PMC:7796072 / 12841-13849 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"359","span":{"begin":323,"end":326},"obj":"Gene"},{"id":"360","span":{"begin":473,"end":488},"obj":"Gene"},{"id":"361","span":{"begin":911,"end":914},"obj":"Gene"},{"id":"362","span":{"begin":46,"end":54},"obj":"Disease"},{"id":"363","span":{"begin":158,"end":169},"obj":"Disease"},{"id":"364","span":{"begin":222,"end":229},"obj":"Disease"},{"id":"365","span":{"begin":386,"end":394},"obj":"Disease"},{"id":"366","span":{"begin":395,"end":404},"obj":"Disease"},{"id":"367","span":{"begin":585,"end":593},"obj":"Disease"},{"id":"368","span":{"begin":594,"end":603},"obj":"Disease"},{"id":"369","span":{"begin":674,"end":681},"obj":"Disease"}],"attributes":[{"id":"A359","pred":"tao:has_database_id","subj":"359","obj":"Gene:28"},{"id":"A360","pred":"tao:has_database_id","subj":"360","obj":"Gene:28"},{"id":"A361","pred":"tao:has_database_id","subj":"361","obj":"Gene:3046"},{"id":"A362","pred":"tao:has_database_id","subj":"362","obj":"MESH:C000657245"},{"id":"A363","pred":"tao:has_database_id","subj":"363","obj":"MESH:D013789"},{"id":"A364","pred":"tao:has_database_id","subj":"364","obj":"MESH:D008288"},{"id":"A365","pred":"tao:has_database_id","subj":"365","obj":"MESH:C000657245"},{"id":"A366","pred":"tao:has_database_id","subj":"366","obj":"MESH:D007239"},{"id":"A367","pred":"tao:has_database_id","subj":"367","obj":"MESH:C000657245"},{"id":"A368","pred":"tao:has_database_id","subj":"368","obj":"MESH:D007239"},{"id":"A369","pred":"tao:has_database_id","subj":"369","obj":"MESH:D008288"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The hypothesized conferred protection against COVID-19 could also derive from local SE Asian HLA-class allotypes, possibly in linkage disequilibrium with the thalassemia mutations. Protection from and resistance to severe malaria has been described in association with HLA antigens in the African continent [54,55] and the ABO blood group system [56]. However, no HLA associations with COVID-19 infection have been noted in a recent report [57] but an association with the ABO blood group system was confirmed, with bearers of the blood group A phenotype showing an increased risk for COVID-19 infection compared to blood group O [58]. The O phenotype appears protective to malaria [56] and its worldwide distribution seems to have been shaped by the parasite’s selective genetic pressure [56]. The frequency of the O blood group in Thailand is 40.5% [59] and its relatively high prevalence along with the high HbE heterozygote frequency could further potentiate the hypothesized antiviral protective effect."}

{"project":"LitCovid-sentences","denotations":[{"id":"T83","span":{"begin":0,"end":180},"obj":"Sentence"},{"id":"T84","span":{"begin":181,"end":351},"obj":"Sentence"},{"id":"T85","span":{"begin":352,"end":635},"obj":"Sentence"},{"id":"T86","span":{"begin":636,"end":794},"obj":"Sentence"},{"id":"T87","span":{"begin":795,"end":1008},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The hypothesized conferred protection against COVID-19 could also derive from local SE Asian HLA-class allotypes, possibly in linkage disequilibrium with the thalassemia mutations. Protection from and resistance to severe malaria has been described in association with HLA antigens in the African continent [54,55] and the ABO blood group system [56]. However, no HLA associations with COVID-19 infection have been noted in a recent report [57] but an association with the ABO blood group system was confirmed, with bearers of the blood group A phenotype showing an increased risk for COVID-19 infection compared to blood group O [58]. The O phenotype appears protective to malaria [56] and its worldwide distribution seems to have been shaped by the parasite’s selective genetic pressure [56]. The frequency of the O blood group in Thailand is 40.5% [59] and its relatively high prevalence along with the high HbE heterozygote frequency could further potentiate the hypothesized antiviral protective effect."}