter the microcirculatory system of the brain, it may access ACE-2 receptors in the capillary endothelium. In such a situation, the virus can cause damage to the endothelium itself, enter the brain, and cause neuronal destruction [116]. Better understanding is urgently needed to elucidate the role of the SARS-CoV-2 virus in the brain and to risk-stratify patients who may be suffering COVID-related brain damage."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T176","span":{"begin":183,"end":203},"obj":"Phenotype"},{"id":"T177","span":{"begin":322,"end":341},"obj":"Phenotype"}],"attributes":[{"id":"A176","pred":"hp_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A177","pred":"hp_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/HP_0002878"}],"text":"It has been postulated that the neuroinvasion of the brain’s medulla oblongata region by the SARS-CoV-2 virus might impair cardiorespiratory control centers and, in that way, lead to respiratory distress and failure [4]. The literature reports a COVID-19 patient who lost the involuntary process of breathing and suffered respiratory failure [115]. ACE-2 receptors are expressed abundantly in the body, even in the brain, and particularly in the brain stem which controls respiration [116]. In the event that the SARS-CoV-2 virus might enter the microcirculatory system of the brain, it may access ACE-2 receptors in the capillary endothelium. In such a situation, the virus can cause damage to the endothelium itself, enter the brain, and cause neuronal destruction [116]. Better understanding is urgently needed to elucidate the role of the SARS-CoV-2 virus in the brain and to risk-stratify patients who may be suffering COVID-related brain damage."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1294","span":{"begin":598,"end":603},"obj":"Gene"},{"id":"1295","span":{"begin":93,"end":103},"obj":"Species"},{"id":"1296","span":{"begin":255,"end":262},"obj":"Species"},{"id":"1297","span":{"begin":513,"end":523},"obj":"Species"},{"id":"1298","span":{"begin":843,"end":853},"obj":"Species"},{"id":"1299","span":{"begin":894,"end":902},"obj":"Species"},{"id":"1300","span":{"begin":183,"end":215},"obj":"Disease"},{"id":"1301","span":{"begin":246,"end":254},"obj":"Disease"},{"id":"1302","span":{"begin":322,"end":341},"obj":"Disease"},{"id":"1303","span":{"begin":924,"end":950},"obj":"Disease"}],"attributes":[{"id":"A1294","pred":"tao:has_database_id","subj":"1294","obj":"Gene:59272"},{"id":"A1295","pred":"tao:has_database_id","subj":"1295","obj":"Tax:2697049"},{"id":"A1296","pred":"tao:has_database_id","subj":"1296","obj":"Tax:9606"},{"id":"A1297","pred":"tao:has_database_id","subj":"1297","obj":"Tax:2697049"},{"id":"A1298","pred":"tao:has_database_id","subj":"1298","obj":"Tax:2697049"},{"id":"A1299","pred":"tao:has_database_id","subj":"1299","obj":"Tax:9606"},{"id":"A1300","pred":"tao:has_database_id","subj":"1300","obj":"MESH:D012131"},{"id":"A1301","pred":"tao:has_database_id","subj":"1301","obj":"MESH:C000657245"},{"id":"A1302","pred":"tao:has_database_id","subj":"1302","obj":"MESH:D012131"},{"id":"A1303","pred":"tao:has_database_id","subj":"1303","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"It has been postulated that the neuroinvasion of the brain’s medulla oblongata region by the SARS-CoV-2 virus might impair cardiorespiratory control centers and, in that way, lead to respiratory distress and failure [4]. The literature reports a COVID-19 patient who lost the involuntary process of breathing and suffered respiratory failure [115]. ACE-2 receptors are expressed abundantly in the body, even in the brain, and particularly in the brain stem which controls respiration [116]. In the event that the SARS-CoV-2 virus might enter the microcirculatory system of the brain, it may access ACE-2 receptors in the capillary endothelium. In such a situation, the virus can cause damage to the endothelium itself, enter the brain, and cause neuronal destruction [116]. Better understanding is urgently needed to elucidate the role of the SARS-CoV-2 virus in the brain and to risk-stratify patients who may be suffering COVID-related brain damage."}